Project measure / variable:   CSNA03   extinction_active_cc_s1

ID, description, units MPD:110400   extinction_active_cc_s1   extinction, active lever presses (intravenous self administration), CC   [n]  session 1  
cocaine study
Data set, strains CSNA03   CC w/par   53 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - extinction, active lever presses (intravenous self administration), CC session 1



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested50 strains51 strains
Mean of the strain means179.6   n 114.5   n
Median of the strain means98.5   n 98.0   n
SD of the strain means± 294.6 ± 124.2
Coefficient of variation (CV)1.6398 1.0853
Min–max range of strain means0.0   –   1888.0   n 0.0   –   818.0   n
Mean sample size per strain3.2   mice 3.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 317481.673 317481.673 3.1619 0.0767
strain 34 11714994.1108 344558.6503 3.4315 < 0.0001
sex:strain 34 2915127.2444 85739.0366 0.8539 0.7017
Residuals 224 22491797.4888 100409.8102


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 55.44 34.431   9 11.477 0.621 7.0, 99.0 -0.42
A/J m 67.86 44.592   7 16.854 0.6572 20.0, 155.0 -0.38
C57BL/6J f 198.2 114.6   12 33.082 0.578 8.0, 476.0 0.06
C57BL/6J m 105.3 58.97   12 17.022 0.5598 18.0, 208.0 -0.07
CAST/EiJ f 108.0 0.0   1   0.0 0.0 108.0, 108.0 -0.24
CAST/EiJ m 79.0 9.8995   2   7.0 0.1253 72.0, 86.0 -0.29
CC001/UncJ f 52.67 38.527   3 22.244 0.7315 15.0, 92.0 -0.43
CC001/UncJ m 216.2 225.3   4 112.6 1.0418 10.0, 527.0 0.82
CC002/UncJ f 1888.0 2661.0   3 1536.0 1.4092 32.0, 4937.0 5.8
CC002/UncJ m 818.0 879.6   2   622.0 1.0754 196.0, 1440.0 5.66
CC003/UncJ f 33.0 7.0711   2   5.0 0.2143 28.0, 38.0 -0.5
CC003/UncJ m 35.0 23.152   4 11.576 0.6615 17.0, 69.0 -0.64
CC004/TauUncJ f 120.9 128.2   9 42.745 1.0608 12.0, 358.0 -0.2
CC004/TauUncJ m 293.8 199.1   19 45.683 0.6778 75.0, 785.0 1.44
CC005/TauUncJ f 57.75 35.697   4 17.848 0.6181 19.0, 91.0 -0.41
CC005/TauUncJ m 17.0 8.4853   2   6.0 0.4991 11.0, 23.0 -0.78
CC006/TauUncJ f 172.0 14.142   2   10.0 0.0822 162.0, 182.0 -0.03
CC006/TauUncJ m 283.0 400.2   2   283.0 1.4142 1.36
CC007/UncJ f 303.0 0.0   1   0.0 0.0 303.0, 303.0 0.42
CC007/UncJ m 108.0 139.9   3 80.75 1.2951 -0.05
CC008/GeniUncJ f 6.5 0.70711   2   0.5 0.1088 6.0, 7.0 -0.59
CC008/GeniUncJ m 49.0 12.728   2   9.0 0.2598 40.0, 58.0 -0.53
CC009/UncJ f 96.0 101.8   3 58.77 1.0604 7.0, 207.0 -0.28
CC009/UncJ m 33.667 53.2   3 30.716 1.5802 -0.65
CC011/UncJ f 245.0 181.9   3 105.0 0.7423 80.0, 440.0 0.22
CC011/UncJ m 64.67 70.61   3 40.769 1.092 19.0, 146.0 -0.4
CC012/GeniUncJ f 174.0 0.0   1   0.0 0.0 174.0, 174.0 -0.02
CC012/GeniUncJ m 91.33 18.148   3 10.477 0.1987 78.0, 112.0 -0.19
CC013/GeniUncJ f 163.3 116.7   3 67.36 0.7143 32.0, 255.0 -0.06
CC013/GeniUncJ m 89.33 59.48   3 34.338 0.6658 54.0, 158.0 -0.2
CC015/UncJ f 41.5 51.62   2   36.5 1.2438 5.0, 78.0 -0.47
CC015/UncJ m 80.0 0.0   1   0.0 0.0 80.0, 80.0 -0.28
CC016/GeniUncJ f 671.0 930.6   2   658.0 1.3868 13.0, 1329.0 1.67
CC016/GeniUncJ m 126.0 171.1   2   121.0 1.3581 5.0, 247.0 0.09
CC017/UncJ f 52.67 49.571   3 28.62 0.9412 8.0, 106.0 -0.43
CC017/UncJ m 10.25 9.6393   4 4.8197 0.9404 -0.84
CC018/UncJ f 211.0 159.9   3 92.32 0.7578 34.0, 345.0 0.11
CC018/UncJ m 142.0 109.7   5 49.043 0.7723 69.0, 333.0 0.22
CC019/TauUncJ f 256.5 300.7   4 150.3 1.1721 29.0, 696.0 0.26
CC019/TauUncJ m 37.0 29.816   3 17.214 0.8058 5.0, 64.0 -0.62
CC020/GeniUncJ f 272.0 0.0   1   0.0 0.0 272.0, 272.0 0.31
CC023/GeniUncJ f 49.0 41.761   3 24.111 0.8523 1.0, 77.0 -0.44
CC023/GeniUncJ m 104.7 136.5   3 78.82 1.3043 9.0, 261.0 -0.08
CC024/GeniUncJ f 57.0 80.61   2   57.0 1.4142 -0.42
CC024/GeniUncJ m 24.0 33.941   2   24.0 1.4142 -0.73
CC025/GeniUncJ f 37.0 35.355   2   25.0 0.9555 12.0, 62.0 -0.48
CC025/GeniUncJ m 145.0 0.0   1   0.0 0.0 145.0, 145.0 0.25
CC026/GeniUncJ f 45.0 18.802   5 8.4083 0.4178 23.0, 74.0 -0.46
CC026/GeniUncJ m 57.0 13.077   3 7.5498 0.2294 48.0, 72.0 -0.46
CC027/GeniUncJ f 420.0 588.4   4 294.2 1.401 35.0, 1281.0 0.82
CC027/GeniUncJ m 102.5 138.2   4 69.11 1.3486 11.0, 308.0 -0.1
CC028/GeniUncJ f 151.5 77.26   4 38.632 0.51 76.0, 255.0 -0.1
CC028/GeniUncJ m 103.0 87.74   4 43.869 0.8518 41.0, 232.0 -0.09
CC029/UncJ f 4.0 0.0   1   0.0 0.0 4.0, 4.0 -0.6
CC029/UncJ m 17.0 0.0   1   0.0 0.0 17.0, 17.0 -0.78
CC030/GeniUncJ f 162.0 0.0   1   0.0 0.0 162.0, 162.0 -0.06
CC030/GeniUncJ m 142.5 0.70711   2   0.5 0.005 142.0, 143.0 0.23
CC032/GeniUncJ f 101.0 79.2   2   56.0 0.7841 45.0, 157.0 -0.27
CC032/GeniUncJ m 181.0 204.1   4 102.0 1.1276 28.0, 465.0 0.54
CC033/GeniUncJ f 36.0 0.0   1   0.0 0.0 36.0, 36.0 -0.49
CC033/GeniUncJ m 86.0 0.0   1   0.0 0.0 86.0, 86.0 -0.23
CC035/UncJ f 52.33 27.465   3 15.857 0.5248 35.0, 84.0 -0.43
CC035/UncJ m 124.0 87.68   2   62.0 0.7071 62.0, 186.0 0.08
CC036/UncJ f 181.7 89.28   3 51.54 0.4914 111.0, 282.0 0.01
CC036/UncJ m 115.5 58.69   2   41.5 0.5081 74.0, 157.0 0.01
CC037/TauUncJ f 8.0 0.0   1   0.0 0.0 8.0, 8.0 -0.58
CC037/TauUncJ m 0.0 0.0   1   0.0 None -0.92
CC040/TauUncJ f 52.0 57.98   2   41.0 1.1151 11.0, 93.0 -0.43
CC040/TauUncJ m 34.0 0.0   1   0.0 0.0 34.0, 34.0 -0.65
CC041/TauUncJ f 30.667 53.12   3 30.667 1.7321 -0.51
CC041/TauUncJ m 4.3333 8.4781   12 2.4474 1.9565 -0.89
CC043/GeniUncJ m 101.0 0.0   1   0.0 0.0 101.0, 101.0 -0.11
CC044/UncJ f 0.0 0.0   1   0.0 None -0.61
CC044/UncJ m 10.0 0.0   1   0.0 0.0 10.0, 10.0 -0.84
CC051/TauUncJ f 108.0 11.314   2   8.0 0.1048 100.0, 116.0 -0.24
CC051/TauUncJ m 80.33 71.68   3 41.382 0.8922 15.0, 157.0 -0.27
CC057/UncJ f 67.5 64.35   2   45.5 0.9533 22.0, 113.0 -0.38
CC057/UncJ m 61.0 25.456   2   18.0 0.4173 43.0, 79.0 -0.43
CC059/TauUncJ f 845.2 939.5   4 469.7 1.1115 50.0, 2103.0 2.26
CC059/TauUncJ m 182.7 123.2   3 71.13 0.6745 77.0, 318.0 0.55
CC060/UncJ m 109.0 0.0   1   0.0 0.0 109.0, 109.0 -0.04
CC061/GeniUncJ f 274.5 255.3   2   180.5 0.9299 94.0, 455.0 0.32
CC061/GeniUncJ m 301.5 217.1   2   153.5 0.72 148.0, 455.0 1.51
CC068/TauUncJ f 0.33333 0.57735   3 0.33333 1.7321 -0.61
CC068/TauUncJ m 0.0 0.0   2   0.0 None -0.92
CC074/UncJ m 181.0 0.0   1   0.0 0.0 181.0, 181.0 0.54
CC078/TauUncJ f 298.0 63.64   2   45.0 0.2136 253.0, 343.0 0.4
CC078/TauUncJ m 194.7 40.216   3 23.219 0.2066 150.0, 228.0 0.65
CC079/TauUncJ f 89.0 0.0   1   0.0 0.0 89.0, 89.0 -0.31
CC079/TauUncJ m 98.0 4.2426   2   3.0 0.0433 95.0, 101.0 -0.13
CC080/TauUncJ f 9.5 4.9497   2   3.5 0.521 6.0, 13.0 -0.58
CC084/TauJ f 323.0 0.0   1   0.0 0.0 323.0, 323.0 0.49
CC084/TauJ m 150.0 0.0   1   0.0 0.0 150.0, 150.0 0.29
NOD/ShiLtJ f 126.3 205.2   10 64.9 1.625 9.0, 700.0 -0.18
NOD/ShiLtJ m 144.8 162.4   6 66.3 1.1213 4.0, 459.0 0.24
NZO/HlLtJ f 72.6 56.85   10 17.977 0.783 4.0, 170.0 -0.36
NZO/HlLtJ m 50.89 33.714   9 11.238 0.6625 16.0, 118.0 -0.51
PWK/PhJ f 142.5 81.12   6 33.117 0.5693 52.0, 237.0 -0.13
PWK/PhJ m 149.9 63.68   7 24.068 0.4249 70.0, 229.0 0.29
WSB/EiJ f 59.5 17.678   2   12.5 0.2971 47.0, 72.0 -0.41
WSB/EiJ m 35.4 26.754   5 11.965 0.7558 8.0, 78.0 -0.64


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 55.4444444444 105.6250234546 263.5902734308 -152.7013845419
A/J m 67.8571428571 119.7675189798 303.8723285428 -168.1580428285
C57BL/6J f 198.25 91.473953587 378.5095755939 17.9904244061
C57BL/6J m 105.3333333333 91.473953587 285.5929089273 -74.9262422606
CC001/UncJ f 52.6666666667 182.947907174 413.1858178545 -307.8524845212
CC001/UncJ m 216.25 158.4375351819 528.4687434795 -95.9687434795
CC002/UncJ f 1888.3333333333 182.947907174 2248.8524845212 1527.8141821454
CC002/UncJ m 818.0 224.0645110432 1259.5439814558 376.4560185442
CC003/UncJ f 33.0 224.0645110432 474.5439814558 -408.5439814558
CC003/UncJ m 35.0 158.4375351819 347.2187434795 -277.2187434795
CC004/TauUncJ f 120.8888888889 105.6250234546 329.0347178752 -87.2569400974
CC004/TauUncJ m 293.7894736842 72.6961268128 437.0452580112 150.5336893572
CC005/TauUncJ f 57.75 158.4375351819 369.9687434795 -254.4687434795
CC005/TauUncJ m 17.0 224.0645110432 458.5439814558 -424.5439814558
CC006/TauUncJ f 172.0 224.0645110432 613.5439814558 -269.5439814558
CC006/TauUncJ m 283.0 224.0645110432 724.5439814558 -158.5439814558
CC008/GeniUncJ f 6.5 224.0645110432 448.0439814558 -435.0439814558
CC008/GeniUncJ m 49.0 224.0645110432 490.5439814558 -392.5439814558
CC009/UncJ f 96.0 182.947907174 456.5191511879 -264.5191511879
CC009/UncJ m 33.6666666667 182.947907174 394.1858178545 -326.8524845212
CC011/UncJ f 245.0 182.947907174 605.5191511879 -115.5191511879
CC011/UncJ m 64.6666666667 182.947907174 425.1858178545 -295.8524845212
CC013/GeniUncJ f 163.3333333333 182.947907174 523.8524845212 -197.1858178545
CC013/GeniUncJ m 89.3333333333 182.947907174 449.8524845212 -271.1858178545
CC016/GeniUncJ f 671.0 224.0645110432 1112.5439814558 229.4560185442
CC016/GeniUncJ m 126.0 224.0645110432 567.5439814558 -315.5439814558
CC017/UncJ f 52.6666666667 182.947907174 413.1858178545 -307.8524845212
CC017/UncJ m 10.25 158.4375351819 322.4687434795 -301.9687434795
CC018/UncJ f 211.0 182.947907174 571.5191511879 -149.5191511879
CC018/UncJ m 142.0 141.7108395417 421.2569337079 -137.2569337079
CC019/TauUncJ f 256.5 158.4375351819 568.7187434795 -55.7187434795
CC019/TauUncJ m 37.0 182.947907174 397.5191511879 -323.5191511879
CC023/GeniUncJ f 49.0 182.947907174 409.5191511879 -311.5191511879
CC023/GeniUncJ m 104.6666666667 182.947907174 465.1858178545 -255.8524845212
CC024/GeniUncJ f 57.0 224.0645110432 498.5439814558 -384.5439814558
CC024/GeniUncJ m 24.0 224.0645110432 465.5439814558 -417.5439814558
CC026/GeniUncJ f 45.0 141.7108395417 324.2569337079 -234.2569337079
CC026/GeniUncJ m 57.0 182.947907174 417.5191511879 -303.5191511879
CC027/GeniUncJ f 420.0 158.4375351819 732.2187434795 107.7812565205
CC027/GeniUncJ m 102.5 158.4375351819 414.7187434795 -209.7187434795
CC028/GeniUncJ f 151.5 158.4375351819 463.7187434795 -160.7187434795
CC028/GeniUncJ m 103.0 158.4375351819 415.2187434795 -209.2187434795
CC032/GeniUncJ f 101.0 224.0645110432 542.5439814558 -340.5439814558
CC032/GeniUncJ m 181.0 158.4375351819 493.2187434795 -131.2187434795
CC035/UncJ f 52.3333333333 182.947907174 412.8524845212 -308.1858178545
CC035/UncJ m 124.0 224.0645110432 565.5439814558 -317.5439814558
CC036/UncJ f 181.6666666667 182.947907174 542.1858178545 -178.8524845212
CC036/UncJ m 115.5 224.0645110432 557.0439814558 -326.0439814558
CC041/TauUncJ f 30.6666666667 182.947907174 391.1858178545 -329.8524845212
CC041/TauUncJ m 4.3333333333 91.473953587 184.5929089273 -175.9262422606
CC051/TauUncJ f 108.0 224.0645110432 549.5439814558 -333.5439814558
CC051/TauUncJ m 80.3333333333 182.947907174 440.8524845212 -280.1858178545
CC057/UncJ f 67.5 224.0645110432 509.0439814558 -374.0439814558
CC057/UncJ m 61.0 224.0645110432 502.5439814558 -380.5439814558
CC059/TauUncJ f 845.25 158.4375351819 1157.4687434795 533.0312565205
CC059/TauUncJ m 182.6666666667 182.947907174 543.1858178545 -177.8524845212
CC061/GeniUncJ f 274.5 224.0645110432 716.0439814558 -167.0439814558
CC061/GeniUncJ m 301.5 224.0645110432 743.0439814558 -140.0439814558
CC068/TauUncJ f 0.3333333333 182.947907174 360.8524845212 -360.1858178545
CC068/TauUncJ m 0.0 224.0645110432 441.5439814558 -441.5439814558
CC078/TauUncJ f 298.0 224.0645110432 739.5439814558 -143.5439814558
CC078/TauUncJ m 194.6666666667 182.947907174 555.1858178545 -165.8524845212
NOD/ShiLtJ f 126.3 100.2046956076 323.7644715182 -71.1644715182
NOD/ShiLtJ m 144.8333333333 129.3637057666 399.7588698859 -110.0922032192
NZO/HlLtJ f 72.6 100.2046956076 270.0644715182 -124.8644715182
NZO/HlLtJ m 50.8888888889 105.6250234546 259.0347178752 -157.2569400974
PWK/PhJ f 142.5 129.3637057666 397.4255365526 -112.4255365526
PWK/PhJ m 149.8571428571 119.7675189798 385.8723285428 -86.1580428285
WSB/EiJ f 59.5 224.0645110432 501.0439814558 -382.0439814558
WSB/EiJ m 35.4 141.7108395417 314.6569337079 -243.8569337079


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 61.6507936508 79.8450126532 218.9942507746 -95.692663473
C57BL/6J both 151.7916666667 64.6818528833 279.2544349429 24.3288983904
CC001/UncJ both 134.4583333333 121.0086663156 372.9193375631 -104.0026708965
CC002/UncJ both 1353.1666666666 144.6330199577 1638.1820811327 1068.1512522006
CC003/UncJ both 34.0 137.2109303805 304.3893633909 -236.3893633909
CC004/TauUncJ both 207.3391812865 64.1119576081 333.6789076868 80.9994548863
CC005/TauUncJ both 37.375 137.2109303805 307.7643633909 -233.0143633909
CC006/TauUncJ both 227.5 158.4375351819 539.7187434795 -84.7187434795
CC008/GeniUncJ both 27.75 158.4375351819 339.9687434795 -284.4687434795
CC009/UncJ both 64.8333333333 129.3637057666 319.7588698859 -190.0922032192
CC011/UncJ both 154.8333333333 129.3637057666 409.7588698859 -100.0922032192
CC013/GeniUncJ both 126.3333333333 129.3637057666 381.2588698859 -128.5922032192
CC016/GeniUncJ both 398.5 158.4375351819 710.7187434795 86.2812565205
CC017/UncJ both 31.4583333333 121.0086663156 269.9193375631 -207.0026708965
CC018/UncJ both 176.5 115.7064159662 404.5123315729 -51.5123315729
CC019/TauUncJ both 146.75 121.0086663156 385.2110042298 -91.7110042298
CC023/GeniUncJ both 76.8333333333 129.3637057666 331.7588698859 -178.0922032192
CC024/GeniUncJ both 40.5 158.4375351819 352.7187434795 -271.7187434795
CC026/GeniUncJ both 51.0 115.7064159662 279.0123315729 -177.0123315729
CC027/GeniUncJ both 261.25 112.0322555216 482.0219907279 40.4780092721
CC028/GeniUncJ both 127.25 112.0322555216 348.0219907279 -93.5219907279
CC032/GeniUncJ both 141.0 137.2109303805 411.3893633909 -129.3893633909
CC035/UncJ both 88.1666666667 144.6330199577 373.1820811327 -196.8487477994
CC036/UncJ both 148.5833333333 144.6330199577 433.5987477994 -136.4320811327
CC041/TauUncJ both 17.5 102.2709891956 219.0363323117 -184.0363323117
CC051/TauUncJ both 94.1666666667 144.6330199577 379.1820811327 -190.8487477994
CC057/UncJ both 64.25 158.4375351819 376.4687434795 -247.9687434795
CC059/TauUncJ both 513.9583333333 121.0086663156 752.4193375631 275.4973291035
CC061/GeniUncJ both 288.0 158.4375351819 600.2187434795 -24.2187434795
CC068/TauUncJ both 0.1666666667 144.6330199577 285.1820811327 -284.8487477994
CC078/TauUncJ both 246.3333333333 144.6330199577 531.3487477994 -38.6820811327
NOD/ShiLtJ both 135.5666666667 81.8167913565 296.795732516 -25.6623991827
NZO/HlLtJ both 61.7444444444 72.7970236369 205.199057159 -81.7101682701
PWK/PhJ both 146.1785714286 88.1465072653 319.8810448284 -27.5239019712
WSB/EiJ both 47.45 132.5583523893 308.670942204 -213.770942204




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA