Project measure / variable:   CGDpheno3   QTc_dispersion

ID, description, units MPD:43938   QTc_dispersion   difference between smallest and largest rate-corrected QT interval   [ms]  
Data set, strains CGDpheno3   CC diallel w/par   42 strains     sex: both     age: 12wks
Procedure ECG
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  STRAIN COMPARISON PLOT
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CGDpheno3 - difference between smallest and largest rate-corrected QT interval



  8-WAY DIALLEL CROSS VIEW
Female animals
129S ♂ A ♂ B6 ♂ CAST ♂ NOD ♂ NZO ♂ PWK ♂ WSB ♂
129S ♀ — 24.0 14.1 21.6 — 27.8 28.3 22.4
A ♀ 42.0 27.6 26.8 13.4 26.8 33.3 — —
B6 ♀ 23.1 25.3 22.1 21.7 21.1 30.0 23.0 22.7
CAST ♀ 14.6 21.8 — — — 26.5 — —
NOD ♀ 18.2 26.8 20.5 14.1 20.7 18.0 19.9 —
NZO ♀ 20.1 23.6 20.9 — 21.1 17.7 — 23.3
PWK ♀ 21.0 28.3 21.5 — — 23.7 — —
WSB ♀ — 21.6 — — — 18.7 — —

Male animals
129S ♂ A ♂ B6 ♂ CAST ♂ NOD ♂ NZO ♂ PWK ♂ WSB ♂
129S ♀ — 18.9 — 13.7 — 22.0 24.0 8.15
A ♀ 24.3 33.9 25.2 — 27.2 21.5 — —
B6 ♀ 20.8 33.0 22.2 20.6 22.1 19.8 29.3 23.4
CAST ♀ 15.2 25.3 — — — 18.3 — —
NOD ♀ 17.2 26.1 15.6 10.4 18.1 21.1 21.7 —
NZO ♀ 19.0 23.0 25.6 — 21.7 15.2 — 20.5
PWK ♀ 25.4 30.3 18.5 — — 18.2 — —
WSB ♀ — — — — — 19.9 — —

Cell coloring is based on strain mean Z-scores.     High-end         Mid         Low-end           Mouse over the cells to see additional info.


  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested42 strains39 strains
Mean of the strain means22.8   ms 21.4   ms
Median of the strain means22.0   ms 21.5   ms
SD of the strain means± 5.30 ± 5.42
Coefficient of variation (CV)0.232 0.253
Min–max range of strain means13.4   –   42.0   ms 8.15   –   33.9   ms
Mean sample size per strain4.8   mice 4.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 278.1644 278.1644 4.5703 0.0333
strain 38 7198.5476 189.4355 3.1124 < 0.0001
sex:strain 38 2614.8012 68.8106 1.1306 0.2828
Residuals 306 18624.3581 60.8639


