Shin1: Observational fear learning, anxiety, locomotor activity, and social behavior in males of 11 inbred strains of mice (2016)

Keum S, Park J, Kim A, Park J, Kim KK, Jeong J, Shin HS. Variability in empathic fear response among 11 inbred strains of mice. Genes Brain Behav. 2016 Feb;15(2):231-42. doi: 10.1111/gbb.12278. Epub 2016 Jan 12.   PubMed 26690560  

Shin1 downloads
• Download Shin1 project data set     animal data, as uploaded
• Download Shin1 animal data matrix     with factor-related expansion applied as necessary
• Download Shin1 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators Hee-Sup Shin       Institute for Basic Science,  Daejeon REPUBLIC OF KOREA
Sehoon Keum       Institute for Basic Science,  Daejeon REPUBLIC OF KOREA
Participants Park J, Kim A, Park J, Kim KK, Jeong J
ContactHee-Sup Shin
AcknowledgementsFunding provided by the Institute for Basic Science (IBS-R001-G1), Republic of Korea
Project type Phenotype strain survey data set
MPD identifiersShin1     MPD:545
Data changelog No updates/corrections.       Initial release date: 04/2016.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Empathy is an important emotional process that involves the ability to recognize and share emotions with others. In the observational fear learning task, a mouse is conditioned for context-dependent fear when it observes a con-specific demonstrator receiving aversive stimuli. Naïve mice that had no prior experience on any behaviors were used only once for each behavioral assay: observational fear learning, Pavlovian fear conditioning, open field test, elevated plus maze, and three-chambered social approach.

Procedures conducted:
• observational fear learning test  Percent time freezing to conditioning and contextual exposure.
• fear conditioning test  Pavlovian fear conditioning.
• open field test  Locomotor activity and exploratory behavior. 5 min test.
• elevated plus maze  Exploratory and anxiety-related behaviors. 5 min test.
• three chamber assay  Sociability testing. Tolerance of a novel mouse, a novel object, and second novel mouse vs. first. 10 min test.

Mice: inbred   11 strains   ♂   age 12-14wks   5 experimental groups