Phenotype measure:   Frankel1   L_MT_SL_TC

ID, description, units MPD:5614   L_MT_SL_TC   median effective dose (ED50) against maximal tonic hindlimb extension seizure (CC97), transcorneal stimulation (at SL)   [mg/kg]
lamotrigine study
Data set, strains Frankel1   inbred   3 strains     sex: m     age: 6-11wks
Procedure electroconvulsion test
Availability note:Individual animal data were not submitted. Some functionality not available.
Ontology mappings


  STRAIN COMPARISON PLOT
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Frankel1 - median effective dose (ED50) against maximal tonic hindlimb extension seizure (CC97), transcorneal stimulation (at SL)



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested3 strains
Mean of the strain means2.25   mg/kg
Median of the strain means2.41   mg/kg
SD of the strain means± 1.27
Coefficient of variation (CV)0.563
Min–max range of strain means0.910   –   3.43   mg/kg
Mean sample size per strain45.3   mice


  STRAIN MEANS (UNADJUSTED)
Strain Sex Mean SD N mice SEM CV Min, Max Z score
BALB/cByJ m 3.43 None   56 None None None, None 0.93
C3HeB/FeJ m 0.91 None   24 None None None, None -1.06
C57BL/6J m 2.41 None   56 None None None, None 0.13