Project measure / variable:   Frankel1   L_MC_BH_TC

ID, description, units MPD:5610   L_MC_BH_TC   median effective dose (ED50) against minimal clonic seizures (CC97), transcorneal stimulation (at BH)   [mg/kg]  
lamotrigine study
Data set, strains Frankel1   inbred   3 strains     sex: m     age: 6-11wks
Procedure electroconvulsion test
Availability note:Individual animal data were not submitted. Some functionality not available.
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Frankel1 - median effective dose (ED50) against minimal clonic seizures (CC97), transcorneal stimulation (at BH)



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested3 strains
Mean of the strain means3.55   mg/kg
Median of the strain means3.20   mg/kg
SD of the strain means± 2.34
Coefficient of variation (CV)0.660
Min–max range of strain means1.40   –   6.05   mg/kg
Mean sample size per strain63.0   mice


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BALB/cByJ m 1.4 None   101 None None -0.92
C3HeB/FeJ m 6.05 None   24 None None 1.07
C57BL/6J m 3.2 None   64 None None -0.15


GWAS analysis not available: Individual animal data not submitted