MPD: Project measures / variables set: Maurer1 R

Project measures / variables set: Maurer1 R_amp

ID, description, units	MPD:33221 R_amp amplitude of R-wave [mV] atenolol, isoproterenol study
Measures	• control • atenolol 10mg • isoprot 1mg • isoprot 10mg
Data set, strains	Maurer1 inbred 23 strains sex: m age: 7-13wks
Procedure	ECG
Comparison	control group vs. multiple treatment / dosage groups
Ontology mappings	VT:0000231 heart excitatory physiology trait VT:0010487 response to xenobiotic stimulus trait MA:0000072 heart MP:0008872 abnormal physiological response to xenobiotic MP:0011919 abnormal R wave

Values Means Δ Means Z-scores

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Maurer1 - amplitude of R-wave

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
group	3	0.1954	0.0651	1.6469	0.1772
group:strain	60	4.966	0.0828	2.0932	< 0.0001
Residuals	695	27.4801	0.0395
strain	20	23.4352	1.1718	29.6349	< 0.0001

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Maurer1	33221	ECG	atenolol, isoproterenol	amplitude of R-wave [mV] control R_amp_ctrl	inbred	23	m	7-13wks
Maurer1	33222	ECG	atenolol, isoproterenol	amplitude of R-wave [mV] atenolol 10mg R_amp_at	inbred	22	m	7-13wks
Maurer1	33223	ECG	atenolol, isoproterenol	amplitude of R-wave [mV] isoprot 1mg R_amp_iso1	inbred	23	m	7-13wks
Maurer1	33224	ECG	atenolol, isoproterenol	amplitude of R-wave [mV] isoprot 10mg R_amp_iso10	inbred	23	m	7-13wks