Willott1: Startle and prepulse inhibition survey of 40 inbred strains of mice (2002)

Willott JF, Tanner L, O'Steen J, Johnson KR, Bogue MA, Gagnon L. Acoustic startle and prepulse inhibition in 40 inbred strains of mice. Behav Neurosci. 2003 Aug;117(4):716-27.   PubMed 12931957  


         
Notes
Individual mice were tested in two rounds (A and B); averages are used (except for the habituation index, which was determined from round 1). Data for individual rounds A and B are available in the supplemental download file.

Willott1 downloads
• Download Willott1 project data set     one row per animal, one column per trait
• Download Willott1 strain means, SD, N, etc.     one row per strain/sex/measure
• Willott1 supplementary data
Participants James F Willott       University of South Florida Tampa, FL
Kenneth R Johnson       The Jackson Laboratory Bar Harbor, ME
With: Gagnon L, Reid MC, Tanner L, O'Steen J
ContactJames F Willott     jimw@niu.edu
AcknowledgementsFunding provided by NIH MH61090.

Generous funds from Hoffmann-LaRoche, Inc. were used to defray the cost of mice through the Mouse Phenome Project.
Project type Phenotype strain survey data set
MPD identifiersWillott1     MPD:91
Data changelog 1 update/correction.       Initial release date: 06/2003.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An investigation of susceptibility to psychiatric gating disorders. Animals were evaluated using Med Associates, Inc prepulse inhibition and startle reflex measurement system. Mice were tested for acoustic startle response and prepulse inhibition at 5-7 weeks of age. These same mice were subjected to a morphological examination of the eye at 6-7 weeks of age by the Hawes1 project and later characterized for bone mineral density, body composition, and craniofacial characterization at 15-16 weeks of age by the Donahue1 project.

Summary of procedures that were conducted
• body weight
• acoustic startle test Acoustic startle response, prepulse inhibition.
Mice: inbred w/CC7   40 strains   ♀♂   age 5-6wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Willott1 9101 body weight (none) body weight   [g]  bw inbred w/CC7 40 both 5-6wks N=8
    Willott1 9102 acoustic startle test (none) acoustic startle response (ASR)   [amplitude]     sound pressure level:    70dB    80dB    90dB    100dB inbred w/CC7 40 both 5-6wks N=10
    Willott1 9106 acoustic startle test (none) mean latency of acoustic startle response (ASR) evoked by 100 dB sound pressure level   [ms]  ASR_latency inbred w/CC7 40 both 5-6wks N=10
    Willott1 9107 acoustic startle test (none) habituation: ratio of final 4 trials to initial 4 trials (<1.0=diminished ASR)   [ratio]  ASR_habituation inbred w/CC7 40 both 5-6wks N=10
    Willott1 9108 acoustic startle test (none) mean prepulse inhibition (PPI), 70dB   [ratio]     4kHz    12kHz    20kHz    all tones inbred w/CC7 40 both 5-6wks N=10
    All boxes