Project measure / variable:   CSNA03   infusions_cc_1p0_2nd

ID, description, units MPD:110399   infusions_cc_1p0_2nd   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, CC   [n]  1.0 (2nd) mg/kg  
cocaine study
Data set, strains CSNA03   CC w/par   51 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, CC 1.0 (2nd) mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested48 strains44 strains
Mean of the strain means33.864   n 34.151   n
Median of the strain means27.125   n 31.491   n
SD of the strain means± 21.002 ± 20.973
Coefficient of variation (CV)0.6202 0.6141
Min–max range of strain means0.0   –   89.83   n 0.0   –   87.15   n
Mean sample size per strain2.4   mice 3.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 39.8322 39.8322 0.0542 0.8163
strain 32 60807.6489 1900.239 2.5835 < 0.0001
sex:strain 32 13645.0997 426.4094 0.5797 0.9628
Residuals 132 97091.1329 735.5389


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 21.85 7.566   2   5.35 0.3463 16.5, 27.2 -0.57
C57BL/6J f 42.25 2.4749   2   1.75 0.0586 40.5, 44.0 0.4
C57BL/6J m 23.25 0.35355   2   0.25 0.0152 23.0, 23.5 -0.52
CC001/UncJ f 89.0 41.328   3 23.861 0.4644 51.0, 133.0 2.63
CC001/UncJ m 87.15 49.342   4 24.671 0.5662 54.0, 159.5 2.53
CC002/UncJ f 72.0 52.05   3 30.05 0.7229 39.0, 132.0 1.82
CC002/UncJ m 66.0 58.69   2   41.5 0.8892 24.5, 107.5 1.52
CC003/UncJ f 12.25 1.7678   2   1.25 0.1443 11.0, 13.5 -1.03
CC003/UncJ m 18.4 12.359   4 6.1794 0.6717 8.6, 36.5 -0.75
CC004/TauUncJ f 28.5 12.728   2   9.0 0.4466 19.5, 37.5 -0.26
CC004/TauUncJ m 43.036 36.521   14 9.7607 0.8486 4.0, 159.5 0.42
CC005/TauUncJ f 42.125 36.1   4 18.05 0.857 14.5, 95.0 0.39
CC005/TauUncJ m 48.91 8.3434   3 4.8171 0.1706 39.4, 55.0 0.7
CC006/TauUncJ f 46.75 3.8891   2   2.75 0.0832 44.0, 49.5 0.61
CC006/TauUncJ m 50.75 71.77   2   50.75 1.4142 0.79
CC007/UncJ f 43.25 18.738   2   13.25 0.4333 30.0, 56.5 0.45
CC007/UncJ m 33.233 31.741   3 18.325 0.9551 0.2, 63.5 -0.04
CC008/GeniUncJ f 8.3 4.9497   2   3.5 0.5964 4.8, 11.8 -1.22
CC008/GeniUncJ m 18.0 3.5355   2   2.5 0.1964 15.5, 20.5 -0.77
CC009/UncJ f 18.833 11.184   3 6.4571 0.5938 6.0, 26.5 -0.72
CC009/UncJ m 8.3333 10.774   3 6.2205 1.2929 -1.23
CC011/UncJ f 44.65 20.591   5 9.2086 0.4612 16.0, 73.5 0.51
CC011/UncJ m 58.95 61.31   4 30.654 1.04 16.5, 150.0 1.18
CC012/GeniUncJ f 41.0 0.0   1   0.0 0.0 41.0, 41.0 0.34
CC012/GeniUncJ m 21.333 16.003   3 9.2391 0.7501 3.0, 32.5 -0.61
CC013/GeniUncJ f 46.333 18.278   3 10.553 0.3945 26.5, 62.5 0.59
CC013/GeniUncJ m 29.667 20.226   3 11.677 0.6818 14.0, 52.5 -0.21
CC015/UncJ f 36.45 48.154   2   34.05 1.3211 2.4, 70.5 0.12
