Project measure / variable:   Berndt2   min_vent_mch5

ID, description, units MPD:35102   min_vent_mch5   minute ventilation   [mL/min]  5 MCh  
methacholine study
Data set, strains Berndt2   inbred   29 strains     sex: both     age: 9-12wks
Procedure plethysmography
Ontology mappings

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  STRAIN COMPARISON PLOT
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Berndt2 - minute ventilation 5 MCh



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains29 strains
Mean of the strain means53.8   mL/min 58.7   mL/min
Median of the strain means51.9   mL/min 54.3   mL/min
SD of the strain means± 13.3 ± 18.4
Coefficient of variation (CV)0.247 0.314
Min–max range of strain means34.2   –   88.3   mL/min 37.4   –   132   mL/min
Mean sample size per strain8.0   mice 8.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 2880.1545 2880.1545 10.9261 0.001
strain 28 104535.3479 3733.4053 14.163 < 0.0001
sex:strain 28 14529.2959 518.9034 1.9685 0.0027
Residuals 412 108604.6031 263.6034


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 36.9 9.41   8 3.33 0.255 24.9, 50.8 -1.27
129S1/SvImJ m 42.8 18.5   8 6.56 0.433 23.7, 73.5 -0.86
A/J f 61.0 10.5   8 3.72 0.173 49.7, 77.9 0.54
A/J m 61.4 10.1   8 3.57 0.165 49.5, 77.1 0.15
AKR/J f 62.2 21.6   8 7.63 0.347 36.3, 107.0 0.63
AKR/J m 48.5 10.6   8 3.76 0.219 37.7, 68.4 -0.55
BALB/cByJ f 65.7 12.5   8 4.42 0.19 46.1, 87.4 0.89
BALB/cByJ m 73.7 14.3   8 5.06 0.194 50.8, 91.5 0.81
BALB/cJ f 88.3 18.2   10 5.77 0.206 62.6, 117.0 2.59
BALB/cJ m 92.4 19.3   10 6.1 0.209 70.3, 133.0 1.83
BTBR T+ Itpr3tf/J f 84.1 28.7   8 10.2 0.342 48.7, 142.0 2.28
BTBR T+ Itpr3tf/J m 132.0 17.4   8 6.15 0.132 109.0, 166.0 3.98
BUB/BnJ f 60.6 19.8   7 7.47 0.326 34.0, 94.1 0.51
BUB/BnJ m 50.7 18.0   8 6.35 0.354 29.9, 86.5 -0.44
C3H/HeJ f 45.0 11.2   8 3.97 0.25 27.7, 65.2 -0.66
C3H/HeJ m 51.1 17.3   8 6.13 0.339 29.4, 86.8 -0.41
C57BL/10J f 64.0 11.6   8 4.1 0.181 46.5, 83.3 0.77
C57BL/10J m 69.4 14.3   7 5.4 0.206 52.7, 94.5 0.58
C57BL/6J f 57.7 11.0   7 4.14 0.19 48.2, 80.9 0.29
C57BL/6J m 55.6 17.2   13 4.78 0.31 28.2, 93.3 -0.17
C57BLKS/J f 52.8 13.8   11 4.17 0.262 27.2, 67.6 -0.08
C57BLKS/J m 54.3 14.5   8 5.13 0.267 30.6, 68.8 -0.24
C57BR/cdJ f 76.3 45.3   6 18.5 0.594 46.4, 167.0 1.69
C57BR/cdJ m 64.8 27.3   8 9.67 0.422 40.4, 121.0 0.33
C57L/J f 52.5 7.4   8 2.62 0.141 41.5, 61.2 -0.1
C57L/J m 65.2 11.3   8 3.98 0.173 50.8, 83.7 0.35
CBA/J f 50.1 3.46   8 1.22 0.069 44.4, 56.3 -0.28
CBA/J m 53.2 8.53   8 3.02 0.16 41.0, 62.6 -0.3
CE/J f 46.2 12.4   8 4.39 0.269 23.5, 67.8 -0.57
CE/J m 53.1 12.4   9 4.15 0.234 25.7, 69.3 -0.31
DBA/1J f 45.0 12.4   10 3.92 0.275 23.7, 63.0 -0.66
DBA/1J m 59.7 10.2   8 3.61 0.171 45.4, 75.1 0.05
DBA/2J f 51.9 9.86   8 3.49 0.19 34.8, 64.4 -0.14
DBA/2J m 50.7 8.47   10 2.68 0.167 36.3, 62.8 -0.44
FVB/NJ f 51.9 23.8   8 8.41 0.458 29.0, 92.6 -0.14
FVB/NJ m 74.2 36.8   7 13.9 0.496 42.9, 145.0 0.84
I/LnJ f 50.2 12.5   7 4.71 0.248 31.2, 67.6 -0.27
I/LnJ m 57.3 9.85   5 4.4 0.172 41.9, 65.4 -0.08
KK/HlJ f 54.9 8.56   8 3.03 0.156 38.2, 64.8 0.08
KK/HlJ m 50.3 13.0   6 5.32 0.259 36.6, 71.7 -0.46
LP/J f 34.2 14.5   8 5.11 0.422 17.0, 57.3 -1.47
LP/J m 41.7 16.1   8 5.69 0.386 20.0, 67.7 -0.92
NOD/ShiLtJ f 43.2 17.4   8 6.16 0.404 30.3, 84.5 -0.8
NOD/ShiLtJ m 57.3 28.1   8 9.92 0.49 34.5, 118.0 -0.08
NON/ShiLtJ f 48.3 13.7   8 4.85 0.284 32.9, 78.4 -0.41
NON/ShiLtJ m 59.9 14.6   8 5.17 0.244 44.7, 84.7 0.06
NZW/LacJ f 55.2 11.9   8 4.2 0.216 37.2, 67.6 0.11
NZW/LacJ m 47.6 9.32   8 3.3 0.196 34.4, 63.8 -0.6
PL/J f 41.5 8.65   8 3.06 0.209 33.6, 58.7 -0.92
PL/J m 41.8 12.0   8 4.25 0.288 26.4, 59.6 -0.92
RIIIS/J f 44.2 6.1   8 2.16 0.138 37.6, 51.6 -0.72
RIIIS/J m 50.4 6.73   8 2.38 0.133 41.6, 63.3 -0.45
SJL/J f 38.9 16.4   8 5.79 0.421 21.3, 60.0 -1.12
SJL/J m 37.4 14.1   8 4.98 0.376 24.4, 59.4 -1.16
SM/J f 61.6 15.5   8 5.46 0.251 43.5, 87.1 0.59
SM/J m 66.2 25.1   8 8.89 0.38 42.9, 121.0 0.41
SWR/J f 35.8 8.81   8 3.11 0.246 22.4, 46.8 -1.35
SWR/J m 40.2 8.54   9 2.85 0.213 30.8, 57.7 -1.01


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 36.9375 5.7402 48.2213 25.6537
129S1/SvImJ m 42.8 5.7402 54.0838 31.5162
A/J f 60.975 5.7402 72.2588 49.6912
A/J m 61.4125 5.7402 72.6963 50.1287
AKR/J f 62.2375 5.7402 73.5213 50.9537
AKR/J m 48.5375 5.7402 59.8213 37.2537
BALB/cByJ f 65.7 5.7402 76.9838 54.4162
BALB/cByJ m 73.7125 5.7402 84.9963 62.4287
BALB/cJ f 88.31 5.1342 98.4026 78.2174
BALB/cJ m 92.41 5.1342 102.5026 82.3174
BTBR T+ Itpr3tf/J f 84.125 5.7402 95.4088 72.8412
BTBR T+ Itpr3tf/J m 131.625 5.7402 142.9088 120.3412
BUB/BnJ f 60.5571 6.1366 72.6201 48.4942
BUB/BnJ m 50.675 5.7402 61.9588 39.3912
C3H/HeJ f 44.9625 5.7402 56.2463 33.6787
C3H/HeJ m 51.1125 5.7402 62.3963 39.8287
C57BL/10J f 63.9625 5.7402 75.2463 52.6787
C57BL/10J m 69.4286 6.1366 81.4915 57.3657
C57BL/6J f 57.6857 6.1366 69.7486 45.6228
C57BL/6J m 55.6462 4.503 64.4979 46.7944
C57BLKS/J f 52.8 4.8953 62.4229 43.1771
C57BLKS/J m 54.275 5.7402 65.5588 42.9912
C57BR/cdJ f 76.35 6.6283 89.3794 63.3206
C57BR/cdJ m 64.7625 5.7402 76.0463 53.4787
C57L/J f 52.5 5.7402 63.7838 41.2162
C57L/J m 65.1625 5.7402 76.4463 53.8787
CBA/J f 50.1125 5.7402 61.3963 38.8287
CBA/J m 53.2375 5.7402 64.5213 41.9537
CE/J f 46.2 5.7402 57.4838 34.9162
CE/J m 53.0778 5.412 63.7163 42.4393
DBA/1J f 45.0 5.1342 55.0926 34.9074
DBA/1J m 59.7125 5.7402 70.9963 48.4287
DBA/2J f 51.9 5.7402 63.1838 40.6162
DBA/2J m 50.67 5.1342 60.7626 40.5774
FVB/NJ f 51.9375 5.7402 63.2213 40.6537
FVB/NJ m 74.1571 6.1366 86.2201 62.0942
I/LnJ f 50.2 6.1366 62.2629 38.1371
I/LnJ m 57.34 7.2609 71.613 43.067
KK/HlJ f 54.8625 5.7402 66.1463 43.5787
KK/HlJ m 50.2667 6.6283 63.2961 37.2372
LP/J f 34.225 5.7402 45.5088 22.9412
LP/J m 41.7 5.7402 52.9838 30.4162
NOD/ShiLtJ f 43.1875 5.7402 54.4713 31.9037
NOD/ShiLtJ m 57.275 5.7402 68.5588 45.9912
NON/ShiLtJ f 48.3125 5.7402 59.5963 37.0287
NON/ShiLtJ m 59.9125 5.7402 71.1963 48.6287
NZW/LacJ f 55.175 5.7402 66.4588 43.8912
NZW/LacJ m 47.5875 5.7402 58.8713 36.3037
PL/J f 41.4625 5.7402 52.7463 30.1787
PL/J m 41.7625 5.7402 53.0463 30.4787
RIIIS/J f 44.1875 5.7402 55.4713 32.9037
RIIIS/J m 50.425 5.7402 61.7088 39.1412
SJL/J f 38.8875 5.7402 50.1713 27.6037
SJL/J m 37.4 5.7402 48.6838 26.1162
SM/J f 61.5625 5.7402 72.8463 50.2787
SM/J m 66.1875 5.7402 77.4713 54.9037
SWR/J f 35.825 5.7402 47.1088 24.5412
SWR/J m 40.1667 5.412 50.8052 29.5282


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 39.8687 4.059 47.8476 31.8899
A/J both 61.1937 4.059 69.1726 53.2149
AKR/J both 55.3875 4.059 63.3664 47.4086
BALB/cByJ both 69.7063 4.059 77.6851 61.7274
BALB/cJ both 90.36 3.6305 97.4965 83.2235
BTBR T+ Itpr3tf/J both 107.875 4.059 115.8539 99.8961
BUB/BnJ both 55.6161 4.2014 63.875 47.3572
C3H/HeJ both 48.0375 4.059 56.0164 40.0586
C57BL/10J both 66.6955 4.2014 74.9544 58.4366
C57BL/6J both 56.6659 3.8057 64.147 49.1848
C57BLKS/J both 53.5375 3.7721 60.9524 46.1226
C57BR/cdJ both 70.5563 4.3842 79.1744 61.9381
C57L/J both 58.8312 4.059 66.8101 50.8524
CBA/J both 51.675 4.059 59.6539 43.6961
CE/J both 49.6389 3.9446 57.393 41.8848
DBA/1J both 52.3562 3.8507 59.9257 44.7868
DBA/2J both 51.285 3.8507 58.8544 43.7156
FVB/NJ both 63.0473 4.2014 71.3062 54.7884
I/LnJ both 53.77 4.7534 63.1139 44.4261
KK/HlJ both 52.5646 4.3842 61.1827 43.9464
LP/J both 37.9625 4.059 45.9414 29.9836
NOD/ShiLtJ both 50.2313 4.059 58.2101 42.2524
NON/ShiLtJ both 54.1125 4.059 62.0914 46.1336
NZW/LacJ both 51.3812 4.059 59.3601 43.4024
PL/J both 41.6125 4.059 49.5914 33.6336
RIIIS/J both 47.3063 4.059 55.2851 39.3274
SJL/J both 38.1437 4.059 46.1226 30.1649
SM/J both 63.875 4.059 71.8539 55.8961
SWR/J both 37.9958 3.9446 45.7499 30.2418




  GWAS USING LINEAR MIXED MODELS