Project measure / variable:   Berndt1   pct_res_mch10

ID, description, units MPD:34223   pct_res_mch10   airway resistance (as % of baseline, H2O pressure)   [%]  MCh challenge 10 mg/mL  
methacholine study
Data set, strains Berndt1   inbred   37 strains     sex: both     age: 9-12wks
Procedure ventilator
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  STRAIN COMPARISON PLOT
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Berndt1 - airway resistance (as % of baseline, H2O pressure) MCh challenge 10 mg/mL



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested36 strains33 strains
Mean of the strain means170   % 188   %
Median of the strain means153   % 178   %
SD of the strain means± 73.5 ± 78.4
Coefficient of variation (CV)0.431 0.416
Min–max range of strain means65.3   –   490   % 78.4   –   477   %
Mean sample size per strain8.5   mice 9.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 101825.0531 101825.0531 13.7261 0.0002
strain 31 2890193.9441 93232.0627 12.5678 < 0.0001
sex:strain 31 394922.9522 12739.4501 1.7173 0.0104
Residuals 504 3738840.5991 7418.3345


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 140.0 32.4   9 10.8 0.231 96.0, 196.0 -0.41
129S1/SvImJ m 157.0 101.0   8 35.6 0.641 60.0, 320.0 -0.4
A/J f 234.0 72.9   10 23.1 0.311 121.0, 340.0 0.87
A/J m 268.0 158.0   9 52.6 0.589 114.0, 545.0 1.02
AKR/J f 109.0 50.0   9 16.7 0.457 48.3, 198.0 -0.84
AKR/J m 167.0 59.5   8 21.0 0.356 103.0, 296.0 -0.27
BALB/cByJ f 143.0 107.0   8 37.8 0.749 47.5, 334.0 -0.37
BALB/cByJ m 158.0 58.0   8 20.5 0.368 79.5, 238.0 -0.39
BALB/cJ f 123.0 35.6   8 12.6 0.29 89.4, 171.0 -0.65
BALB/cJ m 181.0 88.3   10 27.9 0.488 70.8, 319.0 -0.09
BPN/3J f 106.0 45.7   8 16.1 0.432 48.5, 171.0 -0.88
BTBR T+ Itpr3tf/J f 226.0 125.0   10 39.5 0.554 118.0, 528.0 0.76
BTBR T+ Itpr3tf/J m 235.0 71.1   10 22.5 0.303 139.0, 368.0 0.59
BUB/BnJ f 124.0 46.8   9 15.6 0.378 45.2, 178.0 -0.63
BUB/BnJ m 191.0 130.0   10 41.2 0.683 70.6, 466.0 0.03
C3H/HeJ f 121.0 28.9   10 9.15 0.239 55.3, 155.0 -0.67
C3H/HeJ m 154.0 57.5   9 19.2 0.372 78.7, 261.0 -0.44
C57BL/10J f 167.0 48.0   9 16.0 0.287 111.0, 268.0 -0.05
C57BL/10J m 217.0 47.7   10 15.1 0.22 137.0, 294.0 0.36
C57BL/6J f 65.3 13.9   8 4.92 0.213 39.1, 84.1 -1.43
C57BL/6J m 119.0 41.0   8 14.5 0.345 66.7, 172.0 -0.89
C57BLKS/J f 243.0 90.9   9 30.3 0.373 85.7, 348.0 0.99
C57BLKS/J m 290.0 113.0   12 32.6 0.39 152.0, 456.0 1.3
C57BR/cdJ f 235.0 118.0   6 48.3 0.504 98.1, 412.0 0.88
C57BR/cdJ m 235.0 116.0   10 36.6 0.493 100.0, 435.0 0.59
C57L/J f 202.0 89.1   6 36.4 0.44 44.6, 281.0 0.43
C57L/J m 201.0 85.4   10 27.0 0.425 116.0, 330.0 0.16
CBA/J f 141.0 104.0   8 36.7 0.733 49.2, 383.0 -0.4
CBA/J m 128.0 63.1   10 20.0 0.492 73.6, 280.0 -0.77
CE/J f 204.0 76.0   9 25.3 0.372 133.0, 346.0 0.46
CE/J m 128.0 44.1   9 14.7 0.344 85.0, 227.0 -0.77
DBA/1J f 225.0 94.1   9 31.4 0.418 65.3, 342.0 0.74
DBA/1J m 244.0 147.0   10 46.4 0.6 95.2, 553.0 0.71
DBA/2J f 146.0 49.9   10 15.8 0.341 85.0, 226.0 -0.33
DBA/2J m 175.0 61.3   10 19.4 0.349 75.0, 277.0 -0.17
FVB/NJ f 155.0 56.5   10 17.9 0.365 63.0, 246.0 -0.21
FVB/NJ m 240.0 141.0   10 44.6 0.588 43.9, 542.0 0.66
I/LnJ f 213.0 75.5   5 33.8 0.354 96.6, 283.0 0.58
I/LnJ m 214.0 93.3   8 33.0 0.437 22.6, 315.0 0.33
KK/HlJ f 490.0 202.0   9 67.4 0.413 238.0, 795.0 4.35
KK/HlJ m 477.0 168.0   10 53.1 0.352 278.0, 711.0 3.68
LG/J f 117.0 78.7   10 24.9 0.671 34.9, 260.0 -0.73
LG/J m 139.0 79.9   10 25.3 0.574 65.2, 352.0 -0.63
LP/J f 134.0 34.1   9 11.4 0.255 88.0, 190.0 -0.5
LP/J m 317.0 72.1   10 22.8 0.227 226.0, 446.0 1.64
MA/MyJ f 273.0 117.0   9 39.2 0.43 121.0, 438.0 1.4
MRL/MpJ f 176.0 105.0   9 35.0 0.595 65.4, 397.0 0.08
MRL/MpJ m 86.7 56.8   9 18.9 0.655 30.0, 215.0 -1.3
NOD/ShiLtJ f 151.0 20.6   9 6.86 0.136 122.0, 176.0 -0.26
NOD/ShiLtJ m 237.0 107.0   9 35.7 0.452 58.3, 435.0 0.62
NON/ShiLtJ f 121.0 53.9   7 20.4 0.446 40.2, 207.0 -0.67
NON/ShiLtJ m 131.0 57.4   7 21.7 0.437 71.4, 244.0 -0.73
NZB/BlNJ m 78.4 47.3   10 14.9 0.603 18.0, 181.0 -1.4
NZO/HlLtJ f 183.0 52.7   9 17.6 0.288 87.0, 227.0 0.17
NZW/LacJ f 122.0 40.0   8 14.2 0.329 91.3, 194.0 -0.66
NZW/LacJ m 178.0 97.3   10 30.8 0.547 44.7, 336.0 -0.13
P/J f 94.7 39.9   7 15.1 0.421 48.1, 156.0 -1.03
P/J m 101.0 39.9   8 14.1 0.394 52.5, 188.0 -1.12
PL/J f 208.0 110.0   9 36.5 0.527 84.2, 404.0 0.51
PL/J m 197.0 65.2   8 23.0 0.33 78.6, 279.0 0.11
PWD/PhJ f 182.0 47.4   6 19.3 0.261 97.7, 217.0 0.16
RIIIS/J f 158.0 42.5   6 17.4 0.27 126.0, 241.0 -0.17
RIIIS/J m 95.7 35.6   9 11.9 0.372 52.7, 178.0 -1.18
SJL/J f 93.5 37.3   8 13.2 0.399 62.2, 169.0 -1.05
SJL/J m 204.0 92.4   9 30.8 0.454 57.1, 316.0 0.2
SM/J f 165.0 50.7   10 16.0 0.306 86.8, 254.0 -0.07
SM/J m 140.0 40.2   8 14.2 0.287 69.2, 175.0 -0.62
SWR/J f 144.0 47.1   9 15.7 0.327 81.5, 207.0 -0.36
SWR/J m 134.0 85.8   10 27.1 0.643 65.6, 370.0 -0.69


