MPD: Project measures / variables set: Graham1 Treg

Project measures / variables set: Graham1 Treg_spleen

ID, description, units	MPD:63341 Treg_spleen percentage of CD4+ T cells that are Foxp3+ in the spleen, post infection [%] West Nile virus study
Measures	• day 7 • day 12 • day 21 • day 28
Data set, strains	Graham1 CC RIX 2 strains sex: m age: 8-10wks
Procedure	immune cell quantification
Comparison	timecourse but different cohorts
Ontology mappings	VT:0008397 CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology trait VT:0010439 response to viral infection trait MA:0000141 spleen MP:0012773 abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number MP:0020185 altered susceptibility to viral infection

Values Means Δ Means Z-scores

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Graham1 - percentage of CD4+ T cells that are Foxp3+ in the spleen, post infection

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
group	3	38.8304	12.9435	1.2028	0.3406
strain	1	5.434	5.434	0.505	0.4876
group:strain	3	44.5261	14.842	1.3792	0.2851
Residuals	16	172.1765	10.761

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Graham1	63341	immune cell quantification	West Nile virus	percentage of CD4+ T cells that are Foxp3+ in the spleen, post infection [%] day 7 Treg_spleen_d7	CC RIX	2	m	8-10wks
Graham1	63342	immune cell quantification	West Nile virus	percentage of CD4+ T cells that are Foxp3+ in the spleen, post infection [%] day 12 Treg_spleen_d12	CC RIX	2	m	8-10wks
Graham1	63343	immune cell quantification	West Nile virus	percentage of CD4+ T cells that are Foxp3+ in the spleen, post infection [%] day 21 Treg_spleen_d21	CC RIX	2	m	8-10wks
Graham1	63344	immune cell quantification	West Nile virus	percentage of CD4+ T cells that are Foxp3+ in the spleen, post infection [%] day 28 Treg_spleen_d28	CC RIX	2	m	8-10wks