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129SAF1 f 24.0 6.49   5 2.9 0.271 14.8, 31.7 0.22
129SAF1 m 18.9 4.48   5 2.0 0.237 13.1, 24.0 -0.47
129SB6F1 f 14.1 6.03   5 2.7 0.427 6.8, 20.9 -1.65
129SCASTF1 f 21.6 7.91   5 3.54 0.367 7.6, 26.7 -0.24
129SCASTF1 m 13.7 6.09   5 2.72 0.446 7.4, 22.3 -1.43
129SNZOF1 f 27.8 4.74   7 1.79 0.171 20.6, 33.3 0.93
129SNZOF1 m 22.0 8.55   13 2.37 0.389 1.5, 36.2 0.1
129SPWKF1 f 28.3 6.76   3 3.9 0.239 21.8, 35.3 1.03
129SPWKF1 m 24.0 1.41   5 0.631 0.0587 22.4, 25.8 0.47
129SWSBF1 f 22.4 5.73   2   4.05 0.256 18.3, 26.4 -0.08
129SWSBF1 m 8.15 9.83   2   6.95 1.21 1.2, 15.1 -2.45
A129SF1 f 42.0 14.0   5 6.28 0.334 25.0, 53.0 3.62
A129SF1 m 24.3 6.76   5 3.02 0.278 17.1, 31.5 0.53
AB6F1 f 26.8 6.31   5 2.82 0.235 22.6, 37.8 0.75
AB6F1 m 25.2 1.44   5 0.643 0.0572 23.3, 26.7 0.69
ACASTF1 f 13.4 11.3   4 5.64 0.84 3.9, 28.4 -1.78
A/J f 27.6 5.39   5 2.41 0.196 22.4, 33.3 0.9
A/J m 33.9 17.0   5 7.61 0.503 22.6, 63.2 2.3
ANODF1 f 26.8 3.35   5 1.5 0.125 24.3, 32.0 0.75
ANODF1 m 27.2 2.96   5 1.32 0.109 24.5, 32.2 1.06
ANZOF1 f 33.3 16.6   5 7.42 0.497 23.9, 62.9 1.97
ANZOF1 m 21.5 4.4   5 1.97 0.204 17.4, 27.9 0.01
B6129SF1/J f 23.1 6.56   5 2.94 0.285 15.3, 30.7 0.05
B6129SF1/J m 20.8 3.43   5 1.54 0.165 16.1, 25.1 -0.12
B6AF1/J f 25.3 5.88   5 2.63 0.233 19.1, 34.0 0.46
B6AF1/J m 33.0 23.3   5 10.4 0.708 17.3, 73.8 2.13
B6CASTF1 f 21.7 5.82   5 2.6 0.268 14.6, 28.9 -0.22
B6CASTF1 m 20.6 4.0   5 1.79 0.194 16.0, 25.1 -0.16
B6NODF1 f 21.1 4.98   5 2.23 0.236 13.9, 26.2 -0.33
B6NODF1 m 22.1 3.29   5 1.47 0.149 18.9, 26.5 0.12
B6NZOF1 f 30.0 14.4   5 6.45 0.481 18.9, 53.6 1.35
B6NZOF1 m 19.8 5.04   5 2.25 0.254 13.5, 25.8 -0.3
B6PWKF1 f 23.0 4.76   5 2.13 0.207 16.5, 28.4 0.03
B6PWKF1 m 29.3 13.0   5 5.83 0.445 21.3, 52.3 1.45
B6WSBF1 f 22.7 6.24   5 2.79 0.275 16.0, 32.5 -0.03
B6WSBF1 m 23.4 3.12   5 1.4 0.133 19.1, 27.8 0.36
C57BL/6J f 22.1 11.1   5 4.98 0.504 2.9, 31.9 -0.14
C57BL/6J m 22.2 4.57   5 2.05 0.206 14.4, 26.1 0.14
CAST129SF1 f 14.6 9.68   5 4.33 0.661 4.1, 23.5 -1.56
CAST129SF1 m 15.2 10.6   5 4.74 0.699 1.9, 27.3 -1.15
CASTAF1 f 21.8 11.6   3 6.67 0.531 10.3, 33.4 -0.2
CASTAF1 m 25.3 13.2   5 5.91 0.522 14.1, 46.0 0.71
CASTNZOF1 f 26.5 12.5   5 5.59 0.472 13.2, 45.6 0.69
CASTNZOF1 m 18.3 3.48   5 1.56 0.19 13.9, 23.6 -0.58
NOD129SF1 f 18.2 6.42   5 2.87 0.353 12.0, 28.3 -0.88
NOD129SF1 m 17.2 3.09   5 1.38 0.179 13.8, 21.4 -0.78
NODAF1 f 26.8 5.34   5 2.39 0.199 22.2, 34.6 0.75
NODAF1 m 26.1 4.2   5 1.88 0.161 21.4, 31.3 0.86
NODB6F1 f 20.5 6.08   5 2.72 0.297 11.7, 25.7 -0.44
NODB6F1 m 15.6 8.56   5 3.83 0.549 1.3, 24.3 -1.08
NODCASTF1 f 14.1 2.27   5 1.01 0.161 12.1, 17.3 -1.65
NODCASTF1 m 10.4 4.71   5 2.11 0.455 5.2, 15.9 -2.04
NODNZOF1 f 18.0 5.46   5 2.44 0.303 12.0, 24.0 -0.92
NODNZOF1 m 21.1 5.48   5 2.45 0.259 11.7, 24.8 -0.06
NODPWKF1 f 19.9 6.29   7 2.38 0.316 11.9, 27.4 -0.56
NODPWKF1 m 21.7 4.82   5 2.15 0.222 15.9, 28.4 0.05
NOD/ShiLtJ f 20.7 4.33   5 1.93 0.209 14.5, 25.0 -0.41
NOD/ShiLtJ m 18.1 4.58   5 2.05 0.253 12.3, 24.8 -0.62
NZO129SF1 f 20.1 3.01   5 1.34 0.149 15.9, 24.0 -0.52
NZO129SF1 m 19.0 9.51   5 4.25 0.499 2.9, 26.7 -0.45
NZOAF1 f 23.6 1.37   4 0.687 0.0582 22.1, 25.2 0.14
NZOAF1 m 23.0 6.24   5 2.79 0.271 14.3, 29.5 0.29
NZOB6F1 f 20.9 4.45   5 1.99 0.213 14.1, 24.8 -0.37
NZOB6F1 m 25.6 1.6   5 0.716 0.0626 24.2, 28.3 0.77
NZO/HlLtJ f 17.7 4.87   5 2.18 0.275 13.5, 25.4 -0.97
NZO/HlLtJ m 15.2 7.03   5 3.14 0.463 5.7, 22.5 -1.15
NZONODF1 f 21.1 6.52   5 2.91 0.309 13.8, 28.9 -0.33
NZONODF1 m 21.7 7.85   5 3.51 0.361 10.1, 28.3 0.05
NZOWSBF1 f 23.3 10.0   5 4.47 0.429 11.5, 38.7 0.08
NZOWSBF1 m 20.5 1.82   5 0.812 0.0887 18.1, 23.0 -0.17
PWK129SF1 f 21.0 5.67   5 2.54 0.271 16.7, 30.9 -0.35
PWK129SF1 m 25.4 2.97   3 1.72 0.117 22.7, 28.6 0.73
PWKAF1 f 28.3 15.8   5 7.04 0.557 12.5, 49.8 1.03
PWKAF1 m 30.3 11.6   5 5.19 0.382 20.3, 50.2 1.63
PWKB6F1 f 21.5 2.44   5 1.09 0.114 19.4, 25.3 -0.25
PWKB6F1 m 18.5 2.54   5 1.13 0.137 16.1, 21.7 -0.54
PWKNZOF1 f 23.7 0.929   5 0.415 0.0391 22.6, 24.7 0.16
PWKNZOF1 m 18.2 4.13   3 2.39 0.227 14.8, 22.8 -0.6
WSBAF1 f 21.6 0.0   1   0.0 0.0 21.6, 21.6 -0.24
WSBNZOF1 f 18.7 2.4   3 1.39 0.128 16.8, 21.4 -0.78
WSBNZOF1 m 19.9 3.12   4 1.56 0.157 15.2, 21.8 -0.28


