Project measure / variable:   Berndt2   min_vent_mch10

ID, description, units MPD:35103   min_vent_mch10   minute ventilation   [mL/min]  10 MCh  
methacholine study
Data set, strains Berndt2   inbred   29 strains     sex: both     age: 9-12wks
Procedure plethysmography
Ontology mappings

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  STRAIN COMPARISON PLOT
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Berndt2 - minute ventilation 10 MCh



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains29 strains
Mean of the strain means55.9   mL/min 65.9   mL/min
Median of the strain means55.0   mL/min 63.6   mL/min
SD of the strain means± 19.5 ± 22.1
Coefficient of variation (CV)0.349 0.336
Min–max range of strain means27.7   –   116   mL/min 32.4   –   127   mL/min
Mean sample size per strain8.0   mice 8.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 10055.3326 10055.3326 39.776 < 0.0001
strain 28 190483.6824 6802.9887 26.9107 < 0.0001
sex:strain 28 11509.2491 411.0446 1.626 0.0246
Residuals 412 104153.2316 252.7991


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 42.0 15.8   8 5.58 0.376 28.2, 71.4 -0.71
129S1/SvImJ m 55.2 18.5   8 6.53 0.335 29.1, 75.1 -0.48
A/J f 59.7 13.2   8 4.67 0.221 44.1, 77.3 0.19
A/J m 58.8 8.95   8 3.16 0.152 46.6, 71.7 -0.32
AKR/J f 66.7 26.9   8 9.5 0.403 36.1, 117.0 0.55
AKR/J m 71.1 18.6   8 6.59 0.262 42.4, 96.0 0.24
BALB/cByJ f 76.1 13.2   8 4.66 0.173 61.5, 99.9 1.03
BALB/cByJ m 75.5 18.0   8 6.35 0.238 36.8, 97.3 0.44
BALB/cJ f 99.8 32.0   10 10.1 0.321 54.8, 154.0 2.25
BALB/cJ m 108.0 19.6   10 6.21 0.182 70.5, 136.0 1.91
BTBR T+ Itpr3tf/J f 116.0 17.4   8 6.14 0.15 94.0, 136.0 3.08
BTBR T+ Itpr3tf/J m 127.0 20.1   8 7.09 0.158 83.1, 151.0 2.77
BUB/BnJ f 55.9 11.5   7 4.36 0.206 40.6, 68.3 0.0
BUB/BnJ m 71.2 16.5   8 5.84 0.232 52.5, 94.0 0.24
C3H/HeJ f 41.5 9.13   8 3.23 0.22 25.4, 52.2 -0.74
C3H/HeJ m 46.5 17.1   8 6.03 0.367 24.4, 82.5 -0.88
C57BL/10J f 64.6 7.98   8 2.82 0.124 54.0, 79.6 0.45
C57BL/10J m 100.0 14.3   7 5.4 0.142 83.3, 128.0 1.54
C57BL/6J f 52.1 7.33   7 2.77 0.141 40.2, 60.0 -0.19
C57BL/6J m 59.6 19.2   13 5.32 0.322 32.8, 94.2 -0.28
C57BLKS/J f 61.9 12.8   11 3.87 0.207 44.9, 84.4 0.31
C57BLKS/J m 79.1 35.1   8 12.4 0.444 31.1, 115.0 0.6
C57BR/cdJ f 57.6 19.9   6 8.12 0.345 38.3, 83.7 0.09
C57BR/cdJ m 76.7 20.3   8 7.18 0.265 53.3, 112.0 0.49
C57L/J f 53.8 12.1   8 4.27 0.224 38.1, 72.4 -0.11
C57L/J m 82.5 21.0   8 7.42 0.255 49.8, 117.0 0.75
CBA/J f 60.9 6.85   8 2.42 0.112 52.5, 69.8 0.26
CBA/J m 63.6 11.6   8 4.09 0.182 49.5, 83.1 -0.1
CE/J f 41.4 10.8   8 3.82 0.26 27.2, 55.8 -0.74
CE/J m 55.6 16.5   9 5.5 0.297 34.6, 85.1 -0.46
DBA/1J f 59.4 15.4   10 4.86 0.259 34.9, 85.1 0.18
DBA/1J m 66.9 12.1   8 4.29 0.181 45.8, 82.3 0.05
DBA/2J f 55.0 9.29   8 3.28 0.169 39.0, 65.3 -0.05
DBA/2J m 50.4 9.23   10 2.92 0.183 38.8, 68.2 -0.7
FVB/NJ f 46.9 6.37   8 2.25 0.136 37.3, 54.9 -0.46
FVB/NJ m 84.9 18.8   7 7.11 0.222 60.7, 117.0 0.86
I/LnJ f 50.5 16.4   7 6.18 0.324 24.8, 68.8 -0.28
I/LnJ m 59.5 19.9   5 8.9 0.335 42.0, 93.4 -0.29
KK/HlJ f 64.5 14.0   8 4.94 0.217 49.9, 95.7 0.44
KK/HlJ m 70.8 22.2   6 9.05 0.313 38.6, 105.0 0.22
LP/J f 31.1 8.33   8 2.94 0.268 22.9, 46.0 -1.27
LP/J m 35.6 14.5   8 5.11 0.406 26.8, 70.1 -1.37
NOD/ShiLtJ f 58.5 14.8   8 5.23 0.253 40.0, 79.4 0.13
NOD/ShiLtJ m 66.5 17.2   8 6.09 0.259 49.3, 88.8 0.03
NON/ShiLtJ f 28.1 4.46   8 1.58 0.159 20.8, 35.9 -1.42
NON/ShiLtJ m 40.0 12.2   8 4.31 0.305 29.0, 61.4 -1.17
NZW/LacJ f 50.8 8.73   8 3.09 0.172 36.0, 66.9 -0.26
NZW/LacJ m 52.3 19.2   8 6.77 0.366 34.3, 89.5 -0.61
PL/J f 27.7 9.5   8 3.36 0.343 17.2, 41.4 -1.44
PL/J m 35.1 5.78   8 2.04 0.164 28.9, 45.4 -1.39
RIIIS/J f 50.2 7.66   8 2.71 0.152 43.1, 64.8 -0.29
RIIIS/J m 49.4 8.69   8 3.07 0.176 37.9, 62.2 -0.74
SJL/J f 34.4 10.5   8 3.71 0.306 25.3, 55.1 -1.1
SJL/J m 32.4 9.67   8 3.42 0.299 23.1, 51.1 -1.51
SM/J f 78.4 15.5   8 5.49 0.198 58.5, 98.2 1.15
SM/J m 88.0 20.6   8 7.28 0.234 64.7, 121.0 1.0
SWR/J f 35.4 10.0   8 3.55 0.283 23.3, 50.8 -1.05
SWR/J m 47.5 15.9   9 5.31 0.335 30.5, 80.1 -0.83


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 41.975 5.6214 53.0252 30.9248
129S1/SvImJ m 55.175 5.6214 66.2252 44.1248
A/J f 59.6875 5.6214 70.7377 48.6373
A/J m 58.75 5.6214 69.8002 47.6998
AKR/J f 66.6625 5.6214 77.7127 55.6123
AKR/J m 71.1375 5.6214 82.1877 60.0873
BALB/cByJ f 76.1 5.6214 87.1502 65.0498
BALB/cByJ m 75.5125 5.6214 86.5627 64.4623
BALB/cJ f 99.84 5.0279 109.7236 89.9564
BALB/cJ m 108.11 5.0279 117.9936 98.2264
BTBR T+ Itpr3tf/J f 115.8375 5.6214 126.8877 104.7873
BTBR T+ Itpr3tf/J m 127.0125 5.6214 138.0627 115.9623
BUB/BnJ f 55.9429 6.0095 67.756 44.1297
BUB/BnJ m 71.175 5.6214 82.2252 60.1248
C3H/HeJ f 41.525 5.6214 52.5752 30.4748
C3H/HeJ m 46.4625 5.6214 57.5127 35.4123
C57BL/10J f 64.5875 5.6214 75.6377 53.5373
C57BL/10J m 100.4 6.0095 112.2131 88.5869
C57BL/6J f 52.0857 6.0095 63.8988 40.2726
C57BL/6J m 59.5538 4.4098 68.2223 50.8854
C57BLKS/J f 61.9273 4.7939 71.3509 52.5037
C57BLKS/J m 79.05 5.6214 90.1002 67.9998
C57BR/cdJ f 57.6 6.491 70.3596 44.8404
C57BR/cdJ m 76.7125 5.6214 87.7627 65.6623
C57L/J f 53.825 5.6214 64.8752 42.7748
C57L/J m 82.4875 5.6214 93.5377 71.4373
CBA/J f 60.925 5.6214 71.9752 49.8748
CBA/J m 63.5875 5.6214 74.6377 52.5373
CE/J f 41.45 5.6214 52.5002 30.3998
CE/J m 55.5889 5.2999 66.0071 45.1707
DBA/1J f 59.37 5.0279 69.2536 49.4864
DBA/1J m 66.875 5.6214 77.9252 55.8248
DBA/2J f 55.025 5.6214 66.0752 43.9748
DBA/2J m 50.38 5.0279 60.2636 40.4964
FVB/NJ f 46.8875 5.6214 57.9377 35.8373
FVB/NJ m 84.8714 6.0095 96.6845 73.0583
I/LnJ f 50.4857 6.0095 62.2988 38.6726
I/LnJ m 59.5 7.1105 73.4775 45.5225
KK/HlJ f 64.4875 5.6214 75.5377 53.4373
KK/HlJ m 70.8 6.491 83.5596 58.0404
LP/J f 31.0875 5.6214 42.1377 20.0373
LP/J m 35.575 5.6214 46.6252 24.5248
NOD/ShiLtJ f 58.5 5.6214 69.5502 47.4498
NOD/ShiLtJ m 66.5125 5.6214 77.5627 55.4623
NON/ShiLtJ f 28.075 5.6214 39.1252 17.0248
NON/ShiLtJ m 40.05 5.6214 51.1002 28.9998
NZW/LacJ f 50.7625 5.6214 61.8127 39.7123
NZW/LacJ m 52.3125 5.6214 63.3627 41.2623
PL/J f 27.6625 5.6214 38.7127 16.6123
PL/J m 35.15 5.6214 46.2002 24.0998
RIIIS/J f 50.2375 5.6214 61.2877 39.1873
RIIIS/J m 49.4125 5.6214 60.4627 38.3623
SJL/J f 34.3625 5.6214 45.4127 23.3123
SJL/J m 32.35 5.6214 43.4002 21.2998
SM/J f 78.4125 5.6214 89.4627 67.3623
SM/J m 88.0125 5.6214 99.0627 76.9623
SWR/J f 35.4375 5.6214 46.4877 24.3873
SWR/J m 47.5 5.2999 57.9182 37.0818


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 48.575 3.9749 56.3886 40.7614
A/J both 59.2188 3.9749 67.0324 51.4051
AKR/J both 68.9 3.9749 76.7136 61.0864
BALB/cByJ both 75.8062 3.9749 83.6199 67.9926
BALB/cJ both 103.975 3.5553 110.9637 96.9863
BTBR T+ Itpr3tf/J both 121.425 3.9749 129.2386 113.6114
BUB/BnJ both 63.5589 4.1144 71.6468 55.471
C3H/HeJ both 43.9937 3.9749 51.8074 36.1801
C57BL/10J both 82.4938 4.1144 90.5816 74.4059
C57BL/6J both 55.8198 3.7269 63.146 48.4936
C57BLKS/J both 70.4886 3.694 77.75 63.2273
C57BR/cdJ both 67.1562 4.2934 75.5959 58.7166
C57L/J both 68.1562 3.9749 75.9699 60.3426
CBA/J both 62.2563 3.9749 70.0699 54.4426
CE/J both 48.5194 3.8629 56.1129 40.9259
DBA/1J both 63.1225 3.7709 70.5352 55.7098
DBA/2J both 52.7025 3.7709 60.1152 45.2898
FVB/NJ both 65.8795 4.1144 73.9674 57.7916
I/LnJ both 54.9929 4.6549 64.1433 45.8425
KK/HlJ both 67.6437 4.2934 76.0834 59.2041
LP/J both 33.3312 3.9749 41.1449 25.5176
NOD/ShiLtJ both 62.5062 3.9749 70.3199 54.6926
NON/ShiLtJ both 34.0625 3.9749 41.8761 26.2489
NZW/LacJ both 51.5375 3.9749 59.3511 43.7239
PL/J both 31.4063 3.9749 39.2199 23.5926
RIIIS/J both 49.825 3.9749 57.6386 42.0114
SJL/J both 33.3562 3.9749 41.1699 25.5426
SM/J both 83.2125 3.9749 91.0261 75.3989
SWR/J both 41.4688 3.8629 49.0622 33.8753




  GWAS USING LINEAR MIXED MODELS