HMDPpheno8: Liver metabolite levels: Lipids (except lysolipids) in males of 104 strains of the Hybrid Mouse Diversity Panel (HMDP) (2014)

Ghazalpour A, Bennett BJ, Shih D, Che N, Orozco L, Pan C, Hagopian R, He A, Kayne P, Yang WP, Kirchgessner T, Lusis AJ. Genetic regulation of mouse liver metabolite levels. Mol Syst Biol. 2014 May 23;10(5):730. doi: 10.15252/msb.20135004.   PubMed 24860088  


       
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Participants Anatole Ghazalpour       University of California, Los Angeles Los Angeles, CA
Brian J Bennett       University of North Carolina Chapel Hill, NC
Luz Orozco       University of California, Los Angeles Los Angeles, CA
Aldons J Lusis       University of California, Los Angeles Los Angeles, CA
With: Shih D, Che N, Pan C, Hagopian R, He A, Kayne P, Yang W-P
ContactAnatole Ghazalpour     aghazalp@ucla.edu     Lab web site
AffiliationHybrid Mouse Diversity Panel Group (HMDP)
Part of a series: • Metabolite survey: Amino acids   see HMDPpheno6
• Metabolite survey: Carbs, cofactors, vitamins, energy, xenobiotics   see HMDPpheno7
• Metabolite survey: Lipids (non-lysolipids)   (this project) HMDPpheno8
• Metabolite survey: Lipids (lysolipids)   see HMDPpheno9
• Metabolite survey: Nucleotides, peptides   see HMDPpheno10
Project type Phenotype strain survey data set
MPD identifiersHMDPpheno8     MPD:503
Data changelog No updates/corrections.       Initial release date: 06/2014.
Formatted citation
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Summary of procedures that were conducted
• metabolite quantification Liver metabolic profiling. Molecular measures of lipids (non-lysolipids). 16h fast.
Mice: HMDP   106 strains   ♂   age 16wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    HMDPpheno8 50301 metabolite quantification (none) alpha-muricholate (16h fast), relative abundance  alpha_muricholate HMDP 104 m 16wks N=1
    HMDPpheno8 50302 metabolite quantification (none) beta-muricholate (16h fast), relative abundance  beta_muricholate HMDP 106 m 16wks N=1
    HMDPpheno8 50303 metabolite quantification (none) chenodeoxycholate (16h fast), relative abundance  chenodeoxycholate HMDP 105 m 16wks N=1
    HMDPpheno8 50304 metabolite quantification (none) cholate (16h fast), relative abundance  cholate HMDP 106 m 16wks N=1
    HMDPpheno8 50305 metabolite quantification (none) 12-dehydrocholate (16h fast), relative abundance  dehydrocholate HMDP 106 m 16wks N=1
    HMDPpheno8 50306 metabolite quantification (none) 6-beta-hydroxylithocholate (16h fast), relative abundance  hydroxylithocholate HMDP 106 m 16wks N=1
    HMDPpheno8 50307 metabolite quantification (none) tauro-beta-muricholate (16h fast), relative abundance  tauro_muricholate HMDP 106 m 16wks N=1
    HMDPpheno8 50308 metabolite quantification (none) taurocholate (16h fast), relative abundance  taurocholate HMDP 106 m 16wks N=1
    HMDPpheno8 50309 metabolite quantification (none) taurodeoxycholate (16h fast), relative abundance  taurodeoxycholate HMDP 105 m 16wks N=1
    HMDPpheno8 50310 metabolite quantification (none) ursodeoxycholate (16h fast), relative abundance  ursodeoxycholate HMDP 106 m 16wks N=1
    HMDPpheno8 50311 metabolite quantification (none) acetylcarnitine (16h fast), relative abundance  acetylcarnitine HMDP 103 m 16wks N=1
    HMDPpheno8 50312 metabolite quantification (none) carnitine (16h fast), relative abundance  carnitine HMDP 106 m 16wks N=1
    HMDPpheno8 50313 metabolite quantification (none) 3-dehydrocarnitine (16h fast), relative abundance  dehydrocarnitine HMDP 106 m 16wks N=1
    HMDPpheno8 50314 metabolite quantification (none) malonylcarnitine (16h fast), relative abundance  malonylcarnitine HMDP 106 m 16wks N=1
    HMDPpheno8 50315 metabolite quantification (none) 1,2-dipalmitoylglycerol (16h fast), relative abundance  DPG_1_2 HMDP 106 m 16wks N=1
    HMDPpheno8 50316 metabolite quantification (none) 1,3-dipalmitoylglycerol (16h fast), relative abundance  DPG_1_3 HMDP 106 m 16wks N=1
    HMDPpheno8 50317 metabolite quantification (none) 12-HETE (16h fast), relative abundance  HETE_12 HMDP 88 m 16wks N=1
    HMDPpheno8 50318 metabolite quantification (none) 12-HEPE (16h fast), relative abundance  HEPE_12 HMDP 106 m 16wks N=1
    HMDPpheno8 50319 metabolite quantification (none) 18-HEPE (16h fast), relative abundance  HEPE_18 HMDP 104 m 16wks N=1
    HMDPpheno8 50320 metabolite quantification (none) 15-HETE (16h fast), relative abundance  HETE_15 HMDP 94 m 16wks N=1
    HMDPpheno8 50321 metabolite quantification (none) 5-HETE (16h fast), relative abundance  HETE_5 HMDP 105 m 16wks N=1
    HMDPpheno8 50322 metabolite quantification (none) docosahexaenoate (DHA; 22:6n3) (16h fast), relative abundance  DHA HMDP 106 m 16wks N=1
    HMDPpheno8 50323 metabolite quantification (none) dihomo-linolenate (20:3n3 or n6) (16h fast), relative abundance  dihomo_linolenate HMDP 106 m 16wks N=1
    HMDPpheno8 50324 metabolite quantification (none) docosapentaenoate (n3 DPA; 22:5n3) (16h fast), relative abundance  DPA HMDP 106 m 16wks N=1
    HMDPpheno8 50325 metabolite quantification (none) eicosapentaenoate (EPA; 20:5n3) (16h fast), relative abundance  EPA HMDP 106 m 16wks N=1
    HMDPpheno8 50326 metabolite quantification (none) linolenate [alpha or gamma; (18:3n3 or 6)] (16h fast), relative abundance  linolenate HMDP 106 m 16wks N=1
    HMDPpheno8 50327 metabolite quantification (none) valerylglycine (16h fast), relative abundance  valerylglycine HMDP 106 m 16wks N=1
    HMDPpheno8 50328 metabolite quantification (none) hexanoylglycine (16h fast), relative abundance  hexanoylglycine HMDP 106 m 16wks N=1
    HMDPpheno8 50329 metabolite quantification (none) butyrylglycine (16h fast), relative abundance  butyrylglycine HMDP 106 m 16wks N=1
    HMDPpheno8 50330 metabolite quantification (none) propionylcarnitine (16h fast), relative abundance  propionylcarnitine HMDP 106 m 16wks N=1
    HMDPpheno8 50331 metabolite quantification (none) azelate (nonanedioate) (16h fast), relative abundance  azelate HMDP 106 m 16wks N=1
    HMDPpheno8 50332 metabolite quantification (none) dodecanedioate (16h fast), relative abundance  dodecanedioate HMDP 103 m 16wks N=1
    HMDPpheno8 50333 metabolite quantification (none) hexadecanedioate (16h fast), relative abundance  hexadecanedioate HMDP 106 m 16wks N=1
    HMDPpheno8 50334 metabolite quantification (none) tetradecanedioate (16h fast), relative abundance  tetradecanedioate HMDP 106 m 16wks N=1
    HMDPpheno8 50335 metabolite quantification (none) undecanedioate (16h fast), relative abundance  undecanedioate HMDP 105 m 16wks N=1
    HMDPpheno8 50336 metabolite quantification (none) n-Butyl oleate (16h fast), relative abundance  butyl_oleate HMDP 95 m 16wks N=1
    HMDPpheno8 50337 metabolite quantification (none) 13-HODE + 9-HODE (16h fast), relative abundance  HODE HMDP 106 m 16wks N=1
    HMDPpheno8 50338 metabolite quantification (none) 2-hydroxystearate (16h fast), relative abundance  hydroxystearate HMDP 93 m 16wks N=1
    HMDPpheno8 50339 metabolite quantification (none) 1-octadecanol (16h fast), relative abundance  octadecanol HMDP 106 m 16wks N=1
    HMDPpheno8 50340 metabolite quantification (none) ethanolamine (16h fast), relative abundance  ethanolamine HMDP 106 m 16wks N=1
    HMDPpheno8 50341 metabolite quantification (none) glycerol 3-phosphate (G3P) (16h fast), relative abundance  G3P HMDP 106 m 16wks N=1
    HMDPpheno8 50342 metabolite quantification (none) glycerol (16h fast), relative abundance  glycerol HMDP 106 m 16wks N=1
    HMDPpheno8 50343 metabolite quantification (none) choline (16h fast), relative abundance  choline HMDP 106 m 16wks N=1
    HMDPpheno8 50344 metabolite quantification (none) choline phosphate (16h fast), relative abundance  choline_phosphate HMDP 106 m 16wks N=1
    HMDPpheno8 50345 metabolite quantification (none) cytidine 5'-diphosphocholine (16h fast), relative abundance  cytidine_DPC HMDP 106 m 16wks N=1
    HMDPpheno8 50346 metabolite quantification (none) glycerophosphorylcholine (GPC) (16h fast), relative abundance  GPC HMDP 106 m 16wks N=1
    HMDPpheno8 50347 metabolite quantification (none) phosphoethanolamine (16h fast), relative abundance  PEA HMDP 106 m 16wks N=1
    HMDPpheno8 50348 metabolite quantification (none) inositol 1-phosphate (I1P) (16h fast), relative abundance  I1P HMDP 106 m 16wks N=1
    HMDPpheno8 50349 metabolite quantification (none) inositol 2-phosphate (I2P) (16h fast), relative abundance  I2P HMDP 102 m 16wks N=1
    HMDPpheno8 50350 metabolite quantification (none) myo-inositol (16h fast), relative abundance  myo_inositol HMDP 106 m 16wks N=1
    HMDPpheno8 50351 metabolite quantification (none) 3-hydroxybutyrate (BHBA) (16h fast), relative abundance  BHBA HMDP 106 m 16wks N=1
    HMDPpheno8 50352 metabolite quantification (none) 1,2-propanediol (16h fast), relative abundance  propanediol HMDP 104 m 16wks N=1
    HMDPpheno8 50353 metabolite quantification (none) arachidate (20:0) (16h fast), relative abundance  arachidate HMDP 96 m 16wks N=1
    HMDPpheno8 50354 metabolite quantification (none) pentadecanoate (15:0) (16h fast), relative abundance  pentadecanoate HMDP 106 m 16wks N=1
    HMDPpheno8 50355 metabolite quantification (none) adrenate (22:4n6) (16h fast), relative abundance  adrenate HMDP 106 m 16wks N=1
    HMDPpheno8 50356 metabolite quantification (none) arachidonate (20:4n6) (16h fast), relative abundance  arachidonate HMDP 106 m 16wks N=1
    HMDPpheno8 50357 metabolite quantification (none) dihomo-linoleate (20:2n6) (16h fast), relative abundance  dihomo_linoleate HMDP 106 m 16wks N=1
    HMDPpheno8 50358 metabolite quantification (none) docosadienoate (22:2n6) (16h fast), relative abundance  docosadienoate HMDP 106 m 16wks N=1
    HMDPpheno8 50359 metabolite quantification (none) eicosenoate (20:1n9 or 11) (16h fast), relative abundance  eicosenoate HMDP 106 m 16wks N=1
    HMDPpheno8 50360 metabolite quantification (none) 10-heptadecenoate (17:1n7) (16h fast), relative abundance  heptadecenoate HMDP 106 m 16wks N=1
    HMDPpheno8 50361 metabolite quantification (none) linoleate (18:2n6) (16h fast), relative abundance  linoleate HMDP 106 m 16wks N=1
    HMDPpheno8 50362 metabolite quantification (none) margarate (17:0) (16h fast), relative abundance  margarate HMDP 106 m 16wks N=1
    HMDPpheno8 50363 metabolite quantification (none) myristate (14:0) (16h fast), relative abundance  myristate HMDP 106 m 16wks N=1
    HMDPpheno8 50364 metabolite quantification (none) myristoleate (14:1n5) (16h fast), relative abundance  myristoleate HMDP 106 m 16wks N=1
    HMDPpheno8 50365 metabolite quantification (none) nonadecanoate (19:0) (16h fast), relative abundance  nonadecanoate HMDP 106 m 16wks N=1
    HMDPpheno8 50366 metabolite quantification (none) 10-nonadecenoate (19:1n9) (16h fast), relative abundance  nonadecenoate HMDP 106 m 16wks N=1
    HMDPpheno8 50367 metabolite quantification (none) oleate (18:1n9) (16h fast), relative abundance  oleate HMDP 106 m 16wks N=1
    HMDPpheno8 50368 metabolite quantification (none) palmitate (16:0) (16h fast), relative abundance  palmitate HMDP 106 m 16wks N=1
    HMDPpheno8 50369 metabolite quantification (none) palmitoleate (16:1n7) (16h fast), relative abundance  palmitoleate HMDP 106 m 16wks N=1
    HMDPpheno8 50370 metabolite quantification (none) stearate (18:0) (16h fast), relative abundance  stearate HMDP 106 m 16wks N=1
    HMDPpheno8 50371 metabolite quantification (none) stearidonate (18:4n3) (16h fast), relative abundance  stearidonate HMDP 106 m 16wks N=1
    HMDPpheno8 50372 metabolite quantification (none) caprate (10:0) (16h fast), relative abundance  caprate HMDP 106 m 16wks N=1
    HMDPpheno8 50373 metabolite quantification (none) caproate (6:0) (16h fast), relative abundance  caproate HMDP 99 m 16wks N=1
    HMDPpheno8 50374 metabolite quantification (none) laurate (12:0) (16h fast), relative abundance  laurate HMDP 106 m 16wks N=1
    HMDPpheno8 50375 metabolite quantification (none) pelargonate (9:0) (16h fast), relative abundance  pelargonate HMDP 106 m 16wks N=1
    HMDPpheno8 50376 metabolite quantification (none) malonate (propanedioate) (16h fast), relative abundance  malonate HMDP 106 m 16wks N=1
    HMDPpheno8 50377 metabolite quantification (none) 1-linoleoylglycerol (1-monolinolein) (16h fast), relative abundance  LOG HMDP 100 m 16wks N=1
    HMDPpheno8 50378 metabolite quantification (none) 1-oleoylglycerol (1-monoolein) (16h fast), relative abundance  OOG HMDP 104 m 16wks N=1
    HMDPpheno8 50379 metabolite quantification (none) 1-palmitoylglycerol (1-monopalmitin) (16h fast), relative abundance  POG HMDP 106 m 16wks N=1
    HMDPpheno8 50380 metabolite quantification (none) 1-stearoylglycerol (1-monostearin) (16h fast), relative abundance  SOT HMDP 106 m 16wks N=1
    HMDPpheno8 50381 metabolite quantification (none) 1-docosahexaenoylglycerol (1-monodocosahexaenoin) (16h fast), relative abundance  DHG HMDP 89 m 16wks N=1
    HMDPpheno8 50382 metabolite quantification (none) palmitoyl sphingomyelin (16h fast), relative abundance  PO_sphingomyelin HMDP 106 m 16wks N=1
    HMDPpheno8 50383 metabolite quantification (none) stearoyl sphingomyelin (16h fast), relative abundance  SO_sphingomyelin HMDP 96 m 16wks N=1
    HMDPpheno8 50384 metabolite quantification (none) sphingosine (16h fast), relative abundance  sphingosine HMDP 104 m 16wks N=1
    HMDPpheno8 50385 metabolite quantification (none) 7-alpha-hydroxycholesterol (16h fast), relative abundance  alpha_HOC HMDP 105 m 16wks N=1
    HMDPpheno8 50386 metabolite quantification (none) 7-beta-hydroxycholesterol (16h fast), relative abundance  beta_HOC HMDP 105 m 16wks N=1
    HMDPpheno8 50387 metabolite quantification (none) cholesterol (16h fast), relative abundance  cholesterol HMDP 106 m 16wks N=1
    HMDPpheno8 50388 metabolite quantification (none) squalene (16h fast), relative abundance  squalene HMDP 93 m 16wks N=1
    HMDPpheno8 50389 metabolite quantification (none) corticosterone (16h fast), relative abundance  corticosterone HMDP 92 m 16wks N=1
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