Yuan1: Aging study: IGF-1 and body weight for 33 inbred strains of mice (2007)

Yuan R, Tsaih SW, Petkova SB, Marin de Evsikova C, Xing S, Marion MA, Bogue MA, Mills KD, Peters LL, Bult CJ, Rosen CJ, Sundberg JP, Harrison DE, Churchill GA, Paigen B. Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell. 2009 Jun;8(3):277-87. Epub 2009 Apr 9.   PubMed 19627267     FullText

Leduc MS, Hageman RS, Meng Q, Verdugo RA, Tsaih SW, Churchill GA, Paigen B, Yuan R. Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains. Aging Cell. 2010 Oct;9(5):823-36. doi: 10.1111/j.1474-9726.2010.00612.x.   PubMed 20735370     FullText


       
Yuan1 downloads
• Download Yuan1 project data set     one row per animal, one column per trait
• Download Yuan1 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Rong Yuan       The Jackson Laboratory Bar Harbor, ME
Clifford J Rosen       The Jackson Laboratory Bar Harbor, ME
Wesley G Beamer       The Jackson Laboratory Bar Harbor, ME
With: Schultz D, Godfrey D
ContactRong Yuan     rong.yuan@jax.org     Lab web site
AffiliationJAX Nathan Shock Aging Center
AcknowledgementsFunding provided by NIH AG025707 (NIA Nathan Shock Center for Aging Research); The Ellison Medical Foundation
Project type Phenotype strain survey data set
MPD identifiersYuan1     MPD:270
Data changelog 1 update/correction.       Initial release date: 06/2008.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Animals were evaluated for serum IGF-1 levels using radioimmunoassay.

Summary of procedures that were conducted
• body weight Aging study, 6mo, 12mo, and 18mo.
• hormone quantification Insulin-like growth factor 1 (serum). Aging study, 6mo, 12mo, and 18mo.
Mice: inbred   33 strains   ♀♂   age 26, 52, 78 wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Yuan1 27001 hormone quantification (none) insulin-like growth factor 1 (serum IGF-1)   [ng/mL]     6mo    12mo    18mo inbred 33 both N=7
    Yuan1 27011 body weight (none) body weight   [g]     6mo    12mo    18mo inbred 33 both N=7
    All boxes