MPD: Project measures / variables set: Graham1 Treg

Project measures / variables set: Graham1 Treg_brain

ID, description, units	MPD:63337 Treg_brain percentage of CD4+ T cells that are Foxp3+ in the brain, post infection [%] West Nile virus study
Measures	• day 7 • day 12 • day 21 • day 28
Data set, strains	Graham1 CC RIX 5 strains sex: m age: 8-10wks
Procedure	immune cell quantification
Comparison	timecourse but different cohorts
Ontology mappings	VT:0008397 CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology trait VT:0010439 response to viral infection trait MA:0000168 brain MP:0012773 abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number MP:0020185 altered susceptibility to viral infection

Values Means Δ Means Z-scores

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Graham1 - percentage of CD4+ T cells that are Foxp3+ in the brain, post infection

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
group	3	175.5805	58.5268	2.161	0.1189
strain	2	685.7863	342.8932	12.6608	0.0002
group:strain	6	190.3717	31.7286	1.1715	0.354
Residuals	24	649.9944	27.0831

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Graham1	63337	immune cell quantification	West Nile virus	percentage of CD4+ T cells that are Foxp3+ in the brain, post infection [%] day 7 Treg_brain_d7	CC RIX	5	m	8-10wks
Graham1	63338	immune cell quantification	West Nile virus	percentage of CD4+ T cells that are Foxp3+ in the brain, post infection [%] day 12 Treg_brain_d12	CC RIX	5	m	8-10wks
Graham1	63339	immune cell quantification	West Nile virus	percentage of CD4+ T cells that are Foxp3+ in the brain, post infection [%] day 21 Treg_brain_d21	CC RIX	4	m	8-10wks
Graham1	63340	immune cell quantification	West Nile virus	percentage of CD4+ T cells that are Foxp3+ in the brain, post infection [%] day 28 Treg_brain_d28	CC RIX	5	m	8-10wks