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 140.3444 28.7099 196.7503 83.9386
129S1/SvImJ m 157.2875 30.4515 217.1149 97.4601
A/J f 234.33 27.2366 287.8413 180.8187
A/J m 267.8 28.7099 324.2059 211.3941
AKR/J f 109.2 28.7099 165.6059 52.7941
AKR/J m 167.175 30.4515 227.0024 107.3476
BALB/cByJ f 142.75 30.4515 202.5774 82.9226
BALB/cByJ m 157.75 30.4515 217.5774 97.9226
BALB/cJ f 122.6375 30.4515 182.4649 62.8101
BALB/cJ m 180.93 27.2366 234.4413 127.4187
BTBR T+ Itpr3tf/J f 225.54 27.2366 279.0513 172.0287
BTBR T+ Itpr3tf/J m 234.79 27.2366 288.3013 181.2787
BUB/BnJ f 123.6444 28.7099 180.0503 67.2386
BUB/BnJ m 190.95 27.2366 244.4613 137.4387
C3H/HeJ f 121.09 27.2366 174.6013 67.5787
C3H/HeJ m 154.4778 28.7099 210.8836 98.0719
C57BL/10J f 167.3111 28.7099 223.717 110.9053
C57BL/10J m 217.19 27.2366 270.7013 163.6787
C57BL/6J f 65.325 30.4515 125.1524 5.4976
C57BL/6J m 118.6625 30.4515 178.4899 58.8351
C57BLKS/J f 243.4222 28.7099 299.8281 187.0164
C57BLKS/J m 290.2917 24.8635 339.1406 241.4428
C57BR/cdJ f 234.6333 35.1623 303.7161 165.5505
C57BR/cdJ m 234.82 27.2366 288.3313 181.3087
C57L/J f 202.5 35.1623 271.5828 133.4172
C57L/J m 201.13 27.2366 254.6413 147.6187
CBA/J f 141.4875 30.4515 201.3149 81.6601
CBA/J m 128.35 27.2366 181.8613 74.8387
CE/J f 203.9889 28.7099 260.3947 147.583
CE/J m 128.1667 28.7099 184.5725 71.7608
DBA/1J f 224.8667 28.7099 281.2725 168.4608
DBA/1J m 244.36 27.2366 297.8713 190.8487
DBA/2J f 146.04 27.2366 199.5513 92.5287
DBA/2J m 175.37 27.2366 228.8813 121.8587
FVB/NJ f 154.91 27.2366 208.4213 101.3987
FVB/NJ m 240.03 27.2366 293.5413 186.5187
I/LnJ f 212.98 38.5184 288.6564 137.3036
I/LnJ m 213.7125 30.4515 273.5399 153.8851
KK/HlJ f 489.5667 28.7099 545.9725 433.1608
KK/HlJ m 477.1 27.2366 530.6113 423.5887
LG/J f 117.33 27.2366 170.8413 63.8187
LG/J m 139.13 27.2366 192.6413 85.6187
LP/J f 133.6333 28.7099 190.0392 77.2275
LP/J m 317.0 27.2366 370.5113 263.4887
MRL/MpJ f 176.3667 28.7099 232.7725 119.9608
MRL/MpJ m 86.7444 28.7099 143.1503 30.3386
NOD/ShiLtJ f 150.7889 28.7099 207.1947 94.383
NOD/ShiLtJ m 236.6111 28.7099 293.017 180.2053
NON/ShiLtJ f 121.0429 32.554 185.0011 57.0846
NON/ShiLtJ m 131.3286 32.554 195.2868 67.3703
NZW/LacJ f 121.525 30.4515 181.3524 61.6976
NZW/LacJ m 178.04 27.2366 231.5513 124.5287
P/J f 94.7429 32.554 158.7011 30.7846
P/J m 101.3375 30.4515 161.1649 41.5101
PL/J f 207.8667 28.7099 264.2725 151.4608
PL/J m 197.425 30.4515 257.2524 137.5976
RIIIS/J f 157.75 35.1623 226.8328 88.6672
RIIIS/J m 95.7 28.7099 152.1059 39.2941
SJL/J f 93.475 30.4515 153.3024 33.6476
SJL/J m 203.6111 28.7099 260.017 147.2053
SM/J f 165.45 27.2366 218.9613 111.9387
SM/J m 139.8375 30.4515 199.6649 80.0101
SWR/J f 144.3778 28.7099 200.7836 87.9719
SWR/J m 133.53 27.2366 187.0413 80.0187


