Phenotype measure:   Crabbe3   ARR2_chg_20rpm_saline

ID, description, units MPD:15858   ARR2_chg_20rpm_saline   average latency to fall, accelerating rotarod, 20 rpm/min (ARR2), post-injection saline control minus pre-injection saline control (SALPOST - SALBASE)   [s]
Data set, strains Crabbe3   inbred   21 strains     sex: both     age: 9-17wks
Procedure rotarod
Ontology mappings

  STRAIN COMPARISON PLOT
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Crabbe3 - average latency to fall, accelerating rotarod, 20 rpm/min (ARR2), post-injection saline control minus pre-injection saline control (SALPOST - SALBASE)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested21 strains21 strains
Mean of the strain means7.51   s 7.50   s
Median of the strain means10.1   s 7.62   s
SD of the strain means± 10.5 ± 9.87
Coefficient of variation (CV)1.40 1.32
Min–max range of strain means-19.3   –   30.2   s -20.2   –   29.4   s
Mean sample size per strain9.5   mice 9.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 227.6886 227.6886 0.4695 0.4937
strain 20 18975.4687 948.7734 1.9565 0.0088
sex:strain 20 14808.3671 740.4184 1.5268 0.0696
Residuals 347 168272.0231 484.9338


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f -2.95 12.7   10 4.02 -4.31 -21.0, 26.0 -1.0
129S1/SvImJ m 14.3 12.6   10 3.98 0.876 -10.5, 32.5 0.69
A/J f 10.6 12.1   8 4.27 1.14 -6.0, 32.5 0.29
A/J m 6.2 9.49   10 3.0 1.53 -8.5, 20.0 -0.13
AKR/J f 10.9 14.5   10 4.57 1.32 -9.5, 43.5 0.32
AKR/J m 29.4 17.8   8 6.29 0.606 8.0, 57.0 2.22
BALB/cByJ f 17.3 18.4   10 5.81 1.06 -17.5, 53.5 0.93
BALB/cByJ m 8.8 12.5   10 3.95 1.42 -9.0, 30.0 0.13
BTBR T+ Itpr3tf/J f 5.88 12.3   12 3.56 2.1 -18.5, 25.0 -0.16
BTBR T+ Itpr3tf/J m -2.42 9.85   6 4.02 -4.07 -11.5, 15.0 -1.0
C3H/HeJ f 12.7 10.3   10 3.24 0.807 -0.5, 30.5 0.49
C3H/HeJ m 8.31 26.2   8 9.28 3.16 -39.0, 41.5 0.08
C57BL/6J f 12.7 10.0   8 3.53 0.788 0.49
C57BL/6J m 1.85 12.7   10 4.03 6.89 -13.5, 21.5 -0.57
C57L/J f -3.55 14.1   10 4.45 -3.96 -30.5, 18.0 -1.05
C57L/J m 1.44 21.0   8 7.43 14.6 -23.5, 40.0 -0.61
C58/J f 30.2 50.8   10 16.1 1.68 -39.5, 112.0 2.16
C58/J m 10.1 33.0   10 10.4 3.28 -30.5, 70.5 0.26
CAST/EiJ f 18.8 28.8   8 10.2 1.53 -30.5, 65.0 1.07
CAST/EiJ m 17.1 20.9   8 7.37 1.22 -10.5, 48.5 0.97
DBA/2J f 10.8 15.1   10 4.77 1.39 -12.0, 40.0 0.31
DBA/2J m 7.0 12.3   8 4.36 1.76 -8.5, 26.0 -0.05
FVB/NJ f 4.45 16.0   10 5.06 3.6 -16.5, 31.0 -0.29
FVB/NJ m 8.68 11.0   11 3.31 1.26 -2.5, 35.5 0.12
MOLF/EiJ f -6.94 31.0   8 11.0 -4.47 -55.0, 32.0 -1.38
MOLF/EiJ m 19.4 42.4   7 16.0 2.19 -49.0, 90.0 1.21
NOD/ShiLtJ f -19.3 45.0   12 13.0 -2.33 -110.0, 21.5 -2.55
NOD/ShiLtJ m 7.62 19.1   12 5.51 2.5 -18.0, 40.0 0.01
NZB/BlNJ f 3.42 7.86   6 3.21 2.3 -8.0, 15.5 -0.39
NZB/BlNJ m 3.88 14.2   12 4.1 3.67 -23.5, 30.5 -0.37
PERA/EiJ f 17.4 45.8   9 15.3 2.63 -83.0, 80.0 0.94
PERA/EiJ m 19.0 22.7   12 6.54 1.19 -6.5, 59.0 1.16
PL/J f 4.92 15.3   12 4.4 3.1 -17.5, 42.5 -0.25
PL/J m 2.38 13.4   8 4.73 5.63 -19.5, 22.0 -0.52
SJL/J f 10.1 17.6   8 6.22 1.74 -14.0, 45.0 0.25
SJL/J m 5.12 8.49   12 2.45 1.66 -14.0, 16.5 -0.24
SM/J f 9.14 19.1   14 5.1 2.09 -17.0, 42.0 0.16
SM/J m 9.85 16.8   10 5.31 1.71 -14.5, 34.5 0.24
SPRET/EiJ f 11.7 10.1   3 5.84 0.867 0.4
SPRET/EiJ m -20.2 24.4   2   17.2 -1.2 -37.5, -3.0 -2.81
SWR/J f -0.55 18.0   10 5.69 -32.7 -38.0, 29.5 -0.77
SWR/J m -0.278 25.2   9 8.39 -90.7 -37.0, 33.0 -0.79


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f -2.95 6.9637 10.7464 -16.6464
129S1/SvImJ m 14.35 6.9637 28.0464 0.6536
A/J f 10.5625 7.7857 25.8756 -4.7506
A/J m 6.2 6.9637 19.8964 -7.4964
AKR/J f 10.95 6.9637 24.6464 -2.7464
AKR/J m 29.375 7.7857 44.6881 14.0619
BALB/cByJ f 17.3 6.9637 30.9964 3.6036
BALB/cByJ m 8.8 6.9637 22.4964 -4.8964
BTBR T+ Itpr3tf/J f 5.875 6.357 18.3781 -6.6281
BTBR T+ Itpr3tf/J m -2.4167 8.9901 15.2653 -20.0987
C3H/HeJ f 12.7 6.9637 26.3964 -0.9964
C3H/HeJ m 8.3125 7.7857 23.6256 -7.0006
C57BL/6J f 12.6875 7.7857 28.0006 -2.6256
C57BL/6J m 1.85 6.9637 15.5464 -11.8464
C57L/J f -3.55 6.9637 10.1464 -17.2464
C57L/J m 1.4375 7.7857 16.7506 -13.8756
C58/J f 30.25 6.9637 43.9464 16.5536
C58/J m 10.05 6.9637 23.7464 -3.6464
CAST/EiJ f 18.8125 7.7857 34.1256 3.4994
CAST/EiJ m 17.125 7.7857 32.4381 1.8119
DBA/2J f 10.85 6.9637 24.5464 -2.8464
DBA/2J m 7.0 7.7857 22.3131 -8.3131
FVB/NJ f 4.45 6.9637 18.1464 -9.2464
FVB/NJ m 8.6818 6.6396 21.7408 -4.3772
MOLF/EiJ f -6.9375 7.7857 8.3756 -22.2506
MOLF/EiJ m 19.3571 8.3232 35.7275 2.9868
NOD/ShiLtJ f -19.2917 6.357 -6.7886 -31.7947
NOD/ShiLtJ m 7.625 6.357 20.1281 -4.8781
NZB/BlNJ f 3.4167 8.9901 21.0987 -14.2653
NZB/BlNJ m 3.875 6.357 16.3781 -8.6281
PERA/EiJ f 17.3889 7.3404 31.8262 2.9516
PERA/EiJ m 19.0417 6.357 31.5447 6.5386
PL/J f 4.9167 6.357 17.4197 -7.5864
PL/J m 2.375 7.7857 17.6881 -12.9381
SJL/J f 10.125 7.7857 25.4381 -5.1881
SJL/J m 5.125 6.357 17.6281 -7.3781
SM/J f 9.1429 5.8854 20.7184 -2.4327
SM/J m 9.85 6.9637 23.5464 -3.8464
SPRET/EiJ f 11.6667 12.714 36.6728 -13.3394
SPRET/EiJ m -20.25 15.5713 10.3761 -50.8761
SWR/J f -0.55 6.9637 13.1464 -14.2464
SWR/J m -0.2778 7.3404 14.1595 -14.7151


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 5.7 4.9241 15.3848 -3.9848
A/J both 8.3812 5.2228 18.6536 -1.8911
AKR/J both 20.1625 5.2228 30.4348 9.8902
BALB/cByJ both 13.05 4.9241 22.7348 3.3652
BTBR T+ Itpr3tf/J both 1.7292 5.5053 12.5571 -9.0988
C3H/HeJ both 10.5062 5.2228 20.7786 0.2339
C57BL/6J both 7.2687 5.2228 17.5411 -3.0036
C57L/J both -1.0563 5.2228 9.2161 -11.3286
C58/J both 20.15 4.9241 29.8348 10.4652
CAST/EiJ both 17.9688 5.5053 28.7967 7.1408
DBA/2J both 8.925 5.2228 19.1973 -1.3473
FVB/NJ both 6.5659 4.8109 16.0281 -2.8962
MOLF/EiJ both 6.2098 5.6985 17.4178 -4.9982
NOD/ShiLtJ both -5.8333 4.4951 3.0077 -14.6743
NZB/BlNJ both 3.6458 5.5053 14.4738 -7.1821
PERA/EiJ both 18.2153 4.8552 27.7646 8.6659
PL/J both 3.6458 5.0256 13.5304 -6.2387
SJL/J both 7.625 5.0256 17.5095 -2.2595
SM/J both 9.4964 4.5588 18.4628 0.53
SPRET/EiJ both -4.2917 10.0513 15.4774 -24.0607
SWR/J both -0.4139 5.059 9.5363 -10.3641




  GWAS USING LINEAR MIXED MODELS