Project measure / variable:   Rusyn5   liver_GSH_hfe

ID, description, units MPD:43024   liver_GSH_hfe   reduced liver glutathione (GSH)   [nmol/mg]  high-fat and ethanol  
high-fat diet and ethanol study
Data set, strains Rusyn5   inbred   14 strains     sex: m     age: 8-14wks
Procedure metabolite quantification
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  STRAIN COMPARISON PLOT
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Rusyn5 - reduced liver glutathione (GSH) high-fat and ethanol



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested14 strains
Mean of the strain means34.1   nmol/mg
Median of the strain means35.4   nmol/mg
SD of the strain means± 11.8
Coefficient of variation (CV)0.346
Min–max range of strain means9.46   –   53.3   nmol/mg
Mean sample size per strain3.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 13 5133.6678 394.8975 4.1513 0.0009
Residuals 27 2568.3932 95.1257


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 9.46 6.66   3 3.85 0.704 4.78, 17.1 -2.09
AKR/J m 41.5 5.82   3 3.36 0.14 35.2, 46.7 0.63
BALB/cByJ m 26.7 1.33   3 0.769 0.0498 25.3, 27.9 -0.62
BALB/cJ m 35.4 7.28   3 4.21 0.206 27.7, 42.1 0.11
BTBR T+ Itpr3tf/J m 23.7 1.13   3 0.65 0.0474 22.6, 24.9 -0.88
C3H/HeJ m 41.8 21.8   3 12.6 0.521 16.7, 54.8 0.66
C57BL/10J m 42.6 3.68   3 2.12 0.0864 38.9, 46.3 0.72
DBA/2J m 26.3 10.6   3 6.14 0.405 16.5, 37.6 -0.66
FVB/NJ m 23.0 9.96   3 5.75 0.432 11.6, 29.3 -0.94
KK/HlJ m 30.7 18.1   3 10.5 0.591 10.3, 45.1 -0.29
MOLF/EiJ m 53.3 2.37   3 1.37 0.0444 50.9, 55.6 1.63
NZW/LacJ m 35.4 7.62   3 4.4 0.215 30.4, 44.2 0.11
PWD/PhJ m 50.8 2.24   2   1.58 0.0442 49.2, 52.4 1.42
WSB/EiJ m 36.2 7.37   3 4.26 0.203 29.7, 44.2 0.18


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 9.4633 5.631 21.0173 0.0
AKR/J m 41.5133 5.631 53.0673 29.9594
BALB/cByJ m 26.7467 5.631 38.3006 15.1927
BALB/cJ m 35.3967 5.631 46.9506 23.8427
BTBR T+ Itpr3tf/J m 23.74 5.631 35.2939 12.1861
C3H/HeJ m 41.8267 5.631 53.3806 30.2727
C57BL/10J m 42.6167 5.631 54.1706 31.0627
DBA/2J m 26.2667 5.631 37.8206 14.7127
FVB/NJ m 23.0367 5.631 34.5906 11.4827
KK/HlJ m 30.6867 5.631 42.2406 19.1327
MOLF/EiJ m 53.3267 5.631 64.8806 41.7727
NZW/LacJ m 35.4133 5.631 46.9673 23.8594
PWD/PhJ m 50.765 6.8966 64.9156 36.6144
WSB/EiJ m 36.2433 5.631 47.7973 24.6894




  GWAS USING LINEAR MIXED MODELS