MPD: Project measure / variable: Yuan3 Fe

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Yuan3 - iron (serum Fe) at age 18mo

Measure Summary	Female	Male
Number of strains tested	29 strains	28 strains
Mean of the strain means	225 mmol/L	206 mmol/L
Median of the strain means	209 mmol/L	203 mmol/L
SD of the strain means	± 54.3	± 45.9
Coefficient of variation (CV)	0.241	0.222
Min–max range of strain means	130 – 354 mmol/L	135 – 359 mmol/L
Mean sample size per strain	7.1 mice	5.7 mice

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p value (Pr>F)
sex	1	21769.2722	21769.2722	13.1132	0.0003
strain	26	672793.3138	25876.6659	15.5874	< 0.0001
sex:strain	26	133676.9642	5141.4217	3.0971	< 0.0001
Residuals	297	493049.8857	1660.1006

Q-Q normality assessment based on residuals

STRAIN MEANS (UNADJUSTED)

Strain	Sex	Mean	SD	N mice	SEM	CV	Min, Max	Z score
129S1/SvImJ	f	208.0	53.1	7	20.1	0.255	137.0, 303.0	-0.32
129S1/SvImJ	m	218.0	37.5	7	14.2	0.172	167.0, 270.0	0.25
A/J	f	224.0	15.3	7	5.79	0.0685	206.0, 245.0	-0.02
A/J	m	250.0	11.6	5	5.17	0.0463	239.0, 263.0	0.95
BALB/cByJ	f	188.0	20.4	7	7.69	0.108	153.0, 212.0	-0.69
BALB/cByJ	m	194.0	31.1	5	13.9	0.16	168.0, 242.0	-0.27
BTBR T⁺ Itpr3^tf/J	f	279.0	104.0	6	42.6	0.374	166.0, 441.0	0.99
BTBR T⁺ Itpr3^tf/J	m	219.0	11.6	5	5.2	0.053	203.0, 230.0	0.27
BUB/BnJ	f	311.0	31.5	5	14.1	0.101	268.0, 338.0	1.58
C3H/HeJ	f	186.0	64.0	6	26.1	0.343	77.0, 276.0	-0.72
C3H/HeJ	m	205.0	38.8	8	13.7	0.189	122.0, 239.0	-0.03
C57BL/10J	f	130.0	23.7	7	8.95	0.182	101.0, 172.0	-1.75
C57BL/10J	m	155.0	29.7	7	11.2	0.191	108.0, 190.0	-1.12
C57BL/6J	f	166.0	25.5	8	9.01	0.153	135.0, 207.0	-1.09
C57BL/6J	m	158.0	27.0	6	11.0	0.171	117.0, 194.0	-1.06
C57BLKS/J	f	135.0	14.3	7	5.39	0.106	120.0, 163.0	-1.66
C57BLKS/J	m	161.0	14.6	7	5.51	0.0903	143.0, 189.0	-0.99
C57BR/cdJ	f	227.0	40.3	8	14.2	0.177	173.0, 281.0	0.03
C57BR/cdJ	m	183.0	63.9	8	22.6	0.349	67.0, 259.0	-0.51
C57L/J	f	223.0	42.7	8	15.1	0.192	184.0, 322.0	-0.04
C57L/J	m	201.0	2.83	2	2.0	0.0141	199.0, 203.0	-0.12
CBA/J	f	215.0	18.1	8	6.41	0.0842	194.0, 241.0	-0.19
CBA/J	m	222.0	20.6	3	11.9	0.0927	202.0, 243.0	0.34
DBA/2J	f	162.0	15.7	5	7.0	0.0964	142.0, 184.0	-1.16
DBA/2J	m	178.0	23.1	8	8.16	0.13	155.0, 215.0	-0.62
FVB/NJ	f	354.0	49.3	8	17.4	0.139	290.0, 428.0	2.37
FVB/NJ	m	224.0	41.8	4	20.9	0.187	191.0, 278.0	0.38
KK/HlJ	f	208.0	58.6	10	18.5	0.282	126.0, 296.0	-0.32
KK/HlJ	m	196.0	29.1	7	11.0	0.148	145.0, 223.0	-0.23
LP/J	f	230.0	52.8	7	20.0	0.23	169.0, 318.0	0.09
LP/J	m	243.0	21.6	8	7.63	0.0887	212.0, 285.0	0.8
MRL/MpJ	f	265.0	99.0	2	70.0	0.374	195.0, 335.0	0.73
MRL/MpJ	m	359.0	63.0	5	28.2	0.175	274.0, 426.0	3.33
NOD.B10Sn-H2^b/J	f	209.0	68.6	7	25.9	0.328	109.0, 340.0	-0.3
NOD.B10Sn-H2^b/J	m	191.0	24.2	4	12.1	0.127	161.0, 216.0	-0.34
NON/ShiLtJ	f	204.0	37.7	14	10.1	0.185	134.0, 268.0	-0.39
NON/ShiLtJ	m	178.0	14.3	7	5.4	0.08	149.0, 193.0	-0.62
NZO/HlLtJ	f	175.0	29.4	9	9.78	0.168	128.0, 233.0	-0.92
NZO/HlLtJ	m	135.0	0.0	1	0.0	0.0	135.0, 135.0	-1.56
NZW/LacJ	f	199.0	26.8	5	12.0	0.135	169.0, 242.0	-0.48
NZW/LacJ	m	224.0	31.9	7	12.1	0.142	177.0, 259.0	0.38
P/J	f	288.0	57.4	5	25.7	0.199	240.0, 375.0	1.16
P/J	m	216.0	14.4	4	7.19	0.0668	194.0, 224.0	0.21
PL/J	f	200.0	27.5	7	10.4	0.137	159.0, 231.0	-0.46
PL/J	m	205.0	23.4	4	11.7	0.114	177.0, 231.0	-0.03
PWD/PhJ	f	207.0	30.7	7	11.6	0.149	166.0, 246.0	-0.34
PWD/PhJ	m	158.0	16.1	4	8.07	0.102	144.0, 177.0	-1.06
RIIIS/J	f	252.0	69.3	7	26.2	0.275	129.0, 361.0	0.49
RIIIS/J	m	181.0	20.9	8	7.39	0.116	160.0, 211.0	-0.56
SJL/J	f	199.0	32.3	8	11.4	0.163	159.0, 246.0	-0.48
SJL/J	m	171.0	5.98	6	2.44	0.0349	161.0, 178.0	-0.77
SM/J	f	278.0	38.6	7	14.6	0.139	221.0, 335.0	0.97
SM/J	m	219.0	59.3	5	26.5	0.271	163.0, 299.0	0.27
SWR/J	f	313.0	66.0	8	23.4	0.211	216.0, 410.0	1.62
SWR/J	m	300.0	28.8	6	11.8	0.0961	264.0, 345.0	2.04
WSB/EiJ	f	297.0	17.0	8	5.99	0.0571	277.0, 330.0	1.32
WSB/EiJ	m	238.0	29.8	7	11.3	0.125	202.0, 297.0	0.69

LEAST SQUARES MEANS (MODEL-ADJUSTED)

Strain	Sex	Mean	SEM	UpperCL	LowerCL
129S1/SvImJ	f	208.1429	15.3999	238.4496	177.8361
129S1/SvImJ	m	218.1429	15.3999	248.4496	187.8361
A/J	f	223.8571	15.3999	254.1639	193.5504
A/J	m	249.6	18.2214	285.4595	213.7405
BALB/cByJ	f	188.4286	15.3999	218.7353	158.1218
BALB/cByJ	m	194.2	18.2214	230.0595	158.3405
BTBR T⁺ Itpr3^tf/J	f	279.1667	16.6338	311.9017	246.4316
BTBR T⁺ Itpr3^tf/J	m	219.2	18.2214	255.0595	183.3405
C3H/HeJ	f	186.5	16.6338	219.2351	153.7649
C3H/HeJ	m	205.125	14.4053	233.4744	176.7756
C57BL/10J	f	130.0	15.3999	160.3068	99.6932
C57BL/10J	m	155.2857	15.3999	185.5925	124.9789
C57BL/6J	f	166.5	14.4053	194.8494	138.1506
C57BL/6J	m	158.1667	16.6338	190.9017	125.4316
C57BLKS/J	f	134.8571	15.3999	165.1639	104.5504
C57BLKS/J	m	161.2857	15.3999	191.5925	130.9789
C57BR/cdJ	f	227.25	14.4053	255.5994	198.9006
C57BR/cdJ	m	183.125	14.4053	211.4744	154.7756
C57L/J	f	222.625	14.4053	250.9744	194.2756
C57L/J	m	201.0	28.8106	257.6988	144.3012
CBA/J	f	215.375	14.4053	243.7244	187.0256
CBA/J	m	221.6667	23.5238	267.961	175.3723
DBA/2J	f	162.4	18.2214	198.2595	126.5405
DBA/2J	m	178.125	14.4053	206.4744	149.7756
FVB/NJ	f	354.375	14.4053	382.7244	326.0256
FVB/NJ	m	224.0	20.3722	264.0921	183.9079
KK/HlJ	f	208.0	12.8845	233.3565	182.6435
KK/HlJ	m	196.0	15.3999	226.3068	165.6932
LP/J	f	229.5714	15.3999	259.8782	199.2647
LP/J	m	243.25	14.4053	271.5994	214.9006
MRL/MpJ	f	265.0	28.8106	321.6988	208.3012
MRL/MpJ	m	359.2	18.2214	395.0595	323.3405
NOD.B10Sn-H2^b/J	f	208.8571	15.3999	239.1639	178.5504
NOD.B10Sn-H2^b/J	m	191.0	20.3722	231.0921	150.9079
NON/ShiLtJ	f	204.4286	10.8894	225.8587	182.9984
NON/ShiLtJ	m	178.4286	15.3999	208.7353	148.1218
NZW/LacJ	f	199.2	18.2214	235.0595	163.3405
NZW/LacJ	m	224.0	15.3999	254.3068	193.6932
P/J	f	288.0	18.2214	323.8595	252.1405
P/J	m	215.5	20.3722	255.5921	175.4079
PL/J	f	200.4286	15.3999	230.7353	170.1218
PL/J	m	204.75	20.3722	244.8421	164.6579
PWD/PhJ	f	206.7143	15.3999	237.0211	176.4075
PWD/PhJ	m	158.5	20.3722	198.5921	118.4079
RIIIS/J	f	252.1429	15.3999	282.4496	221.8361
RIIIS/J	m	181.0	14.4053	209.3494	152.6506
SJL/J	f	198.75	14.4053	227.0994	170.4006
SJL/J	m	171.1667	16.6338	203.9017	138.4316
SM/J	f	277.8571	15.3999	308.1639	247.5504
SM/J	m	219.0	18.2214	254.8595	183.1405
SWR/J	f	312.75	14.4053	341.0994	284.4006
SWR/J	m	300.1667	16.6338	332.9017	267.4316
WSB/EiJ	f	296.75	14.4053	325.0994	268.4006
WSB/EiJ	m	238.4286	15.3999	268.7353	208.1218

LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED

Strain	Sex	Mean	SEM	UpperCL	LowerCL
129S1/SvImJ	both	213.1429	10.8894	234.573	191.7127
A/J	both	236.7286	11.9287	260.2041	213.253
BALB/cByJ	both	191.3143	11.9287	214.7898	167.8388
BTBR T⁺ Itpr3^tf/J	both	249.1833	12.336	273.4603	224.9064
C3H/HeJ	both	195.8125	11.0022	217.4647	174.1603
C57BL/10J	both	142.6429	10.8894	164.073	121.2127
C57BL/6J	both	162.3333	11.0022	183.9855	140.6811
C57BLKS/J	both	148.0714	10.8894	169.5016	126.6413
C57BR/cdJ	both	205.1875	10.1861	225.2335	185.1415
C57L/J	both	211.8125	16.1056	243.5081	180.1169
CBA/J	both	218.5208	13.792	245.6633	191.3784
DBA/2J	both	170.2625	11.6139	193.1185	147.4065
FVB/NJ	both	289.1875	12.4754	313.7388	264.6362
KK/HlJ	both	202.0	10.0395	221.7576	182.2424
LP/J	both	236.4107	10.5436	257.1603	215.6611
MRL/MpJ	both	312.1	17.0446	345.6434	278.5566
NOD.B10Sn-H2^b/J	both	199.9286	12.7689	225.0576	174.7995
NON/ShiLtJ	both	191.4286	9.4305	209.9876	172.8695
NZW/LacJ	both	211.6	11.9287	235.0755	188.1245
P/J	both	251.75	13.6661	278.6446	224.8554
PL/J	both	202.5893	12.7689	227.7183	177.4602
PWD/PhJ	both	182.6071	12.7689	207.7362	157.4781
RIIIS/J	both	216.5714	10.5436	237.3211	195.8218
SJL/J	both	184.9583	11.0022	206.6105	163.3061
SM/J	both	248.4286	11.9287	271.9041	224.953
SWR/J	both	306.4583	11.0022	328.1105	284.8061
WSB/EiJ	both	267.5893	10.5436	288.3389	246.8397

INDIVIDUAL ANIMAL VALUES

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GWAS USING LINEAR MIXED MODELS

ID, description, units	MPD:24428 Fe_M18 iron (serum Fe) [mmol/L] at age 18mo
Data set, strains	Yuan3 inbred 29 strains sex: both age: 78wks
Procedure	metabolic panel
Ontology mappings	MA:0002502 serum MP:0004152 abnormal circulating iron level VT:0004152 blood iron amount