Project measure / variable:   Crowley1   haloperidol_d30

ID, description, units MPD:39403   haloperidol_d30   plasma haloperidol concentration   [nM]  on day 30  
haloperidol study
Data set, strains Crowley1   inbred w/CC8   27 strains     sex: m     age: 9-28wks
Procedure drug and metabolite quantification
Ontology mappings

  STRAIN COMPARISON PLOT
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Crowley1 - plasma haloperidol concentration on day 30



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested27 strains
Mean of the strain means26.0   nM
Median of the strain means23.9   nM
SD of the strain means± 11.7
Coefficient of variation (CV)0.450
Min–max range of strain means11.5   –   61.2   nM
Mean sample size per strain5.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 26 20942.7328 805.4897 12.4122 < 0.0001
Residuals 132 8566.1608 64.8952


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 21.6 3.62   8 1.28 0.167 16.1, 26.3 -0.38
A/J m 23.1 5.69   5 2.54 0.246 16.1, 31.2 -0.25
AKR/J m 12.7 2.52   5 1.13 0.199 9.9, 16.6 -1.14
BALB/cByJ m 11.5 1.17   5 0.525 0.102 9.6, 12.5 -1.24
BTBR T+ Itpr3tf/J m 38.7 5.63   8 1.99 0.146 31.2, 49.4 1.08
C3H/HeJ m 18.8 4.71   5 2.11 0.25 14.4, 25.5 -0.62
C57BL/6J m 12.0 2.75   5 1.23 0.229 9.4, 16.4 -1.2
C57BLKS/J m 25.0 3.49   5 1.56 0.14 23.1, 31.2 -0.09
CAST/EiJ m 22.2 7.47   5 3.34 0.337 13.8, 33.8 -0.33
CBA/J m 17.5 3.29   5 1.47 0.188 13.8, 22.1 -0.73
DBA/2J m 19.7 2.89   9 0.963 0.147 15.2, 23.9 -0.54
DDY/JclSidSeyFrkJ m 28.7 9.29   7 3.51 0.324 14.1, 43.0 0.23
FVB/NJ m 23.9 2.26   5 1.01 0.0946 20.8, 26.0 -0.18
KK/HlJ m 31.7 13.7   7 5.16 0.431 18.3, 59.8 0.48
MA/MyJ m 20.2 3.78   6 1.54 0.187 16.3, 27.4 -0.5
MOLF/EiJ m 23.3 1.46   5 0.651 0.0626 21.5, 25.4 -0.23
MRL/MpJ m 22.2 3.8   5 1.7 0.171 17.2, 26.0 -0.33
MSM/MsJ m 26.1 5.92   6 2.42 0.226 19.5, 34.6 0.01
NOD/ShiLtJ m 18.2 2.86   5 1.28 0.158 14.3, 20.5 -0.67
NON/ShiLtJ m 23.9 5.6   8 1.98 0.235 18.4, 35.1 -0.18
NZL/LtJ m 60.2 24.8   8 8.77 0.412 19.4, 104.0 2.91
NZO/HlLtJ m 61.2 11.5   4 5.76 0.188 47.6, 74.5 3.0
NZW/LacJ m 29.6 3.94   5 1.76 0.133 23.4, 33.8 0.3
PWK/PhJ m 29.8 6.08   5 2.72 0.204 21.7, 36.4 0.32
SJL/J m 26.1 1.42   5 0.637 0.0545 25.0, 28.6 0.01
SM/J m 24.6 4.6   8 1.63 0.187 16.5, 30.4 -0.12
WSB/EiJ m 30.5 8.68   5 3.88 0.285 23.1, 44.2 0.38


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 21.6375 2.8481 27.2714 16.0036
A/J m 23.12 3.6026 30.2464 15.9936
AKR/J m 12.68 3.6026 19.8064 5.5536
BALB/cByJ m 11.48 3.6026 18.6064 4.3536
BTBR T+ Itpr3tf/J m 38.675 2.8481 44.3089 33.0411
C3H/HeJ m 18.84 3.6026 25.9664 11.7136
C57BL/6J m 12.02 3.6026 19.1464 4.8936
C57BLKS/J m 25.0 3.6026 32.1264 17.8736
CAST/EiJ m 22.2 3.6026 29.3264 15.0736
CBA/J m 17.52 3.6026 24.6464 10.3936
DBA/2J m 19.7111 2.6853 25.0228 14.3994
DDY/JclSidSeyFrkJ m 28.6714 3.0448 34.6943 22.6485
FVB/NJ m 23.9 3.6026 31.0264 16.7736
KK/HlJ m 31.7 3.0448 37.7229 25.6771
MA/MyJ m 20.25 3.2887 26.7555 13.7445
MOLF/EiJ m 23.26 3.6026 30.3864 16.1336
MRL/MpJ m 22.22 3.6026 29.3464 15.0936
MSM/MsJ m 26.1333 3.2887 32.6388 19.6279
NOD/ShiLtJ m 18.16 3.6026 25.2864 11.0336
NON/ShiLtJ m 23.8625 2.8481 29.4964 18.2286
NZL/LtJ m 60.2 2.8481 65.8339 54.5661
NZO/HlLtJ m 61.25 4.0279 69.2175 53.2825
NZW/LacJ m 29.64 3.6026 36.7664 22.5136
PWK/PhJ m 29.78 3.6026 36.9064 22.6536
SJL/J m 26.14 3.6026 33.2664 19.0136
SM/J m 24.6375 2.8481 30.2714 19.0036
WSB/EiJ m 30.46 3.6026 37.5864 23.3336




  GWAS USING LINEAR MIXED MODELS