Project measure / variable:   Maurer1   QTc_area_at

ID, description, units MPD:33262   QTc_area_at   area of QTc   [ms*mV]  atenolol 10mg  
atenolol, isoproterenol study
Data set, strains Maurer1   inbred   23 strains     sex: m     age: 7-13wks
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  STRAIN COMPARISON PLOT
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Maurer1 - area of QTc atenolol 10mg



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested23 strains
Mean of the strain means46.5   ms*mV
Median of the strain means46.8   ms*mV
SD of the strain means± 3.93
Coefficient of variation (CV)0.0846
Min–max range of strain means40.0   –   55.4   ms*mV
Mean sample size per strain9.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 22 2918.6256 132.6648 2.8164 0.0001
Residuals 196 9232.5378 47.1048


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 46.9 9.09   13 2.52 0.194 33.5, 71.2 0.1
A/J m 42.2 2.55   10 0.808 0.0605 39.7, 47.5 -1.1
AKR/J m 55.4 5.17   7 1.95 0.0932 47.6, 64.2 2.26
BALB/cByJ m 48.0 9.39   8 3.32 0.195 42.3, 70.8 0.38
BALB/cJ m 45.3 2.84   10 0.898 0.0626 40.9, 49.4 -0.31
BTBR T+ Itpr3tf/J m 46.8 1.57   9 0.522 0.0334 44.6, 49.9 0.07
C3H/HeJ m 40.0 4.99   8 1.76 0.125 29.4, 44.9 -1.66
C3H/HeOuJ m 51.1 3.47   9 1.16 0.0679 47.4, 57.3 1.17
C57BL/6J m 43.2 2.14   9 0.714 0.0496 40.4, 47.4 -0.84
C57BLKS/J m 44.6 4.51   9 1.5 0.101 39.7, 54.4 -0.49
C58/J m 47.1 3.5   12 1.01 0.0742 42.3, 50.9 0.15
CBA/J m 41.1 9.78   6 3.99 0.238 31.9, 58.7 -1.38
DBA/2J m 49.2 10.7   6 4.39 0.218 30.6, 60.5 0.68
FVB/NJ m 43.7 2.77   14 0.742 0.0635 38.2, 49.6 -0.72
I/LnJ m 49.6 23.8   9 7.94 0.481 15.1, 103.0 0.78
KK/HlJ m 51.0 3.21   9 1.07 0.0629 44.8, 55.5 1.14
LP/J m 42.9 2.23   10 0.706 0.0521 40.1, 46.6 -0.92
NOD/ShiLtJ m 43.4 3.04   10 0.96 0.0699 35.4, 47.0 -0.79
NZB/BlNJ m 50.8 5.51   9 1.84 0.108 44.3, 61.8 1.09
PL/J m 45.3 4.16   10 1.31 0.0917 39.0, 52.7 -0.31
SJL/J m 42.6 3.31   9 1.1 0.0777 38.2, 46.5 -1.0
SM/J m 51.6 2.47   12 0.713 0.0479 46.1, 54.5 1.29
SWR/J m 48.1 4.98   11 1.5 0.104 41.4, 57.4 0.4


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 46.9 1.9035 50.654 43.146
A/J m 42.24 2.1704 46.5203 37.9597
AKR/J m 55.4286 2.5941 60.5445 50.3127
BALB/cByJ m 48.025 2.4265 52.8105 43.2395
BALB/cJ m 45.34 2.1704 49.6203 41.0597
BTBR T+ Itpr3tf/J m 46.8444 2.2878 51.3562 42.3327
C3H/HeJ m 40.0 2.4265 44.7855 35.2145
C3H/HeOuJ m 51.0889 2.2878 55.6007 46.5771
C57BL/6J m 43.1889 2.2878 47.7007 38.6771
C57BLKS/J m 44.6444 2.2878 49.1562 40.1327
C58/J m 47.0917 1.9813 50.999 43.1843
CBA/J m 41.1 2.8019 46.6258 35.5742
DBA/2J m 49.2333 2.8019 54.7591 43.7075
FVB/NJ m 43.6857 1.8343 47.3032 40.0682
I/LnJ m 49.5556 2.2878 54.0673 45.0438
KK/HlJ m 51.0111 2.2878 55.5229 46.4993
LP/J m 42.86 2.1704 47.1403 38.5797
NOD/ShiLtJ m 43.44 2.1704 47.7203 39.1597
NZB/BlNJ m 50.8111 2.2878 55.3229 46.2993
PL/J m 45.32 2.1704 49.6003 41.0397
SJL/J m 42.6 2.2878 47.1118 38.0882
SM/J m 51.5917 1.9813 55.499 47.6843
SWR/J m 48.1364 2.0694 52.2174 44.0553




  GWAS USING LINEAR MIXED MODELS