Project measure / variable:   Auwerx2   vco2_max_treadmill_HFD

ID, description, units MPD:114644   vco2_max_treadmill_HFD   maximum carbon dioxide production, treadmill test   [mL/kg/min]  HFD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 19wks
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  STRAIN COMPARISON PLOT
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Auwerx2 - maximum carbon dioxide production, treadmill test HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means116.5   mL/kg/min 104.3   mL/kg/min
Median of the strain means114.3   mL/kg/min 95.06   mL/kg/min
SD of the strain means± 23.789 ± 26.909
Coefficient of variation (CV)0.2043 0.258
Min–max range of strain means88.27   –   165.0   mL/kg/min 69.24   –   147.1   mL/kg/min
Mean sample size per strain4.4   mice 3.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 858.0142 858.0142 12.8245 0.0008
strain 7 26481.7098 3783.1014 56.5449 < 0.0001
sex:strain 7 6287.9447 898.2778 13.4263 < 0.0001
Residuals 50 3345.2183 66.9044


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 114.3 2.1652   5 0.9683 0.0189 112.6, 117.8 -0.09
129S1/SvImJ m 87.85 4.3699   2   3.09 0.0497 84.76, 90.94 -0.61
A/J f 97.61 8.9313   4 4.4657 0.0915 85.24, 105.9 -0.79
A/J m 86.38 2.4704   5 1.1048 0.0286 84.11, 89.7 -0.67
C57BL/6J f 105.6 4.6605   3 2.6907 0.0441 100.4, 109.4 -0.46
C57BL/6J m 95.06 14.259   3 8.2326 0.15 82.39, 110.5 -0.34
CAST/EiJ f 141.2 12.325   5 5.5118 0.0873 129.4, 160.5 1.04
CAST/EiJ m 103.8 8.6479   2   6.115 0.0833 97.67, 109.9 -0.02
DBA/2J f 118.6 6.2562   5 2.7979 0.0528 111.3, 126.5 0.09
DBA/2J m 127.1 7.8107   5 3.4931 0.0614 116.2, 135.9 0.85
NOD/ShiLtJ f 99.72 4.3009   6 1.7558 0.0431 94.72, 105.9 -0.7
NOD/ShiLtJ m 84.33 6.8406   5 3.0592 0.0811 77.38, 94.42 -0.74
NZO/HlLtJ f 88.27 5.7122   5 2.5546 0.0647 79.49, 94.03 -1.18
NZO/HlLtJ m 69.24 0.0   1   0.0 0.0 69.24, 69.24 -1.3
PWK/PhJ f 117.8 10.298   4 5.1489 0.0874 106.2, 127.3 0.06
PWK/PhJ m 147.1 10.113   5 4.5227 0.0688 135.6, 162.3 1.59
WSB/EiJ f 165.0 8.199   3 4.7337 0.0497 160.2, 174.5 2.04
WSB/EiJ m 138.0 11.094   4 5.5472 0.0804 126.4, 153.0 1.25


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 114.26 3.6579875815 121.6072842888 106.9127157112
129S1/SvImJ m 87.85 5.7837862051 99.4670764848 76.2329235152
A/J f 97.615 4.0897544466 105.8295135599 89.4004864401
A/J m 86.38 3.6579875815 93.7272842888 79.0327157112
C57BL/6J f 105.6 4.7224416613 115.0853032302 96.1146967698
C57BL/6J m 95.0566666667 4.7224416613 104.5419698968 85.5713634365
CAST/EiJ f 141.22 3.6579875815 148.5672842888 133.8727157112
CAST/EiJ m 103.785 5.7837862051 115.4020764848 92.1679235152
DBA/2J f 118.6 3.6579875815 125.9472842888 111.2527157112
DBA/2J m 127.12 3.6579875815 134.4672842888 119.7727157112
NOD/ShiLtJ f 99.7183333333 3.3392705225 106.425455569 93.0112110977
NOD/ShiLtJ m 84.334 3.6579875815 91.6812842888 76.9867157112
PWK/PhJ f 117.8 4.0897544466 126.0145135599 109.5854864401
PWK/PhJ m 147.06 3.6579875815 154.4072842888 139.7127157112
WSB/EiJ f 165.0333333333 4.7224416613 174.5186365635 155.5480301032
WSB/EiJ m 138.0 4.0897544466 146.2145135599 129.7854864401


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 101.055 3.4217340638 107.927755133 94.182244867
A/J both 91.9975 2.7434906862 97.5079632166 86.4870367834
C57BL/6J both 100.3283333333 3.3392705225 107.035455569 93.6212110977
CAST/EiJ both 122.5025 3.4217340638 129.375255133 115.629744867
DBA/2J both 122.86 2.5865878244 128.0553145439 117.6646854561
NOD/ShiLtJ both 92.0261666667 2.4764692997 97.0003016444 87.052031689
PWK/PhJ both 132.43 2.7434906862 137.9404632166 126.9195367834
WSB/EiJ both 151.5166666667 3.1236015542 157.7906050309 145.2427283024




  GWAS USING LINEAR MIXED MODELS