Frankel1: Drug study: Induced seizures and their suppression with lamotrigine in 16 inbred strains of mice (2000)

Frankel WN, Taylor L, Beyer B, Tempel BL, White HS. Electroconvulsive thresholds of inbred mouse strains. Genomics. 2001 Jun 15;74(3):306-12.   PubMed 11414758  

Frankel1 downloads
• Download Frankel1 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators Wayne N Frankel       The Jackson Laboratory,  Bar Harbor, ME
H Steve White       University of Utah,  Salt Lake City, UT
Participants Taylor L, Beyer B, Tempel BL
ContactWayne N Frankel
AcknowledgementsFunding provided by NIH NS40246.
Project type Phenotype strain survey data set
MPD identifiersFrankel1     MPD:56
Data changelog 1 update/correction.       Initial release date: 05/2001.
Formatted citation
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An electroconvulsive threshold test was applied to assess frontal and transcorneal induced seizures and their suppression with lamotrigene. For each strain/sex/measurement the following summary data were supplied: median value, N, and the 95% confidence interval. (In this project these median values are referred to as "means" in MPD data displays but they are really medians as described). Measurements for individual mice were not supplied. Assays were performed at two sites, Bar Harbor and Salt Lake City. Measurement descriptions use the following abbreviations:
"CC50" = Critical current (milli Amps) for 50% of the mice of a strain to reach seizure response (endpoint)
"CC97" = Critical current (milli Amps) for 97% of the mice of a strain to reach seizure response (endpoint)
"ED50" = Median effective dose (mg/kg)
"BH" = Assays performed in Bar Harbor
"SL" = Assays performed in Salt Lake City

Procedures conducted:
• electroconvulsion test  Electroconvulsive thresholds. Lamotrigine. 2 test sites.

Mice: inbred   16 strains   ♀♂   age 6-11wks   3 experimental groups