Maurer1: Drug study: Cardiovascular response to beta-adrenergic blockade or activation in males of 23 inbred strains of mice (2009)

Berthonneche C, Peter B, Schüpfer F, Hayoz P, Kutalik Z, Abriel H, Pedrazzini T, Beckmann JS, Bergmann S, Maurer F. Cardiovascular response to beta-adrenergic blockade or activation in 23 inbred mouse strains. PLoS One. 2009 Aug 12;4(8):e6610.   PubMed 19672458     FullText


       
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Participants Fabienne Maurer       University of Lausanne Lausanne SWITZERLAND
Jacques Beckmann       University of Lausanne Lausanne SWITZERLAND
Hugues Abriel       University of Lausanne Lausanne SWITZERLAND
Thierry Pedrazzini       University of Lausanne Lausanne SWITZERLAND
With: Berthonneche C, Peter B, Schüpfer F, Hayoz P, Kutalik Z, Bergmann S,
ContactFabienne Maurer     fabienne.maurer@chuv.ch     Lab web site
AcknowledgementsFunding provided by Centre Hospitalier Universitaire Vaudois, University of Lausanne, Swiss National Science Foundation, Giorgi-Cavaglieri Foundation
Project type Phenotype strain survey data set
MPD identifiersMaurer1     MPD:332
Data changelog No updates/corrections.       Initial release date: 03/2010.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An investigation of the cardiovascular effect of a β-adrenergic receptor blocker and a β-agonist in four treatment group cohorts: (1) Control; (2) Treated with 10 mg/kg/day atenolol for 2 wks; (3) Treated with 1 mg/kg/day isoproterenol for 2 wks; (4) Treated with 10 mg/kg/day isoproterenol for 2 wks.

Summary of procedures that were conducted
• body weight Isoproterenol or atenolol vs. control.
• organ weights Heart, atria, ventricle weights. Isoproterenol or atenolol vs. control.
• tail cuff Heart rate and blood pressure. Conscious mice. Isoproterenol or atenolol vs. control.
• ECG Heart rate and wave amplitudes and intervals. Unconscious. Isoproterenol or atenolol vs. control.
Mice: inbred   23 strains   ♂   age 10-12wks   4 cohorts