Phenotype measure:   Yuan1   IGF1_M18

ID, description, units MPD:27003   IGF1_M18   insulin-like growth factor 1 (serum IGF-1)   [ng/mL]  at age 18mo
Data set, strains Yuan1   inbred   30 strains     sex: both     age: 78wks
Procedure hormone quantification
Ontology mappings

  STRAIN COMPARISON PLOT
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Yuan1 - insulin-like growth factor 1 (serum IGF-1) at age 18mo



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains27 strains
Mean of the strain means301   ng/mL 299   ng/mL
Median of the strain means305   ng/mL 296   ng/mL
SD of the strain means± 55.6 ± 39.5
Coefficient of variation (CV)0.185 0.132
Min–max range of strain means194   –   436   ng/mL 225   –   384   ng/mL
Mean sample size per strain6.1   mice 6.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 246.6806 246.6806 0.1515 0.6974
strain 25 575753.3796 23030.1352 14.1398 < 0.0001
sex:strain 25 166216.0123 6648.6405 4.0821 < 0.0001
Residuals 289 470707.9275 1628.7472


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 305.0 53.7   7 20.3 0.176 215.0, 387.0 0.08
129S1/SvImJ m 302.0 44.8   14 12.0 0.148 187.0, 350.0 0.07
A/J f 303.0 18.1   7 6.85 0.0598 281.0, 329.0 0.04
A/J m 330.0 22.2   5 9.93 0.0673 297.0, 353.0 0.78
BALB/cByJ f 361.0 35.1   8 12.4 0.0971 313.0, 423.0 1.09
BALB/cByJ m 267.0 22.5   5 10.0 0.0841 244.0, 294.0 -0.82
BTBR T+ Itpr3tf/J f 363.0 36.9   4 18.4 0.102 325.0, 412.0 1.12
BTBR T+ Itpr3tf/J m 301.0 48.0   6 19.6 0.16 216.0, 344.0 0.04
BUB/BnJ f 305.0 48.6   11 14.7 0.159 251.0, 394.0 0.08
BUB/BnJ m 358.0 24.7   6 10.1 0.069 318.0, 382.0 1.48
C3H/HeJ f 300.0 44.2   8 15.6 0.147 268.0, 398.0 -0.01
C3H/HeJ m 334.0 23.2   8 8.22 0.0696 302.0, 367.0 0.88
C57BL/10J f 256.0 75.2   7 28.4 0.293 139.0, 381.0 -0.8
C57BL/10J m 267.0 26.6   7 10.1 0.0997 231.0, 310.0 -0.82
C57BL/6J f 310.0 44.3   7 16.7 0.143 261.0, 373.0 0.17
C57BL/6J m 272.0 17.4   8 6.15 0.0641 232.0, 290.0 -0.69
C57BLKS/J f 235.0 36.6   7 13.8 0.156 189.0, 273.0 -1.18
C57BLKS/J m 270.0 22.2   8 7.85 0.0821 229.0, 291.0 -0.74
C57BR/cdJ f 321.0 41.0   8 14.5 0.128 248.0, 371.0 0.37
C57BR/cdJ m 296.0 36.2   8 12.8 0.123 241.0, 338.0 -0.09
C57L/J f 332.0 38.7   7 14.6 0.117 282.0, 401.0 0.57
C57L/J m 291.0 11.5   6 4.7 0.0395 278.0, 307.0 -0.21
CAST/EiJ f 356.0 14.5   3 8.37 0.0407 342.0, 371.0 1.0
CBA/J f 298.0 46.7   9 15.6 0.157 212.0, 355.0 -0.05
CBA/J m 307.0 16.2   6 6.6 0.0527 288.0, 327.0 0.19
DBA/2J f 223.0 32.0   5 14.3 0.143 198.0, 277.0 -1.4
DBA/2J m 248.0 35.4   6 14.5 0.143 194.0, 291.0 -1.3
FVB/NJ f 273.0 43.0   7 16.3 0.157 215.0, 331.0 -0.5
FVB/NJ m 302.0 92.9   4 46.5 0.308 165.0, 366.0 0.07
KK/HlJ f 292.0 16.2   4 8.1 0.0556 273.0, 307.0 -0.15
KK/HlJ m 280.0 40.3   7 15.2 0.144 227.0, 335.0 -0.49
LP/J f 310.0 34.1   7 12.9 0.11 259.0, 372.0 0.17
LP/J m 352.0 32.7   8 11.6 0.093 295.0, 413.0 1.33
MRL/MpJ f 204.0 17.3   5 7.73 0.0847 177.0, 222.0 -1.74
MRL/MpJ m 271.0 51.6   7 19.5 0.19 221.0, 374.0 -0.72
NOD.B10Sn-H2b/J m 324.0 4.95   2   3.5 0.0153 321.0, 328.0 0.62
NON/ShiLtJ f 342.0 71.4   6 29.1 0.209 224.0, 429.0 0.75
NON/ShiLtJ m 368.0 57.8   7 21.8 0.157 303.0, 471.0 1.74
NZO/HlLtJ f 436.0 37.5   7 14.2 0.0861 384.0, 489.0 2.44
NZO/HlLtJ m 339.0 24.3   5 10.9 0.0715 303.0, 367.0 1.0
NZW/LacJ f 370.0 47.5   7 18.0 0.129 296.0, 435.0 1.25
NZW/LacJ m 384.0 16.7   6 6.82 0.0435 368.0, 413.0 2.14
P/J f 352.0 31.0   4 15.5 0.0881 315.0, 385.0 0.93
PL/J f 264.0 8.49   2   6.0 0.0321 258.0, 270.0 -0.66
PWD/PhJ f 328.0 44.5   4 22.3 0.136 287.0, 388.0 0.49
PWD/PhJ m 290.0 52.5   7 19.9 0.181 217.0, 389.0 -0.24
RIIIS/J f 215.0 52.1   8 18.4 0.242 160.0, 287.0 -1.54
RIIIS/J m 291.0 23.9   8 8.43 0.0819 254.0, 323.0 -0.21
SJL/J f 300.0 44.9   4 22.4 0.15 258.0, 341.0 -0.01
SJL/J m 250.0 33.2   4 16.6 0.133 223.0, 298.0 -1.25
SM/J f 246.0 28.6   6 11.7 0.116 209.0, 288.0 -0.98
SM/J m 225.0 27.3   9 9.1 0.121 186.0, 260.0 -1.88
SWR/J f 322.0 12.4   4 6.22 0.0387 310.0, 333.0 0.39
SWR/J m 312.0 28.8   4 14.4 0.0921 270.0, 334.0 0.32
WSB/EiJ f 194.0 52.5   4 26.3 0.27 138.0, 249.0 -1.92
WSB/EiJ m 252.0 32.0   4 16.0 0.127 219.0, 283.0 -1.2