CC015/UncJ m 33.5 0.0   1   0.0 0.0 33.5, 33.5 -0.03
CC016/GeniUncJ f 60.75 56.21   2   39.75 0.9253 21.0, 100.5 1.28
CC016/GeniUncJ m 35.6 12.162   2   8.6 0.3416 27.0, 44.2 0.07
CC017/UncJ f 19.667 9.5699   3 5.5252 0.4866 9.5, 28.5 -0.68
CC017/UncJ m 13.875 11.665   4 5.8323 0.8407 3.5, 29.0 -0.97
CC018/UncJ f 89.83 68.42   3 39.502 0.7616 12.5, 142.5 2.66
CC018/UncJ m 34.8 15.23   5 6.811 0.4376 12.5, 52.5 0.03
CC019/TauUncJ f 42.2 12.317   5 5.5082 0.2919 28.0, 61.0 0.4
CC019/TauUncJ m 38.167 19.502   3 11.26 0.511 24.5, 60.5 0.19
CC020/GeniUncJ f 56.5 0.0   1   0.0 0.0 56.5, 56.5 1.08
CC023/GeniUncJ f 17.25 11.701   4 5.8506 0.6783 -0.79
CC023/GeniUncJ m 52.83 41.756   3 24.108 0.7903 19.0, 99.5 0.89
CC024/GeniUncJ f 22.8 32.244   2   22.8 1.4142 -0.53
CC024/GeniUncJ m 4.2 5.9397   2   4.2 1.4142 -1.43
CC025/GeniUncJ f 22.6 17.536   2   12.4 0.7759 10.2, 35.0 -0.54
CC025/GeniUncJ m 43.2 0.0   1   0.0 0.0 43.2, 43.2 0.43
CC027/GeniUncJ f 25.75 11.92   4 5.9599 0.4629 11.0, 39.0 -0.39
CC027/GeniUncJ m 39.96 19.44   5 8.6941 0.4865 23.0, 66.0 0.28
CC028/GeniUncJ f 36.875 22.425   4 11.213 0.6081 25.0, 70.5 0.14
CC028/GeniUncJ m 28.0 10.943   5 4.8939 0.3908 18.0, 43.5 -0.29
CC029/UncJ f 4.0 0.0   1   0.0 0.0 4.0, 4.0 -1.42
CC029/UncJ m 17.5 0.0   1   0.0 0.0 17.5, 17.5 -0.79
CC030/GeniUncJ f 25.5 9.8995   2   7.0 0.3882 18.5, 32.5 -0.4
CC030/GeniUncJ m 29.5 8.4853   2   6.0 0.2876 23.5, 35.5 -0.22
CC032/GeniUncJ f 39.333 15.695   3 9.0615 0.399 27.0, 57.0 0.26
CC032/GeniUncJ m 29.75 25.174   4 12.587 0.8462 11.5, 67.0 -0.21
CC033/GeniUncJ f 23.5 0.0   1   0.0 0.0 23.5, 23.5 -0.49
CC033/GeniUncJ m 45.65 22.84   2   16.15 0.5003 29.5, 61.8 0.55
CC035/UncJ f 24.333 10.128   3 5.8476 0.4162 13.0, 32.5 -0.45
CC035/UncJ m 28.55 5.7276   2   4.05 0.2006 24.5, 32.6 -0.27
CC036/UncJ f 25.833 3.2146   3 1.8559 0.1244 23.5, 29.5 -0.38
CC036/UncJ m 13.75 3.182   2   2.25 0.2314 11.5, 16.0 -0.97
CC037/TauUncJ f 6.5 0.0   1   0.0 0.0 6.5, 6.5 -1.3
CC037/TauUncJ m 0.0 0.0   1   0.0 None -1.63
CC040/TauUncJ f 23.75 18.031   2   12.75 0.7592 11.0, 36.5 -0.48
CC040/TauUncJ m 52.75 10.253   2   7.25 0.1944 45.5, 60.0 0.89
CC041/TauUncJ m 3.4182 9.1234   11 2.7508 2.6691 -1.47
CC043/GeniUncJ m 21.0 0.0   1   0.0 0.0 21.0, 21.0 -0.63
CC044/UncJ f 8.0 11.314   2   8.0 1.4142 -1.23
CC044/UncJ m 10.5 0.70711   2   0.5 0.0673 10.0, 11.0 -1.13
CC051/TauUncJ f 26.25 6.0104   2   4.25 0.229 22.0, 30.5 -0.36
CC051/TauUncJ m 24.5 4.3589   3 2.5166 0.1779 21.5, 29.5 -0.46
CC057/UncJ f 18.0 7.7782   2   5.5 0.4321 12.5, 23.5 -0.76
CC057/UncJ m 16.75 6.7175   2   4.75 0.401 12.0, 21.5 -0.83
CC059/TauUncJ f 42.3 11.761   4 5.8806 0.278 28.5, 54.5 0.4
CC059/TauUncJ m 41.0 7.3655   3 4.2525 0.1796 32.5, 45.5 0.33
CC060/UncJ m 49.5 0.0   1   0.0 0.0 49.5, 49.5 0.73
CC061/GeniUncJ f 28.0 6.364   2   4.5 0.2273 23.5, 32.5 -0.28
CC061/GeniUncJ m 49.0 9.8995   2   7.0 0.202 42.0, 56.0 0.71
CC068/TauUncJ f 0.0 0.0   3 0.0 None -1.61
CC068/TauUncJ m 0.1 0.14142   2   0.1 1.4142 -1.62
CC074/UncJ f 8.5 0.0   1   0.0 0.0 8.5, 8.5 -1.21
CC074/UncJ m 81.2 0.0   1   0.0 0.0 81.2, 81.2 2.24
CC075/UncJ f 25.4 0.0   1   0.0 0.0 25.4, 25.4 -0.4
CC078/TauUncJ f 66.75 32.88   2   23.25 0.4926 43.5, 90.0 1.57
CC078/TauUncJ m 53.83 37.538   3 21.672 0.6973 21.5, 95.0 0.94
CC079/TauUncJ f 42.0 16.971   2   12.0 0.4041 30.0, 54.0 0.39
CC079/TauUncJ m 26.75 10.253   2   7.25 0.3833 19.5, 34.0 -0.35
CC080/TauUncJ f 63.6 44.689   2   31.6 0.7027 32.0, 95.2 1.42
CC084/TauJ f 43.9 9.7581   2   6.9 0.2223 37.0, 50.8 0.48
CC084/TauJ m 76.5 0.0   1   0.0 0.0 76.5, 76.5 2.02
NOD/ShiLtJ f 11.0 0.0   1   0.0 0.0 11.0, 11.0 -1.09
PWK/PhJ f 62.5 0.0   1   0.0 0.0 62.5, 62.5 1.36
WSB/EiJ f 18.75 7.4246   2   5.25 0.396 13.5, 24.0 -0.72


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C57BL/6J f 42.25 19.1773158403 80.1846262549 4.3153737451
C57BL/6J m 23.25 19.1773158403 61.1846262549 -14.6846262549
CC001/UncJ f 89.0 15.658212815 119.9734926359 58.0265073641
CC001/UncJ m 87.15 13.5604100756 113.9738314666 60.3261685334
CC002/UncJ f 72.0 15.658212815 102.9734926359 41.0265073641
CC002/UncJ m 66.0 19.1773158403 103.9346262549 28.0653737451
CC003/UncJ f 12.25 19.1773158403 50.1846262549 -25.6846262549
CC003/UncJ m 18.4 13.5604100756 45.2238314666 -8.4238314666
CC004/TauUncJ f 28.5 19.1773158403 66.4346262549 -9.4346262549
CC004/TauUncJ m 43.0357142857 7.2483440753 57.373655307 28.6977732645
CC005/TauUncJ f 42.125 13.5604100756 68.9488314666 15.3011685334
CC005/TauUncJ m 48.91 15.658212815 79.8834926359 17.9365073641
CC006/TauUncJ f 46.75 19.1773158403 84.6846262549 8.8153737451
CC006/TauUncJ m 50.75 19.1773158403 88.6846262549 12.8153737451
CC007/UncJ f 43.25 19.1773158403 81.1846262549 5.3153737451
CC007/UncJ m 33.2333333333 15.658212815 64.2068259693 2.2598406974
CC008/GeniUncJ f 8.3 19.1773158403 46.2346262549 -29.6346262549
CC008/GeniUncJ m 18.0 19.1773158403 55.9346262549 -19.9346262549
CC009/UncJ f 18.8333333333 15.658212815 49.8068259693 -12.1401593026
CC009/UncJ m 8.3333333333 15.658212815 39.3068259693 -22.6401593026
CC011/UncJ f 44.65 12.1287994928 68.6419642306 20.6580357694
CC011/UncJ m 58.95 13.5604100756 85.7738314666 32.1261685334
CC013/GeniUncJ f 46.3333333333 15.658212815 77.3068259693 15.3598406974
CC013/GeniUncJ m 29.6666666667 15.658212815 60.6401593026 -1.3068259693
CC016/GeniUncJ f 60.75 19.1773158403 98.6846262549 22.8153737451
CC016/GeniUncJ m 35.6 19.1773158403 73.5346262549 -2.3346262549
CC017/UncJ f 19.6666666667 15.658212815 50.6401593026 -11.3068259693
CC017/UncJ m 13.875 13.5604100756 40.6988314666 -12.9488314666
CC018/UncJ f 89.8333333333 15.658212815 120.8068259693 58.8598406974
CC018/UncJ m 34.8 12.1287994928 58.7919642306 10.8080357694
CC019/TauUncJ f 42.2 12.1287994928 66.1919642306 18.2080357694
CC019/TauUncJ m 38.1666666667 15.658212815 69.1401593026 7.1931740307
CC023/GeniUncJ f 17.25 13.5604100756 44.0738314666 -9.5738314666
CC023/GeniUncJ m 52.8333333333 15.658212815 83.8068259693 21.8598406974
CC024/GeniUncJ f 22.8 19.1773158403 60.7346262549 -15.1346262549
CC024/GeniUncJ m 4.2 19.1773158403 42.1346262549 -33.7346262549
CC027/GeniUncJ f 25.75 13.5604100756 52.5738314666 -1.0738314666
CC027/GeniUncJ m 39.96 12.1287994928 63.9519642306 15.9680357694
CC028/GeniUncJ f 36.875 13.5604100756 63.6988314666 10.0511685334
CC028/GeniUncJ m 28.0 12.1287994928 51.9919642306 4.0080357694
CC030/GeniUncJ f 25.5 19.1773158403 63.4346262549 -12.4346262549
CC030/GeniUncJ m 29.5 19.1773158403 67.4346262549 -8.4346262549
CC032/GeniUncJ f 39.3333333333 15.658212815 70.3068259693 8.3598406974
CC032/GeniUncJ m 29.75 13.5604100756 56.5738314666 2.9261685334
CC035/UncJ f 24.3333333333 15.658212815 55.3068259693 -6.6401593026
CC035/UncJ m 28.55 19.1773158403 66.4846262549 -9.3846262549
CC036/UncJ f 25.8333333333 15.658212815 56.8068259693 -5.1401593026
CC036/UncJ m 13.75 19.1773158403 51.6846262549 -24.1846262549
CC040/TauUncJ f 23.75 19.1773158403 61.6846262549 -14.1846262549
CC040/TauUncJ m 52.75 19.1773158403 90.6846262549 14.8153737451
CC044/UncJ f 8.0 19.1773158403 45.9346262549 -29.9346262549
CC044/UncJ m 10.5 19.1773158403 48.4346262549 -27.4346262549
CC051/TauUncJ f 26.25 19.1773158403 64.1846262549 -11.6846262549
CC051/TauUncJ m 24.5 15.658212815 55.4734926359 -6.4734926359
CC057/UncJ f 18.0 19.1773158403 55.9346262549 -19.9346262549
CC057/UncJ m 16.75 19.1773158403 54.6846262549 -21.1846262549
CC059/TauUncJ f 42.3 13.5604100756 69.1238314666 15.4761685334
CC059/TauUncJ m 41.0 15.658212815 71.9734926359 10.0265073641
CC061/GeniUncJ f 28.0 19.1773158403 65.9346262549 -9.9346262549
CC061/GeniUncJ m 49.0 19.1773158403 86.9346262549 11.0653737451
CC068/TauUncJ f 0.0 15.658212815 30.9734926359 -30.9734926359
CC068/TauUncJ m 0.1 19.1773158403 38.0346262549 -37.8346262549
CC078/TauUncJ f 66.75 19.1773158403 104.6846262549 28.8153737451
CC078/TauUncJ m 53.8333333333 15.658212815 84.8068259693 22.8598406974
CC079/TauUncJ f 42.0 19.1773158403 79.9346262549 4.0653737451
CC079/TauUncJ m 26.75 19.1773158403 64.6846262549 -11.1846262549


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
C57BL/6J both 32.75 13.5604100756 59.5738314666 5.9261685334
CC001/UncJ both 88.075 10.356934271 108.5620396874 67.5879603126
CC002/UncJ both 69.0 12.3789041457 93.486695955 44.513304045
CC003/UncJ both 15.325 11.7436596112 38.5551194769 -7.9051194769
CC004/TauUncJ both 35.7678571429 10.2507064961 56.0447677916 15.4909464941
CC005/TauUncJ both 45.5175 10.356934271 66.0045396874 25.0304603126
CC006/TauUncJ both 48.75 13.5604100756 75.5738314666 21.9261685334
CC007/UncJ both 38.2416666667 12.3789041457 62.7283626217 13.7549707117
CC008/GeniUncJ both 13.15 13.5604100756 39.9738314666 -13.6738314666
CC009/UncJ both 13.5833333333 11.0720284627 35.4849000132 -8.3182333466
CC011/UncJ both 51.8 9.0965996196 69.7939731729 33.8060268271
CC013/GeniUncJ both 38.0 11.0720284627 59.9015666799 16.0984333201
CC016/GeniUncJ both 48.175 13.5604100756 74.9988314666 21.3511685334
CC017/UncJ both 16.7708333333 10.356934271 37.2578730208 -3.7162063541
CC018/UncJ both 62.3166666667 9.9031233166 81.9060234307 42.7273099027
CC019/TauUncJ both 40.1833333333 9.9031233166 59.7726900973 20.5939765693
CC023/GeniUncJ both 35.0416666667 10.356934271 55.5287063541 14.5546269792
CC024/GeniUncJ both 13.5 13.5604100756 40.3238314666 -13.3238314666
CC027/GeniUncJ both 32.855 9.0965996196 50.8489731729 14.8610268271
CC028/GeniUncJ both 32.4375 9.0965996196 50.4314731729 14.4435268271
CC030/GeniUncJ both 27.5 13.5604100756 54.3238314666 0.6761685334
CC032/GeniUncJ both 34.5416666667 10.356934271 55.0287063541 14.0546269792
CC035/UncJ both 26.4416666667 12.3789041457 50.9283626217 1.9549707117
CC036/UncJ both 19.7916666667 12.3789041457 44.2783626217 -4.6950292883
CC040/TauUncJ both 38.25 13.5604100756 65.0738314666 11.4261685334
CC044/UncJ both 9.25 13.5604100756 36.0738314666 -17.5738314666
CC051/TauUncJ both 25.375 12.3789041457 49.861695955 0.888304045
CC057/UncJ both 17.375 13.5604100756 44.1988314666 -9.4488314666
CC059/TauUncJ both 41.65 10.356934271 62.1370396874 21.1629603126
CC061/GeniUncJ both 38.5 13.5604100756 65.3238314666 11.6761685334
CC068/TauUncJ both 0.05 12.3789041457 24.536695955 -24.436695955
CC078/TauUncJ both 60.2916666667 12.3789041457 84.7783626217 35.8049707117
CC079/TauUncJ both 34.375 13.5604100756 61.1988314666 7.5511685334




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA