Shin1: Observational fear learning, anxiety, locomotor activity, and social behavior in males of 11 inbred strains of mice (2016)

Keum S, Park J, Kim A, Park J, Kim KK, Jeong J, Shin HS. Variability in empathic fear response among 11 inbred strains of mice. Genes Brain Behav. 2016 Feb;15(2):231-42. doi: 10.1111/gbb.12278. Epub 2016 Jan 12.   PubMed 26690560  

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Investigators Hee-Sup Shin       Institute for Basic Science,  Daejeon REPUBLIC OF KOREA
Sehoon Keum       Institute for Basic Science,  Daejeon REPUBLIC OF KOREA
Participants Park J, Kim A, Park J, Kim KK, Jeong J
ContactHee-Sup Shin
AcknowledgementsFunding provided by the Institute for Basic Science (IBS-R001-G1), Republic of Korea
Project type Phenotype strain survey data set
MPD identifiersShin1     MPD:545
Data changelog No updates/corrections.       Initial release date: 04/2016.
Formatted citation
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Empathy is an important emotional process that involves the ability to recognize and share emotions with others. In the observational fear learning task, a mouse is conditioned for context-dependent fear when it observes a con-specific demonstrator receiving aversive stimuli. Naïve mice that had no prior experience on any behaviors were used only once for each behavioral assay: observational fear learning, Pavlovian fear conditioning, open field test, elevated plus maze, and three-chambered social approach.

Summary of procedures that were conducted
• observational fear learning test Percent time freezing to conditioning and contextual exposure.
• fear conditioning test Pavlovian fear conditioning.
• open field test Locomotor activity and exploratory behavior. 5 min test.
• elevated plus maze Exploratory and anxiety-related behaviors. 5 min test.
• three chamber assay Sociability testing. Tolerance of a novel mouse, a novel object, and second novel mouse vs. first. 10 min test.
Mice: inbred   11 strains   ♂   age 12-14wks   5 experimental groups