MPD: Project measures / variables set: Maurer1 QTc

Project measures / variables set: Maurer1 QTc_area

ID, description, units	MPD:33261 QTc_area area of QTc [ms*mV] atenolol, isoproterenol study
Measures	• control • atenolol 10mg • isoprot 1mg • isoprot 10mg
Data set, strains	Maurer1 inbred 23 strains sex: m age: 7-13wks
Procedure	ECG
Comparison	control group vs. multiple treatment / dosage groups
Ontology mappings	VT:0000231 heart excitatory physiology trait VT:0010487 response to xenobiotic stimulus trait MA:0000072 heart MP:0008872 abnormal physiological response to xenobiotic MP:0003899 abnormal QT interval

Values Means Δ Means Z-scores

Graph Type Points Bars

Dimensions Width: × Height: px

Plot Options Hide Error Bars Strains on X-axis

Data Type:

Dimensions Height: px

Toggle Series

Plot Options Show Standard Error Show Point Labels Flip Axes Shared Tooltip Connect Gaps

Advanced Plot Options

Separate Plot Factor(s)

Legend Factor(s)

X-Axis Factor(s)

Include/Exclude Factor Values

Maurer1 - area of QTc

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
group	3	336.1876	112.0625	2.1135	0.0971
strain	22	11766.5441	534.8429	10.0873	< 0.0001
group:strain	66	5686.6982	86.1621	1.625	0.0017
Residuals	804	42629.2156	53.0214

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Maurer1	33261	ECG	atenolol, isoproterenol	area of QTc [ms*mV] control QTc_area_ctrl	inbred	23	m	7-13wks
Maurer1	33262	ECG	atenolol, isoproterenol	area of QTc [ms*mV] atenolol 10mg QTc_area_at	inbred	23	m	7-13wks
Maurer1	33263	ECG	atenolol, isoproterenol	area of QTc [ms*mV] isoprot 1mg QTc_area_iso1	inbred	23	m	7-13wks
Maurer1	33264	ECG	atenolol, isoproterenol	area of QTc [ms*mV] isoprot 10mg QTc_area_iso10	inbred	23	m	7-13wks