Project measure / variable:   Rusyn2   DCV_glutathione2_tce

ID, description, units MPD:36195   DCV_glutathione2_tce   DCV glutathione (serum DCVG x 10-3)   [nmol/mL]  2h after treatment  
trichloroethylene study
Data set, strains Rusyn2   inbred   15 strains     sex: m     age: 7wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Rusyn2 - DCV glutathione (serum DCVG x 10-3) 2h after treatment



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested15 strains
Mean of the strain means11.6   nmol/mL
Median of the strain means5.71   nmol/mL
SD of the strain means± 13.3
Coefficient of variation (CV)1.15
Min–max range of strain means0.135   –   37.5   nmol/mL
Mean sample size per strain2.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 13 6451.6507 496.2808 3.6579 0.0033
Residuals 23 3120.4532 135.6719


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 2.69 3.66   2   2.59 1.36 0.108, 5.28 -0.67
A/J m 0.662 0.0   1   0.0 0.0 0.662, 0.662 -0.82
B6C3F1/J m 37.3 14.8   3 8.52 0.396 27.2, 54.2 1.94
BALB/cByJ m 0.811 1.17   3 0.678 1.45 0.0156, 2.16 -0.81
BTBR T+ Itpr3tf/J m 5.71 1.73   3 1.0 0.304 4.63, 7.71 -0.44
C3H/HeJ m 21.2 11.5   3 6.63 0.541 9.45, 32.4 0.72
C57BL/6J m 25.7 5.49   3 3.17 0.213 19.4, 29.2 1.06
CAST/EiJ m 37.5 30.1   3 17.4 0.802 16.3, 72.0 1.95
DBA/2J m 8.98 5.07   3 2.93 0.565 3.86, 14.0 -0.2
FVB/NJ m 17.4 12.2   3 7.01 0.7 3.37, 25.3 0.44
KK/HlJ m 11.8 13.0   2   9.17 1.1 2.66, 21.0 0.02
MOLF/EiJ m 0.135 0.0   2   0.0 0.0 0.135, 0.135 -0.86
NOD/ShiLtJ m 0.181 0.0   2   0.0 0.0 0.181, 0.181 -0.86
NZW/LacJ m 2.06 2.07   3 1.2 1.01 0.781, 4.45 -0.72
PWD/PhJ m 1.62 1.22   2   0.866 0.754 0.758, 2.49 -0.75


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 2.694 8.2363 19.732 0.0
B6C3F1/J m 37.2667 6.7249 51.1781 23.3552
BALB/cByJ m 0.8112 6.7249 14.7227 0.0
BTBR T+ Itpr3tf/J m 5.71 6.7249 19.6215 0.0
C3H/HeJ m 21.2167 6.7249 35.1281 7.3052
C57BL/6J m 25.7333 6.7249 39.6448 11.8219
CAST/EiJ m 37.5333 6.7249 51.4448 23.6219
DBA/2J m 8.98 6.7249 22.8915 0.0
FVB/NJ m 17.3567 6.7249 31.2681 3.4452
KK/HlJ m 11.83 8.2363 28.868 0.0
MOLF/EiJ m 0.135 8.2363 17.173 0.0
NOD/ShiLtJ m 0.181 8.2363 17.219 0.0
NZW/LacJ m 2.0577 6.7249 15.9691 0.0
PWD/PhJ m 1.624 8.2363 18.662 0.0




  GWAS USING LINEAR MIXED MODELS