Project measure / variable:   Berndt2   insp_flow_mch20

ID, description, units MPD:35144   insp_flow_mch20   inspiratory flow rate   [mL/kg/s]  20 MCh  
methacholine study
Data set, strains Berndt2   inbred   29 strains     sex: both     age: 9-12wks
Procedure plethysmography
Ontology mappings

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  STRAIN COMPARISON PLOT
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Berndt2 - inspiratory flow rate 20 MCh



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains29 strains
Mean of the strain means3.06   mL/kg/s 3.27   mL/kg/s
Median of the strain means3.08   mL/kg/s 3.05   mL/kg/s
SD of the strain means± 0.909 ± 0.901
Coefficient of variation (CV)0.297 0.276
Min–max range of strain means1.56   –   4.95   mL/kg/s 1.94   –   4.70   mL/kg/s
Mean sample size per strain8.0   mice 8.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 6.4073 6.4073 14.0254 0.0002
strain 28 342.274 12.2241 26.758 < 0.0001
sex:strain 28 24.277 0.867 1.8979 0.0043
Residuals 412 188.217 0.4568


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 3.45 0.978   8 0.346 0.283 2.26, 5.04 0.43
129S1/SvImJ m 3.63 1.14   8 0.402 0.313 1.71, 5.29 0.4
A/J f 1.86 0.326   8 0.115 0.175 1.54, 2.59 -1.32
A/J m 1.98 0.271   8 0.0959 0.137 1.55, 2.35 -1.43
AKR/J f 3.31 0.99   8 0.35 0.299 1.95, 5.43 0.28
AKR/J m 4.28 0.646   8 0.229 0.151 2.95, 4.89 1.12
BALB/cByJ f 3.29 0.752   8 0.266 0.228 2.74, 4.82 0.25
BALB/cByJ m 3.86 0.931   8 0.329 0.241 2.0, 4.79 0.66
BALB/cJ f 3.48 0.437   10 0.138 0.126 2.68, 4.09 0.46
BALB/cJ m 3.79 0.618   10 0.195 0.163 2.42, 4.51 0.58
BTBR T+ Itpr3tf/J f 4.08 0.571   8 0.202 0.14 3.44, 4.89 1.12
BTBR T+ Itpr3tf/J m 4.46 0.55   8 0.195 0.124 3.59, 5.24 1.32
BUB/BnJ f 3.52 0.885   7 0.335 0.251 1.95, 4.85 0.51
BUB/BnJ m 3.02 0.595   8 0.21 0.197 2.31, 4.1 -0.28
C3H/HeJ f 2.45 0.652   8 0.231 0.266 1.53, 3.32 -0.67
C3H/HeJ m 2.7 0.893   8 0.316 0.331 1.36, 4.15 -0.63
C57BL/10J f 4.55 0.537   8 0.19 0.118 3.77, 5.21 1.64
C57BL/10J m 4.7 0.789   7 0.298 0.168 3.71, 5.91 1.59
C57BL/6J f 3.84 0.5   7 0.189 0.13 3.16, 4.49 0.86
C57BL/6J m 4.56 0.881   13 0.244 0.193 2.42, 5.53 1.43
C57BLKS/J f 3.61 0.871   11 0.263 0.241 2.2, 5.04 0.61
C57BLKS/J m 3.72 0.892   8 0.315 0.239 2.54, 5.19 0.5
C57BR/cdJ f 4.95 1.08   6 0.443 0.219 3.1, 6.45 2.08
C57BR/cdJ m 4.64 0.728   8 0.257 0.157 3.56, 5.94 1.52
C57L/J f 3.88 0.507   8 0.179 0.13 2.99, 4.47 0.9
C57L/J m 4.19 0.347   8 0.123 0.0829 3.71, 4.71 1.02
CBA/J f 3.87 0.429   8 0.152 0.111 3.29, 4.49 0.89
CBA/J m 4.17 0.394   8 0.139 0.0945 3.56, 4.62 1.0
CE/J f 2.47 0.763   8 0.27 0.309 1.67, 3.84 -0.65
CE/J m 2.42 0.456   9 0.152 0.188 1.54, 3.03 -0.94
DBA/1J f 2.97 0.496   10 0.157 0.167 2.17, 3.8 -0.1
DBA/1J m 2.61 0.408   8 0.144 0.157 2.09, 3.22 -0.73
DBA/2J f 2.98 0.399   8 0.141 0.134 2.33, 3.62 -0.09
DBA/2J m 2.94 0.54   10 0.171 0.183 2.14, 3.92 -0.36
FVB/NJ f 2.66 0.983   8 0.348 0.37 1.52, 3.95 -0.44
FVB/NJ m 4.21 0.808   7 0.305 0.192 2.52, 4.84 1.05
I/LnJ f 2.54 1.08   7 0.408 0.426 1.02, 3.64 -0.57
I/LnJ m 3.05 1.34   5 0.599 0.44 1.42, 4.15 -0.24
KK/HlJ f 3.71 0.744   8 0.263 0.201 3.12, 5.27 0.72
KK/HlJ m 3.24 0.295   6 0.12 0.0908 2.86, 3.63 -0.03
LP/J f 1.56 0.541   8 0.191 0.347 0.949, 2.69 -1.65
LP/J m 2.28 0.714   8 0.253 0.314 1.5, 3.86 -1.1
NOD/ShiLtJ f 4.14 0.622   8 0.22 0.15 3.32, 5.02 1.19
NOD/ShiLtJ m 3.81 0.539   8 0.191 0.142 2.92, 4.71 0.6
NON/ShiLtJ f 1.99 0.427   8 0.151 0.214 1.42, 2.67 -1.18
NON/ShiLtJ m 2.05 0.399   8 0.141 0.195 1.54, 2.75 -1.35
NZW/LacJ f 3.08 0.407   8 0.144 0.132 2.57, 3.65 0.02
NZW/LacJ m 2.83 0.977   8 0.345 0.345 1.64, 4.28 -0.49
PL/J f 1.68 0.467   8 0.165 0.278 1.17, 2.59 -1.52
PL/J m 2.05 0.891   8 0.315 0.434 1.41, 3.99 -1.35
RIIIS/J f 2.72 0.409   8 0.144 0.15 2.13, 3.53 -0.37
RIIIS/J m 2.41 0.547   8 0.193 0.227 1.87, 3.33 -0.95
SJL/J f 1.87 0.528   8 0.187 0.282 1.28, 2.77 -1.31
SJL/J m 1.94 0.518   8 0.183 0.267 1.22, 3.06 -1.47
SM/J f 2.64 0.375   8 0.132 0.142 2.14, 3.07 -0.46
SM/J m 2.75 0.229   8 0.081 0.0832 2.37, 3.12 -0.58
SWR/J f 1.57 0.463   8 0.164 0.294 1.0, 2.27 -1.64
SWR/J m 2.49 0.513   9 0.171 0.206 1.73, 3.14 -0.86


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 3.4512 0.239 3.921 2.9815
129S1/SvImJ m 3.6325 0.239 4.1022 3.1628
A/J f 1.865 0.239 2.3347 1.3953
A/J m 1.9825 0.239 2.4522 1.5128
AKR/J f 3.3088 0.239 3.7785 2.839
AKR/J m 4.2763 0.239 4.746 3.8065
BALB/cByJ f 3.2937 0.239 3.7635 2.824
BALB/cByJ m 3.865 0.239 4.3347 3.3953
BALB/cJ f 3.479 0.2137 3.8992 3.0588
BALB/cJ m 3.794 0.2137 4.2142 3.3738
BTBR T+ Itpr3tf/J f 4.0825 0.239 4.5522 3.6128
BTBR T+ Itpr3tf/J m 4.455 0.239 4.9247 3.9853
BUB/BnJ f 3.5229 0.2555 4.025 3.0207
BUB/BnJ m 3.0225 0.239 3.4922 2.5528
C3H/HeJ f 2.4487 0.239 2.9185 1.979
C3H/HeJ m 2.6987 0.239 3.1685 2.229
C57BL/10J f 4.5475 0.239 5.0172 4.0778
C57BL/10J m 4.6986 0.2555 5.2007 4.1964
C57BL/6J f 3.8357 0.2555 4.3379 3.3335
C57BL/6J m 4.5569 0.1875 4.9254 4.1884
C57BLKS/J f 3.6073 0.2038 4.0079 3.2067
C57BLKS/J m 3.725 0.239 4.1947 3.2553
C57BR/cdJ f 4.945 0.2759 5.4874 4.4026
C57BR/cdJ m 4.6425 0.239 5.1122 4.1728
C57L/J f 3.885 0.239 4.3547 3.4153
C57L/J m 4.1862 0.239 4.656 3.7165
CBA/J f 3.8675 0.239 4.3372 3.3978
CBA/J m 4.1738 0.239 4.6435 3.704
CE/J f 2.4737 0.239 2.9435 2.004
CE/J m 2.42 0.2253 2.8629 1.9771
DBA/1J f 2.972 0.2137 3.3922 2.5518
DBA/1J m 2.6062 0.239 3.076 2.1365
DBA/2J f 2.9762 0.239 3.446 2.5065
DBA/2J m 2.943 0.2137 3.3632 2.5228
FVB/NJ f 2.6575 0.239 3.1272 2.1878
FVB/NJ m 4.2086 0.2555 4.7107 3.7064
I/LnJ f 2.5371 0.2555 3.0393 2.035
I/LnJ m 3.048 0.3023 3.6422 2.4538
KK/HlJ f 3.7062 0.239 4.176 3.2365
KK/HlJ m 3.2433 0.2759 3.7857 2.7009
LP/J f 1.5599 0.239 2.0296 1.0901
LP/J m 2.2762 0.239 2.746 1.8065
NOD/ShiLtJ f 4.1437 0.239 4.6135 3.674
NOD/ShiLtJ m 3.805 0.239 4.2747 3.3353
NON/ShiLtJ f 1.9937 0.239 2.4635 1.524
NON/ShiLtJ m 2.0488 0.239 2.5185 1.579
NZW/LacJ f 3.0762 0.239 3.546 2.6065
NZW/LacJ m 2.8287 0.239 3.2985 2.359
PL/J f 1.6775 0.239 2.1472 1.2078
PL/J m 2.0538 0.239 2.5235 1.584
RIIIS/J f 2.7237 0.239 3.1935 2.254
RIIIS/J m 2.4125 0.239 2.8822 1.9428
SJL/J f 1.8712 0.239 2.341 1.4015
SJL/J m 1.9412 0.239 2.411 1.4715
SM/J f 2.6425 0.239 3.1122 2.1728
SM/J m 2.7537 0.239 3.2235 2.284
SWR/J f 1.5738 0.239 2.0435 1.104
SWR/J m 2.4911 0.2253 2.934 2.0482


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 3.5419 0.169 3.874 3.2097
A/J both 1.9238 0.169 2.2559 1.5916
AKR/J both 3.7925 0.169 4.1247 3.4603
BALB/cByJ both 3.5794 0.169 3.9115 3.2472
BALB/cJ both 3.6365 0.1511 3.9336 3.3394
BTBR T+ Itpr3tf/J both 4.2687 0.169 4.6009 3.9366
BUB/BnJ both 3.2727 0.1749 3.6165 2.9289
C3H/HeJ both 2.5737 0.169 2.9059 2.2416
C57BL/10J both 4.623 0.1749 4.9669 4.2792
C57BL/6J both 4.1963 0.1584 4.5078 3.8849
C57BLKS/J both 3.6661 0.157 3.9748 3.3575
C57BR/cdJ both 4.7938 0.1825 5.1525 4.435
C57L/J both 4.0356 0.169 4.3678 3.7035
CBA/J both 4.0206 0.169 4.3528 3.6885
CE/J both 2.4469 0.1642 2.7697 2.1241
DBA/1J both 2.7891 0.1603 3.1042 2.474
DBA/2J both 2.9596 0.1603 3.2747 2.6445
FVB/NJ both 3.433 0.1749 3.7769 3.0892
I/LnJ both 2.7926 0.1979 3.1816 2.4036
KK/HlJ both 3.4748 0.1825 3.8336 3.116
LP/J both 1.9181 0.169 2.2502 1.5859
NOD/ShiLtJ both 3.9744 0.169 4.3065 3.6422
NON/ShiLtJ both 2.0212 0.169 2.3534 1.6891
NZW/LacJ both 2.9525 0.169 3.2847 2.6203
PL/J both 1.8656 0.169 2.1978 1.5335
RIIIS/J both 2.5681 0.169 2.9003 2.236
SJL/J both 1.9062 0.169 2.2384 1.5741
SM/J both 2.6981 0.169 3.0303 2.366
SWR/J both 2.0324 0.1642 2.3552 1.7096




  GWAS USING LINEAR MIXED MODELS