Project measure / variable:   CSNA03   extinction_active_in_s2

ID, description, units MPD:110199   extinction_active_in_s2   extinction, active lever presses (intravenous self administration), founders   [n]  session 2  
cocaine study
Data set, strains CSNA03   inbred w/CC8   7 strains     sex: both     age:
Procedure operant conditioning chamber
Ontology mappings

  STRAIN COMPARISON PLOT
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CSNA03 - extinction, active lever presses (intravenous self administration), founders session 2



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means108.2   n 54.92   n
Median of the strain means117.2   n 44.0   n
SD of the strain means± 80.22 ± 29.174
Coefficient of variation (CV)0.7415 0.5312
Min–max range of strain means24.333   –   265.0   n 25.2   –   105.7   n
Mean sample size per strain7.0   mice 6.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 81922.2017 81922.2017 4.2471 0.0425
strain 5 260250.8442 52050.1688 2.6985 0.0262
sex:strain 5 150168.3201 30033.664 1.557 0.1815
Residuals 82 1581686.6872 19288.862


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 24.333 24.454   9 8.1513 1.005 4.0, 80.0 -1.05
A/J m 37.5 45.148   6 18.431 1.2039 6.0, 106.0 -0.6
C57BL/6J f 265.0 346.2   11 104.4 1.3065 5.0, 1241.0 1.96
C57BL/6J m 63.83 48.848   12 14.101 0.7652 16.0, 184.0 0.31
CAST/EiJ f 121.0 0.0   1   0.0 0.0 121.0, 121.0 0.16
CAST/EiJ m 44.0 8.4853   2   6.0 0.1928 38.0, 50.0 -0.37
NOD/ShiLtJ f 117.2 150.0   11 45.213 1.2797 7.0, 503.0 0.11
NOD/ShiLtJ m 78.0 81.1   7 30.652 1.0397 3.0, 211.0 0.79
NZO/HlLtJ f 45.7 46.819   10 14.805 1.0245 -0.78
NZO/HlLtJ m 30.222 21.919   9 7.3063 0.7253 10.0, 80.0 -0.85
PWK/PhJ f 126.0 86.25   5 38.571 0.6845 40.0, 243.0 0.22
PWK/PhJ m 105.7 60.2   7 22.755 0.5695 12.0, 182.0 1.74
WSB/EiJ f 58.0 36.77   2   26.0 0.634 32.0, 84.0 -0.63
WSB/EiJ m 25.2 16.392   5 7.3308 0.6505 15.0, 54.0 -1.02


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 24.3333333333 46.2947825696 116.4284033977 -67.761736731
A/J m 37.5 56.6992975243 150.2929647417 -75.2929647417
C57BL/6J f 265.0 41.8752064185 348.3031252122 181.6968747878
C57BL/6J m 63.8333333333 40.092457768 143.5900035723 -15.9233369057
NOD/ShiLtJ f 117.1818181818 41.8752064185 200.484943394 33.8786929696
NOD/ShiLtJ m 78.0 52.493349291 182.4259938708 -26.4259938708
NZO/HlLtJ f 45.7 43.9190870107 133.0690548028 -41.6690548028
NZO/HlLtJ m 30.2222222222 46.2947825696 122.3172922865 -61.8728478421
PWK/PhJ f 126.0 62.1109684975 249.5585022339 2.4414977661
PWK/PhJ m 105.7142857143 52.493349291 210.1402795851 1.2882918435
WSB/EiJ f 58.0 98.2060640656 253.363145669 -137.363145669
WSB/EiJ m 25.2 62.1109684975 148.7585022339 -98.3585022339


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 30.9166666667 36.5992391756 103.7242123357 -41.8908790023
C57BL/6J both 164.4166666667 28.986799075 222.0806439786 106.7526893547
NOD/ShiLtJ both 97.5909090909 33.5748590182 164.3819991891 30.7998189927
NZO/HlLtJ both 37.9611111111 31.9064769953 101.4332578908 -25.5110356686
PWK/PhJ both 115.8571428571 40.6611735181 196.7451698917 34.9691158226
WSB/EiJ both 41.6 58.0994910196 157.1783956455 -73.9783956455




  GWAS USING LINEAR MIXED MODELS