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 305.0 15.2538 335.0226 274.9774
129S1/SvImJ m 302.4286 10.7861 323.6578 281.1994
A/J f 302.8571 15.2538 332.8798 272.8345
A/J m 329.8 18.0485 365.3232 294.2768
BALB/cByJ f 361.125 14.2686 389.2086 333.0414
BALB/cByJ m 267.2 18.0485 302.7232 231.6768
BTBR T+ Itpr3tf/J f 362.75 20.1789 402.4662 323.0338
BTBR T+ Itpr3tf/J m 300.6667 16.476 333.0948 268.2385
BUB/BnJ f 305.2727 12.1683 329.2225 281.323
BUB/BnJ m 357.8333 16.476 390.2615 325.4052
C3H/HeJ f 299.75 14.2686 327.8336 271.6664
C3H/HeJ m 334.0 14.2686 362.0836 305.9164
C57BL/10J f 256.2857 15.2538 286.3083 226.2631
C57BL/10J m 266.7143 15.2538 296.7369 236.6917
C57BL/6J f 309.7143 15.2538 339.7369 279.6917
C57BL/6J m 271.75 14.2686 299.8336 243.6664
C57BLKS/J f 234.8571 15.2538 264.8798 204.8345
C57BLKS/J m 270.375 14.2686 298.4586 242.2914
C57BR/cdJ f 321.125 14.2686 349.2086 293.0414
C57BR/cdJ m 295.75 14.2686 323.8336 267.6664
C57L/J f 332.0 15.2538 362.0226 301.9774
C57L/J m 291.0 16.476 323.4281 258.5719
CBA/J f 297.7778 13.4526 324.2552 271.3003
CBA/J m 306.8333 16.476 339.2615 274.4052
DBA/2J f 223.2 18.0485 258.7232 187.6768
DBA/2J m 248.3333 16.476 280.7615 215.9052
FVB/NJ f 273.2857 15.2538 303.3083 243.2631
FVB/NJ m 301.75 20.1789 341.4662 262.0338
KK/HlJ f 291.5 20.1789 331.2162 251.7838
KK/HlJ m 279.8571 15.2538 309.8798 249.8345
LP/J f 310.0 15.2538 340.0226 279.9774
LP/J m 351.625 14.2686 379.7086 323.5414
MRL/MpJ f 204.0 18.0485 239.5232 168.4768
MRL/MpJ m 271.2857 15.2538 301.3083 241.2631
NON/ShiLtJ f 342.1667 16.476 374.5948 309.7385
NON/ShiLtJ m 367.8571 15.2538 397.8798 337.8345
NZO/HlLtJ f 436.0 15.2538 466.0226 405.9774
NZO/HlLtJ m 339.2 18.0485 374.7232 303.6768
NZW/LacJ f 369.5714 15.2538 399.594 339.5488
NZW/LacJ m 383.6667 16.476 416.0948 351.2385
PWD/PhJ f 328.0 20.1789 367.7162 288.2838
PWD/PhJ m 290.2857 15.2538 320.3083 260.2631
RIIIS/J f 215.0 14.2686 243.0836 186.9164
RIIIS/J m 291.375 14.2686 319.4586 263.2914
SJL/J f 299.75 20.1789 339.4662 260.0338
SJL/J m 249.75 20.1789 289.4662 210.0338
SM/J f 245.6667 16.476 278.0948 213.2385
SM/J m 224.8889 13.4526 251.3663 198.4114
SWR/J f 321.75 20.1789 361.4662 282.0338
SWR/J m 312.25 20.1789 351.9662 272.5338
WSB/EiJ f 194.5 20.1789 234.2162 154.7838
WSB/EiJ m 251.75 20.1789 291.4662 212.0338