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 148.816 20.9258 189.9285 107.7035
A/J both 251.065 19.7869 289.9401 212.1899
AKR/J both 138.1875 20.9258 179.3 97.075
BALB/cByJ both 150.25 21.5324 192.5544 107.9456
BALB/cJ both 151.7837 20.4275 191.9172 111.6503
BTBR T+ Itpr3tf/J both 230.165 19.2592 268.0032 192.3268
BUB/BnJ both 157.2972 19.7869 196.1723 118.4222
C3H/HeJ both 137.7839 19.7869 176.6589 98.9088
C57BL/10J both 192.2506 19.7869 231.1256 153.3755
C57BL/6J both 91.9937 21.5324 134.2981 49.6894
C57BLKS/J both 266.8569 18.9898 304.1659 229.548
C57BR/cdJ both 234.7267 22.2386 278.4185 191.0349
C57L/J both 201.815 22.2386 245.5068 158.1232
CBA/J both 134.9187 20.4275 175.0522 94.7853
CE/J both 166.0778 20.301 205.9627 126.1928
DBA/1J both 234.6133 19.7869 273.4884 195.7383
DBA/2J both 160.705 19.2592 198.5432 122.8668
FVB/NJ both 197.47 19.2592 235.3082 159.6318
I/LnJ both 213.3462 24.5508 261.5807 165.1118
KK/HlJ both 483.3333 19.7869 522.2084 444.4583
LG/J both 128.23 19.2592 166.0682 90.3918
LP/J both 225.3167 19.7869 264.1917 186.4416
MRL/MpJ both 131.5556 20.301 171.4405 91.6706
NOD/ShiLtJ both 193.7 20.301 233.585 153.815
NON/ShiLtJ both 126.1857 23.0191 171.411 80.9604
NZW/LacJ both 149.7825 20.4275 189.916 109.649
P/J both 98.0402 22.2882 141.8294 54.251
PL/J both 202.6458 20.9258 243.7583 161.5334
RIIIS/J both 126.725 22.6972 171.3177 82.1323
SJL/J both 148.5431 20.9258 189.6555 107.4306
SM/J both 152.6437 20.4275 192.7772 112.5103
SWR/J both 138.9539 19.7869 177.8289 100.0788




  GWAS USING LINEAR MIXED MODELS