Project measure / variable:   Maurer1   QTc_area_iso10

ID, description, units MPD:33264   QTc_area_iso10   area of QTc   [ms*mV]  isoprot 10mg  
atenolol, isoproterenol study
Data set, strains Maurer1   inbred   23 strains     sex: m     age: 7-13wks
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  STRAIN COMPARISON PLOT
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Maurer1 - area of QTc isoprot 10mg



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested23 strains
Mean of the strain means47.8   ms*mV
Median of the strain means46.9   ms*mV
SD of the strain means± 5.31
Coefficient of variation (CV)0.111
Min–max range of strain means36.4   –   58.0   ms*mV
Mean sample size per strain9.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 22 5893.479 267.8854 4.3555 < 0.0001
Residuals 199 12239.4337 61.5047


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 50.8 6.4   12 1.85 0.126 40.4, 60.2 0.56
A/J m 50.0 6.57   10 2.08 0.131 37.0, 58.5 0.41
AKR/J m 53.4 7.43   9 2.48 0.139 38.5, 64.7 1.05
BALB/cByJ m 46.4 10.1   9 3.37 0.218 21.0, 56.6 -0.27
BALB/cJ m 50.1 16.7   8 5.91 0.333 25.2, 68.4 0.43
BTBR T+ Itpr3tf/J m 58.0 5.68   8 2.01 0.0978 49.1, 66.8 1.91
C3H/HeJ m 39.7 6.81   9 2.27 0.172 27.6, 47.4 -1.53
C3H/HeOuJ m 46.3 3.49   11 1.05 0.0754 39.7, 50.7 -0.29
C57BL/6J m 46.9 5.52   7 2.09 0.118 41.5, 53.6 -0.17
C57BLKS/J m 53.2 8.37   10 2.65 0.157 41.4, 69.5 1.01
C58/J m 47.5 8.1   12 2.34 0.171 32.9, 60.0 -0.06
CBA/J m 45.5 4.39   10 1.39 0.0965 38.3, 55.7 -0.44
DBA/2J m 45.8 16.4   7 6.2 0.358 30.2, 78.6 -0.38
FVB/NJ m 46.4 6.07   13 1.68 0.131 35.7, 55.9 -0.27
I/LnJ m 48.8 8.43   10 2.67 0.173 38.1, 66.4 0.18
KK/HlJ m 55.8 4.33   10 1.37 0.0775 49.4, 61.7 1.5
LP/J m 51.0 7.69   8 2.72 0.151 39.4, 60.9 0.6
NOD/ShiLtJ m 44.8 2.49   10 0.788 0.0556 41.1, 48.8 -0.57
NZB/BlNJ m 40.9 6.5   7 2.46 0.159 30.9, 50.7 -1.3
PL/J m 42.0 9.84   10 3.11 0.234 28.0, 57.8 -1.1
SJL/J m 36.4 2.05   10 0.648 0.0563 33.5, 39.1 -2.15
SM/J m 55.1 2.94   13 0.815 0.0533 51.4, 61.4 1.37
SWR/J m 45.2 12.1   9 4.02 0.267 28.2, 69.6 -0.49


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 50.7583 2.2639 55.2227 46.294
A/J m 50.0 2.48 54.8905 45.1095
AKR/J m 53.3889 2.6142 58.5439 48.2339
BALB/cByJ m 46.3667 2.6142 51.5217 41.2116
BALB/cJ m 50.15 2.7727 55.6177 44.6823
BTBR T+ Itpr3tf/J m 58.025 2.7727 63.4927 52.5573
C3H/HeJ m 39.6778 2.6142 44.8328 34.5228
C3H/HeOuJ m 46.3273 2.3646 50.9902 41.6644
C57BL/6J m 46.9286 2.9642 52.7738 41.0833
C57BLKS/J m 53.2 2.48 58.0905 48.3095
C58/J m 47.4833 2.2639 51.9477 43.019
CBA/J m 45.51 2.48 50.4005 40.6195
DBA/2J m 45.8 2.9642 51.6452 39.9548
FVB/NJ m 46.3692 2.1751 50.6585 42.08
I/LnJ m 48.84 2.48 53.7305 43.9495
KK/HlJ m 55.8 2.48 60.6905 50.9095
LP/J m 51.0375 2.7727 56.5052 45.5698
NOD/ShiLtJ m 44.82 2.48 49.7105 39.9295
NZB/BlNJ m 40.9 2.9642 46.7452 35.0548
PL/J m 42.0 2.48 46.8905 37.1095
SJL/J m 36.4 2.48 41.2905 31.5095
SM/J m 55.0846 2.1751 59.3738 50.7954
SWR/J m 45.2333 2.6142 50.3884 40.0783




  GWAS USING LINEAR MIXED MODELS