Phenotype measure:   Yuan1   IGF1_M06

ID, description, units MPD:27001   IGF1_M06   insulin-like growth factor 1 (serum IGF-1)   [ng/mL]  at age 6mo
Data set, strains Yuan1   inbred   33 strains     sex: both     age: 26wks
Procedure hormone quantification
Ontology mappings

  STRAIN COMPARISON PLOT
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Yuan1 - insulin-like growth factor 1 (serum IGF-1) at age 6mo



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested33 strains32 strains
Mean of the strain means329   ng/mL 318   ng/mL
Median of the strain means330   ng/mL 320   ng/mL
SD of the strain means± 75.1 ± 53.2
Coefficient of variation (CV)0.228 0.167
Min–max range of strain means159   –   468   ng/mL 228   –   422   ng/mL
Mean sample size per strain7.7   mice 7.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 13665.2179 13665.2179 8.3686 0.004
strain 31 1785408.1632 57593.8117 35.2705 < 0.0001
sex:strain 31 259417.7657 8368.315 5.1248 < 0.0001
Residuals 419 684192.994 1632.9188


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 260.0 44.7   8 15.8 0.172 204.0, 328.0 -0.92
129S1/SvImJ m 320.0 54.7   8 19.3 0.171 261.0, 406.0 0.04
A/J f 332.0 31.3   8 11.1 0.0943 278.0, 378.0 0.04
A/J m 284.0 25.4   8 8.99 0.0895 240.0, 315.0 -0.64
AKR/J f 381.0 19.5   5 8.72 0.0512 354.0, 408.0 0.69
AKR/J m 303.0 77.5   8 27.4 0.256 138.0, 364.0 -0.28
BALB/cByJ f 330.0 21.8   8 7.71 0.0661 289.0, 358.0 0.01
BALB/cByJ m 354.0 35.2   8 12.4 0.0994 315.0, 417.0 0.68
BTBR T+ Itpr3tf/J f 456.0 44.3   8 15.7 0.0972 402.0, 540.0 1.69
BTBR T+ Itpr3tf/J m 367.0 38.1   8 13.5 0.104 301.0, 423.0 0.93
BUB/BnJ f 431.0 92.4   8 32.7 0.214 321.0, 552.0 1.36
BUB/BnJ m 374.0 29.2   4 14.6 0.0782 334.0, 399.0 1.06
C3H/HeJ f 366.0 46.7   8 16.5 0.128 321.0, 439.0 0.49
C3H/HeJ m 343.0 34.5   8 12.2 0.101 309.0, 420.0 0.47
C57BL/10J f 253.0 24.4   16 6.11 0.0967 203.0, 292.0 -1.01
C57BL/10J m 258.0 27.2   8 9.62 0.105 227.0, 304.0 -1.12
C57BL/6J f 258.0 39.4   8 13.9 0.153 204.0, 327.0 -0.95
C57BL/6J m 256.0 26.1   7 9.88 0.102 209.0, 296.0 -1.16
C57BLKS/J f 287.0 28.5   8 10.1 0.0991 227.0, 318.0 -0.56
C57BLKS/J m 278.0 14.6   8 5.16 0.0525 261.0, 304.0 -0.75
C57BR/cdJ f 376.0 16.0   5 7.13 0.0424 354.0, 394.0 0.63
C57BR/cdJ m 336.0 26.2   4 13.1 0.0778 308.0, 369.0 0.34
C57L/J f 374.0 39.1   8 13.8 0.105 297.0, 420.0 0.6
C57L/J m 319.0 16.7   7 6.31 0.0523 289.0, 337.0 0.02
CAST/EiJ f 320.0 32.3   7 12.2 0.101 287.0, 364.0 -0.12
CAST/EiJ m 396.0 22.7   4 11.4 0.0575 368.0, 417.0 1.47
CBA/J f 306.0 21.2   8 7.48 0.069 277.0, 348.0 -0.31
CBA/J m 319.0 12.3   8 4.35 0.0386 300.0, 337.0 0.02
DBA/2J f 248.0 28.9   8 10.2 0.116 213.0, 292.0 -1.08
DBA/2J m 285.0 28.3   8 10.0 0.0993 237.0, 327.0 -0.62
FVB/NJ f 272.0 34.9   8 12.3 0.128 224.0, 317.0 -0.76
FVB/NJ m 300.0 45.1   8 16.0 0.15 196.0, 348.0 -0.34
KK/HlJ f 418.0 66.3   8 23.5 0.159 317.0, 522.0 1.18
KK/HlJ m 382.0 53.1   4 26.6 0.139 307.0, 429.0 1.21
LP/J f 262.0 41.7   8 14.8 0.159 208.0, 320.0 -0.89
LP/J m 346.0 33.9   8 12.0 0.098 287.0, 394.0 0.53
MOLF/EiJ f 241.0 49.8   6 20.3 0.207 176.0, 300.0 -1.17
MOLF/EiJ m 229.0 34.5   6 14.1 0.151 189.0, 281.0 -1.67
MRL/MpJ f 395.0 27.7   8 9.79 0.0701 363.0, 454.0 0.88
MRL/MpJ m 422.0 35.7   8 12.6 0.0845 376.0, 497.0 1.96
NOD.B10Sn-H2b/J f 468.0 62.0   8 21.9 0.133 392.0, 596.0 1.85
NOD.B10Sn-H2b/J m 382.0 18.2   8 6.42 0.0476 358.0, 410.0 1.21
NON/ShiLtJ f 365.0 46.3   8 16.4 0.127 308.0, 439.0 0.48
NON/ShiLtJ m 322.0 42.8   6 17.5 0.133 241.0, 364.0 0.08
NZO/HlLtJ f 449.0 29.9   8 10.6 0.0666 405.0, 487.0 1.6
NZO/HlLtJ m 390.0 26.2   7 9.89 0.0671 354.0, 428.0 1.36
NZW/LacJ f 374.0 22.6   7 8.53 0.0603 336.0, 410.0 0.6
NZW/LacJ m 368.0 31.0   8 11.0 0.0844 334.0, 422.0 0.94
P/J f 388.0 78.0   8 27.6 0.201 306.0, 501.0 0.79
P/J m 309.0 33.7   8 11.9 0.109 248.0, 336.0 -0.17
PL/J f 267.0 33.7   7 12.7 0.126 234.0, 333.0 -0.83
PL/J m 282.0 18.3   8 6.48 0.0649 259.0, 305.0 -0.67
Pohn/Deh f 323.0 34.4   8 12.2 0.106 278.0, 373.0 -0.08
PWD/PhJ f 331.0 62.5   8 22.1 0.189 217.0, 402.0 0.03
PWD/PhJ m 321.0 51.4   8 18.2 0.16 224.0, 401.0 0.06
RIIIS/J f 296.0 35.2   8 12.4 0.119 261.0, 342.0 -0.44
RIIIS/J m 275.0 19.7   8 6.95 0.0714 255.0, 312.0 -0.81
SJL/J f 291.0 42.3   8 15.0 0.146 200.0, 326.0 -0.51
SJL/J m 236.0 29.1   7 11.0 0.123 198.0, 286.0 -1.54
SM/J f 159.0 47.2   8 16.7 0.296 101.0, 216.0 -2.27
SM/J m 228.0 17.6   8 6.21 0.0772 202.0, 255.0 -1.69
SWR/J f 376.0 42.5   8 15.0 0.113 308.0, 447.0 0.63
SWR/J m 353.0 55.5   8 19.6 0.157 276.0, 441.0 0.66
WSB/EiJ f 206.0 55.6   8 19.7 0.269 110.0, 251.0 -1.64
WSB/EiJ m 233.0 12.6   6 5.15 0.0542 216.0, 249.0 -1.6


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 260.375 14.2869 288.4579 232.2921
129S1/SvImJ m 320.125 14.2869 348.2079 292.0421
A/J f 331.75 14.2869 359.8329 303.6671
A/J m 284.0 14.2869 312.0829 255.9171
AKR/J f 381.0 18.0716 416.5223 345.4777
AKR/J m 302.75 14.2869 330.8329 274.6671
BALB/cByJ f 330.125 14.2869 358.2079 302.0421
BALB/cByJ m 354.0 14.2869 382.0829 325.9171
BTBR T+ Itpr3tf/J f 455.625 14.2869 483.7079 427.5421
BTBR T+ Itpr3tf/J m 367.125 14.2869 395.2079 339.0421
BUB/BnJ f 430.875 14.2869 458.9579 402.7921
BUB/BnJ m 373.75 20.2047 413.4652 334.0348
C3H/HeJ f 366.125 14.2869 394.2079 338.0421
C3H/HeJ m 342.875 14.2869 370.9579 314.7921
C57BL/10J f 252.625 10.1023 272.4826 232.7674
C57BL/10J m 258.5 14.2869 286.5829 230.4171
C57BL/6J f 257.875 14.2869 285.9579 229.7921
C57BL/6J m 255.8571 15.2733 285.879 225.8353
C57BLKS/J f 287.25 14.2869 315.3329 259.1671
C57BLKS/J m 277.875 14.2869 305.9579 249.7921
C57BR/cdJ f 376.0 18.0716 411.5223 340.4777
C57BR/cdJ m 336.5 20.2047 376.2152 296.7848
C57L/J f 373.875 14.2869 401.9579 345.7921
C57L/J m 318.8571 15.2733 348.879 288.8353
CAST/EiJ f 320.2857 15.2733 350.3076 290.2638
CAST/EiJ m 395.5 20.2047 435.2152 355.7848
CBA/J f 306.5 14.2869 334.5829 278.4171
CBA/J m 319.0 14.2869 347.0829 290.9171
DBA/2J f 248.25 14.2869 276.3329 220.1671
DBA/2J m 285.25 14.2869 313.3329 257.1671
FVB/NJ f 272.0 14.2869 300.0829 243.9171
FVB/NJ m 300.5 14.2869 328.5829 272.4171
KK/HlJ f 417.5 14.2869 445.5829 389.4171
KK/HlJ m 381.75 20.2047 421.4652 342.0348
LP/J f 261.875 14.2869 289.9579 233.7921
LP/J m 345.625 14.2869 373.7079 317.5421
MOLF/EiJ f 240.8333 16.4971 273.2607 208.406
MOLF/EiJ m 229.1667 16.4971 261.594 196.7393
MRL/MpJ f 394.75 14.2869 422.8329 366.6671
MRL/MpJ m 422.5 14.2869 450.5829 394.4171
NOD.B10Sn-H2b/J f 467.5 14.2869 495.5829 439.4171
NOD.B10Sn-H2b/J m 381.75 14.2869 409.8329 353.6671
NON/ShiLtJ f 364.75 14.2869 392.8329 336.6671
NON/ShiLtJ m 321.6667 16.4971 354.094 289.2393
NZO/HlLtJ f 449.25 14.2869 477.3329 421.1671
NZO/HlLtJ m 389.8571 15.2733 419.879 359.8353
NZW/LacJ f 374.0 15.2733 404.0219 343.9781
NZW/LacJ m 367.5 14.2869 395.5829 339.4171
P/J f 387.75 14.2869 415.8329 359.6671
P/J m 308.75 14.2869 336.8329 280.6671
PL/J f 266.7143 15.2733 296.7362 236.6924
PL/J m 282.5 14.2869 310.5829 254.4171
PWD/PhJ f 331.125 14.2869 359.2079 303.0421
PWD/PhJ m 320.625 14.2869 348.7079 292.5421
RIIIS/J f 296.125 14.2869 324.2079 268.0421
RIIIS/J m 275.375 14.2869 303.4579 247.2921
SJL/J f 290.75 14.2869 318.8329 262.6671
SJL/J m 236.1429 15.2733 266.1647 206.121
SM/J f 159.375 14.2869 187.4579 131.2921
SM/J m 227.75 14.2869 255.8329 199.6671
SWR/J f 376.5 14.2869 404.5829 348.4171
SWR/J m 353.0 14.2869 381.0829 324.9171
WSB/EiJ f 206.375 14.2869 234.4579 178.2921
WSB/EiJ m 232.6667 16.4971 265.094 200.2393


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 290.25 10.1023 310.1076 270.3924
A/J both 307.875 10.1023 327.7326 288.0174
AKR/J both 341.875 11.5184 364.5161 319.2339
BALB/cByJ both 342.0625 10.1023 361.9201 322.2049
BTBR T+ Itpr3tf/J both 411.375 10.1023 431.2326 391.5174
BUB/BnJ both 402.3125 12.3728 426.633 377.992
C3H/HeJ both 354.5 10.1023 374.3576 334.6424
C57BL/10J both 255.5625 8.7489 272.7597 238.3653
C57BL/6J both 256.8661 10.4569 277.4206 236.3115
C57BLKS/J both 282.5625 10.1023 302.4201 262.7049
C57BR/cdJ both 356.25 13.5537 382.8918 329.6082
C57L/J both 346.3661 10.4569 366.9206 325.8115
CAST/EiJ both 357.8929 12.664 382.7857 333.0
CBA/J both 312.75 10.1023 332.6076 292.8924
DBA/2J both 266.75 10.1023 286.6076 246.8924
FVB/NJ both 286.25 10.1023 306.1076 266.3924
KK/HlJ both 399.625 12.3728 423.9455 375.3045
LP/J both 303.75 10.1023 323.6076 283.8924
MOLF/EiJ both 235.0 11.6652 257.9296 212.0704
MRL/MpJ both 408.625 10.1023 428.4826 388.7674
NOD.B10Sn-H2b/J both 424.625 10.1023 444.4826 404.7674
NON/ShiLtJ both 343.2083 10.9118 364.657 321.7597
NZO/HlLtJ both 419.5536 10.4569 440.1081 398.999
NZW/LacJ both 370.75 10.4569 391.3046 350.1954
P/J both 348.25 10.1023 368.1076 328.3924
PL/J both 274.6071 10.4569 295.1617 254.0526
PWD/PhJ both 325.875 10.1023 345.7326 306.0174
RIIIS/J both 285.75 10.1023 305.6076 265.8924
SJL/J both 263.4464 10.4569 284.001 242.8919
SM/J both 193.5625 10.1023 213.4201 173.7049
SWR/J both 364.75 10.1023 384.6076 344.8924
WSB/EiJ both 219.5208 10.9118 240.9695 198.0722




  GWAS USING LINEAR MIXED MODELS