Phenotype measure:   Yuan1   IGF1_M12

ID, description, units MPD:27002   IGF1_M12   insulin-like growth factor 1 (serum IGF-1)   [ng/mL]  at age 12mo
Data set, strains Yuan1   inbred   30 strains     sex: both     age: 52wks
Procedure hormone quantification
Ontology mappings

  STRAIN COMPARISON PLOT
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Yuan1 - insulin-like growth factor 1 (serum IGF-1) at age 12mo



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested30 strains28 strains
Mean of the strain means321   ng/mL 312   ng/mL
Median of the strain means316   ng/mL 314   ng/mL
SD of the strain means± 64.9 ± 47.3
Coefficient of variation (CV)0.202 0.152
Min–max range of strain means224   –   465   ng/mL 228   –   396   ng/mL
Mean sample size per strain7.4   mice 7.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 4374.841 4374.841 2.7342 0.0991
strain 27 1074431.9791 39793.777 24.8706 < 0.0001
sex:strain 27 208770.1701 7732.2285 4.8325 < 0.0001
Residuals 360 576011.8921 1600.033


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 302.0 44.8   7 16.9 0.148 223.0, 354.0 -0.29
129S1/SvImJ m 315.0 25.9   8 9.16 0.0823 280.0, 350.0 0.07
A/J f 322.0 19.7   8 6.98 0.0612 295.0, 352.0 0.02
A/J m 383.0 29.2   6 11.9 0.0762 332.0, 413.0 1.51
BALB/cByJ f 369.0 32.3   8 11.4 0.0876 329.0, 412.0 0.74
BALB/cByJ m 344.0 32.1   7 12.1 0.0934 294.0, 392.0 0.68
BTBR T+ Itpr3tf/J f 465.0 39.9   8 14.1 0.0858 410.0, 523.0 2.22
BTBR T+ Itpr3tf/J m 369.0 99.4   7 37.6 0.269 200.0, 473.0 1.21
BUB/BnJ f 297.0 19.5   3 11.3 0.0656 278.0, 317.0 -0.37
BUB/BnJ m 338.0 38.6   5 17.2 0.114 278.0, 374.0 0.55
C3H/HeJ f 300.0 37.8   8 13.4 0.126 240.0, 346.0 -0.32
C3H/HeJ m 290.0 24.6   8 8.7 0.085 243.0, 316.0 -0.46
C57BL/10J f 262.0 37.2   7 14.1 0.142 222.0, 331.0 -0.9
C57BL/10J m 236.0 13.1   8 4.64 0.0557 218.0, 253.0 -1.6
C57BL/6J f 231.0 21.7   8 7.69 0.0941 208.0, 277.0 -1.38
C57BL/6J m 264.0 13.5   8 4.79 0.0514 247.0, 283.0 -1.01
C57BLKS/J f 224.0 17.8   8 6.29 0.0795 192.0, 244.0 -1.49
C57BLKS/J m 292.0 26.4   8 9.35 0.0906 244.0, 327.0 -0.42
C57BR/cdJ f 344.0 37.1   8 13.1 0.108 288.0, 400.0 0.36
C57BR/cdJ m 352.0 35.9   8 12.7 0.102 307.0, 430.0 0.85
C57L/J f 393.0 51.4   8 18.2 0.131 283.0, 451.0 1.11
C57L/J m 304.0 23.2   8 8.2 0.0764 279.0, 346.0 -0.17
CAST/EiJ f 365.0 50.0   4 25.0 0.137 315.0, 432.0 0.68
CBA/J f 312.0 30.7   8 10.9 0.0986 269.0, 354.0 -0.13
CBA/J m 368.0 29.6   6 12.1 0.0805 324.0, 416.0 1.19
DBA/2J f 264.0 39.2   7 14.8 0.148 209.0, 311.0 -0.87
DBA/2J m 248.0 24.8   7 9.39 0.1 207.0, 275.0 -1.35
FVB/NJ f 288.0 39.3   7 14.9 0.136 221.0, 353.0 -0.5
FVB/NJ m 312.0 33.3   7 12.6 0.107 252.0, 338.0 0.0
KK/HlJ f 325.0 71.0   7 26.8 0.219 241.0, 429.0 0.07
KK/HlJ m 261.0 55.0   7 20.8 0.211 169.0, 330.0 -1.08
LP/J f 315.0 33.9   8 12.0 0.108 255.0, 356.0 -0.09
LP/J m 322.0 29.0   7 11.0 0.09 273.0, 359.0 0.22
MRL/MpJ f 317.0 60.8   7 23.0 0.192 236.0, 400.0 -0.06
MRL/MpJ m 343.0 35.3   8 12.5 0.103 284.0, 387.0 0.66
NOD.B10Sn-H2b/J f 381.0 18.5   8 6.53 0.0484 346.0, 403.0 0.93
NOD.B10Sn-H2b/J m 396.0 34.7   7 13.1 0.0878 365.0, 458.0 1.78
NON/ShiLtJ f 392.0 56.1   7 21.2 0.143 284.0, 472.0 1.1
NON/ShiLtJ m 360.0 32.8   8 11.6 0.0911 319.0, 410.0 1.02
NZO/HlLtJ f 418.0 24.0   6 9.8 0.0574 380.0, 455.0 1.5
NZO/HlLtJ m 370.0 68.9   4 34.4 0.186 296.0, 435.0 1.23
NZW/LacJ f 342.0 55.3   8 19.5 0.161 272.0, 400.0 0.33
NZW/LacJ m 279.0 21.4   7 8.09 0.0767 243.0, 305.0 -0.69
P/J f 412.0 23.9   7 9.03 0.058 391.0, 455.0 1.4
PL/J f 228.0 35.4   7 13.4 0.155 185.0, 286.0 -1.43
PL/J m 261.0 20.2   5 9.04 0.0776 241.0, 294.0 -1.08
PWD/PhJ f 406.0 78.8   9 26.3 0.194 286.0, 524.0 1.31
PWD/PhJ m 331.0 28.5   12 8.22 0.086 283.0, 386.0 0.41
RIIIS/J f 245.0 51.0   8 18.0 0.208 182.0, 314.0 -1.17
RIIIS/J m 286.0 30.7   8 10.9 0.108 242.0, 325.0 -0.55
SJL/J f 273.0 37.2   7 14.1 0.137 226.0, 342.0 -0.74
SJL/J m 262.0 23.8   8 8.41 0.0909 220.0, 287.0 -1.05
SM/J f 236.0 36.5   8 12.9 0.155 191.0, 311.0 -1.31
SM/J m 228.0 22.3   8 7.87 0.0974 187.0, 257.0 -1.77
SWR/J f 351.0 62.0   7 23.4 0.177 254.0, 411.0 0.47
SWR/J m 338.0 52.9   8 18.7 0.157 261.0, 434.0 0.55
WSB/EiJ f 244.0 35.8   9 11.9 0.147 179.0, 275.0 -1.18
WSB/EiJ m 279.0 25.8   9 8.61 0.0927 242.0, 329.0 -0.69


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 302.0 15.1187 331.7321 272.2679
129S1/SvImJ m 314.75 14.1423 342.5619 286.9381
A/J f 322.5 14.1423 350.3119 294.6881
A/J m 383.0 16.3301 415.1144 350.8856
BALB/cByJ f 368.625 14.1423 396.4369 340.8131
BALB/cByJ m 343.8571 15.1187 373.5893 314.125
BTBR T+ Itpr3tf/J f 464.75 14.1423 492.5619 436.9381
BTBR T+ Itpr3tf/J m 368.8571 15.1187 398.5893 339.125
BUB/BnJ f 297.3333 23.0942 342.7499 251.9167
BUB/BnJ m 337.6 17.8887 372.7795 302.4205
C3H/HeJ f 299.75 14.1423 327.5619 271.9381
C3H/HeJ m 289.5 14.1423 317.3119 261.6881
C57BL/10J f 261.7143 15.1187 291.4464 231.9822
C57BL/10J m 235.625 14.1423 263.4369 207.8131
C57BL/6J f 231.125 14.1423 258.9369 203.3131
C57BL/6J m 263.625 14.1423 291.4369 235.8131
C57BLKS/J f 223.875 14.1423 251.6869 196.0631
C57BLKS/J m 291.875 14.1423 319.6869 264.0631
C57BR/cdJ f 343.75 14.1423 371.5619 315.9381
C57BR/cdJ m 351.875 14.1423 379.6869 324.0631
C57L/J f 392.75 14.1423 420.5619 364.9381
C57L/J m 303.5 14.1423 331.3119 275.6881
CBA/J f 311.5 14.1423 339.3119 283.6881
CBA/J m 367.8333 16.3301 399.9477 335.719
DBA/2J f 264.1429 15.1187 293.875 234.4107
DBA/2J m 248.0 15.1187 277.7321 218.2679
FVB/NJ f 288.1429 15.1187 317.875 258.4107
FVB/NJ m 312.0 15.1187 341.7321 282.2679
KK/HlJ f 324.7143 15.1187 354.4464 294.9822
KK/HlJ m 261.1429 15.1187 290.875 231.4107
LP/J f 314.75 14.1423 342.5619 286.9381
LP/J m 322.2857 15.1187 352.0178 292.5536
MRL/MpJ f 317.0 15.1187 346.7321 287.2679
MRL/MpJ m 343.375 14.1423 371.1869 315.5631
NOD.B10Sn-H2b/J f 381.125 14.1423 408.9369 353.3131
NOD.B10Sn-H2b/J m 395.8571 15.1187 425.5893 366.125
NON/ShiLtJ f 391.5714 15.1187 421.3036 361.8393
NON/ShiLtJ m 360.25 14.1423 388.0619 332.4381
NZO/HlLtJ f 418.5 16.3301 450.6144 386.3856
NZO/HlLtJ m 369.5 20.0002 408.8319 330.1681
NZW/LacJ f 342.125 14.1423 369.9369 314.3131
NZW/LacJ m 279.0 15.1187 308.7321 249.2679
PL/J f 228.2857 15.1187 258.0178 198.5536
PL/J m 260.6 17.8887 295.7795 225.4205
PWD/PhJ f 406.2222 13.3335 432.4435 380.0009
PWD/PhJ m 331.0833 11.5471 353.7916 308.375
RIIIS/J f 245.375 14.1423 273.1869 217.5631
RIIIS/J m 285.625 14.1423 313.4369 257.8131
SJL/J f 272.5714 15.1187 302.3036 242.8393
SJL/J m 261.625 14.1423 289.4369 233.8131
SM/J f 236.125 14.1423 263.9369 208.3131
SM/J m 228.5 14.1423 256.3119 200.6881
SWR/J f 351.2857 15.1187 381.0178 321.5536
SWR/J m 337.5 14.1423 365.3119 309.6881
WSB/EiJ f 243.7778 13.3335 269.9991 217.5565
WSB/EiJ m 278.6667 13.3335 304.8879 252.4454


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 308.375 10.3511 328.7312 288.0188
A/J both 352.75 10.8013 373.9917 331.5083
BALB/cByJ both 356.2411 10.3511 376.5973 335.8849
BTBR T+ Itpr3tf/J both 416.8036 10.3511 437.1598 396.4474
BUB/BnJ both 317.4667 14.6061 346.1906 288.7427
C3H/HeJ both 294.625 10.0001 314.291 274.959
C57BL/10J both 248.6696 10.3511 269.0258 228.3134
C57BL/6J both 247.375 10.0001 267.041 227.709
C57BLKS/J both 257.875 10.0001 277.541 238.209
C57BR/cdJ both 347.8125 10.0001 367.4785 328.1465
C57L/J both 348.125 10.0001 367.791 328.459
CBA/J both 339.6667 10.8013 360.9083 318.425
DBA/2J both 256.0714 10.6906 277.0952 235.0476
FVB/NJ both 300.0714 10.6906 321.0952 279.0476
KK/HlJ both 292.9286 10.6906 313.9524 271.9048
LP/J both 318.5179 10.3511 338.8741 298.1617
MRL/MpJ both 330.1875 10.3511 350.5437 309.8313
NOD.B10Sn-H2b/J both 388.4911 10.3511 408.8473 368.1349
NON/ShiLtJ both 375.9107 10.3511 396.2669 355.5545
NZO/HlLtJ both 394.0 12.9101 419.3886 368.6114
NZW/LacJ both 310.5625 10.3511 330.9187 290.2063
PL/J both 244.4429 11.7109 267.4733 221.4124
PWD/PhJ both 368.6528 8.8193 385.9965 351.309
RIIIS/J both 265.5 10.0001 285.166 245.834
SJL/J both 267.0982 10.3511 287.4544 246.742
SM/J both 232.3125 10.0001 251.9785 212.6465
SWR/J both 344.3929 10.3511 364.7491 324.0367
WSB/EiJ both 261.2222 9.4282 279.7635 242.681




  GWAS USING LINEAR MIXED MODELS