Project measure / variable:   Berndt2   min_vent_slope

ID, description, units MPD:35105   min_vent_slope   minute ventilation   [mL/min]  response index  
methacholine study
Data set, strains Berndt2   inbred   29 strains     sex: both     age: 9-12wks
Procedure plethysmography
Ontology mappings

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  STRAIN COMPARISON PLOT
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Berndt2 - minute ventilation response index



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains29 strains
Mean of the strain means0.148   mL/min 0.170   mL/min
Median of the strain means0.139   mL/min 0.151   mL/min
SD of the strain means± 0.217 ± 0.218
Coefficient of variation (CV)1.47 1.28
Min–max range of strain means-0.302   –   0.548   mL/min -0.277   –   0.518   mL/min
Mean sample size per strain8.0   mice 8.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.0707 0.0707 1.0691 0.3018
strain 28 18.9131 0.6755 10.2122 < 0.0001
sex:strain 28 2.8919 0.1033 1.5615 0.036
Residuals 412 27.2511 0.0661


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.529 0.33   8 0.117 0.623 -0.033, 0.894 1.76
129S1/SvImJ m 0.478 0.329   8 0.116 0.688 0.057, 0.937 1.42
A/J f -0.275 0.134   8 0.0474 -0.487 -0.415, -0.048 -1.95
A/J m -0.277 0.119   8 0.0421 -0.43 -0.506, -0.086 -2.05
AKR/J f 0.148 0.127   8 0.0448 0.858 -0.063, 0.341 0.0
AKR/J m 0.518 0.228   8 0.0805 0.44 0.089, 0.783 1.6
BALB/cByJ f 0.102 0.18   8 0.0637 1.76 -0.115, 0.452 -0.21
BALB/cByJ m 0.127 0.114   8 0.0402 0.894 -0.045, 0.302 -0.2
BALB/cJ f -0.0435 0.119   10 0.0376 -2.74 -0.258, 0.1 -0.88
BALB/cJ m -0.0009 0.168   10 0.0532 -187.0 -0.343, 0.287 -0.78
BTBR T+ Itpr3tf/J f 0.0375 0.296   8 0.105 7.91 -0.305, 0.658 -0.51
BTBR T+ Itpr3tf/J m -0.198 0.128   8 0.0454 -0.648 -0.377, 0.0 -1.69
BUB/BnJ f 0.161 0.302   7 0.114 1.87 -0.244, 0.707 0.06
BUB/BnJ m 0.172 0.294   8 0.104 1.71 -0.138, 0.519 0.01
C3H/HeJ f 0.0958 0.305   8 0.108 3.19 -0.335, 0.394 -0.24
C3H/HeJ m 0.0826 0.316   8 0.112 3.82 -0.331, 0.547 -0.4
C57BL/10J f 0.313 0.139   8 0.0493 0.445 0.149, 0.498 0.76
C57BL/10J m 0.273 0.12   7 0.0452 0.438 0.022, 0.368 0.47
C57BL/6J f 0.3 0.179   7 0.0675 0.595 0.089, 0.574 0.7
C57BL/6J m 0.483 0.263   13 0.0729 0.544 0.166, 0.977 1.44
C57BLKS/J f 0.372 0.303   11 0.0912 0.812 -0.06, 0.908 1.03
C57BLKS/J m 0.406 0.301   8 0.107 0.742 0.009, 0.941 1.08
C57BR/cdJ f 0.368 0.381   6 0.155 1.03 -0.313, 0.697 1.01
C57BR/cdJ m 0.402 0.233   8 0.0825 0.581 0.072, 0.717 1.07
C57L/J f 0.384 0.0559   8 0.0198 0.146 0.32, 0.477 1.09
C57L/J m 0.336 0.141   8 0.05 0.42 0.06, 0.476 0.76
CBA/J f 0.44 0.131   8 0.0462 0.297 0.261, 0.658 1.35
CBA/J m 0.466 0.143   8 0.0504 0.306 0.259, 0.627 1.36
CE/J f 0.139 0.369   8 0.13 2.66 -0.187, 0.939 -0.04
CE/J m 0.0159 0.13   9 0.0433 8.17 -0.167, 0.237 -0.71
DBA/1J f 0.273 0.157   10 0.0496 0.574 -0.013, 0.468 0.58
DBA/1J m -0.0724 0.129   8 0.0457 -1.79 -0.26, 0.091 -1.11
DBA/2J f 0.154 0.178   8 0.0628 1.16 -0.07, 0.5 0.03
DBA/2J m 0.2 0.213   10 0.0672 1.06 0.031, 0.712 0.14
FVB/NJ f 0.0788 0.512   8 0.181 6.51 -0.7, 0.733 -0.32
FVB/NJ m 0.31 0.385   7 0.146 1.24 -0.229, 0.68 0.64
I/LnJ f 0.03 0.329   7 0.124 11.0 -0.436, 0.387 -0.54
I/LnJ m 0.151 0.459   5 0.205 3.04 -0.409, 0.675 -0.09
KK/HlJ f 0.341 0.137   8 0.0483 0.401 0.163, 0.517 0.89
KK/HlJ m 0.301 0.224   6 0.0915 0.744 0.066, 0.653 0.6
LP/J f -0.0711 0.341   8 0.121 -4.8 -0.669, 0.463 -1.01
LP/J m 0.151 0.259   8 0.0914 1.71 -0.269, 0.607 -0.09
NOD/ShiLtJ f 0.548 0.226   8 0.08 0.412 0.137, 0.859 1.84
NOD/ShiLtJ m 0.35 0.37   8 0.131 1.06 -0.351, 0.66 0.83
NON/ShiLtJ f -0.126 0.276   8 0.0976 -2.19 -0.606, 0.377 -1.26
NON/ShiLtJ m -0.202 0.213   8 0.0751 -1.05 -0.48, 0.184 -1.71
NZW/LacJ f 0.036 0.159   8 0.0561 4.41 -0.226, 0.262 -0.52
NZW/LacJ m 0.151 0.182   8 0.0644 1.21 -0.112, 0.415 -0.09
PL/J f -0.302 0.277   8 0.0979 -0.916 -0.649, 0.149 -2.08
PL/J m -0.0917 0.479   8 0.169 -5.22 -0.563, 0.845 -1.2
RIIIS/J f 0.241 0.0996   8 0.0352 0.413 0.103, 0.373 0.43
RIIIS/J m 0.0265 0.17   8 0.06 6.4 -0.172, 0.259 -0.66
SJL/J f -0.0421 0.449   8 0.159 -10.7 -0.582, 0.59 -0.88
SJL/J m 0.067 0.389   8 0.137 5.8 -0.544, 0.609 -0.47
SM/J f 0.0889 0.171   8 0.0605 1.93 -0.117, 0.347 -0.27
SM/J m 0.0683 0.263   8 0.0928 3.85 -0.439, 0.438 -0.47
SWR/J f -0.0279 0.275   8 0.0973 -9.88 -0.385, 0.375 -0.81
SWR/J m 0.227 0.142   9 0.0472 0.622 -0.023, 0.425 0.26


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.5293 0.0909 0.708 0.3505
129S1/SvImJ m 0.4778 0.0909 0.6565 0.299
A/J f -0.2754 0.0909 -0.0966 -0.4541
A/J m -0.2771 0.0909 -0.0984 -0.4559
AKR/J f 0.1479 0.0909 0.3266 -0.0309
AKR/J m 0.5176 0.0909 0.6964 0.3389
BALB/cByJ f 0.1022 0.0909 0.281 -0.0765
BALB/cByJ m 0.1271 0.0909 0.3059 -0.0516
BALB/cJ f -0.0435 0.0813 0.1164 -0.2034
BALB/cJ m -0.0009 0.0813 0.159 -0.1608
BTBR T+ Itpr3tf/J f 0.0375 0.0909 0.2162 -0.1412
BTBR T+ Itpr3tf/J m -0.1981 0.0909 -0.0194 -0.3769
BUB/BnJ f 0.161 0.0972 0.3521 -0.0301
BUB/BnJ m 0.1719 0.0909 0.3506 -0.0069
C3H/HeJ f 0.0957 0.0909 0.2745 -0.083
C3H/HeJ m 0.0826 0.0909 0.2614 -0.0961
C57BL/10J f 0.313 0.0909 0.4917 0.1343
C57BL/10J m 0.2731 0.0972 0.4642 0.0821
C57BL/6J f 0.3004 0.0972 0.4915 0.1093
C57BL/6J m 0.483 0.0713 0.6232 0.3428
C57BLKS/J f 0.3724 0.0775 0.5248 0.2199
C57BLKS/J m 0.4065 0.0909 0.5852 0.2278
C57BR/cdJ f 0.3683 0.105 0.5747 0.1619
C57BR/cdJ m 0.4016 0.0909 0.5804 0.2229
C57L/J f 0.3837 0.0909 0.5625 0.205
C57L/J m 0.3364 0.0909 0.5151 0.1576
CBA/J f 0.4401 0.0909 0.6189 0.2614
CBA/J m 0.4659 0.0909 0.6446 0.2871
CE/J f 0.1389 0.0909 0.3176 -0.0399
CE/J m 0.0159 0.0857 0.1844 -0.1526
DBA/1J f 0.2732 0.0813 0.4331 0.1133
DBA/1J m -0.0724 0.0909 0.1064 -0.2511
DBA/2J f 0.1536 0.0909 0.3324 -0.0251
DBA/2J m 0.2001 0.0813 0.36 0.0402
FVB/NJ f 0.0787 0.0909 0.2575 -0.1
FVB/NJ m 0.3097 0.0972 0.5008 0.1186
I/LnJ f 0.03 0.0972 0.2211 -0.1611
I/LnJ m 0.1512 0.115 0.3773 -0.0749
KK/HlJ f 0.3406 0.0909 0.5194 0.1619
KK/HlJ m 0.301 0.105 0.5074 0.0946
LP/J f -0.0711 0.0909 0.1076 -0.2499
LP/J m 0.1511 0.0909 0.3299 -0.0276
NOD/ShiLtJ f 0.5485 0.0909 0.7272 0.3698
NOD/ShiLtJ m 0.3497 0.0909 0.5285 0.171
NON/ShiLtJ f -0.126 0.0909 0.0527 -0.3047
NON/ShiLtJ m -0.2021 0.0909 -0.0234 -0.3809
NZW/LacJ f 0.036 0.0909 0.2147 -0.1427
NZW/LacJ m 0.1509 0.0909 0.3296 -0.0279
PL/J f -0.3023 0.0909 -0.1235 -0.481
PL/J m -0.0918 0.0909 0.087 -0.2705
RIIIS/J f 0.2411 0.0909 0.4199 0.0624
RIIIS/J m 0.0265 0.0909 0.2052 -0.1522
SJL/J f -0.0421 0.0909 0.1366 -0.2209
SJL/J m 0.067 0.0909 0.2457 -0.1117
SM/J f 0.0889 0.0909 0.2676 -0.0899
SM/J m 0.0683 0.0909 0.247 -0.1105
SWR/J f -0.0279 0.0909 0.1509 -0.2066
SWR/J m 0.2274 0.0857 0.396 0.0589


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.5035 0.0643 0.6299 0.3771
A/J both -0.2762 0.0643 -0.1499 -0.4026
AKR/J both 0.3327 0.0643 0.4591 0.2064
BALB/cByJ both 0.1147 0.0643 0.2411 -0.0117
BALB/cJ both -0.0222 0.0575 0.0908 -0.1352
BTBR T+ Itpr3tf/J both -0.0803 0.0643 0.0461 -0.2067
BUB/BnJ both 0.1664 0.0666 0.2973 0.0356
C3H/HeJ both 0.0892 0.0643 0.2156 -0.0372
C57BL/10J both 0.2931 0.0666 0.4239 0.1622
C57BL/6J both 0.3917 0.0603 0.5102 0.2732
C57BLKS/J both 0.3894 0.0598 0.5069 0.272
C57BR/cdJ both 0.385 0.0694 0.5215 0.2485
C57L/J both 0.3601 0.0643 0.4865 0.2337
CBA/J both 0.453 0.0643 0.5794 0.3266
CE/J both 0.0774 0.0625 0.2002 -0.0454
DBA/1J both 0.1004 0.061 0.2203 -0.0195
DBA/2J both 0.1769 0.061 0.2968 0.057
FVB/NJ both 0.1942 0.0666 0.3251 0.0634
I/LnJ both 0.0906 0.0753 0.2386 -0.0574
KK/HlJ both 0.3208 0.0694 0.4573 0.1843
LP/J both 0.04 0.0643 0.1664 -0.0864
NOD/ShiLtJ both 0.4491 0.0643 0.5755 0.3227
NON/ShiLtJ both -0.1641 0.0643 -0.0377 -0.2905
NZW/LacJ both 0.0934 0.0643 0.2198 -0.033
PL/J both -0.197 0.0643 -0.0706 -0.3234
RIIIS/J both 0.1338 0.0643 0.2602 0.0074
SJL/J both 0.0124 0.0643 0.1388 -0.114
SM/J both 0.0786 0.0643 0.205 -0.0478
SWR/J both 0.0998 0.0625 0.2226 -0.023




  GWAS USING LINEAR MIXED MODELS