Project measure / variable:   GMC16   CHOL_21

ID, description, units MPD:56547   CHOL_21   total cholesterol (plasma CHOL)   [mmol/L]  at age 20-21wks  
Data set, strains GMC16   inbred w/CC8   8 strains     sex: both     age: 20-21wks
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  STRAIN COMPARISON PLOT
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GMC16 - total cholesterol (plasma CHOL) at age 20-21wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means2.44   mmol/L 2.89   mmol/L
Median of the strain means1.84   mmol/L 2.30   mmol/L
SD of the strain means± 1.42 ± 1.55
Coefficient of variation (CV)0.581 0.536
Min–max range of strain means1.32   –   5.74   mmol/L 1.86   –   6.49   mmol/L
Mean sample size per strain10.1   mice 11.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 10.7866 10.7866 49.6529 < 0.0001
strain 7 333.9088 47.7013 219.5794 < 0.0001
sex:strain 7 6.3713 0.9102 4.1898 0.0003
Residuals 158 34.3238 0.2172


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 2.88 0.331   10 0.105 0.115 2.41, 3.54 0.31
129S1/SvImJ m 3.44 0.233   12 0.0674 0.0678 3.08, 3.93 0.36
A/J f 1.7 0.198   10 0.0627 0.116 1.45, 2.04 -0.52
A/J m 2.01 0.133   11 0.0402 0.0663 1.81, 2.27 -0.57
C57BL/6J f 1.83 0.282   10 0.0893 0.154 1.42, 2.4 -0.43
C57BL/6J m 2.3 0.428   12 0.124 0.186 1.4, 2.9 -0.38
CAST/EiJ f 1.32 0.131   12 0.0379 0.0997 1.04, 1.45 -0.79
CAST/EiJ m 1.86 0.211   11 0.0636 0.113 1.57, 2.22 -0.66
NOD/ShiLtJ f 1.85 0.618   9 0.206 0.334 1.01, 2.5 -0.41
NOD/ShiLtJ m 2.31 0.212   12 0.0612 0.0919 2.08, 2.79 -0.37
NZO/HlLtJ f 5.74 0.33   10 0.104 0.0575 5.15, 6.25 2.33
NZO/HlLtJ m 6.49 1.44   12 0.415 0.222 3.88, 8.18 2.33
PWK/PhJ f 2.38 0.184   10 0.0581 0.0771 2.16, 2.69 -0.04
PWK/PhJ m 1.93 0.217   11 0.0653 0.112 1.65, 2.34 -0.62
WSB/EiJ f 1.79 0.137   10 0.0434 0.0767 1.63, 2.04 -0.46
WSB/EiJ m 2.75 0.24   12 0.0692 0.0872 2.36, 3.15 -0.09


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 2.8826 0.1474 3.1737 2.5915
129S1/SvImJ m 3.4412 0.1345 3.7069 3.1754
A/J f 1.7018 0.1474 1.9929 1.4107
A/J m 2.0123 0.1405 2.2898 1.7347
C57BL/6J f 1.8346 0.1474 2.1257 1.5435
C57BL/6J m 2.2966 0.1345 2.5623 2.0308
CAST/EiJ f 1.3189 0.1345 1.5847 1.0532
CAST/EiJ m 1.8596 0.1405 2.1372 1.5821
NOD/ShiLtJ f 1.8481 0.1554 2.155 1.5413
NOD/ShiLtJ m 2.3066 0.1345 2.5723 2.0408
NZO/HlLtJ f 5.7397 0.1474 6.0308 5.4486
NZO/HlLtJ m 6.489 0.1345 6.7547 6.2233
PWK/PhJ f 2.381 0.1474 2.6721 2.0899
PWK/PhJ m 1.9288 0.1405 2.2064 1.6513
WSB/EiJ f 1.7906 0.1474 2.0817 1.4995
WSB/EiJ m 2.7482 0.1345 3.0139 2.4824


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 3.1619 0.0998 3.359 2.9648
A/J both 1.857 0.1018 2.0581 1.6559
C57BL/6J both 2.0656 0.0998 2.2627 1.8685
CAST/EiJ both 1.5893 0.0973 1.7814 1.3971
NOD/ShiLtJ both 2.0773 0.1028 2.2803 1.8744
NZO/HlLtJ both 6.1143 0.0998 6.3114 5.9173
PWK/PhJ both 2.1549 0.1018 2.356 1.9538
WSB/EiJ both 2.2694 0.0998 2.4665 2.0723




  GWAS USING LINEAR MIXED MODELS