Project measure / variable:   Yuan3   ALP_M18

ID, description, units MPD:24413   ALP_M18   alkaline phosphatase (serum ALP)   [IU/L]  at age 18mo  
Data set, strains Yuan3   inbred   29 strains     sex: both     age: 78wks
Procedure metabolic panel
Ontology mappings

  STRAIN COMPARISON PLOT
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Yuan3 - alkaline phosphatase (serum ALP) at age 18mo



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains28 strains
Mean of the strain means139   IU/L 80.8   IU/L
Median of the strain means108   IU/L 72.2   IU/L
SD of the strain means± 112 ± 45.4
Coefficient of variation (CV)0.802 0.562
Min–max range of strain means30.5   –   624   IU/L 28.0   –   213   IU/L
Mean sample size per strain7.1   mice 6.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 279664.9552 279664.9552 85.9228 < 0.0001
strain 26 2061698.4794 79296.0954 24.3625 < 0.0001
sex:strain 26 1176020.7086 45231.5657 13.8967 < 0.0001
Residuals 312 1015509.6929 3254.8388


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 152.0 80.2   7 30.3 0.529 70.0, 264.0 0.11
129S1/SvImJ m 46.8 17.9   8 6.33 0.383 30.0, 80.0 -0.75
A/J f 66.6 14.5   8 5.13 0.218 48.0, 93.0 -0.65
A/J m 60.8 23.3   6 9.5 0.382 25.0, 78.0 -0.44
BALB/cByJ f 85.6 21.8   7 8.25 0.255 59.0, 121.0 -0.48
BALB/cByJ m 82.5 20.4   6 8.31 0.247 68.0, 123.0 0.04
BTBR T+ Itpr3tf/J f 65.8 36.0   6 14.7 0.546 26.0, 122.0 -0.66
BTBR T+ Itpr3tf/J m 62.0 4.0   5 1.79 0.0645 59.0, 69.0 -0.41
BUB/BnJ f 175.0 46.1   5 20.6 0.264 144.0, 256.0 0.32
C3H/HeJ f 87.7 24.1   6 9.86 0.275 47.0, 118.0 -0.46
C3H/HeJ m 76.5 20.0   8 7.09 0.262 31.0, 93.0 -0.09
C57BL/10J f 177.0 39.9   7 15.1 0.225 134.0, 242.0 0.34
C57BL/10J m 86.9 18.5   7 6.99 0.213 59.0, 111.0 0.13
C57BL/6J f 127.0 57.0   8 20.2 0.448 49.0, 204.0 -0.11
C57BL/6J m 103.0 8.05   7 3.04 0.0783 90.0, 113.0 0.49
C57BLKS/J f 99.0 14.2   6 5.81 0.144 83.0, 121.0 -0.36
C57BLKS/J m 72.4 5.94   7 2.25 0.082 63.0, 81.0 -0.18
C57BR/cdJ f 83.2 17.9   8 6.34 0.215 47.0, 109.0 -0.5
C57BR/cdJ m 48.1 5.3   8 1.88 0.11 41.0, 55.0 -0.72
C57L/J f 36.1 14.2   8 5.04 0.394 15.0, 55.0 -0.92
C57L/J m 38.7 4.23   6 1.73 0.109 33.0, 43.0 -0.93
CBA/J f 178.0 128.0   8 45.4 0.72 83.0, 465.0 0.35
CBA/J m 71.5 16.6   6 6.8 0.233 49.0, 98.0 -0.2
DBA/2J f 171.0 28.0   5 12.5 0.164 129.0, 204.0 0.28
DBA/2J m 104.0 20.0   8 7.08 0.192 69.0, 141.0 0.51
FVB/NJ f 123.0 41.0   8 14.5 0.333 79.0, 200.0 -0.15
FVB/NJ m 61.8 13.0   5 5.82 0.21 48.0, 83.0 -0.42
KK/HlJ f 624.0 210.0   9 69.8 0.336 371.0, 884.0 4.34
KK/HlJ m 85.3 22.0   7 8.31 0.258 51.0, 115.0 0.1
LP/J f 104.0 26.5   7 10.0 0.256 60.0, 140.0 -0.32
LP/J m 42.4 6.25   8 2.21 0.148 32.0, 50.0 -0.85
MRL/MpJ f 238.0 96.9   2   68.5 0.408 169.0, 306.0 0.88
MRL/MpJ m 213.0 49.3   5 22.0 0.232 150.0, 270.0 2.91
NOD.B10Sn-H2b/J f 68.3 52.3   7 19.8 0.766 37.0, 186.0 -0.64
NOD.B10Sn-H2b/J m 32.5 1.29   4 0.645 0.0397 31.0, 34.0 -1.06
NON/ShiLtJ f 30.5 11.4   14 3.04 0.374 17.0, 51.0 -0.97
NON/ShiLtJ m 30.3 4.61   7 1.74 0.152 22.0, 37.0 -1.11
NZO/HlLtJ f 73.8 15.8   9 5.27 0.214 54.0, 98.0 -0.59
NZO/HlLtJ m 28.0 0.0   1   0.0 0.0 28.0, 28.0 -1.16
NZW/LacJ f 249.0 201.0   5 90.1 0.809 99.0, 571.0 0.98
NZW/LacJ m 72.1 10.8   7 4.08 0.15 56.0, 90.0 -0.19
P/J f 124.0 67.4   5 30.1 0.543 44.0, 191.0 -0.14
P/J m 77.5 72.6   4 36.3 0.937 32.0, 185.0 -0.07
PL/J f 128.0 16.8   7 6.33 0.131 109.0, 147.0 -0.1
PL/J m 121.0 14.2   4 7.1 0.118 109.0, 139.0 0.89
PWD/PhJ f 186.0 44.9   7 17.0 0.242 99.0, 229.0 0.42
PWD/PhJ m 195.0 34.1   8 12.1 0.175 135.0, 235.0 2.52
RIIIS/J f 69.9 4.56   7 1.72 0.0653 63.0, 75.0 -0.62
RIIIS/J m 80.2 9.41   8 3.33 0.117 65.0, 92.0 -0.01
SJL/J f 52.0 7.27   8 2.57 0.14 43.0, 66.0 -0.78
SJL/J m 43.7 6.77   6 2.76 0.155 36.0, 54.0 -0.82
SM/J f 96.7 17.5   7 6.61 0.181 72.0, 114.0 -0.38
SM/J m 158.0 150.0   5 67.1 0.948 52.0, 422.0 1.7
SWR/J f 108.0 29.4   8 10.4 0.272 63.0, 140.0 -0.28
SWR/J m 66.8 15.4   6 6.28 0.23 46.0, 85.0 -0.31
WSB/EiJ f 261.0 93.0   8 32.9 0.356 96.0, 407.0 1.09
WSB/EiJ m 101.0 15.9   7 6.0 0.158 78.0, 126.0 0.45


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 151.7143 21.5633 194.1422 109.2864
129S1/SvImJ m 46.75 20.1706 86.4377 7.0623
A/J f 66.625 20.1706 106.3127 26.9373
A/J m 60.8333 23.2911 106.6607 15.0059
BALB/cByJ f 85.5714 21.5633 127.9994 43.1435
BALB/cByJ m 82.5 23.2911 128.3274 36.6726
BTBR T+ Itpr3tf/J f 65.8333 23.2911 111.6607 20.0059
BTBR T+ Itpr3tf/J m 62.0 25.5141 112.2014 11.7986
C3H/HeJ f 87.6667 23.2911 133.4941 41.8393
C3H/HeJ m 76.5 20.1706 116.1877 36.8123
C57BL/10J f 177.4286 21.5633 219.8565 135.0006
C57BL/10J m 86.8571 21.5633 129.2851 44.4292
C57BL/6J f 127.375 20.1706 167.0627 87.6873
C57BL/6J m 102.8571 21.5633 145.2851 60.4292
C57BLKS/J f 99.0 23.2911 144.8274 53.1726
C57BLKS/J m 72.4286 21.5633 114.8565 30.0006
C57BR/cdJ f 83.25 20.1706 122.9377 43.5623
C57BR/cdJ m 48.125 20.1706 87.8127 8.4373
C57L/J f 36.125 20.1706 75.8127 0.0
C57L/J m 38.6667 23.2911 84.4941 0.0
CBA/J f 178.375 20.1706 218.0627 138.6873
CBA/J m 71.5 23.2911 117.3274 25.6726
DBA/2J f 171.2 25.5141 221.4014 120.9986
DBA/2J m 104.5 20.1706 144.1877 64.8123
FVB/NJ f 123.125 20.1706 162.8127 83.4373
FVB/NJ m 61.8 25.5141 112.0014 11.5986
KK/HlJ f 623.6667 19.0171 661.0846 586.2488
KK/HlJ m 85.2857 21.5633 127.7136 42.8578
LP/J f 103.7143 21.5633 146.1422 61.2864
LP/J m 42.375 20.1706 82.0627 2.6873
MRL/MpJ f 237.5 40.3413 316.8754 158.1246
MRL/MpJ m 212.6 25.5141 262.8014 162.3986
NOD.B10Sn-H2b/J f 68.2857 21.5633 110.7136 25.8578
NOD.B10Sn-H2b/J m 32.5 28.5256 88.6269 0.0
NON/ShiLtJ f 30.5 15.2476 60.5011 0.4989
NON/ShiLtJ m 30.2857 21.5633 72.7136 0.0
NZW/LacJ f 249.0 25.5141 299.2014 198.7986
NZW/LacJ m 72.1429 21.5633 114.5708 29.7149
P/J f 124.2 25.5141 174.4014 73.9986
P/J m 77.5 28.5256 133.6269 21.3731
PL/J f 128.1429 21.5633 170.5708 85.7149
PL/J m 120.75 28.5256 176.8769 64.6231
PWD/PhJ f 185.5714 21.5633 227.9994 143.1435
PWD/PhJ m 195.375 20.1706 235.0627 155.6873
RIIIS/J f 69.8571 21.5633 112.2851 27.4292
RIIIS/J m 80.25 20.1706 119.9377 40.5623
SJL/J f 52.0 20.1706 91.6877 12.3123
SJL/J m 43.6667 23.2911 89.4941 0.0
SM/J f 96.7143 21.5633 139.1422 54.2864
SM/J m 158.4 25.5141 208.6014 108.1986
SWR/J f 108.25 20.1706 147.9377 68.5623
SWR/J m 66.8333 23.2911 112.6607 21.0059
WSB/EiJ f 261.25 20.1706 300.9377 221.5623
WSB/EiJ m 100.7143 21.5633 143.1422 58.2864


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 99.2321 14.7634 128.2806 70.1837
A/J both 63.7292 15.4056 94.0411 33.4172
BALB/cByJ both 84.0357 15.8702 115.2618 52.8096
BTBR T+ Itpr3tf/J both 63.9167 17.2731 97.9032 29.9302
C3H/HeJ both 82.0833 15.4056 112.3953 51.7714
C57BL/10J both 132.1429 15.2476 162.1439 102.1418
C57BL/6J both 115.1161 14.7634 144.1645 86.0677
C57BLKS/J both 85.7143 15.8702 116.9404 54.4882
C57BR/cdJ both 65.6875 14.2628 93.7509 37.6241
C57L/J both 37.3958 15.4056 67.7078 7.0839
CBA/J both 124.9375 15.4056 155.2495 94.6255
DBA/2J both 137.85 16.2621 169.8472 105.8528
FVB/NJ both 92.4625 16.2621 124.4597 60.4653
KK/HlJ both 354.4762 14.3755 382.7615 326.1909
LP/J both 73.0446 14.7634 102.0931 43.9962
MRL/MpJ both 225.05 23.8662 272.0091 178.0909
NOD.B10Sn-H2b/J both 50.3929 17.8794 85.5722 15.2135
NON/ShiLtJ both 30.3929 13.2048 56.3745 4.4112
NZW/LacJ both 160.5714 16.7029 193.436 127.7069
P/J both 100.85 19.1356 138.501 63.199
PL/J both 124.4464 17.8794 159.6258 89.2671
PWD/PhJ both 190.4732 14.7634 219.5216 161.4248
RIIIS/J both 75.0536 14.7634 104.102 46.0052
SJL/J both 47.8333 15.4056 78.1453 17.5214
SM/J both 127.5571 16.7029 160.4217 94.6926
SWR/J both 87.5417 15.4056 117.8536 57.2297
WSB/EiJ both 180.9821 14.7634 210.0306 151.9337




  GWAS USING LINEAR MIXED MODELS