Project measure / variable:   CSNA03   extinction_inactive_cc_s2

ID, description, units MPD:110410   extinction_inactive_cc_s2   extinction, inactive lever presses (intravenous self administration), CC   [n]  session 2  
cocaine study
Data set, strains CSNA03   CC w/par   53 strains     sex: both     age:
Procedure operant conditioning chamber
Ontology mappings

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  STRAIN COMPARISON PLOT
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CSNA03 - extinction, inactive lever presses (intravenous self administration), CC session 2



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested50 strains51 strains
Mean of the strain means61.42   n 73.56   n
Median of the strain means32.25   n 27.0   n
SD of the strain means± 80.45 ± 155.1
Coefficient of variation (CV)1.31 2.1082
Min–max range of strain means0.0   –   498.0   n 0.0   –   820.7   n
Mean sample size per strain3.1   mice 3.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 4036.1396 4036.1396 0.3312 0.5655
strain 36 2612658.0482 72573.8347 5.9562 < 0.0001
sex:strain 36 402763.8785 11187.8855 0.9182 0.6065
Residuals 221 2692807.371 12184.6487


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 7.1111 8.8097   9 2.9366 1.2389 -0.67
A/J m 55.83 78.2   6 31.926 1.4007 -0.11
C57BL/6J f 52.18 61.7   11 18.604 1.1824 2.0, 206.0 -0.11
C57BL/6J m 10.333 12.766   12 3.6852 1.2354 -0.41
CAST/EiJ f 33.0 0.0   1   0.0 0.0 33.0, 33.0 -0.35
CAST/EiJ m 24.5 24.749   2   17.5 1.0102 7.0, 42.0 -0.32
CC001/UncJ f 29.0 14.0   3 8.0829 0.4828 19.0, 45.0 -0.4
CC001/UncJ m 73.33 75.53   3 43.606 1.0299 6.0, 155.0 0.0
CC002/UncJ f 123.0 166.3   3 96.02 1.3521 24.0, 315.0 0.77
CC002/UncJ m 22.0 24.042   2   17.0 1.0928 5.0, 39.0 -0.33
CC003/UncJ f 38.0 14.142   2   10.0 0.3722 28.0, 48.0 -0.29
CC003/UncJ m 56.25 101.2   4 50.62 1.7998 2.0, 208.0 -0.11
CC004/TauUncJ f 57.0 70.13   9 23.376 1.2303 -0.05
CC004/TauUncJ m 133.8 151.7   19 34.801 1.1334 6.0, 680.0 0.39
CC005/TauUncJ f 19.5 29.0   4 14.5 1.4872 5.0, 63.0 -0.52
CC005/TauUncJ m 18.0 12.728   2   9.0 0.7071 9.0, 27.0 -0.36
CC006/TauUncJ f 121.5 98.29   2   69.5 0.809 52.0, 191.0 0.75
CC006/TauUncJ m 7.0 9.8995   2   7.0 1.4142 -0.43
CC007/UncJ f 83.0 0.0   1   0.0 0.0 83.0, 83.0 0.27
CC007/UncJ m 13.333 13.013   3 7.513 0.976 -0.39
CC008/GeniUncJ f 3.0 2.8284   2   2.0 0.9428 1.0, 5.0 -0.73
CC008/GeniUncJ m 28.0 32.527   2   23.0 1.1617 5.0, 51.0 -0.29
CC009/UncJ f 59.33 85.92   3 49.606 1.4481 1.0, 158.0 -0.03
CC009/UncJ m 2.3333 3.2146   3 1.8559 1.3777 -0.46
CC011/UncJ f 64.0 52.72   3 30.436 0.8237 7.0, 111.0 0.03
CC011/UncJ m 123.3 19.14   3 11.05 0.1552 103.0, 141.0 0.32
CC012/GeniUncJ f 116.0 0.0   1   0.0 0.0 116.0, 116.0 0.68
CC012/GeniUncJ m 33.333 23.159   3 13.371 0.6948 14.0, 59.0 -0.26
CC013/GeniUncJ f 191.0 133.8   3 77.27 0.7007 42.0, 301.0 1.61
CC013/GeniUncJ m 67.0 26.211   3 15.133 0.3912 45.0, 96.0 -0.04
