Project measure / variable:   Shockley1   CHOL

ID, description, units MPD:33406   CHOL   total cholesterol (CHOL)   [mg/dL]  control diet  
high-fat diet study
Data set, strains Shockley1   inbred   10 strains     sex: both     age: 10-13wks
Procedure lipid profile
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  STRAIN COMPARISON PLOT
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Shockley1 - total cholesterol (CHOL) control diet



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means87.7   mg/dL 116   mg/dL
Median of the strain means77.6   mg/dL 107   mg/dL
SD of the strain means± 22.5 ± 35.4
Coefficient of variation (CV)0.256 0.305
Min–max range of strain means62.6   –   127   mg/dL 68.4   –   166   mg/dL
Mean sample size per strain5.0   mice 5.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 19348.8849 19348.8849 105.1689 < 0.0001
strain 9 67923.5894 7547.0655 41.0213 < 0.0001
sex:strain 9 11457.014 1273.0016 6.9193 < 0.0001
Residuals 79 14534.35 183.9791


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 120.0 11.7   5 5.25 0.0976 107.0, 134.0 1.44
129S1/SvImJ m 163.0 15.7   5 7.02 0.0962 146.0, 184.0 1.33
A/J f 75.4 6.19   5 2.77 0.0821 68.0, 85.0 -0.55
A/J m 81.4 4.34   5 1.94 0.0533 75.0, 87.0 -0.98
BALB/cJ f 73.4 5.59   5 2.5 0.0762 66.0, 79.0 -0.64
BALB/cJ m 68.4 6.07   5 2.71 0.0887 64.0, 79.0 -1.34
C3H/HeJ f 104.0 11.4   5 5.11 0.11 90.0, 118.0 0.73
C3H/HeJ m 125.0 17.2   5 7.71 0.138 102.0, 139.0 0.26
C57BL/6J f 74.4 5.13   5 2.29 0.0689 70.0, 82.0 -0.59
C57BL/6J m 89.6 12.0   5 5.38 0.134 78.0, 107.0 -0.74
DBA/2J f 67.0 9.51   5 4.25 0.142 55.0, 80.0 -0.92
DBA/2J m 106.0 4.39   5 1.96 0.0416 101.0, 112.0 -0.28
I/LnJ f 79.8 27.2   4 13.6 0.341 52.0, 106.0 -0.35
I/LnJ m 94.6 8.73   5 3.91 0.0923 86.0, 105.0 -0.6
MRL/MpJ-Faslpr/J f 93.4 24.6   5 11.0 0.263 61.0, 122.0 0.25
MRL/MpJ-Faslpr/J m 166.0 17.7   5 7.91 0.106 149.0, 195.0 1.42
NZB/BlNJ f 127.0 15.5   5 6.95 0.122 112.0, 152.0 1.75
NZB/BlNJ m 157.0 21.1   5 9.44 0.134 132.0, 181.0 1.16
SM/J f 62.6 6.88   5 3.08 0.11 55.0, 72.0 -1.12
SM/J m 108.0 11.5   5 5.13 0.107 95.0, 126.0 -0.22


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 120.2 6.066 132.274 108.126
129S1/SvImJ m 163.2 6.066 175.274 151.126
A/J f 75.4 6.066 87.474 63.326
A/J m 81.4 6.066 93.474 69.326
BALB/cJ f 73.4 6.066 85.474 61.326
BALB/cJ m 68.4 6.066 80.474 56.326
C3H/HeJ f 104.4 6.066 116.474 92.326
C3H/HeJ m 125.0 6.066 137.074 112.926
C57BL/6J f 74.4 6.066 86.474 62.326
C57BL/6J m 89.6 6.066 101.674 77.526
DBA/2J f 67.0 6.066 79.074 54.926
DBA/2J m 105.6 6.066 117.674 93.526
I/LnJ f 79.75 6.7819 93.2491 66.2509
I/LnJ m 94.6 6.066 106.674 82.526
MRL/MpJ-Faslpr/J f 93.4 6.066 105.474 81.326
MRL/MpJ-Faslpr/J m 166.2 6.066 178.274 154.126
NZB/BlNJ f 127.0 6.066 139.074 114.926
NZB/BlNJ m 157.2 6.066 169.274 145.126
SM/J f 62.6 6.066 74.674 50.526
SM/J m 107.6 6.066 119.674 95.526


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 141.7 4.2893 150.2376 133.1624
A/J both 78.4 4.2893 86.9376 69.8624
BALB/cJ both 70.9 4.2893 79.4376 62.3624
C3H/HeJ both 114.7 4.2893 123.2376 106.1624
C57BL/6J both 82.0 4.2893 90.5376 73.4624
DBA/2J both 86.3 4.2893 94.8376 77.7624
I/LnJ both 87.175 4.5495 96.2305 78.1195
MRL/MpJ-Faslpr/J both 129.8 4.2893 138.3376 121.2624
NZB/BlNJ both 142.1 4.2893 150.6376 133.5624
SM/J both 85.1 4.2893 93.6376 76.5624




  GWAS USING LINEAR MIXED MODELS