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Project measure / variable:   Berndt1   pct_res_mch30

ID, description, units MPD:34224   pct_res_mch30   airway resistance (as % of baseline, H2O pressure)   [%]  MCh challenge 30 mg/mL  
methacholine study
Data set, strains Berndt1   inbred   37 strains     sex: both     age: 9-12wks
Procedure ventilator
Ontology mappings

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  STRAIN COMPARISON PLOT
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Berndt1 - airway resistance (as % of baseline, H2O pressure) MCh challenge 30 mg/mL



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested35 strains31 strains
Mean of the strain means311   % 336   %
Median of the strain means293   % 315   %
SD of the strain means± 105 ± 90.5
Coefficient of variation (CV)0.337 0.269
Min–max range of strain means111   –   545   % 195   –   579   %
Mean sample size per strain7.0   mice 6.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 278266.2458 278266.2458 16.0042 0.0001
strain 28 2201932.5573 78640.4485 4.5229 < 0.0001
sex:strain 28 805525.4838 28768.7673 1.6546 0.022
Residuals 327 5685568.9631 17387.061


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 251.0 109.0   9 36.4 0.436 138.0, 482.0 -0.57
129S1/SvImJ m 306.0 213.0   7 80.5 0.697 80.0, 570.0 -0.33
A/J f 391.0 86.2   6 35.2 0.22 243.0, 474.0 0.76
AKR/J f 247.0 88.5   9 29.5 0.358 161.0, 430.0 -0.61
AKR/J m 230.0 63.4   2   44.8 0.275 186.0, 275.0 -1.17
BALB/cByJ f 204.0 52.1   5 23.3 0.255 127.0, 260.0 -1.02
BALB/cByJ m 297.0 84.1   6 34.3 0.284 196.0, 400.0 -0.43
BALB/cJ f 288.0 81.0   5 36.2 0.282 195.0, 377.0 -0.22
BALB/cJ m 377.0 121.0   7 45.9 0.321 252.0, 589.0 0.45
BPN/3J f 223.0 92.6   8 32.7 0.415 87.9, 340.0 -0.84
BTBR T+ Itpr3tf/J f 370.0 147.0   4 73.5 0.398 229.0, 564.0 0.56
BTBR T+ Itpr3tf/J m 395.0 85.9   5 38.4 0.217 267.0, 480.0 0.65
BUB/BnJ f 243.0 97.2   8 34.4 0.4 119.0, 429.0 -0.65
BUB/BnJ m 312.0 62.9   5 28.1 0.202 232.0, 381.0 -0.27
C3H/HeJ f 234.0 90.2   7 34.1 0.386 114.0, 367.0 -0.74
C3H/HeJ m 299.0 102.0   5 45.8 0.343 166.0, 410.0 -0.41
C57BL/10J f 253.0 84.7   8 29.9 0.334 114.0, 364.0 -0.56
C57BL/10J m 473.0 108.0   6 44.1 0.228 356.0, 641.0 1.51
C57BL/6J f 111.0 30.4   7 11.5 0.273 77.3, 140.0 -1.91
C57BL/6J m 195.0 104.0   5 46.5 0.535 96.8, 349.0 -1.56
C57BLKS/J f 545.0 261.0   6 107.0 0.48 209.0, 870.0 2.23
C57BLKS/J m 520.0 179.0   6 73.1 0.344 207.0, 696.0 2.03
C57BR/cdJ f 452.0 208.0   4 104.0 0.459 309.0, 750.0 1.34
C57BR/cdJ m 315.0 95.5   8 33.8 0.303 222.0, 518.0 -0.23
C57L/J f 394.0 108.0   4 54.2 0.275 292.0, 504.0 0.79
C57L/J m 391.0 137.0   9 45.8 0.352 203.0, 654.0 0.61
CBA/J f 241.0 118.0   8 41.6 0.488 129.0, 464.0 -0.67
CBA/J m 282.0 116.0   9 38.6 0.411 166.0, 512.0 -0.6
CE/J f 392.0 143.0   9 47.5 0.364 168.0, 583.0 0.77
CE/J m 378.0 99.6   9 33.2 0.264 230.0, 498.0 0.46
DBA/1J f 319.0 56.9   2   40.2 0.178 279.0, 359.0 0.07
DBA/1J m 315.0 86.6   3 50.0 0.275 233.0, 406.0 -0.23
DBA/2J f 380.0 192.0   9 64.2 0.507 200.0, 826.0 0.65
DBA/2J m 328.0 85.4   4 42.7 0.26 214.0, 410.0 -0.09
FVB/NJ f 293.0 94.8   10 30.0 0.323 143.0, 416.0 -0.17
FVB/NJ m 400.0 90.4   6 36.9 0.226 273.0, 530.0 0.71
I/LnJ m 315.0 91.1   3 52.6 0.289 215.0, 392.0 -0.23
KK/HlJ f 541.0 275.0   6 112.0 0.509 273.0, 928.0 2.19
LG/J f 406.0 250.0   9 83.4 0.616 117.0, 935.0 0.9
LG/J m 363.0 135.0   9 45.1 0.373 178.0, 528.0 0.3
LP/J f 289.0 93.9   8 33.2 0.325 164.0, 443.0 -0.21
LP/J m 579.0 87.0   3 50.2 0.15 506.0, 675.0 2.68
MA/MyJ f 442.0 174.0   5 77.9 0.394 283.0, 700.0 1.25
MRL/MpJ f 347.0 118.0   7 44.7 0.341 200.0, 491.0 0.34
MRL/MpJ m 314.0 130.0   9 43.4 0.415 156.0, 538.0 -0.24
NOD/ShiLtJ f 408.0 98.9   7 37.4 0.243 274.0, 538.0 0.92
NOD/ShiLtJ m 340.0 151.0   6 61.7 0.444 49.1, 463.0 0.04
NON/ShiLtJ f 224.0 62.1   7 23.5 0.277 168.0, 346.0 -0.83
NON/ShiLtJ m 351.0 130.0   7 49.1 0.37 204.0, 578.0 0.16
NZB/BlNJ m 231.0 103.0   10 32.7 0.448 139.0, 464.0 -1.16
NZO/HlLtJ f 407.0 90.8   9 30.3 0.223 239.0, 532.0 0.91
NZW/LacJ f 351.0 158.0   7 59.8 0.451 168.0, 568.0 0.38
NZW/LacJ m 479.0 275.0   9 91.6 0.574 190.0, 952.0 1.58
P/J f 146.0 65.3   5 29.2 0.448 76.9, 237.0 -1.57
P/J m 204.0 46.5   7 17.6 0.228 144.0, 277.0 -1.46
PL/J f 276.0 119.0   9 39.5 0.43 158.0, 493.0 -0.34
PL/J m 275.0 117.0   6 47.8 0.426 131.0, 400.0 -0.68
PWD/PhJ f 337.0 134.0   6 54.9 0.399 167.0, 496.0 0.24
RIIIS/J f 297.0 85.2   5 38.1 0.287 203.0, 378.0 -0.14
RIIIS/J m 204.0 77.9   6 31.8 0.381 133.0, 345.0 -1.46
SJL/J f 124.0 55.2   8 19.5 0.446 44.4, 224.0 -1.78
SJL/J m 368.0 137.0   6 55.9 0.372 114.0, 522.0 0.35
SM/J f 254.0 77.9   10 24.6 0.307 183.0, 400.0 -0.55
SM/J m 247.0 112.0   3 64.9 0.455 125.0, 346.0 -0.98
SWR/J f 215.0 39.3   8 13.9 0.183 163.0, 272.0 -0.92
SWR/J m 338.0 241.0   8 85.2 0.713 75.9, 856.0 0.02


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 250.5222 43.9533 336.9892 164.0552
129S1/SvImJ m 305.5857 49.8384 403.6301 207.5414
AKR/J f 247.3444 43.9533 333.8114 160.8775
AKR/J m 230.5 93.2391 413.9242 47.0758
BALB/cByJ f 203.86 58.9696 319.8676 87.8524
BALB/cByJ m 296.65 53.8316 402.55 190.75
BALB/cJ f 287.58 58.9696 403.5876 171.5724
BALB/cJ m 377.3857 49.8384 475.4301 279.3414
BTBR T+ Itpr3tf/J f 369.775 65.93 499.4755 240.0745
BTBR T+ Itpr3tf/J m 395.3 58.9696 511.3076 279.2924
BUB/BnJ f 242.7875 46.6196 334.4996 151.0754
BUB/BnJ m 311.72 58.9696 427.7276 195.7124
C3H/HeJ f 233.6143 49.8384 331.6586 135.5699
C3H/HeJ m 298.86 58.9696 414.8676 182.8524
C57BL/10J f 253.2625 46.6196 344.9746 161.5504
C57BL/10J m 473.3333 53.8316 579.2333 367.4333
C57BL/6J f 111.2429 49.8384 209.2872 13.1985
C57BL/6J m 194.52 58.9696 310.5276 78.5124
C57BLKS/J f 544.8667 53.8316 650.7667 438.9667
C57BLKS/J m 520.0333 53.8316 625.9333 414.1333
C57BR/cdJ f 452.225 65.93 581.9255 322.5245
C57BR/cdJ m 315.475 46.6196 407.1871 223.7629
C57L/J f 394.35 65.93 524.0505 264.6495
C57L/J m 390.9667 43.9533 477.4337 304.4997
CBA/J f 241.4375 46.6196 333.1496 149.7254
CBA/J m 281.6889 43.9533 368.1559 195.2219
CE/J f 392.0333 43.9533 478.5003 305.5663
CE/J m 377.7667 43.9533 464.2337 291.2997
DBA/1J f 318.95 93.2391 502.3742 135.5258
DBA/1J m 315.3 76.1294 465.0652 165.5348
DBA/2J f 379.8889 43.9533 466.3559 293.4219
DBA/2J m 327.9 65.93 457.6005 198.1995
FVB/NJ f 293.43 41.6978 375.4598 211.4002
FVB/NJ m 399.5333 53.8316 505.4333 293.6333
LG/J f 406.1222 43.9533 492.5892 319.6552
LG/J m 363.3222 43.9533 449.7892 276.8552
LP/J f 289.3125 46.6196 381.0246 197.6004
LP/J m 578.5667 76.1294 728.3319 428.8015
MRL/MpJ f 347.0 49.8384 445.0443 248.9557
MRL/MpJ m 314.0778 43.9533 400.5448 227.6108
NOD/ShiLtJ f 407.5 49.8384 505.5443 309.4557
NOD/ShiLtJ m 340.3 53.8316 446.2 234.4
NON/ShiLtJ f 224.1714 49.8384 322.2158 126.1271
NON/ShiLtJ m 351.3429 49.8384 449.3872 253.2985
NZW/LacJ f 351.3143 49.8384 449.3586 253.2699
NZW/LacJ m 478.5222 43.9533 564.9892 392.0552
P/J f 145.82 58.9696 261.8276 29.8124
P/J m 203.9571 49.8384 302.0015 105.9128
PL/J f 275.6111 43.9533 362.0781 189.1441
PL/J m 274.9167 53.8316 380.8167 169.0167
RIIIS/J f 296.78 58.9696 412.7876 180.7724
RIIIS/J m 204.3167 53.8316 310.2167 98.4167
SJL/J f 123.7875 46.6196 215.4996 32.0754
SJL/J m 368.3833 53.8316 474.2833 262.4833
SM/J f 254.13 41.6978 336.1598 172.1002
SM/J m 247.0667 76.1294 396.8319 97.3015
SWR/J f 215.3 46.6196 307.0121 123.5879
SWR/J m 338.075 46.6196 429.7871 246.3629


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 278.054 33.2256 343.4169 212.6911
AKR/J both 238.9222 51.5399 340.3137 137.5307
BALB/cByJ both 250.255 39.9226 328.7925 171.7175
BALB/cJ both 332.4829 38.6047 408.4277 256.538
BTBR T+ Itpr3tf/J both 382.5375 44.2272 469.5432 295.5318
BUB/BnJ both 277.2538 37.5859 351.1944 203.3131
C3H/HeJ both 266.2371 38.6047 342.182 190.2923
C57BL/10J both 363.2979 35.6063 433.3442 293.2517
C57BL/6J both 152.8814 38.6047 228.8263 76.9366
C57BLKS/J both 532.45 38.0647 607.3326 457.5674
C57BR/cdJ both 383.85 40.3737 463.275 304.425
C57L/J both 392.6583 39.619 470.5986 314.718
CBA/J both 261.5632 32.0362 324.5863 198.5401
CE/J both 384.9 31.0797 446.0414 323.7586
DBA/1J both 317.125 60.1856 435.5248 198.7252
DBA/2J both 353.8944 39.619 431.8347 275.9542
FVB/NJ both 346.4817 34.0461 413.4587 279.5046
LG/J both 384.7222 31.0797 445.8636 323.5808
LP/J both 433.9396 44.6348 521.7472 346.1319
MRL/MpJ both 330.5389 33.2256 395.9018 265.176
NOD/ShiLtJ both 373.9 36.6801 446.0587 301.7413
NON/ShiLtJ both 287.7571 35.2411 357.085 218.4293
NZW/LacJ both 414.9183 33.2256 480.2811 349.5554
P/J both 174.8886 38.6047 250.8334 98.9437
PL/J both 275.2639 34.7482 343.622 206.9057
RIIIS/J both 250.5483 39.9226 329.0859 172.0108
SJL/J both 246.0854 35.6063 316.1317 176.0392
SM/J both 250.5983 43.4004 335.9776 165.219
SWR/J both 276.6875 32.965 341.5377 211.8373




  GWAS USING LINEAR MIXED MODELS