Project measure / variable:   CSNA03   extinction_active_cc_s7

ID, description, units MPD:110406   extinction_active_cc_s7   extinction, active lever presses (intravenous self administration), CC   [n]  session 7  
cocaine study
Data set, strains CSNA03   CC w/par   43 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - extinction, active lever presses (intravenous self administration), CC session 7



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested36 strains33 strains
Mean of the strain means465.2   n 144.2   n
Median of the strain means161.9   n 73.0   n
SD of the strain means± 964.9 ± 225.1
Coefficient of variation (CV)2.0741 1.5616
Min–max range of strain means6.0   –   4357.0   n 10.0   –   1234.0   n
Mean sample size per strain2.9   mice 3.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 856428.8617 856428.8617 36.6459 < 0.0001
strain 12 15943048.3159 1328587.3597 56.8492 < 0.0001
sex:strain 12 14301299.3329 1191774.9444 50.9951 < 0.0001
Residuals 121 2827815.4623 23370.3757


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 25.0 27.092   7 10.24 1.0837 -0.46
A/J m 17.857 17.563   7 6.6384 0.9836 -0.56
C57BL/6J f 139.3 174.9   11 52.75 1.2561 16.0, 530.0 -0.34
C57BL/6J m 33.909 27.197   11 8.2003 0.8021 6.0, 95.0 -0.49
CAST/EiJ f 78.0 0.0   1   0.0 0.0 78.0, 78.0 -0.4
CAST/EiJ m 42.0 7.0711   2   5.0 0.1684 37.0, 47.0 -0.45
CC001/UncJ m 513.5 535.3   2   378.5 1.0424 135.0, 892.0 1.64
CC002/UncJ f 4357.0 5084.0   3 2935.0 1.1669 28.0, 9956.0 4.03
CC003/UncJ f 74.0 0.0   1   0.0 0.0 74.0, 74.0 -0.41
CC003/UncJ m 12.0 0.0   1   0.0 0.0 12.0, 12.0 -0.59
CC004/TauUncJ f 201.5 160.3   8 56.67 0.7955 21.0, 474.0 -0.27
CC004/TauUncJ m 231.9 149.9   14 40.068 0.6466 23.0, 516.0 0.39
CC005/TauUncJ f 186.0 0.0   1   0.0 0.0 186.0, 186.0 -0.29
CC006/TauUncJ f 236.0 0.0   1   0.0 0.0 236.0, 236.0 -0.24
CC006/TauUncJ m 1234.0 0.0   1   0.0 0.0 1234.0, 1234.0 4.84
CC007/UncJ f 225.0 0.0   1   0.0 0.0 225.0, 225.0 -0.25
CC007/UncJ m 149.0 168.3   2   119.0 1.1295 30.0, 268.0 0.02
CC008/GeniUncJ m 36.5 21.92   2   15.5 0.6006 21.0, 52.0 -0.48
CC009/UncJ f 279.0 0.0   1   0.0 0.0 279.0, 279.0 -0.19
CC011/UncJ f 184.5 102.5   2   72.5 0.5557 112.0, 257.0 -0.29
CC011/UncJ m 107.0 0.0   1   0.0 0.0 107.0, 107.0 -0.17
CC012/GeniUncJ f 6.0 0.0   1   0.0 0.0 6.0, 6.0 -0.48
CC012/GeniUncJ m 196.0 0.0   1   0.0 0.0 196.0, 196.0 0.23
CC013/GeniUncJ f 441.5 152.0   2   107.5 0.3443 334.0, 549.0 -0.02
CC013/GeniUncJ m 69.0 12.728   2   9.0 0.1845 60.0, 78.0 -0.33
CC016/GeniUncJ f 1691.0 0.0   1   0.0 0.0 1691.0, 1691.0 1.27