CC015/UncJ f 7.0 0.0   1   0.0 0.0 7.0, 7.0 -0.68
CC015/UncJ m 85.0 0.0   1   0.0 0.0 85.0, 85.0 0.07
CC016/GeniUncJ f 14.0 16.971   2   12.0 1.2122 2.0, 26.0 -0.59
CC016/GeniUncJ m 2.5 2.1213   2   1.5 0.8485 1.0, 4.0 -0.46
CC017/UncJ f 15.333 17.214   3 9.9387 1.1227 3.0, 35.0 -0.57
CC017/UncJ m 0.5 0.57735   4 0.28868 1.1547 -0.47
CC018/UncJ f 158.7 145.2   3 83.84 0.9152 28.0, 315.0 1.21
CC018/UncJ m 32.4 10.574   5 4.7286 0.3263 17.0, 46.0 -0.27
CC019/TauUncJ f 25.6 21.466   5 9.6 0.8385 7.0, 61.0 -0.45
CC019/TauUncJ m 40.5 16.263   2   11.5 0.4016 29.0, 52.0 -0.21
CC020/GeniUncJ f 10.0 0.0   1   0.0 0.0 10.0, 10.0 -0.64
CC023/GeniUncJ f 14.0 18.358   3 10.599 1.3113 1.0, 35.0 -0.59
CC023/GeniUncJ m 64.67 97.65   3 56.38 1.5101 -0.06
CC024/GeniUncJ f 31.5 44.548   2   31.5 1.4142 -0.37
CC024/GeniUncJ m 78.0 87.68   2   62.0 1.1241 16.0, 140.0 0.03
CC025/GeniUncJ f 36.5 41.719   2   29.5 1.143 7.0, 66.0 -0.31
CC025/GeniUncJ m 726.0 0.0   1   0.0 0.0 726.0, 726.0 4.21
CC026/GeniUncJ f 13.4 14.398   5 6.4389 1.0745 2.0, 37.0 -0.6
CC026/GeniUncJ m 23.333 23.965   3 13.836 1.0271 9.0, 51.0 -0.32
CC027/GeniUncJ f 151.0 193.4   3 111.6 1.2805 13.0, 372.0 1.11
CC027/GeniUncJ m 11.25 15.65   4 7.8249 1.3911 -0.4
CC028/GeniUncJ f 71.25 64.81   4 32.405 0.9096 16.0, 151.0 0.12
CC028/GeniUncJ m 76.67 52.58   3 30.355 0.6858 16.0, 109.0 0.02
CC029/UncJ f 0.0 0.0   1   0.0 None -0.76
CC029/UncJ m 6.0 0.0   1   0.0 0.0 6.0, 6.0 -0.44
CC030/GeniUncJ f 152.5 118.1   2   83.5 0.7743 69.0, 236.0 1.13
CC030/GeniUncJ m 83.5 72.83   2   51.5 0.8722 32.0, 135.0 0.06
CC032/GeniUncJ f 43.333 20.133   3 11.624 0.4646 22.0, 62.0 -0.22
CC032/GeniUncJ m 30.25 25.224   4 12.612 0.8339 2.0, 53.0 -0.28
CC033/GeniUncJ f 2.0 0.0   1   0.0 0.0 2.0, 2.0 -0.74
CC033/GeniUncJ m 27.0 0.0   1   0.0 0.0 27.0, 27.0 -0.3
CC035/UncJ f 30.5 10.607   2   7.5 0.3478 23.0, 38.0 -0.38
CC035/UncJ m 41.0 26.87   2   19.0 0.6554 22.0, 60.0 -0.21
CC036/UncJ f 149.0 113.3   3 65.39 0.7601 25.0, 247.0 1.09
CC036/UncJ m 323.5 0.70711   2   0.5 0.0022 323.0, 324.0 1.61
CC037/TauUncJ f 74.0 0.0   1   0.0 0.0 74.0, 74.0 0.16
CC037/TauUncJ m 0.0 0.0   1   0.0 None -0.47
CC040/TauUncJ f 12.5 16.263   2   11.5 1.3011 1.0, 24.0 -0.61
CC040/TauUncJ m 49.0 31.113   2   22.0 0.635 27.0, 71.0 -0.16
CC041/TauUncJ f 12.333 21.362   3 12.333 1.7321 -0.61
CC041/TauUncJ m 0.58333 1.4434   12 0.41667 2.4744 -0.47
CC043/GeniUncJ m 12.0 0.0   1   0.0 0.0 12.0, 12.0 -0.4
CC044/UncJ f 0.0 0.0   1   0.0 None -0.76
CC044/UncJ m 4.5 3.5355   2   2.5 0.7857 2.0, 7.0 -0.45
CC051/TauUncJ f 70.0 0.0   1   0.0 0.0 70.0, 70.0 0.11
CC051/TauUncJ m 25.333 22.368   3 12.914 0.883 1.0, 45.0 -0.31
CC057/UncJ f 20.5 7.7782   2   5.5 0.3794 15.0, 26.0 -0.51
CC057/UncJ m 3.5 4.9497   2   3.5 1.4142 -0.45
CC059/TauUncJ f 101.3 72.46   3 41.834 0.7151 20.0, 159.0 0.5
CC059/TauUncJ m 264.0 195.0   3 112.6 0.7387 70.0, 460.0 1.23
CC060/UncJ m 50.0 0.0   1   0.0 0.0 50.0, 50.0 -0.15
CC061/GeniUncJ f 108.0 137.2   2   97.0 1.2702 11.0, 205.0 0.58
CC061/GeniUncJ m 66.0 84.85   2   60.0 1.2856 6.0, 126.0 -0.05
CC068/TauUncJ f 0.0 0.0   2   0.0 None -0.76
CC068/TauUncJ m 1.0 1.4142   2   1.0 1.4142 -0.47
CC074/UncJ m 9.0 0.0   1   0.0 0.0 9.0, 9.0 -0.42
CC078/TauUncJ f 498.0 212.1   2   150.0 0.426 348.0, 648.0 5.43
CC078/TauUncJ m 820.7 875.5   3 505.5 1.0669 253.0, 1829.0 4.82
CC079/TauUncJ f 20.0 11.314   2   8.0 0.5657 12.0, 28.0 -0.51
CC079/TauUncJ m 18.5 17.678   2   12.5 0.9555 6.0, 31.0 -0.36
CC080/TauUncJ f 1.5 0.70711   2   0.5 0.4714 1.0, 2.0 -0.74
CC084/TauJ f 100.5 51.62   2   36.5 0.5136 64.0, 137.0 0.49
CC084/TauJ m 46.0 0.0   1   0.0 0.0 46.0, 46.0 -0.18
NOD/ShiLtJ f 51.91 84.26   11 25.405 1.6232 -0.12
NOD/ShiLtJ m 18.143 26.429   7 9.9891 1.4567 -0.36
NZO/HlLtJ f 17.8 24.625   10 7.7872 1.3834 -0.54
NZO/HlLtJ m 14.222 13.236   9 4.412 0.9307 3.0, 41.0 -0.38
PWK/PhJ f 29.2 17.612   5 7.8765 0.6032 7.0, 55.0 -0.4
PWK/PhJ m 21.429 8.3038   7 3.1385 0.3875 11.0, 32.0 -0.34
WSB/EiJ f 31.0 36.77   2   26.0 1.1861 5.0, 57.0 -0.38
WSB/EiJ m 7.4 6.6558   5 2.9766 0.8994 1.0, 15.0 -0.43


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 7.1111111111 36.7946987991 79.6244944902 -65.402272268
A/J m 55.8333333333 45.0641186486 144.6437277341 -32.9770610675
C57BL/6J f 52.1818181818 33.2820573248 117.7726413494 -13.4090049857
C57BL/6J m 10.3333333333 31.8651438846 73.131765454 -52.4650987873
CC001/UncJ f 29.0 63.7302877692 154.5968642413 -96.5968642413
CC001/UncJ m 73.3333333333 63.7302877692 198.9301975747 -52.263530908
CC002/UncJ f 123.0 63.7302877692 248.5968642413 -2.5968642413
CC002/UncJ m 22.0 78.0533430977 175.8241153424 -131.8241153424
CC003/UncJ f 38.0 78.0533430977 191.8241153424 -115.8241153424
CC003/UncJ m 56.25 55.1920481987 165.0200750687 -52.5200750687
CC004/TauUncJ f 57.0 36.7946987991 129.5133833791 -15.5133833791
CC004/TauUncJ m 133.8421052632 25.3238484826 183.7492384532 83.9349720731
CC005/TauUncJ f 19.5 55.1920481987 128.2700750687 -89.2700750687
CC005/TauUncJ m 18.0 78.0533430977 171.8241153424 -135.8241153424
CC006/TauUncJ f 121.5 78.0533430977 275.3241153424 -32.3241153424
CC006/TauUncJ m 7.0 78.0533430977 160.8241153424 -146.8241153424
CC008/GeniUncJ f 3.0 78.0533430977 156.8241153424 -150.8241153424
CC008/GeniUncJ m 28.0 78.0533430977 181.8241153424 -125.8241153424
CC009/UncJ f 59.3333333333 63.7302877692 184.9301975747 -66.263530908
CC009/UncJ m 2.3333333333 63.7302877692 127.9301975747 -123.263530908
CC011/UncJ f 64.0 63.7302877692 189.5968642413 -61.5968642413
CC011/UncJ m 123.3333333333 63.7302877692 248.9301975747 -2.263530908
CC013/GeniUncJ f 191.0 63.7302877692 316.5968642413 65.4031357587
CC013/GeniUncJ m 67.0 63.7302877692 192.5968642413 -58.5968642413
CC016/GeniUncJ f 14.0 78.0533430977 167.8241153424 -139.8241153424
CC016/GeniUncJ m 2.5 78.0533430977 156.3241153424 -151.3241153424
CC017/UncJ f 15.3333333333 63.7302877692 140.9301975747 -110.263530908
CC017/UncJ m 0.5 55.1920481987 109.2700750687 -108.2700750687
CC018/UncJ f 158.6666666667 63.7302877692 284.263530908 33.0698024253
CC018/UncJ m 32.4 49.3652686359 129.6869127085 -64.8869127085
CC019/TauUncJ f 25.6 49.3652686359 122.8869127085 -71.6869127085
CC019/TauUncJ m 40.5 78.0533430977 194.3241153424 -113.3241153424
CC023/GeniUncJ f 14.0 63.7302877692 139.5968642413 -111.5968642413
CC023/GeniUncJ m 64.6666666667 63.7302877692 190.263530908 -60.9301975747
CC024/GeniUncJ f 31.5 78.0533430977 185.3241153424 -122.3241153424
CC024/GeniUncJ m 78.0 78.0533430977 231.8241153424 -75.8241153424
CC026/GeniUncJ f 13.4 49.3652686359 110.6869127085 -83.8869127085
CC026/GeniUncJ m 23.3333333333 63.7302877692 148.9301975747 -102.263530908
CC027/GeniUncJ f 151.0 63.7302877692 276.5968642413 25.4031357587
CC027/GeniUncJ m 11.25 55.1920481987 120.0200750687 -97.5200750687
CC028/GeniUncJ f 71.25 55.1920481987 180.0200750687 -37.5200750687
CC028/GeniUncJ m 76.6666666667 63.7302877692 202.263530908 -48.9301975747
CC030/GeniUncJ f 152.5 78.0533430977 306.3241153424 -1.3241153424
CC030/GeniUncJ m 83.5 78.0533430977 237.3241153424 -70.3241153424
CC032/GeniUncJ f 43.3333333333 63.7302877692 168.9301975747 -82.263530908
CC032/GeniUncJ m 30.25 55.1920481987 139.0200750687 -78.5200750687
CC035/UncJ f 30.5 78.0533430977 184.3241153424 -123.3241153424
CC035/UncJ m 41.0 78.0533430977 194.8241153424 -112.8241153424
CC036/UncJ f 149.0 63.7302877692 274.5968642413 23.4031357587
CC036/UncJ m 323.5 78.0533430977 477.3241153424 169.6758846576
CC040/TauUncJ f 12.5 78.0533430977 166.3241153424 -141.3241153424
CC040/TauUncJ m 49.0 78.0533430977 202.8241153424 -104.8241153424
CC041/TauUncJ f 12.3333333333 63.7302877692 137.9301975747 -113.263530908
CC041/TauUncJ m 0.5833333333 31.8651438846 63.381765454 -62.2150987873
CC057/UncJ f 20.5 78.0533430977 174.3241153424 -133.3241153424
CC057/UncJ m 3.5 78.0533430977 157.3241153424 -150.3241153424
CC059/TauUncJ f 101.3333333333 63.7302877692 226.9301975747 -24.263530908
CC059/TauUncJ m 264.0 63.7302877692 389.5968642413 138.4031357587
CC061/GeniUncJ f 108.0 78.0533430977 261.8241153424 -45.8241153424
CC061/GeniUncJ m 66.0 78.0533430977 219.8241153424 -87.8241153424
CC068/TauUncJ f 0.0 78.0533430977 153.8241153424 -153.8241153424
CC068/TauUncJ m 1.0 78.0533430977 154.8241153424 -152.8241153424
CC078/TauUncJ f 498.0 78.0533430977 651.8241153424 344.1758846576
CC078/TauUncJ m 820.6666666667 63.7302877692 946.263530908 695.0698024253
CC079/TauUncJ f 20.0 78.0533430977 173.8241153424 -133.8241153424
CC079/TauUncJ m 18.5 78.0533430977 172.3241153424 -135.3241153424
NOD/ShiLtJ f 51.9090909091 33.2820573248 117.4999140766 -13.6817322585
NOD/ShiLtJ m 18.1428571429 41.7212668234 100.3653053479 -64.0795910621
NZO/HlLtJ f 17.8 34.9065162075 86.5922356969 -50.9922356969
NZO/HlLtJ m 14.2222222222 36.7946987991 86.7356056013 -58.2911611569
PWK/PhJ f 29.2 49.3652686359 126.4869127085 -68.0869127085
PWK/PhJ m 21.4285714286 41.7212668234 103.6510196336 -60.7938767764
WSB/EiJ f 31.0 78.0533430977 184.8241153424 -122.8241153424
WSB/EiJ m 7.4 49.3652686359 104.6869127085 -89.8869127085


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 31.4722222222 29.0887635063 88.799085303 -25.8546408585
C57BL/6J both 31.2575757576 23.0384609651 76.6607671669 -14.1456156518
CC001/UncJ both 51.1666666667 45.0641186486 139.9770610675 -37.6437277341
CC002/UncJ both 72.5 50.3832163222 171.7930394944 -26.7930394944
CC003/UncJ both 47.125 47.7977158269 141.322648181 -47.072648181
CC004/TauUncJ both 95.4210526316 22.333535108 139.4350069879 51.4070982752
CC005/TauUncJ both 18.75 47.7977158269 112.947648181 -75.447648181
CC006/TauUncJ both 64.25 55.1920481987 173.0200750687 -44.5200750687
CC008/GeniUncJ both 15.5 55.1920481987 124.2700750687 -93.2700750687
CC009/UncJ both 30.8333333333 45.0641186486 119.6437277341 -57.9770610675
CC011/UncJ both 93.6666666667 45.0641186486 182.4770610675 4.8562722659
CC013/GeniUncJ both 129.0 45.0641186486 217.8103944008 40.1896055992
CC016/GeniUncJ both 8.25 55.1920481987 117.0200750687 -100.5200750687
CC017/UncJ both 7.9166666667 42.153623105 90.9911837247 -75.1578503914
CC018/UncJ both 95.5333333333 40.3065730578 174.9677649288 16.0989017378
CC019/TauUncJ both 33.05 46.1769805104 124.0535738931 -57.9535738931
CC023/GeniUncJ both 39.3333333333 45.0641186486 128.1437277341 -49.4770610675
CC024/GeniUncJ both 54.75 55.1920481987 163.5200750687 -54.0200750687
CC026/GeniUncJ both 18.3666666667 40.3065730578 97.8010982622 -61.0677649288
CC027/GeniUncJ both 81.125 42.153623105 164.199517058 -1.949517058
CC028/GeniUncJ both 73.9583333333 42.153623105 157.0328503914 -9.1161837247
CC030/GeniUncJ both 118.0 55.1920481987 226.7700750687 9.2299249313
CC032/GeniUncJ both 36.7916666667 42.153623105 119.8661837247 -46.2828503914
CC035/UncJ both 35.75 55.1920481987 144.5200750687 -73.0200750687
CC036/UncJ both 236.25 50.3832163222 335.5430394944 136.9569605056
CC040/TauUncJ both 30.75 55.1920481987 139.5200750687 -78.0200750687
CC041/TauUncJ both 6.4583333333 35.6263139194 76.6691148844 -63.7524482178
CC057/UncJ both 12.0 55.1920481987 120.7700750687 -96.7700750687
CC059/TauUncJ both 182.6666666667 45.0641186486 271.4770610675 93.8562722659
CC061/GeniUncJ both 87.0 55.1920481987 195.7700750687 -21.7700750687
CC068/TauUncJ both 0.5 55.1920481987 109.2700750687 -108.2700750687
CC078/TauUncJ both 659.3333333333 50.3832163222 758.6263728277 560.0402938389
CC079/TauUncJ both 19.25 55.1920481987 128.0200750687 -89.5200750687
NOD/ShiLtJ both 35.025974026 26.685011922 87.6156285994 -17.5636805475
NZO/HlLtJ both 16.0111111111 25.3589961033 65.9875116949 -33.9652894727
PWK/PhJ both 25.3142857143 32.3171543179 89.0035202308 -38.3749488022
WSB/EiJ both 19.2 46.1769805104 110.2035738931 -71.8035738931




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA