Project measure / variable:   Crowley1   haloperidol_d90

ID, description, units MPD:39405   haloperidol_d90   plasma haloperidol concentration   [nM]  on day 90  
haloperidol study
Data set, strains Crowley1   inbred w/CC8   26 strains     sex: m     age: 9-28wks
Procedure drug and metabolite quantification
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  STRAIN COMPARISON PLOT
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Crowley1 - plasma haloperidol concentration on day 90



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested26 strains
Mean of the strain means10.6   nM
Median of the strain means9.86   nM
SD of the strain means± 4.92
Coefficient of variation (CV)0.465
Min–max range of strain means3.77   –   24.7   nM
Mean sample size per strain5.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 25 3332.2513 133.2901 7.4874 < 0.0001
Residuals 123 2189.6413 17.802


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 10.7 2.95   8 1.04 0.276 7.3, 15.3 0.03
A/J m 9.74 2.38   5 1.06 0.244 6.8, 13.1 -0.17
AKR/J m 4.62 0.782   5 0.35 0.169 3.6, 5.4 -1.21
BALB/cByJ m 3.77 1.37   4 0.686 0.363 2.6, 5.2 -1.38
BTBR T+ Itpr3tf/J m 16.1 6.05   8 2.14 0.376 9.8, 27.4 1.13
C3H/HeJ m 7.8 0.455   4 0.227 0.0583 7.2, 8.3 -0.56
C57BL/6J m 5.52 1.54   5 0.688 0.279 3.6, 7.5 -1.03
C57BLKS/J m 8.66 2.43   5 1.09 0.28 5.2, 10.6 -0.39
CAST/EiJ m 4.92 0.817   5 0.365 0.166 4.1, 6.0 -1.15
CBA/J m 8.54 1.34   5 0.601 0.157 6.5, 9.8 -0.41
DBA/2J m 9.14 2.82   9 0.939 0.308 5.2, 15.3 -0.29
DDY/JclSidSeyFrkJ m 13.7 6.07   7 2.29 0.444 5.9, 20.4 0.64
FVB/NJ m 12.8 2.08   5 0.928 0.162 10.1, 14.8 0.45
KK/HlJ m 11.4 4.17   7 1.58 0.365 5.7, 19.4 0.17
MA/MyJ m 8.93 2.68   6 1.09 0.3 5.1, 12.9 -0.33
MOLF/EiJ m 9.98 3.5   5 1.56 0.351 6.3, 15.3 -0.12
MRL/MpJ m 5.38 1.04   5 0.466 0.194 3.9, 6.5 -1.05
MSM/MsJ m 12.0 3.86   5 1.73 0.322 8.3, 18.4 0.29
NOD/ShiLtJ m 8.28 1.88   5 0.842 0.227 6.5, 11.4 -0.46
NON/ShiLtJ m 11.8 5.99   8 2.12 0.508 6.4, 21.4 0.25
NZL/LtJ m 24.7 11.0   7 4.15 0.444 12.6, 43.7 2.88
NZO/HlLtJ m 22.9 5.64   4 2.82 0.246 16.7, 28.0 2.51
NZW/LacJ m 8.32 2.39   5 1.07 0.287 5.9, 11.7 -0.46
PWK/PhJ m 11.9 3.42   5 1.53 0.288 7.2, 16.4 0.27
SJL/J m 12.4 3.67   4 1.83 0.295 8.5, 16.9 0.37
SM/J m 10.7 2.65   8 0.937 0.248 5.6, 14.3 0.03


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 10.7 1.4917 13.6528 7.7472
A/J m 9.74 1.8869 13.475 6.005
AKR/J m 4.62 1.8869 8.355 0.885
BALB/cByJ m 3.775 2.1096 7.9509 0.0
BTBR T+ Itpr3tf/J m 16.1125 1.4917 19.0653 13.1597
C3H/HeJ m 7.8 2.1096 11.9759 3.6241
C57BL/6J m 5.52 1.8869 9.255 1.785
C57BLKS/J m 8.66 1.8869 12.395 4.925
CAST/EiJ m 4.92 1.8869 8.655 1.185
CBA/J m 8.54 1.8869 12.275 4.805
DBA/2J m 9.1444 1.4064 11.9284 6.3605
DDY/JclSidSeyFrkJ m 13.6714 1.5947 16.8281 10.5148
FVB/NJ m 12.8 1.8869 16.535 9.065
KK/HlJ m 11.4429 1.5947 14.5995 8.2862
MA/MyJ m 8.9333 1.7225 12.3429 5.5238
MOLF/EiJ m 9.98 1.8869 13.715 6.245
MRL/MpJ m 5.38 1.8869 9.115 1.645
MSM/MsJ m 12.0 1.8869 15.735 8.265
NOD/ShiLtJ m 8.28 1.8869 12.015 4.545
NON/ShiLtJ m 11.7875 1.4917 14.7403 8.8347
NZL/LtJ m 24.7286 1.5947 27.8852 21.5719
NZO/HlLtJ m 22.925 2.1096 27.1009 18.7491
NZW/LacJ m 8.32 1.8869 12.055 4.585
PWK/PhJ m 11.88 1.8869 15.615 8.145
SJL/J m 12.425 2.1096 16.6009 8.2491
SM/J m 10.7 1.4917 13.6528 7.7472




  GWAS USING LINEAR MIXED MODELS