Project measure / variable:   Gould2   nicotine_chr

ID, description, units MPD:47102   nicotine_chr   plasma nicotine   [ng/mL]  chronic 6.3mg dose  
nicotine study
Data set, strains Gould2   inbred   8 strains     sex: m     age:
Procedure drug and metabolite quantification
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  STRAIN COMPARISON PLOT
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Gould2 - plasma nicotine chronic 6.3mg dose



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested8 strains
Mean of the strain means31.9   ng/mL
Median of the strain means28.6   ng/mL
SD of the strain means± 8.48
Coefficient of variation (CV)0.266
Min–max range of strain means24.0   –   47.5   ng/mL
Mean sample size per strain10.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 7 5030.4619 718.6374 7.5846 < 0.0001
Residuals 72 6821.963 94.7495


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S6/SvEvTac m 25.9 3.97   10 1.26 0.153 20.9, 31.2 -0.7
A/J m 42.7 15.9   10 5.02 0.372 27.3, 80.1 1.28
BALB/cByJ m 24.0 5.62   10 1.78 0.234 11.4, 30.2 -0.93
C3H/HeJ m 27.6 3.5   10 1.11 0.127 19.6, 31.5 -0.5
C57BL/6J m 27.6 2.7   10 0.854 0.0978 24.5, 32.0 -0.5
CBA/J m 29.6 5.38   10 1.7 0.182 23.1, 39.7 -0.27
DBA/1J m 47.5 18.7   10 5.91 0.393 33.3, 95.6 1.84
DBA/2J m 30.1 7.86   10 2.48 0.261 21.3, 45.6 -0.21


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S6/SvEvTac m 25.94 3.0781 32.0762 19.8038
A/J m 42.69 3.0781 48.8262 36.5538
BALB/cByJ m 23.97 3.0781 30.1062 17.8338
C3H/HeJ m 27.58 3.0781 33.7162 21.4438
C57BL/6J m 27.6 3.0781 33.7362 21.4638
CBA/J m 29.62 3.0781 35.7562 23.4838
DBA/1J m 47.48 3.0781 53.6162 41.3438
DBA/2J m 30.13 3.0781 36.2662 23.9938




  GWAS USING LINEAR MIXED MODELS