Project measure / variable:   Rusyn2   ALT_2_tce

ID, description, units MPD:36117   ALT_2_tce   alanine transaminase (serum ALT), treated group   [IU/L]  2h after treatment  
trichloroethylene study
Data set, strains Rusyn2   inbred   16 strains     sex: m     age: 7wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Rusyn2 - alanine transaminase (serum ALT), treated group 2h after treatment



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested16 strains
Mean of the strain means59.2   IU/L
Median of the strain means56.1   IU/L
SD of the strain means± 32.2
Coefficient of variation (CV)0.544
Min–max range of strain means27.4   –   159   IU/L
Mean sample size per strain3.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 15 46536.8149 3102.4543 2.5082 0.0149
Residuals 31 38345.08 1236.9381


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 27.4 5.66   3 3.27 0.207 21.5, 32.8 -0.99
A/J m 159.0 93.2   3 53.8 0.587 62.9, 249.0 3.1
AKR/J m 56.4 3.08   3 1.78 0.0546 52.9, 58.7 -0.09
B6C3F1/J m 37.7 22.5   3 13.0 0.596 17.4, 61.9 -0.67
BALB/cByJ m 55.9 14.4   3 8.31 0.257 42.2, 70.9 -0.1
BTBR T+ Itpr3tf/J m 31.1 15.4   3 8.88 0.495 13.3, 40.0 -0.87
C3H/HeJ m 58.8 19.8   3 11.4 0.337 42.5, 80.9 -0.01
C57BL/6J m 60.3 26.3   2   18.6 0.436 41.7, 78.9 0.03
CAST/EiJ m 45.9 11.6   3 6.71 0.253 32.6, 54.2 -0.41
DBA/2J m 30.0 6.92   3 4.0 0.231 25.0, 37.9 -0.91
FVB/NJ m 85.8 53.9   3 31.1 0.628 52.2, 148.0 0.83
KK/HlJ m 42.2 9.58   3 5.53 0.227 31.3, 49.4 -0.53
MOLF/EiJ m 87.0 15.2   3 8.76 0.175 70.3, 100.0 0.86
NOD/ShiLtJ m 61.2 22.1   3 12.8 0.362 47.6, 86.7 0.06
NZW/LacJ m 38.7 3.82   3 2.21 0.0987 34.4, 41.7 -0.64
PWD/PhJ m 69.9 69.6   3 40.2 0.996 23.6, 150.0 0.33


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 27.3667 20.3055 68.78 0.0
A/J m 158.6333 20.3055 200.0466 117.22
AKR/J m 56.4 20.3055 97.8133 14.9867
B6C3F1/J m 37.7333 20.3055 79.1466 0.0
BALB/cByJ m 55.9333 20.3055 97.3466 14.52
BTBR T+ Itpr3tf/J m 31.0667 20.3055 72.48 0.0
C3H/HeJ m 58.8333 20.3055 100.2466 17.42
C57BL/6J m 60.3 24.869 111.0207 9.5793
CAST/EiJ m 45.8667 20.3055 87.28 4.4534
DBA/2J m 30.0 20.3055 71.4133 0.0
FVB/NJ m 85.8333 20.3055 127.2466 44.42
KK/HlJ m 42.1667 20.3055 83.58 0.7534
MOLF/EiJ m 86.9667 20.3055 128.38 45.5534
NOD/ShiLtJ m 61.1667 20.3055 102.58 19.7534
NZW/LacJ m 38.7 20.3055 80.1133 0.0
PWD/PhJ m 69.9333 20.3055 111.3466 28.52




  GWAS USING LINEAR MIXED MODELS