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 303.7143 9.341 322.0993 285.3293
A/J both 316.3286 11.8155 339.584 293.0732
BALB/cByJ both 314.1625 11.5037 336.8042 291.5208
BTBR T+ Itpr3tf/J both 331.7083 13.0254 357.345 306.0716
BUB/BnJ both 331.553 10.2412 351.7098 311.3963
C3H/HeJ both 316.875 10.0894 336.7331 297.0169
C57BL/10J both 261.5 10.7861 282.7292 240.2708
C57BL/6J both 290.7321 10.4436 311.2872 270.1771
C57BLKS/J both 252.6161 10.4436 273.1711 232.061
C57BR/cdJ both 308.4375 10.0894 328.2956 288.5794
C57L/J both 311.5 11.2265 333.596 289.404
CBA/J both 302.3056 10.6352 323.2378 281.3733
DBA/2J both 235.7667 12.2189 259.816 211.7173
FVB/NJ both 287.5179 12.6478 312.4113 262.6244
KK/HlJ both 285.6786 12.6478 310.572 260.7851
LP/J both 330.8125 10.4436 351.3676 310.2574
MRL/MpJ both 237.6429 11.8155 260.8983 214.3874
NON/ShiLtJ both 355.0119 11.2265 377.1079 332.9159
NZO/HlLtJ both 387.6 11.8155 410.8554 364.3446
NZW/LacJ both 376.619 11.2265 398.7151 354.523
PWD/PhJ both 309.1429 12.6478 334.0363 284.2494
RIIIS/J both 253.1875 10.0894 273.0456 233.3294
SJL/J both 274.75 14.2686 302.8336 246.6664
SM/J both 235.2778 10.6352 256.21 214.3455
SWR/J both 317.0 14.2686 345.0836 288.9164
WSB/EiJ both 223.125 14.2686 251.2086 195.0414




  GWAS USING LINEAR MIXED MODELS