Project measure / variable:   Berndt2   min_vent_mch20

ID, description, units MPD:35104   min_vent_mch20   minute ventilation   [mL/min]  20 MCh  
methacholine study
Data set, strains Berndt2   inbred   29 strains     sex: both     age: 9-12wks
Procedure plethysmography
Ontology mappings

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  STRAIN COMPARISON PLOT
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Berndt2 - minute ventilation 20 MCh



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains29 strains
Mean of the strain means68.2   mL/min 75.0   mL/min
Median of the strain means68.0   mL/min 75.0   mL/min
SD of the strain means± 22.7 ± 23.2
Coefficient of variation (CV)0.333 0.310
Min–max range of strain means28.3   –   118   mL/min 38.7   –   108   mL/min
Mean sample size per strain8.0   mice 8.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 6194.2407 6194.2407 19.929 < 0.0001
strain 28 219233.466 7829.7666 25.1911 < 0.0001
sex:strain 28 18264.1063 652.2895 2.0986 0.0011
Residuals 412 128055.7969 310.815


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 78.2 25.3   8 8.94 0.323 48.0, 124.0 0.44
129S1/SvImJ m 81.2 25.6   8 9.05 0.315 34.6, 111.0 0.27
A/J f 42.2 10.8   8 3.81 0.255 29.2, 64.5 -1.14
A/J m 41.8 7.09   8 2.51 0.17 35.1, 56.4 -1.43
AKR/J f 77.4 32.0   8 11.3 0.413 44.3, 150.0 0.41
AKR/J m 99.5 19.8   8 7.02 0.199 64.2, 121.0 1.05
BALB/cByJ f 76.8 21.4   8 7.58 0.279 56.9, 122.0 0.38
BALB/cByJ m 89.7 23.9   8 8.44 0.266 47.7, 121.0 0.63
BALB/cJ f 82.4 12.5   10 3.97 0.152 60.5, 105.0 0.63
BALB/cJ m 92.5 17.0   10 5.38 0.184 53.9, 111.0 0.75
BTBR T+ Itpr3tf/J f 85.6 15.7   8 5.55 0.183 72.4, 121.0 0.77
BTBR T+ Itpr3tf/J m 101.0 18.2   8 6.43 0.18 64.7, 122.0 1.12
BUB/BnJ f 76.2 24.4   7 9.22 0.32 32.8, 113.0 0.35
BUB/BnJ m 63.5 19.1   8 6.75 0.301 38.0, 101.0 -0.49
C3H/HeJ f 52.3 17.5   8 6.17 0.334 31.6, 82.9 -0.7
C3H/HeJ m 59.7 25.0   8 8.82 0.418 21.7, 102.0 -0.66
C57BL/10J f 98.6 16.5   8 5.84 0.168 71.8, 122.0 1.34
C57BL/10J m 101.0 18.1   7 6.85 0.179 78.6, 130.0 1.12
C57BL/6J f 88.0 18.1   7 6.85 0.206 66.0, 111.0 0.87
C57BL/6J m 107.0 24.2   13 6.71 0.226 50.3, 136.0 1.38
C57BLKS/J f 88.5 23.9   11 7.22 0.271 48.0, 117.0 0.89
C57BLKS/J m 94.1 22.9   8 8.1 0.243 66.7, 138.0 0.82
C57BR/cdJ f 118.0 29.8   6 12.1 0.253 74.3, 165.0 2.19
C57BR/cdJ m 108.0 25.2   8 8.9 0.233 67.0, 148.0 1.42
C57L/J f 89.7 14.5   8 5.13 0.162 64.9, 104.0 0.95
C57L/J m 103.0 9.4   8 3.32 0.0912 91.0, 116.0 1.21
CBA/J f 92.8 12.3   8 4.36 0.133 75.7, 111.0 1.08
CBA/J m 101.0 10.1   8 3.59 0.101 86.3, 112.0 1.12
CE/J f 56.4 18.0   8 6.35 0.319 38.5, 86.4 -0.52
CE/J m 53.9 12.1   9 4.04 0.225 33.8, 70.3 -0.91
DBA/1J f 64.4 13.1   10 4.16 0.204 45.3, 95.3 -0.17
DBA/1J m 54.1 9.8   8 3.47 0.181 39.8, 66.7 -0.9
DBA/2J f 64.0 12.3   8 4.34 0.192 52.1, 88.0 -0.18
DBA/2J m 67.0 12.9   10 4.07 0.192 50.4, 97.4 -0.34
FVB/NJ f 56.5 20.4   8 7.21 0.36 31.4, 80.1 -0.51
FVB/NJ m 105.0 16.7   7 6.3 0.158 71.1, 123.0 1.29
I/LnJ f 55.8 23.4   7 8.84 0.419 20.6, 89.5 -0.55
I/LnJ m 78.3 37.1   5 16.6 0.474 37.1, 107.0 0.14
KK/HlJ f 87.8 13.5   8 4.79 0.154 77.4, 118.0 0.86
KK/HlJ m 75.0 11.1   6 4.53 0.148 62.4, 90.6 0.0
LP/J f 31.0 12.9   8 4.57 0.417 13.8, 54.3 -1.64
LP/J m 50.4 19.5   8 6.9 0.387 34.4, 94.1 -1.06
NOD/ShiLtJ f 89.1 17.6   8 6.21 0.197 68.3, 122.0 0.92
NOD/ShiLtJ m 86.7 14.9   8 5.25 0.171 67.7, 104.0 0.5
NON/ShiLtJ f 40.2 9.31   8 3.29 0.231 28.2, 55.4 -1.23
NON/ShiLtJ m 44.9 9.33   8 3.3 0.208 35.9, 59.8 -1.3
NZW/LacJ f 57.1 7.44   8 2.63 0.13 47.1, 67.4 -0.49
NZW/LacJ m 60.6 19.8   8 7.01 0.327 38.9, 86.7 -0.62
PL/J f 28.3 10.4   8 3.69 0.369 16.9, 49.5 -1.76
PL/J m 38.7 20.4   8 7.22 0.528 25.3, 85.1 -1.56
RIIIS/J f 61.9 10.4   8 3.69 0.169 51.9, 85.6 -0.28
RIIIS/J m 52.9 11.6   8 4.1 0.219 41.9, 74.1 -0.95
SJL/J f 35.6 12.7   8 4.49 0.357 22.0, 59.0 -1.44
SJL/J m 39.9 10.7   8 3.78 0.269 28.0, 62.3 -1.51
SM/J f 68.0 6.99   8 2.47 0.103 60.9, 78.1 -0.01
SM/J m 69.7 10.6   8 3.74 0.152 53.9, 83.9 -0.23
SWR/J f 34.6 9.15   8 3.23 0.265 22.2, 47.1 -1.48
SWR/J m 54.7 8.73   9 2.91 0.16 40.9, 67.3 -0.87


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 78.25 6.2331 90.5027 65.9973
129S1/SvImJ m 81.2 6.2331 93.4527 68.9473
A/J f 42.2 6.2331 54.4527 29.9473
A/J m 41.8125 6.2331 54.0652 29.5598
AKR/J f 77.3875 6.2331 89.6402 65.1348
AKR/J m 99.475 6.2331 111.7277 87.2223
BALB/cByJ f 76.75 6.2331 89.0027 64.4973
BALB/cByJ m 89.6625 6.2331 101.9152 77.4098
BALB/cJ f 82.43 5.5751 93.3891 71.4709
BALB/cJ m 92.46 5.5751 103.4191 81.5009
BTBR T+ Itpr3tf/J f 85.625 6.2331 97.8777 73.3723
BTBR T+ Itpr3tf/J m 100.8125 6.2331 113.0652 88.5598
BUB/BnJ f 76.2429 6.6635 89.3415 63.1442
BUB/BnJ m 63.525 6.2331 75.7777 51.2723
C3H/HeJ f 52.2625 6.2331 64.5152 40.0098
C3H/HeJ m 59.65 6.2331 71.9027 47.3973
C57BL/10J f 98.575 6.2331 110.8277 86.3223
C57BL/10J m 101.1 6.6635 114.1987 88.0013
C57BL/6J f 87.9571 6.6635 101.0558 74.8585
C57BL/6J m 107.0769 4.8897 116.6887 97.4651
C57BLKS/J f 88.5 5.3156 98.9491 78.0509
C57BLKS/J m 94.05 6.2331 106.3027 81.7973
C57BR/cdJ f 117.7167 7.1974 131.8649 103.5685
C57BR/cdJ m 108.1625 6.2331 120.4152 95.9098
C57L/J f 89.675 6.2331 101.9277 77.4223
C57L/J m 102.9875 6.2331 115.2402 90.7348
CBA/J f 92.8 6.2331 105.0527 80.5473
CBA/J m 100.8875 6.2331 113.1402 88.6348
CE/J f 56.3625 6.2331 68.6152 44.1098
CE/J m 53.9 5.8766 65.452 42.348
DBA/1J f 64.44 5.5751 75.3991 53.4809
DBA/1J m 54.125 6.2331 66.3777 41.8723
DBA/2J f 64.0375 6.2331 76.2902 51.7848
DBA/2J m 66.97 5.5751 77.9291 56.0109
FVB/NJ f 56.5375 6.2331 68.7902 44.2848
FVB/NJ m 105.3 6.6635 118.3987 92.2013
I/LnJ f 55.8429 6.6635 68.9415 42.7442
I/LnJ m 78.26 7.8844 93.7586 62.7614
KK/HlJ f 87.8 6.2331 100.0527 75.5473
KK/HlJ m 74.9833 7.1974 89.1315 60.8351
LP/J f 30.975 6.2331 43.2277 18.7223
LP/J m 50.375 6.2331 62.6277 38.1223
NOD/ShiLtJ f 89.0625 6.2331 101.3152 76.8098
NOD/ShiLtJ m 86.65 6.2331 98.9027 74.3973
NON/ShiLtJ f 40.2375 6.2331 52.4902 27.9848
NON/ShiLtJ m 44.9 6.2331 57.1527 32.6473
NZW/LacJ f 57.1 6.2331 69.3527 44.8473
NZW/LacJ m 60.6125 6.2331 72.8652 48.3598
PL/J f 28.3 6.2331 40.5527 16.0473
PL/J m 38.6625 6.2331 50.9152 26.4098
RIIIS/J f 61.9 6.2331 74.1527 49.6473
RIIIS/J m 52.9375 6.2331 65.1902 40.6848
SJL/J f 35.55 6.2331 47.8027 23.2973
SJL/J m 39.85 6.2331 52.1027 27.5973
SM/J f 68.0 6.2331 80.2527 55.7473
SM/J m 69.7125 6.2331 81.9652 57.4598
SWR/J f 34.575 6.2331 46.8277 22.3223
SWR/J m 54.7 5.8766 66.252 43.148


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 79.725 4.4075 88.389 71.061
A/J both 42.0063 4.4075 50.6702 33.3423
AKR/J both 88.4313 4.4075 97.0952 79.7673
BALB/cByJ both 83.2063 4.4075 91.8702 74.5423
BALB/cJ both 87.445 3.9422 95.1943 79.6957
BTBR T+ Itpr3tf/J both 93.2188 4.4075 101.8827 84.5548
BUB/BnJ both 69.8839 4.5622 78.852 60.9159
C3H/HeJ both 55.9563 4.4075 64.6202 47.2923
C57BL/10J both 99.8375 4.5622 108.8056 90.8694
C57BL/6J both 97.517 4.1325 105.6405 89.3936
C57BLKS/J both 91.275 4.096 99.3266 83.2234
C57BR/cdJ both 112.9396 4.7606 122.2977 103.5814
C57L/J both 96.3313 4.4075 104.9952 87.6673
CBA/J both 96.8438 4.4075 105.5077 88.1798
CE/J both 55.1313 4.2833 63.5511 46.7114
DBA/1J both 59.2825 4.1813 67.5019 51.0631
DBA/2J both 65.5038 4.1813 73.7231 57.2844
FVB/NJ both 80.9188 4.5622 89.8868 71.9507
I/LnJ both 67.0514 5.1615 77.1976 56.9052
KK/HlJ both 81.3917 4.7606 90.7498 72.0335
LP/J both 40.675 4.4075 49.339 32.011
NOD/ShiLtJ both 87.8563 4.4075 96.5202 79.1923
NON/ShiLtJ both 42.5688 4.4075 51.2327 33.9048
NZW/LacJ both 58.8563 4.4075 67.5202 50.1923
PL/J both 33.4813 4.4075 42.1452 24.8173
RIIIS/J both 57.4188 4.4075 66.0827 48.7548
SJL/J both 37.7 4.4075 46.364 29.036
SM/J both 68.8563 4.4075 77.5202 60.1923
SWR/J both 44.6375 4.2833 53.0574 36.2176




  GWAS USING LINEAR MIXED MODELS