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129SAF1 f 23.98 3.489 30.8454 17.1146
129SAF1 m 18.9 3.489 25.7654 12.0346
129SCASTF1 f 21.58 3.489 28.4454 14.7146
129SCASTF1 m 13.66 3.489 20.5254 6.7946
129SNZOF1 f 27.7571 2.9487 33.5594 21.9548
129SNZOF1 m 21.9846 2.1638 26.2423 17.7269
129SPWKF1 f 28.3333 4.5042 37.1965 19.4702
129SPWKF1 m 24.04 3.489 30.9054 17.1746
129SWSBF1 f 22.35 5.5165 33.2051 11.4949
129SWSBF1 m 8.15 5.5165 19.0051 0.0
A129SF1 f 41.96 3.489 48.8254 35.0946
A129SF1 m 24.3 3.489 31.1654 17.4346
AB6F1 f 26.82 3.489 33.6854 19.9546
AB6F1 m 25.16 3.489 32.0254 18.2946
A/J f 27.56 3.489 34.4254 20.6946
A/J m 33.86 3.489 40.7254 26.9946
ANODF1 f 26.78 3.489 33.6454 19.9146
ANODF1 m 27.24 3.489 34.1054 20.3746
ANZOF1 f 33.34 3.489 40.2054 26.4746
ANZOF1 m 21.52 3.489 28.3854 14.6546
B6129SF1/J f 23.06 3.489 29.9254 16.1946
B6129SF1/J m 20.82 3.489 27.6854 13.9546
B6AF1/J f 25.28 3.489 32.1454 18.4146
B6AF1/J m 32.98 3.489 39.8454 26.1146
B6CASTF1 f 21.74 3.489 28.6054 14.8746
B6CASTF1 m 20.64 3.489 27.5054 13.7746
B6NODF1 f 21.12 3.489 27.9854 14.2546
B6NODF1 m 22.08 3.489 28.9454 15.2146
B6NZOF1 f 30.0 3.489 36.8654 23.1346
B6NZOF1 m 19.84 3.489 26.7054 12.9746
B6PWKF1 f 23.04 3.489 29.9054 16.1746
B6PWKF1 m 29.32 3.489 36.1854 22.4546
B6WSBF1 f 22.66 3.489 29.5254 15.7946
B6WSBF1 m 23.4 3.489 30.2654 16.5346
C57BL/6J f 22.12 3.489 28.9854 15.2546
C57BL/6J m 22.2 3.489 29.0654 15.3346
CAST129SF1 f 14.64 3.489 21.5054 7.7746
CAST129SF1 m 15.18 3.489 22.0454 8.3146
CASTAF1 f 21.7667 4.5042 30.6298 12.9035
CASTAF1 m 25.3 3.489 32.1654 18.4346
CASTNZOF1 f 26.48 3.489 33.3454 19.6146
CASTNZOF1 m 18.32 3.489 25.1854 11.4546
NOD129SF1 f 18.16 3.489 25.0254 11.2946
NOD129SF1 m 17.24 3.489 24.1054 10.3746
NODAF1 f 26.78 3.489 33.6454 19.9146
NODAF1 m 26.12 3.489 32.9854 19.2546
NODB6F1 f 20.5 3.489 27.3654 13.6346
NODB6F1 m 15.6 3.489 22.4654 8.7346
NODCASTF1 f 14.12 3.489 20.9854 7.2546
NODCASTF1 m 10.36 3.489 17.2254 3.4946
NODNZOF1 f 18.0 3.489 24.8654 11.1346
NODNZOF1 m 21.12 3.489 27.9854 14.2546
NODPWKF1 f 19.9 2.9487 25.7023 14.0977
NODPWKF1 m 21.7 3.489 28.5654 14.8346
NOD/ShiLtJ f 20.66 3.489 27.5254 13.7946
NOD/ShiLtJ m 18.1 3.489 24.9654 11.2346
NZO129SF1 f 20.12 3.489 26.9854 13.2546
NZO129SF1 m 19.04 3.489 25.9054 12.1746
NZOAF1 f 23.6 3.9008 31.2757 15.9243
NZOAF1 m 23.02 3.489 29.8854 16.1546
NZOB6F1 f 20.9 3.489 27.7654 14.0346
NZOB6F1 m 25.58 3.489 32.4454 18.7146
NZO/HlLtJ f 17.68 3.489 24.5454 10.8146
NZO/HlLtJ m 15.18 3.489 22.0454 8.3146
NZONODF1 f 21.06 3.489 27.9254 14.1946
NZONODF1 m 21.72 3.489 28.5854 14.8546
NZOWSBF1 f 23.34 3.489 30.2054 16.4746
NZOWSBF1 m 20.48 3.489 27.3454 13.6146
PWK129SF1 f 20.96 3.489 27.8254 14.0946
PWK129SF1 m 25.4333 4.5042 34.2965 16.5702
PWKAF1 f 28.26 3.489 35.1254 21.3946
PWKAF1 m 30.34 3.489 37.2054 23.4746
PWKB6F1 f 21.46 3.489 28.3254 14.5946
PWKB6F1 m 18.54 3.489 25.4054 11.6746
PWKNZOF1 f 23.74 3.489 30.6054 16.8746
PWKNZOF1 m 18.2 4.5042 27.0632 9.3368
WSBNZOF1 f 18.7 4.5042 27.5632 9.8368
WSBNZOF1 m 19.85 3.9008 27.5257 12.1743


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129SAF1 both 21.44 2.4671 26.2946 16.5854
129SCASTF1 both 17.62 2.4671 22.4746 12.7654
129SNZOF1 both 24.8709 1.8287 28.4693 21.2724
129SPWKF1 both 26.1867 2.8487 31.7922 20.5811
129SWSBF1 both 15.25 3.9008 22.9257 7.5743
A129SF1 both 33.13 2.4671 37.9846 28.2754
AB6F1 both 25.99 2.4671 30.8446 21.1354
A/J both 30.71 2.4671 35.5646 25.8554
ANODF1 both 27.01 2.4671 31.8646 22.1554
ANZOF1 both 27.43 2.4671 32.2846 22.5754
B6129SF1/J both 21.94 2.4671 26.7946 17.0854
B6AF1/J both 29.13 2.4671 33.9846 24.2754
B6CASTF1 both 21.19 2.4671 26.0446 16.3354
B6NODF1 both 21.6 2.4671 26.4546 16.7454
B6NZOF1 both 24.92 2.4671 29.7746 20.0654
B6PWKF1 both 26.18 2.4671 31.0346 21.3254
B6WSBF1 both 23.03 2.4671 27.8846 18.1754
C57BL/6J both 22.16 2.4671 27.0146 17.3054
CAST129SF1 both 14.91 2.4671 19.7646 10.0554
CASTAF1 both 23.5333 2.8487 29.1389 17.9278
CASTNZOF1 both 22.4 2.4671 27.2546 17.5454
NOD129SF1 both 17.7 2.4671 22.5546 12.8454
NODAF1 both 26.45 2.4671 31.3046 21.5954
NODB6F1 both 18.05 2.4671 22.9046 13.1954
NODCASTF1 both 12.24 2.4671 17.0946 7.3854
NODNZOF1 both 19.56 2.4671 24.4146 14.7054
NODPWKF1 both 20.8 2.2841 25.2944 16.3056
NOD/ShiLtJ both 19.38 2.4671 24.2346 14.5254
NZO129SF1 both 19.58 2.4671 24.4346 14.7254
NZOAF1 both 23.31 2.6167 28.459 18.161
NZOB6F1 both 23.24 2.4671 28.0946 18.3854
NZO/HlLtJ both 16.43 2.4671 21.2846 11.5754
NZONODF1 both 21.39 2.4671 26.2446 16.5354
NZOWSBF1 both 21.91 2.4671 26.7646 17.0554
PWK129SF1 both 23.1967 2.8487 28.8022 17.5911
PWKAF1 both 29.3 2.4671 34.1546 24.4454
PWKB6F1 both 20.0 2.4671 24.8546 15.1454
PWKNZOF1 both 20.97 2.8487 26.5756 15.3644
WSBNZOF1 both 19.275 2.9793 25.1374 13.4126




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA