Project measure / variable:   Paigen2   TG_chg

ID, description, units MPD:9923   TG_chg   triglycerides (plasma, 4h fast)   [mg/dL]  fold change  
high-fat diet study
Data set, strains Paigen2   inbred w/CC7   41 strains     sex: both     age: 7-9wks
Procedure lipid profile
Ontology mappings

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  STRAIN COMPARISON PLOT
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Paigen2 - triglycerides (plasma, 4h fast) fold change



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested40 strains35 strains
Mean of the strain means0.964   mg/dL 0.830   mg/dL
Median of the strain means0.746   mg/dL 0.637   mg/dL
SD of the strain means± 0.859 ± 0.518
Coefficient of variation (CV)0.891 0.624
Min–max range of strain means0.222   –   5.30   mg/dL 0.356   –   2.44   mg/dL
Mean sample size per strain8.0   mice 8.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.4175 0.4175 0.8311 0.3624
strain 33 165.8922 5.027 10.0081 < 0.0001
sex:strain 33 40.5323 1.2283 2.4453 < 0.0001
Residuals 483 242.6105 0.5023


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.912 0.366   5 0.164 0.401 0.491, 1.36 -0.06
129S1/SvImJ m 0.609 0.153   8 0.0543 0.252 0.386, 0.868 -0.43
A/J f 0.986 0.307   10 0.0972 0.312 0.616, 1.41 0.03
A/J m 0.698 0.235   8 0.083 0.337 0.346, 1.14 -0.25
AKR/J f 1.01 1.29   12 0.372 1.27 0.243, 5.01 0.05
BALB/cByJ f 0.266 0.0986   11 0.0297 0.371 0.159, 0.454 -0.81
BALB/cByJ m 0.49 0.142   8 0.0503 0.29 0.281, 0.65 -0.66
BTBR T+ Itpr3tf/J f 0.384 0.0979   8 0.0346 0.255 0.257, 0.511 -0.68
BTBR T+ Itpr3tf/J m 0.438 0.0582   7 0.022 0.133 0.322, 0.491 -0.76
BUB/BnJ f 0.62 0.31   9 0.103 0.5 0.267, 1.02 -0.4
BUB/BnJ m 0.399 0.225   5 0.101 0.564 0.123, 0.699 -0.83
C3H/HeJ f 0.898 0.228   10 0.0723 0.254 0.548, 1.35 -0.08
C3H/HeJ m 0.743 0.311   8 0.11 0.419 0.286, 1.2 -0.17
C57BL/10J f 0.615 0.239   7 0.0904 0.389 0.42, 1.08 -0.41
C57BL/10J m 0.547 0.209   10 0.0661 0.382 0.311, 0.925 -0.55
C57BL/6J f 0.599 0.0757   10 0.0239 0.126 0.494, 0.741 -0.43
C57BL/6J m 0.637 0.293   10 0.0927 0.46 0.23, 1.21 -0.37
C57BLKS/J f 0.443 0.168   4 0.0838 0.379 0.238, 0.646 -0.61
C57BR/cdJ f 0.702 0.152   10 0.0481 0.217 0.454, 1.03 -0.31
C57BR/cdJ m 0.87 0.175   10 0.0553 0.201 0.682, 1.23 0.08
C57L/J f 0.803 0.369   8 0.131 0.46 0.29, 1.26 -0.19
C57L/J m 0.908 0.2   10 0.0634 0.221 0.63, 1.23 0.15
C58/J f 0.838 0.494   5 0.221 0.59 0.554, 1.71 -0.15
C58/J m 1.13 0.48   7 0.181 0.426 0.473, 2.0 0.58
CAST/EiJ f 2.51 2.57   8 0.907 1.02 0.809, 8.26 1.8
CAST/EiJ m 1.4 1.12   5 0.5 0.798 0.426, 2.76 1.1
CBA/J f 0.545 0.138   8 0.0487 0.253 0.42, 0.778 -0.49
CBA/J m 0.629 0.202   8 0.0714 0.321 0.233, 0.886 -0.39
CZECHII/EiJ f 0.75 0.494   10 0.156 0.659 0.268, 1.78 -0.25
CZECHII/EiJ m 0.751 0.458   8 0.162 0.61 0.188, 1.55 -0.15
DBA/1J f 0.758 0.218   4 0.109 0.287 0.602, 1.07 -0.24
DBA/1J m 0.54 0.108   6 0.0441 0.2 0.44, 0.718 -0.56
DBA/2J f 0.742 0.271   9 0.0905 0.366 0.329, 1.07 -0.26
DBA/2J m 0.649 0.183   9 0.0609 0.281 0.425, 0.925 -0.35
FVB/NJ f 0.482 0.134   8 0.0472 0.277 0.306, 0.689 -0.56
FVB/NJ m 0.517 0.169   5 0.0754 0.326 0.266, 0.721 -0.6
I/LnJ f 0.898 0.521   5 0.233 0.58 0.282, 1.59 -0.08
JF1/MsJ f 0.628 0.329   10 0.104 0.524 0.22, 1.33 -0.39
JF1/MsJ m 0.581 0.124   7 0.0467 0.213 0.36, 0.724 -0.48
KK/HlJ f 0.803 0.244   7 0.0921 0.304 0.548, 1.31 -0.19
LP/J f 1.09 0.634   10 0.201 0.581 0.479, 2.39 0.15
LP/J m 0.888 0.326   11 0.0983 0.367 0.432, 1.39 0.11
MA/MyJ f 0.705 0.198   10 0.0626 0.281 0.426, 1.15 -0.3
MA/MyJ m 0.503 0.154   10 0.0487 0.306 0.345, 0.855 -0.63
MOLF/EiJ f 1.8 1.21   7 0.457 0.67 0.681, 4.05 0.97
MOLF/EiJ m 1.93 1.02   9 0.34 0.529 0.661, 4.09 2.13
MSM/MsJ f 2.19 0.987   5 0.442 0.452 1.62, 3.94 1.43
MSM/MsJ m 2.1 0.697   11 0.21 0.331 1.29, 3.22 2.45
NOD/ShiLtJ f 0.62 0.13   5 0.0579 0.209 0.471, 0.746 -0.4
NOD/ShiLtJ m 2.44 4.01   4 2.01 1.64 0.368, 8.46 3.11
NON/ShiLtJ f 0.222 0.0438   10 0.0139 0.197 0.155, 0.268 -0.86
NON/ShiLtJ m 0.356 0.128   12 0.0368 0.359 0.186, 0.625 -0.91
NZB/BlNJ f 0.824 0.264   10 0.0833 0.32 0.464, 1.38 -0.16
NZB/BlNJ m 0.535 0.228   9 0.0758 0.425 0.186, 0.94 -0.57
NZW/LacJ f 0.613 0.2   9 0.0667 0.326 0.338, 0.963 -0.41
NZW/LacJ m 0.395 0.124   8 0.0439 0.315 0.244, 0.602 -0.84
PERA/EiJ f 1.55 0.556   9 0.185 0.359 0.884, 2.29 0.68
PERA/EiJ m 1.18 0.397   7 0.15 0.337 0.618, 1.73 0.68
PL/J f 1.35 1.03   10 0.326 0.764 0.111, 2.89 0.45
PWK/PhJ m 0.714 0.255   7 0.0966 0.358 0.43, 1.05 -0.22
RF/J f 1.65 1.71   7 0.646 1.03 0.503, 5.37 0.8
RIIIS/J f 0.432 0.103   5 0.0461 0.238 0.339, 0.605 -0.62
RIIIS/J m 0.526 0.197   8 0.0698 0.375 0.3, 0.876 -0.59
SEA/GnJ f 0.549 0.187   9 0.0624 0.341 0.237, 0.776 -0.48
SEA/GnJ m 0.512 0.0887   7 0.0335 0.173 0.39, 0.671 -0.61
SJL/J f 0.404 0.186   8 0.0658 0.461 0.226, 0.77 -0.65
SJL/J m 0.726 0.61   12 0.176 0.84 0.348, 2.61 -0.2
SM/J f 0.358 0.108   8 0.0382 0.302 0.183, 0.557 -0.71
SM/J m 0.516 0.37   9 0.123 0.717 0.0983, 1.32 -0.61
SPRET/EiJ f 5.3 5.09   4 2.55 0.96 1.4, 12.7 5.05
SPRET/EiJ m 1.89 0.765   5 0.342 0.405 1.01, 2.99 2.05
SWR/J f 0.638 0.325   8 0.115 0.51 0.192, 1.32 -0.38
SWR/J m 0.469 0.336   6 0.137 0.717 0.181, 1.09 -0.7
WSB/EiJ f 1.08 0.582   8 0.206 0.54 0.759, 2.5 0.13
WSB/EiJ m 0.818 0.226   9 0.0754 0.276 0.495, 1.22 -0.02


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.9124 0.317 1.5352 0.2896
129S1/SvImJ m 0.6095 0.2506 1.1018 0.1171
A/J f 0.9859 0.2241 1.4262 0.5455
A/J m 0.6979 0.2506 1.1902 0.2055
BALB/cByJ f 0.2658 0.2137 0.6857 0.0
BALB/cByJ m 0.4901 0.2506 0.9824 0.0
BTBR T+ Itpr3tf/J f 0.3841 0.2506 0.8764 0.0
BTBR T+ Itpr3tf/J m 0.4383 0.2679 0.9647 0.0
BUB/BnJ f 0.6196 0.2362 1.0838 0.1554
BUB/BnJ m 0.399 0.317 1.0218 0.0
C3H/HeJ f 0.8983 0.2241 1.3387 0.458
C3H/HeJ m 0.7426 0.2506 1.235 0.2503
C57BL/10J f 0.6151 0.2679 1.1415 0.0888
C57BL/10J m 0.5472 0.2241 0.9876 0.1068
C57BL/6J f 0.5988 0.2241 1.0392 0.1584
C57BL/6J m 0.6374 0.2241 1.0778 0.197
C57BR/cdJ f 0.7024 0.2241 1.1428 0.2621
C57BR/cdJ m 0.8701 0.2241 1.3105 0.4297
C57L/J f 0.8033 0.2506 1.2957 0.311
C57L/J m 0.9076 0.2241 1.348 0.4673
C58/J f 0.8377 0.317 1.4604 0.2149
C58/J m 1.1279 0.2679 1.6542 0.6015
CAST/EiJ f 2.5087 0.2506 3.001 2.0163
CAST/EiJ m 1.4004 0.317 2.0232 0.7777
CBA/J f 0.5446 0.2506 1.037 0.0523
CBA/J m 0.6294 0.2506 1.1218 0.1371
CZECHII/EiJ f 0.7498 0.2241 1.1901 0.3094
CZECHII/EiJ m 0.751 0.2506 1.2434 0.2587
DBA/1J f 0.7584 0.3544 1.4547 0.0621
DBA/1J m 0.5395 0.2893 1.108 0.0
DBA/2J f 0.742 0.2362 1.2062 0.2778
DBA/2J m 0.6492 0.2362 1.1134 0.185
FVB/NJ f 0.4816 0.2506 0.9739 0.0
FVB/NJ m 0.5174 0.317 1.1402 0.0
JF1/MsJ f 0.6283 0.2241 1.0687 0.1879
JF1/MsJ m 0.5809 0.2679 1.1072 0.0545
LP/J f 1.0907 0.2241 1.5311 0.6503
LP/J m 0.8878 0.2137 1.3076 0.4679
MA/MyJ f 0.7052 0.2241 1.1456 0.2648
MA/MyJ m 0.5033 0.2241 0.9437 0.0629
MOLF/EiJ f 1.8028 0.2679 2.3292 1.2765
MOLF/EiJ m 1.9309 0.2362 2.3951 1.4667
MSM/MsJ f 2.1861 0.317 2.8088 1.5633
MSM/MsJ m 2.1041 0.2137 2.5239 1.6842
NOD/ShiLtJ f 0.6203 0.317 1.2431 0.0
NOD/ShiLtJ m 2.4409 0.3544 3.1372 1.7447
NON/ShiLtJ f 0.222 0.2241 0.6624 0.0
NON/ShiLtJ m 0.3556 0.2046 0.7576 0.0
NZB/BlNJ f 0.8239 0.2241 1.2642 0.3835
NZB/BlNJ m 0.5351 0.2362 0.9993 0.0709
NZW/LacJ f 0.6135 0.2362 1.0777 0.1493
NZW/LacJ m 0.3948 0.2506 0.8872 0.0
PERA/EiJ f 1.5503 0.2362 2.0144 1.0861
PERA/EiJ m 1.1787 0.2679 1.705 0.6523
RIIIS/J f 0.432 0.317 1.0547 0.0
RIIIS/J m 0.526 0.2506 1.0184 0.0337
SEA/GnJ f 0.5494 0.2362 1.0136 0.0852
SEA/GnJ m 0.5118 0.2679 1.0381 0.0
SJL/J f 0.404 0.2506 0.8963 0.0
SJL/J m 0.7261 0.2046 1.1281 0.3241
SM/J f 0.3577 0.2506 0.85 0.0
SM/J m 0.5158 0.2362 0.98 0.0517
SPRET/EiJ f 5.3033 0.3544 5.9996 4.607
SPRET/EiJ m 1.8894 0.317 2.5121 1.2666
SWR/J f 0.638 0.2506 1.1303 0.1456
SWR/J m 0.4689 0.2893 1.0374 0.0
WSB/EiJ f 1.0774 0.2506 1.5698 0.5851
WSB/EiJ m 0.8182 0.2362 1.2823 0.354


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.7609 0.202 1.1579 0.364
A/J both 0.8419 0.1681 1.1721 0.5116
BALB/cByJ both 0.378 0.1647 0.7015 0.0544
BTBR T+ Itpr3tf/J both 0.4112 0.1834 0.7716 0.0508
BUB/BnJ both 0.5093 0.1977 0.8977 0.1209
C3H/HeJ both 0.8205 0.1681 1.1507 0.4902
C57BL/10J both 0.5812 0.1746 0.9243 0.238
C57BL/6J both 0.6181 0.1585 0.9295 0.3067
C57BR/cdJ both 0.7863 0.1585 1.0977 0.4749
C57L/J both 0.8555 0.1681 1.1858 0.5252
C58/J both 0.9828 0.2075 1.3905 0.575
CAST/EiJ both 1.9545 0.202 2.3515 1.5576
CBA/J both 0.587 0.1772 0.9352 0.2389
CZECHII/EiJ both 0.7504 0.1681 1.0807 0.4201
DBA/1J both 0.649 0.2287 1.0984 0.1995
DBA/2J both 0.6956 0.167 1.0238 0.3674
FVB/NJ both 0.4995 0.202 0.8964 0.1025
JF1/MsJ both 0.6046 0.1746 0.9477 0.2615
LP/J both 0.9892 0.1548 1.2935 0.685
MA/MyJ both 0.6042 0.1585 0.9156 0.2928
MOLF/EiJ both 1.8669 0.1786 2.2177 1.516
MSM/MsJ both 2.1451 0.1911 2.5206 1.7695
NOD/ShiLtJ both 1.5306 0.2377 1.9977 1.0635
NON/ShiLtJ both 0.2888 0.1517 0.587 0.0
NZB/BlNJ both 0.6795 0.1628 0.9994 0.3595
NZW/LacJ both 0.5042 0.1722 0.8425 0.1658
PERA/EiJ both 1.3645 0.1786 1.7154 1.0136
RIIIS/J both 0.479 0.202 0.8759 0.082
SEA/GnJ both 0.5306 0.1786 0.8815 0.1797
SJL/J both 0.565 0.1617 0.8828 0.2472
SM/J both 0.4368 0.1722 0.7751 0.0984
SPRET/EiJ both 3.5964 0.2377 4.0634 3.1293
SWR/J both 0.5534 0.1914 0.9295 0.1774
WSB/EiJ both 0.9478 0.1722 1.2861 0.6095




  GWAS USING LINEAR MIXED MODELS