HMDPpheno6: Liver metabolite levels: Amino acids in males of 104 strains of the Hybrid Mouse Diversity Panel (HMDP) (2014)

Ghazalpour A, Bennett BJ, Shih D, Che N, Orozco L, Pan C, Hagopian R, He A, Kayne P, Yang WP, Kirchgessner T, Lusis AJ. Genetic regulation of mouse liver metabolite levels. Mol Syst Biol. 2014 May 23;10(5):730. doi: 10.15252/msb.20135004.   PubMed 24860088  


       
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Participants Anatole Ghazalpour       University of California, Los Angeles Los Angeles, CA
Brian J Bennett       University of North Carolina Chapel Hill, NC
Luz Orozco       University of California, Los Angeles Los Angeles, CA
Aldons J Lusis       University of California, Los Angeles Los Angeles, CA
With: Shih D, Che N, Pan C, Hagopian R, He A, Kayne P, Yang W-P
ContactAnatole Ghazalpour     aghazalp@ucla.edu     Lab web site
AffiliationHybrid Mouse Diversity Panel Group (HMDP)
Part of a series: • Metabolite survey: Amino acids   (this project) HMDPpheno6
• Metabolite survey: Carbs, cofactors, vitamins, energy, xenobiotics   see HMDPpheno7
• Metabolite survey: Lipids (non-lysolipids)   see HMDPpheno8
• Metabolite survey: Lipids (lysolipids)   see HMDPpheno9
• Metabolite survey: Nucleotides, peptides   see HMDPpheno10
AcknowledgementsFunding provided by NIH HL30568, HL28481, HL102223, HG002536, GM07104
Project type Phenotype strain survey data set
MPD identifiersHMDPpheno6     MPD:501
Data changelog No updates/corrections.       Initial release date: 06/2014.
Formatted citation
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Summary of procedures that were conducted
• metabolite quantification Liver metabolic profiling. Molecular measures of amino acids. 16h fast.
Mice: HMDP   106 strains including progenitors   ♂   age 16wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    HMDPpheno6 50101 metabolite quantification (none) alanine (16h fast), relative abundance  Ala HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50102 metabolite quantification (none) asparagine (16h fast), relative abundance  Asn HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50103 metabolite quantification (none) aspartate (16h fast), relative abundance  Asp HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50104 metabolite quantification (none) beta-alanine (16h fast), relative abundance  beta_Ala HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50105 metabolite quantification (none) N-acetylasparagine (16h fast), relative abundance  acetyl_Asn HMDP w/par 103 m 16wks N=1
    HMDPpheno6 50106 metabolite quantification (none) N-acetylalanine (16h fast), relative abundance  acetyl_Ala HMDP w/par 104 m 16wks N=1
    HMDPpheno6 50107 metabolite quantification (none) 2-aminobutyrate (16h fast), relative abundance  aminobutyrate HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50108 metabolite quantification (none) creatine (16h fast), relative abundance  creatine HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50109 metabolite quantification (none) 2-hydroxybutyrate (AHB) (16h fast), relative abundance  AHB HMDP w/par 99 m 16wks N=1
    HMDPpheno6 50110 metabolite quantification (none) cysteine (16h fast), relative abundance  Cys HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50111 metabolite quantification (none) hypotaurine (16h fast), relative abundance  hypotaurine HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50112 metabolite quantification (none) methionine (16h fast), relative abundance  Met HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50113 metabolite quantification (none) methionine sulfoxide (16h fast), relative abundance  Met_sulf HMDP w/par 104 m 16wks N=1
    HMDPpheno6 50114 metabolite quantification (none) taurine (16h fast), relative abundance  taurine HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50115 metabolite quantification (none) N-acetylmethionine (16h fast), relative abundance  acetyl_Met HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50116 metabolite quantification (none) S-adenosylhomocysteine (SAH) (16h fast), relative abundance  SAH HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50117 metabolite quantification (none) gamma-aminobutyrate (GABA) (16h fast), relative abundance  GABA HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50118 metabolite quantification (none) N-acetylglutamate (16h fast), relative abundance  acetyl_Glu HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50119 metabolite quantification (none) glutamine (16h fast), relative abundance  Gln HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50120 metabolite quantification (none) glutamate (16h fast), relative abundance  Glu HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50121 metabolite quantification (none) cysteine-glutathione disulfide (16h fast), relative abundance  CySSG HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50122 metabolite quantification (none) glutathione, reduced (GSH) (16h fast), relative abundance  GSH HMDP w/par 104 m 16wks N=1
    HMDPpheno6 50123 metabolite quantification (none) glutathione, oxidized (GSSG) (16h fast), relative abundance  GSSG HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50124 metabolite quantification (none) S-methylglutathione (16h fast), relative abundance  Me_glutathione HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50125 metabolite quantification (none) ophthalmate (16h fast), relative abundance  ophthalmate HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50126 metabolite quantification (none) 5-oxoproline (16h fast), relative abundance  oxoproline HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50127 metabolite quantification (none) N-acetylglycine (16h fast), relative abundance  acetyl_Gly HMDP w/par 96 m 16wks N=1
    HMDPpheno6 50128 metabolite quantification (none) dimethylglycine (16h fast), relative abundance  diMe_Gly HMDP w/par 96 m 16wks N=1
    HMDPpheno6 50129 metabolite quantification (none) glycine (16h fast), relative abundance  Gly HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50130 metabolite quantification (none) homoserine (16h fast), relative abundance  homo_Ser HMDP w/par 104 m 16wks N=1
    HMDPpheno6 50131 metabolite quantification (none) serine (16h fast), relative abundance  Ser HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50132 metabolite quantification (none) threonine (16h fast), relative abundance  Thr HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50133 metabolite quantification (none) betaine (16h fast), relative abundance  betaine HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50134 metabolite quantification (none) betaine aldehyde (16h fast), relative abundance  betaine_aldehyde HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50135 metabolite quantification (none) 3-methylcrotonylglycine (16h fast), relative abundance  MeC_Gly HMDP w/par 98 m 16wks N=1
    HMDPpheno6 50136 metabolite quantification (none) 4-guanidinobutanoate (16h fast), relative abundance  guanidino HMDP w/par 94 m 16wks N=1
    HMDPpheno6 50137 metabolite quantification (none) 1-methylimidazoleacetate (16h fast), relative abundance  MeLAA HMDP w/par 91 m 16wks N=1
    HMDPpheno6 50138 metabolite quantification (none) histidine (16h fast), relative abundance  His HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50139 metabolite quantification (none) glutarate (pentanedioate) (16h fast), relative abundance  glutarate HMDP w/par 100 m 16wks N=1
    HMDPpheno6 50140 metabolite quantification (none) N2-acetyllysine (16h fast), relative abundance  acetyl_Lys HMDP w/par 105 m 16wks N=1
    HMDPpheno6 50141 metabolite quantification (none) 2-aminoadipate (16h fast), relative abundance  aminoadipate HMDP w/par 98 m 16wks N=1
    HMDPpheno6 50142 metabolite quantification (none) glutaroyl carnitine (16h fast), relative abundance  GO_carnitine HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50143 metabolite quantification (none) lysine (16h fast), relative abundance  Lys HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50144 metabolite quantification (none) pipecolate (16h fast), relative abundance  pipecolate HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50145 metabolite quantification (none) phenylalanine (16h fast), relative abundance  Phe HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50146 metabolite quantification (none) tyrosine (16h fast), relative abundance  Tyr HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50147 metabolite quantification (none) 3-(4-hydroxyphenyl)lactate (16h fast), relative abundance  HP_lactate HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50148 metabolite quantification (none) phenylacetylglycine (16h fast), relative abundance  PA_Gly HMDP w/par 105 m 16wks N=1
    HMDPpheno6 50149 metabolite quantification (none) phenol sulfate (16h fast), relative abundance  phenol_sulfate HMDP w/par 103 m 16wks N=1
    HMDPpheno6 50150 metabolite quantification (none) 5-methylthioadenosine (MTA) (16h fast), relative abundance  MTA HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50151 metabolite quantification (none) spermidine (16h fast), relative abundance  spermidine HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50152 metabolite quantification (none) anthranilate (16h fast), relative abundance  anthranilate HMDP w/par 105 m 16wks N=1
    HMDPpheno6 50153 metabolite quantification (none) C-glycosyltryptophan (16h fast), relative abundance  glycosyl_Trp HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50154 metabolite quantification (none) kynurenine (16h fast), relative abundance  kynurenine HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50155 metabolite quantification (none) tryptophan (16h fast), relative abundance  Trp HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50156 metabolite quantification (none) kynurenate (16h fast), relative abundance  kynurenate HMDP w/par 105 m 16wks N=1
    HMDPpheno6 50157 metabolite quantification (none) trans-4-hydroxyproline (16h fast), relative abundance  hydroxy_Pro HMDP w/par 103 m 16wks N=1
    HMDPpheno6 50158 metabolite quantification (none) ornithine (16h fast), relative abundance  ornithine HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50159 metabolite quantification (none) urea (16h fast), relative abundance  urea HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50160 metabolite quantification (none) N-acetylornithine (16h fast), relative abundance  acetylornithine HMDP w/par 103 m 16wks N=1
    HMDPpheno6 50161 metabolite quantification (none) 5-aminovalerate (16h fast), relative abundance  aminovalerate HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50162 metabolite quantification (none) citrulline (16h fast), relative abundance  citrulline HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50163 metabolite quantification (none) homostachydrine (16h fast), relative abundance  homostachydrine HMDP w/par 105 m 16wks N=1
    HMDPpheno6 50164 metabolite quantification (none) proline (16h fast), relative abundance  Pro HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50165 metabolite quantification (none) dimethylarginine (SDMA + ADMA) (16h fast), relative abundance  SMDA_ADMA HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50166 metabolite quantification (none) stachydrine (16h fast), relative abundance  stachydrine HMDP w/par 104 m 16wks N=1
    HMDPpheno6 50167 metabolite quantification (none) hydroxyisovaleroyl carnitine (16h fast), relative abundance  HV_carnitine HMDP w/par 104 m 16wks N=1
    HMDPpheno6 50168 metabolite quantification (none) isobutyrylcarnitine (16h fast), relative abundance  IB_carnitine HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50169 metabolite quantification (none) isoleucine (16h fast), relative abundance  Ile HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50170 metabolite quantification (none) isovalerylcarnitine (16h fast), relative abundance  IV_carnitine HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50171 metabolite quantification (none) isovalerylglycine (16h fast), relative abundance  IV_Gly HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50172 metabolite quantification (none) leucine (16h fast), relative abundance  Leu HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50173 metabolite quantification (none) 2-methylbutyroylcarnitine (16h fast), relative abundance  MeB_carnitine HMDP w/par 105 m 16wks N=1
    HMDPpheno6 50174 metabolite quantification (none) methylglutaroylcarnitine (16h fast), relative abundance  MeG_carnitine HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50175 metabolite quantification (none) tigloylglycine (16h fast), relative abundance  tigloyl_Gly HMDP w/par 92 m 16wks N=1
    HMDPpheno6 50176 metabolite quantification (none) tiglyl carnitine (16h fast), relative abundance  tiglyl_carnitine HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50177 metabolite quantification (none) valine (16h fast), relative abundance  Val HMDP w/par 106 m 16wks N=1
    HMDPpheno6 50178 metabolite quantification (none) methylmalonate (MMA) (16h fast), relative abundance  MMA HMDP w/par 106 m 16wks N=1
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