Project measure / variable:   Maurer1   QTc_area_iso1

ID, description, units MPD:33263   QTc_area_iso1   area of QTc   [ms*mV]  isoprot 1mg  
atenolol, isoproterenol study
Data set, strains Maurer1   inbred   23 strains     sex: m     age: 7-13wks
Procedure ECG
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  STRAIN COMPARISON PLOT
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Maurer1 - area of QTc isoprot 1mg



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested23 strains
Mean of the strain means47.4   ms*mV
Median of the strain means47.1   ms*mV
SD of the strain means± 4.34
Coefficient of variation (CV)0.0916
Min–max range of strain means40.1   –   55.1   ms*mV
Mean sample size per strain10.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 22 4108.0824 186.731 4.1992 < 0.0001
Residuals 207 9205.0135 44.4687


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 47.4 7.07   13 1.96 0.149 30.4, 57.7 0.01
A/J m 48.2 8.65   10 2.74 0.179 36.6, 59.4 0.19
AKR/J m 53.5 3.23   10 1.02 0.0604 47.6, 57.1 1.41
BALB/cByJ m 48.9 7.77   9 2.59 0.159 32.3, 58.3 0.35
BALB/cJ m 46.4 1.43   10 0.451 0.0308 43.3, 48.0 -0.23
BTBR T+ Itpr3tf/J m 51.9 6.67   9 2.22 0.128 42.6, 63.0 1.04
C3H/HeJ m 42.4 10.4   9 3.45 0.244 28.4, 63.0 -1.15
C3H/HeOuJ m 46.6 2.31   10 0.73 0.0495 43.3, 51.5 -0.18
C57BL/6J m 45.9 2.02   9 0.672 0.0439 42.9, 49.0 -0.34
C57BLKS/J m 44.6 4.7   10 1.49 0.105 32.5, 49.3 -0.64
C58/J m 47.9 6.73   12 1.94 0.141 37.6, 60.6 0.12
CBA/J m 47.7 9.7   10 3.07 0.203 32.9, 63.7 0.07
DBA/2J m 53.4 14.0   7 5.28 0.262 39.7, 76.2 1.39
FVB/NJ m 45.2 3.14   13 0.87 0.0695 40.1, 51.3 -0.5
I/LnJ m 40.1 9.04   9 3.01 0.225 29.3, 62.4 -1.68
KK/HlJ m 55.1 2.79   10 0.883 0.0507 50.2, 57.8 1.78
LP/J m 47.1 2.71   10 0.856 0.0574 42.6, 51.4 -0.06
NOD/ShiLtJ m 41.5 4.89   10 1.55 0.118 31.5, 47.8 -1.35
NZB/BlNJ m 45.0 3.44   9 1.15 0.0764 40.0, 49.2 -0.55
PL/J m 50.7 12.1   9 4.02 0.238 39.4, 66.9 0.77
SJL/J m 40.9 5.17   9 1.72 0.126 33.7, 46.5 -1.49
SM/J m 55.1 5.28   14 1.41 0.0958 46.4, 69.6 1.78
SWR/J m 44.2 6.79   9 2.26 0.154 32.8, 52.2 -0.73


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 47.4462 1.8495 51.0924 43.7999
A/J m 48.25 2.1088 52.4074 44.0926
AKR/J m 53.46 2.1088 57.6174 49.3026
BALB/cByJ m 48.9111 2.2228 53.2934 44.5288
BALB/cJ m 46.35 2.1088 50.5074 42.1926
BTBR T+ Itpr3tf/J m 51.9 2.2228 56.2823 47.5177
C3H/HeJ m 42.4333 2.2228 46.8156 38.0511
C3H/HeOuJ m 46.6 2.1088 50.7574 42.4426
C57BL/6J m 45.8778 2.2228 50.2601 41.4955
C57BLKS/J m 44.6 2.1088 48.7574 40.4426
C58/J m 47.8667 1.925 51.6618 44.0715
CBA/J m 47.68 2.1088 51.8374 43.5226
DBA/2J m 53.4286 2.5204 58.3976 48.4595
FVB/NJ m 45.1538 1.8495 48.8001 41.5076
I/LnJ m 40.0889 2.2228 44.4712 35.7066
KK/HlJ m 55.08 2.1088 59.2374 50.9226
LP/J m 47.14 2.1088 51.2974 42.9826
NOD/ShiLtJ m 41.51 2.1088 45.6674 37.3526
NZB/BlNJ m 45.0444 2.2228 49.4267 40.6622
PL/J m 50.6889 2.2228 55.0712 46.3066
SJL/J m 40.8778 2.2228 45.2601 36.4955
SM/J m 55.1 1.7822 58.6136 51.5864
SWR/J m 44.2111 2.2228 48.5934 39.8288




  GWAS USING LINEAR MIXED MODELS