CC018/UncJ f 202.3 169.2   3 97.68 0.8362 15.0, 344.0 -0.27
CC018/UncJ m 145.6 71.86   5 32.138 0.4936 41.0, 228.0 0.01
CC019/TauUncJ f 570.0 625.4   4 312.7 1.0972 119.0, 1464.0 0.11
CC019/TauUncJ m 128.5 82.73   2   58.5 0.6438 70.0, 187.0 -0.07
CC023/GeniUncJ f 88.0 0.0   1   0.0 0.0 88.0, 88.0 -0.39
CC023/GeniUncJ m 101.0 0.0   1   0.0 0.0 101.0, 101.0 -0.19
CC024/GeniUncJ f 128.0 0.0   1   0.0 0.0 128.0, 128.0 -0.35
CC025/GeniUncJ f 443.0 0.0   1   0.0 0.0 443.0, 443.0 -0.02
CC025/GeniUncJ m 56.0 0.0   1   0.0 0.0 56.0, 56.0 -0.39
CC026/GeniUncJ f 18.8 6.3797   5 2.8531 0.3393 11.0, 26.0 -0.46
CC026/GeniUncJ m 22.333 10.786   3 6.2272 0.4829 10.0, 30.0 -0.54
CC027/GeniUncJ f 1048.0 0.0   1   0.0 0.0 1048.0, 1048.0 0.6
CC028/GeniUncJ f 184.7 134.3   3 77.55 0.7274 69.0, 332.0 -0.29
CC028/GeniUncJ m 24.0 0.0   1   0.0 0.0 24.0, 24.0 -0.53
CC030/GeniUncJ f 85.0 14.142   2   10.0 0.1664 75.0, 95.0 -0.39
CC032/GeniUncJ f 44.0 0.0   1   0.0 0.0 44.0, 44.0 -0.44
CC032/GeniUncJ m 320.0 386.1   2   273.0 1.2065 47.0, 593.0 0.78
CC033/GeniUncJ m 28.0 0.0   1   0.0 0.0 28.0, 28.0 -0.52
CC036/UncJ f 128.3 57.29   3 33.077 0.4464 68.0, 182.0 -0.35
CC036/UncJ m 224.0 0.0   1   0.0 0.0 224.0, 224.0 0.35
CC040/TauUncJ m 65.0 0.0   1   0.0 0.0 65.0, 65.0 -0.35
CC041/TauUncJ f 293.5 415.1   2   293.5 1.4142 -0.18
CC041/TauUncJ m 10.0 2.8284   2   2.0 0.2828 8.0, 12.0 -0.6
CC044/UncJ f 12.0 0.0   1   0.0 0.0 12.0, 12.0 -0.47
CC044/UncJ m 73.0 0.0   1   0.0 0.0 73.0, 73.0 -0.32
CC051/TauUncJ m 185.0 0.0   1   0.0 0.0 185.0, 185.0 0.18
CC057/UncJ f 519.0 0.0   1   0.0 0.0 519.0, 519.0 0.06
CC059/TauUncJ f 3950.0 711.3   2   503.0 0.1801 3447.0, 4453.0 3.61
CC059/TauUncJ m 119.5 7.7782   2   5.5 0.0651 114.0, 125.0 -0.11
CC060/UncJ m 90.0 0.0   1   0.0 0.0 90.0, 90.0 -0.24
CC061/GeniUncJ m 322.0 0.0   1   0.0 0.0 322.0, 322.0 0.79
CC078/TauUncJ f 534.0 0.0   1   0.0 0.0 534.0, 534.0 0.07
CC078/TauUncJ m 20.0 0.0   1   0.0 0.0 20.0, 20.0 -0.55
CC079/TauUncJ f 103.0 45.255   2   32.0 0.4394 71.0, 135.0 -0.38
CC084/TauJ f 60.0 0.0   1   0.0 0.0 60.0, 60.0 -0.42
NOD/ShiLtJ f 54.0 64.23   9 21.409 1.1894 -0.43
NOD/ShiLtJ m 31.167 19.753   6 8.064 0.6338 5.0, 53.0 -0.5
NZO/HlLtJ f 28.8 29.813   10 9.4279 1.0352 -0.45
NZO/HlLtJ m 21.9 10.115   10 3.1988 0.4619 7.0, 36.0 -0.54
PWK/PhJ f 74.5 39.889   6 16.284 0.5354 31.0, 131.0 -0.4
PWK/PhJ m 77.83 55.46   6 22.643 0.7126 28.0, 172.0 -0.29
WSB/EiJ f 55.0 55.97   3 32.316 1.0177 6.0, 116.0 -0.43
WSB/EiJ m 49.8 24.773   5 11.079 0.4974 22.0, 77.0 -0.42


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 25.0 57.7808368156 139.3924068948 -89.3924068948
A/J m 17.8571428571 57.7808368156 132.249549752 -96.5352640377
C57BL/6J f 139.2727272727 46.0931623028 230.5262996991 48.0191548464
C57BL/6J m 33.9090909091 46.0931623028 125.1626633355 -57.3444815173
CC004/TauUncJ f 201.5 54.0490237213 308.5042985622 94.4957014378
CC004/TauUncJ m 231.8571428571 40.857221535 312.7447894887 150.9694962256
CC013/GeniUncJ f 441.5 108.0980474426 655.5085971244 227.4914028756
CC013/GeniUncJ m 69.0 108.0980474426 283.0085971244 -145.0085971244
CC018/UncJ f 202.3333333333 88.2616861418 377.0706211746 27.5960454921
CC018/UncJ m 145.6 68.3672081071 280.9509211541 10.2490788459
CC019/TauUncJ f 570.0 76.4368623797 721.3269302589 418.6730697411
CC019/TauUncJ m 128.5 108.0980474426 342.5085971244 -85.5085971244
CC026/GeniUncJ f 18.8 68.3672081071 154.1509211541 -116.5509211541
CC026/GeniUncJ m 22.3333333333 88.2616861418 197.0706211746 -152.4039545079
CC041/TauUncJ f 293.5 108.0980474426 507.5085971244 79.4914028756
CC041/TauUncJ m 10.0 108.0980474426 224.0085971244 -204.0085971244
CC059/TauUncJ f 3950.0 108.0980474426 4164.0085971244 3735.9914028756
CC059/TauUncJ m 119.5 108.0980474426 333.5085971244 -94.5085971244
NOD/ShiLtJ f 54.0 50.9579082531 154.8846201726 -46.8846201726
NOD/ShiLtJ m 31.1666666667 62.4104367898 154.7245878253 -92.391254492
NZO/HlLtJ f 28.8 48.3429164633 124.5075541879 -66.9075541879
NZO/HlLtJ m 21.9 48.3429164633 117.6075541879 -73.8075541879
PWK/PhJ f 74.5 62.4104367898 198.0579211587 -49.0579211587
PWK/PhJ m 77.8333333333 62.4104367898 201.391254492 -45.7245878253
WSB/EiJ f 55.0 88.2616861418 229.7372878412 -119.7372878412
WSB/EiJ m 49.8 68.3672081071 185.1509211541 -85.5509211541


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 21.4285714286 40.857221535 102.3162180601 -59.459075203
C57BL/6J both 86.5909090909 32.5927876306 151.1169289611 22.0648892207
CC004/TauUncJ both 216.6785714286 33.877018452 283.7470649415 149.6100779156
CC013/GeniUncJ both 255.25 76.4368623797 406.5769302589 103.9230697411
CC018/UncJ both 173.9666666667 55.821591667 284.4802310144 63.4531023189
CC019/TauUncJ both 349.25 66.1962646064 480.3029658809 218.1970341191
CC026/GeniUncJ both 20.5666666667 55.821591667 131.0802310144 -89.9468976811
CC041/TauUncJ both 151.75 76.4368623797 303.0769302589 0.4230697411
CC059/TauUncJ both 2034.75 76.4368623797 2186.0769302589 1883.4230697411
NOD/ShiLtJ both 42.5833333333 40.2857637194 122.3396284899 -37.1729618233
NZO/HlLtJ both 25.35 34.1836040536 93.0254605771 -42.3254605771
PWK/PhJ both 76.1666666667 44.1308430709 163.5353105873 -11.2019772539
WSB/EiJ both 52.4 55.821591667 162.9135643477 -58.1135643477




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA