Project measure / variable:   CSNA03   infusions_cc_0p032

ID, description, units MPD:110398   infusions_cc_0p032   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, CC   [n]  0.032 mg/kg  
cocaine study
Data set, strains CSNA03   CC w/par   55 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, CC 0.032 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested53 strains51 strains
Mean of the strain means60.83   n 61.6   n
Median of the strain means57.5   n 61.5   n
SD of the strain means± 40.585 ± 38.435
Coefficient of variation (CV)0.6672 0.6239
Min–max range of strain means0.0   –   204.5   n 0.0   –   174.8   n
Mean sample size per strain3.4   mice 3.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 415.9285 415.9285 0.3037 0.5821
strain 41 417639.5885 10186.3314 7.4368 < 0.0001
sex:strain 41 83392.84 2033.9717 1.4849 0.0357
Residuals 268 367086.7633 1369.7267


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 43.322 15.428   9 5.1427 0.3561 11.5, 62.0 -0.43
A/J m 121.5 55.51   7 20.982 0.4569 27.6, 189.5 1.56
C57BL/6J f 88.21 35.479   13 9.8401 0.4022 34.5, 149.0 0.67
C57BL/6J m 55.26 27.251   13 7.558 0.4931 9.0, 97.5 -0.17
CAST/EiJ f 107.0 0.0   1   0.0 0.0 107.0, 107.0 1.14
CAST/EiJ m 60.33 31.758   3 18.336 0.5264 41.5, 97.0 -0.03
CC001/UncJ f 69.33 30.534   3 17.629 0.4404 38.0, 99.0 0.21
CC001/UncJ m 53.75 27.379   4 13.689 0.5094 19.5, 83.5 -0.2
CC002/UncJ f 103.5 76.45   3 44.137 0.7386 38.0, 187.5 1.05
CC002/UncJ m 174.8 33.588   2   23.75 0.1922 151.0, 198.5 2.95
CC003/UncJ f 35.15 3.7477   2   2.65 0.1066 32.5, 37.8 -0.63
CC003/UncJ m 18.05 6.5709   4 3.2854 0.364 9.5, 25.5 -1.13
CC004/TauUncJ f 127.4 44.647   10 14.119 0.3504 73.0, 200.5 1.64
CC004/TauUncJ m 149.9 29.134   20 6.5145 0.1944 91.5, 211.0 2.3
CC005/TauUncJ f 51.7 30.494   4 15.247 0.5898 23.5, 95.0 -0.23
CC005/TauUncJ m 43.067 33.514   3 19.35 0.7782 9.0, 76.0 -0.48
CC006/TauUncJ f 79.0 39.598   2   28.0 0.5012 51.0, 107.0 0.45
CC006/TauUncJ m 64.25 90.86   2   64.25 1.4142 0.07
CC007/UncJ f 48.25 26.517   2   18.75 0.5496 29.5, 67.0 -0.31
CC007/UncJ m 33.567 31.674   3 18.287 0.9436 1.2, 64.5 -0.73
CC008/GeniUncJ f 10.9 7.2125   2   5.1 0.6617 5.8, 16.0 -1.23
CC008/GeniUncJ m 28.5 17.678   2   12.5 0.6203 16.0, 41.0 -0.86
CC009/UncJ f 60.4 52.95   3 30.569 0.8766 6.2, 112.0 -0.01
CC009/UncJ m 23.567 34.75   3 20.063 1.4745 0.2, 63.5 -0.99
CC011/UncJ f 83.6 43.202   5 19.321 0.5168 38.5, 137.0 0.56
CC011/UncJ m 87.6 28.054   5 12.546 0.3203 49.5, 119.5 0.68
CC012/GeniUncJ f 90.5 0.0   1   0.0 0.0 90.5, 90.5 0.73
CC012/GeniUncJ m 63.17 76.97   3 44.438 1.2185 10.5, 151.5 0.04
CC013/GeniUncJ f 69.83 33.632   3 19.417 0.4816 31.0, 89.5 0.22
CC013/GeniUncJ m 68.5 40.066   3 23.132 0.5849 38.5, 114.0 0.18
CC015/UncJ f 36.8 51.19   2   36.2 1.3912 0.6, 73.0 -0.59
CC015/UncJ m 55.5 0.0   1   0.0 0.0 55.5, 55.5 -0.16
CC016/GeniUncJ f 57.3 57.84   2   40.9 1.0094 16.4, 98.2 -0.09
CC016/GeniUncJ m 66.4 51.19   2   36.2 0.771 30.2, 102.6 0.12
CC017/UncJ f 67.33 51.73   3 29.868 0.7683 25.0, 125.0 0.16
CC017/UncJ m 25.2 27.744   4 13.872 1.101 6.0, 65.5 -0.95
CC018/UncJ f 103.2 68.6   3 39.605 0.6645 31.0, 167.5 1.04
CC018/UncJ m 73.8 33.501   5 14.982 0.4539 34.0, 119.5 0.32
CC019/TauUncJ f 80.84 48.76   5 21.806 0.6032 13.0, 146.0 0.49
CC019/TauUncJ m 38.3 14.29   3 8.2501 0.3731 21.8, 46.6 -0.61
CC020/GeniUncJ f 25.6 0.0   1   0.0 0.0 25.6, 25.6 -0.87
CC023/GeniUncJ f 41.05 26.821   4 13.41 0.6534 1.2, 59.0 -0.49
CC023/GeniUncJ m 61.5 54.71   3 31.585 0.8895 26.0, 124.5 0.0
CC024/GeniUncJ f 39.0 55.15   2   39.0 1.4142 -0.54
CC024/GeniUncJ m 2.2 1.4142   2   1.0 0.6428 1.2, 3.2 -1.55
CC025/GeniUncJ f 21.6 27.719   2   19.6 1.2833 2.0, 41.2 -0.97
CC025/GeniUncJ m 85.0 5.6569   2   4.0 0.0666 81.0, 89.0 0.61
CC026/GeniUncJ f 28.7 27.574   5 12.331 0.9608 10.0, 77.5 -0.79
CC026/GeniUncJ m 16.0 7.3655   3 4.2525 0.4603 11.5, 24.5 -1.19
CC027/GeniUncJ f 81.05 86.03   4 43.017 1.0615 9.4, 194.0 0.5
CC027/GeniUncJ m 64.6 66.61   5 29.788 1.0311 11.0, 179.0 0.08
CC028/GeniUncJ f 68.37 32.647   5 14.6 0.4775 23.333, 112.0 0.19
CC028/GeniUncJ m 86.36 37.885   5 16.943 0.4387 47.0, 129.0 0.64
CC029/UncJ f 3.6 0.0   1   0.0 0.0 3.6, 3.6 -1.41
CC029/UncJ m 16.4 0.0   1   0.0 0.0 16.4, 16.4 -1.18
CC030/GeniUncJ f 125.0 50.2   2   35.5 0.4016 89.5, 160.5 1.58
CC030/GeniUncJ m 108.0 7.7782   2   5.5 0.072 102.5, 113.5 1.21
CC032/GeniUncJ f 49.133 29.354   3 16.948 0.5974 31.0, 83.0 -0.29
CC032/GeniUncJ m 38.275 25.756   4 12.878 0.6729 7.0, 69.5 -0.61
CC033/GeniUncJ f 36.0 0.0   1   0.0 0.0 36.0, 36.0 -0.61
CC033/GeniUncJ m 26.5 26.163   2   18.5 0.9873 8.0, 45.0 -0.91
CC035/UncJ f 31.667 17.265   3 9.968 0.5452 12.5, 46.0 -0.72
CC035/UncJ m 62.25 47.73   2   33.75 0.7667 28.5, 96.0 0.02
CC036/UncJ f 106.2 28.733   3 16.589 0.2706 73.0, 123.5 1.12
CC036/UncJ m 59.25 7.4246   2   5.25 0.1253 54.0, 64.5 -0.06
CC037/TauUncJ f 5.5 0.0   1   0.0 0.0 5.5, 5.5 -1.36
CC037/TauUncJ m 0.8 0.0   1   0.0 0.0 0.8, 0.8 -1.58
CC040/TauUncJ f 20.7 4.9497   2   3.5 0.2391 17.2, 24.2 -0.99
CC040/TauUncJ m 85.5 48.79   2   34.5 0.5706 51.0, 120.0 0.62
CC041/TauUncJ f 10.833 18.764   3 10.833 1.7321 -1.23
CC041/TauUncJ m 2.95 6.8798   12 1.986 2.3321 -1.53
CC043/GeniUncJ m 107.0 0.0   1   0.0 0.0 107.0, 107.0 1.18
CC044/UncJ f 5.5 7.7782   2   5.5 1.4142 -1.36
CC044/UncJ m 7.1 6.9296   2   4.9 0.976 2.2, 12.0 -1.42
CC045/GeniUncJ f 204.5 0.0   1   0.0 0.0 204.5, 204.5 3.54
CC051/TauUncJ f 57.5 36.77   2   26.0 0.6395 31.5, 83.5 -0.08
CC051/TauUncJ m 51.33 34.872   3 20.134 0.6793 25.5, 91.0 -0.27
CC057/UncJ f 67.0 46.669   2   33.0 0.6966 34.0, 100.0 0.15
CC057/UncJ m 45.75 8.8388   2   6.25 0.1932 39.5, 52.0 -0.41
CC059/TauUncJ f 115.5 62.18   4 31.089 0.5383 31.5, 179.0 1.35
CC059/TauUncJ m 96.07 13.732   3 7.9281 0.1429 85.2, 111.5 0.9
CC060/UncJ m 68.2 0.0   1   0.0 0.0 68.2, 68.2 0.17
CC061/GeniUncJ f 101.0 15.556   2   11.0 0.154 90.0, 112.0 0.99
CC061/GeniUncJ m 96.5 60.81   2   43.0 0.6302 53.5, 139.5 0.91
CC068/TauUncJ f 0.0 0.0   3 0.0 None -1.5
CC068/TauUncJ m 0.0 0.0   2   0.0 None -1.6
CC074/UncJ f 13.5 0.0   1   0.0 0.0 13.5, 13.5 -1.17
CC074/UncJ m 139.6 0.0   1   0.0 0.0 139.6, 139.6 2.03
CC075/UncJ f 4.5 0.0   1   0.0 0.0 4.5, 4.5 -1.39
CC078/TauUncJ f 60.6 31.678   2   22.4 0.5227 38.2, 83.0 -0.01
CC078/TauUncJ m 73.27 31.218   3 18.024 0.4261 40.6, 102.8 0.3
CC079/TauUncJ f 126.8 26.517   2   18.75 0.2092 108.0, 145.5 1.63
CC079/TauUncJ m 62.0 0.0   2   0.0 0.0 62.0, 62.0 0.01
CC080/TauUncJ f 33.5 25.456   2   18.0 0.7599 15.5, 51.5 -0.67
CC084/TauJ f 91.75 39.244   2   27.75 0.4277 64.0, 119.5 0.76
CC084/TauJ m 77.0 19.679   3 11.361 0.2556 63.0, 99.5 0.4
NOD/ShiLtJ f 49.045 36.738   11 11.077 0.7491 8.5, 131.5 -0.29
NOD/ShiLtJ m 89.71 45.023   7 17.017 0.5018 6.4, 132.5 0.73
NZO/HlLtJ f 59.85 32.935   11 9.9303 0.5503 17.0, 104.5 -0.02
NZO/HlLtJ m 53.39 23.524   10 7.4388 0.4406 12.6, 86.0 -0.21
PWK/PhJ f 86.05 42.224   10 13.352 0.4907 28.0, 159.5 0.62
PWK/PhJ m 102.5 35.635   10 11.269 0.3475 43.6, 161.5 1.06
WSB/EiJ f 39.933 28.308   3 16.344 0.7089 16.8, 71.5 -0.51
WSB/EiJ m 51.75 52.63   6 21.485 1.017 19.0, 151.5 -0.26


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 43.3222222222 12.3366064524 67.611213658 19.0332307864
A/J m 121.5 13.9883968695 149.0411275439 93.9588724561
C57BL/6J f 88.2076923077 10.2646770299 108.417354781 67.9980298344
C57BL/6J m 55.2615384615 10.2646770299 75.4712009349 35.0518759882
CC001/UncJ f 69.3333333333 21.3676291686 111.4031005647 27.2635661019
CC001/UncJ m 53.75 18.5049096786 90.1834871537 17.3165128463
CC002/UncJ f 103.5 21.3676291686 145.5697672314 61.4302327686
CC002/UncJ m 174.75 26.169894238 226.2747316573 123.2252683427
CC003/UncJ f 35.15 26.169894238 86.6747316573 -16.3747316573
CC003/UncJ m 18.05 18.5049096786 54.4834871537 -18.3834871537
CC004/TauUncJ f 127.4 11.703532496 150.4425605016 104.3574394984
CC004/TauUncJ m 149.9 8.2756471918 166.1935507866 133.6064492134
CC005/TauUncJ f 51.7 18.5049096786 88.1334871537 15.2665128463
CC005/TauUncJ m 43.0666666667 21.3676291686 85.1364338981 0.9968994353
CC006/TauUncJ f 79.0 26.169894238 130.5247316573 27.4752683427
CC006/TauUncJ m 64.25 26.169894238 115.7747316573 12.7252683427
CC007/UncJ f 48.25 26.169894238 99.7747316573 -3.2747316573
CC007/UncJ m 33.5666666667 21.3676291686 75.6364338981 -8.5031005647
CC008/GeniUncJ f 10.9 26.169894238 62.4247316573 -40.6247316573
CC008/GeniUncJ m 28.5 26.169894238 80.0247316573 -23.0247316573
CC009/UncJ f 60.4 21.3676291686 102.4697672314 18.3302327686
CC009/UncJ m 23.5666666667 21.3676291686 65.6364338981 -18.5031005647
CC011/UncJ f 83.6 16.5512943836 116.1871015732 51.0128984268
CC011/UncJ m 87.6 16.5512943836 120.1871015732 55.0128984268
CC013/GeniUncJ f 69.8333333333 21.3676291686 111.9031005647 27.7635661019
CC013/GeniUncJ m 68.5 21.3676291686 110.5697672314 26.4302327686
CC016/GeniUncJ f 57.3 26.169894238 108.8247316573 5.7752683427
CC016/GeniUncJ m 66.4 26.169894238 117.9247316573 14.8752683427
CC017/UncJ f 67.3333333333 21.3676291686 109.4031005647 25.2635661019
CC017/UncJ m 25.2 18.5049096786 61.6334871537 -11.2334871537
CC018/UncJ f 103.2333333333 21.3676291686 145.3031005647 61.1635661019
CC018/UncJ m 73.8 16.5512943836 106.3871015732 41.2128984268
CC019/TauUncJ f 80.84 16.5512943836 113.4271015732 48.2528984268
CC019/TauUncJ m 38.3 21.3676291686 80.3697672314 -3.7697672314
CC023/GeniUncJ f 41.05 18.5049096786 77.4834871537 4.6165128463
CC023/GeniUncJ m 61.5 21.3676291686 103.5697672314 19.4302327686
CC024/GeniUncJ f 39.0 26.169894238 90.5247316573 -12.5247316573
CC024/GeniUncJ m 2.2 26.169894238 53.7247316573 -49.3247316573
CC025/GeniUncJ f 21.6 26.169894238 73.1247316573 -29.9247316573
CC025/GeniUncJ m 85.0 26.169894238 136.5247316573 33.4752683427
CC026/GeniUncJ f 28.7 16.5512943836 61.2871015732 -3.8871015732
CC026/GeniUncJ m 16.0 21.3676291686 58.0697672314 -26.0697672314
CC027/GeniUncJ f 81.05 18.5049096786 117.4834871537 44.6165128463
CC027/GeniUncJ m 64.6 16.5512943836 97.1871015732 32.0128984268
CC028/GeniUncJ f 68.3666 16.5512943836 100.9537015732 35.7794984268
CC028/GeniUncJ m 86.36 16.5512943836 118.9471015732 53.7728984268
CC030/GeniUncJ f 125.0 26.169894238 176.5247316573 73.4752683427
CC030/GeniUncJ m 108.0 26.169894238 159.5247316573 56.4752683427
CC032/GeniUncJ f 49.1333333333 21.3676291686 91.2031005647 7.0635661019
CC032/GeniUncJ m 38.275 18.5049096786 74.7084871537 1.8415128463
CC035/UncJ f 31.6666666667 21.3676291686 73.7364338981 -10.4031005647
CC035/UncJ m 62.25 26.169894238 113.7747316573 10.7252683427
CC036/UncJ f 106.1666666667 21.3676291686 148.2364338981 64.0968994353
CC036/UncJ m 59.25 26.169894238 110.7747316573 7.7252683427
CC040/TauUncJ f 20.7 26.169894238 72.2247316573 -30.8247316573
CC040/TauUncJ m 85.5 26.169894238 137.0247316573 33.9752683427
CC041/TauUncJ f 10.8333333333 21.3676291686 52.9031005647 -31.2364338981
CC041/TauUncJ m 2.95 10.6838145843 23.9848836157 -18.0848836157
CC044/UncJ f 5.5 26.169894238 57.0247316573 -46.0247316573
CC044/UncJ m 7.1 26.169894238 58.6247316573 -44.4247316573
CC051/TauUncJ f 57.5 26.169894238 109.0247316573 5.9752683427
CC051/TauUncJ m 51.3333333333 21.3676291686 93.4031005647 9.2635661019
CC057/UncJ f 67.0 26.169894238 118.5247316573 15.4752683427
CC057/UncJ m 45.75 26.169894238 97.2747316573 -5.7747316573
CC059/TauUncJ f 115.5 18.5049096786 151.9334871537 79.0665128463
CC059/TauUncJ m 96.0666666667 21.3676291686 138.1364338981 53.9968994353
CC061/GeniUncJ f 101.0 26.169894238 152.5247316573 49.4752683427
CC061/GeniUncJ m 96.5 26.169894238 148.0247316573 44.9752683427
CC068/TauUncJ f 0.0 21.3676291686 42.0697672314 -42.0697672314
CC068/TauUncJ m 0.0 26.169894238 51.5247316573 -51.5247316573
CC078/TauUncJ f 60.6 26.169894238 112.1247316573 9.0752683427
CC078/TauUncJ m 73.2666666667 21.3676291686 115.3364338981 31.1968994353
CC079/TauUncJ f 126.75 26.169894238 178.2747316573 75.2252683427
CC079/TauUncJ m 62.0 26.169894238 113.5247316573 10.4752683427
CC084/TauJ f 91.75 26.169894238 143.2747316573 40.2252683427
CC084/TauJ m 77.0 21.3676291686 119.0697672314 34.9302327686
NOD/ShiLtJ f 49.0454545455 11.158880397 71.0156739442 27.0752351467
NOD/ShiLtJ m 89.7142857143 13.9883968695 117.2554132582 62.1731581704
NZO/HlLtJ f 59.8545454545 11.158880397 81.8247648533 37.8843260558
NZO/HlLtJ m 53.39 11.703532496 76.4325605016 30.3474394984
PWK/PhJ f 86.05 11.703532496 109.0925605016 63.0074394984
PWK/PhJ m 102.535 11.703532496 125.5775605016 79.4924394984
WSB/EiJ f 39.9333333333 21.3676291686 82.0031005647 -2.1364338981
WSB/EiJ m 51.75 15.109195483 81.4978176923 22.0021823077


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 82.4111111111 9.325597913 100.771862807 64.0503594152
C57BL/6J both 71.7346153846 7.2582227345 86.025004765 57.4442260042
CC001/UncJ both 61.5416666667 14.1333582218 89.3682021188 33.7151312145
CC002/UncJ both 139.125 16.8925940926 172.3840712711 105.8659287289
CC003/UncJ both 26.6 16.0257218764 58.1523254236 -4.9523254236
CC004/TauUncJ both 138.65 7.1669207008 152.7606288991 124.5393711009
CC005/TauUncJ both 47.3833333333 14.1333582218 75.2098687855 19.5567978812
CC006/TauUncJ both 71.625 18.5049096786 108.0584871537 35.1915128463
CC007/UncJ both 40.9083333333 16.8925940926 74.1674046044 7.6492620622
CC008/GeniUncJ both 19.7 18.5049096786 56.1334871537 -16.7334871537
CC009/UncJ both 41.9833333333 15.109195483 71.7311510256 12.2355156411
CC011/UncJ both 85.6 11.703532496 108.6425605016 62.5574394984
CC013/GeniUncJ both 69.1666666667 15.109195483 98.9144843589 39.4188489744
CC016/GeniUncJ both 61.85 18.5049096786 98.2834871537 25.4165128463
CC017/UncJ both 46.2666666667 14.1333582218 74.0932021188 18.4401312145
CC018/UncJ both 88.5166666667 13.5140752741 115.1239236835 61.9094096498
CC019/TauUncJ both 59.57 13.5140752741 86.1772570169 32.9627429831
CC023/GeniUncJ both 51.275 14.1333582218 79.1015354522 23.4484645478
CC024/GeniUncJ both 20.6 18.5049096786 57.0334871537 -15.8334871537
CC025/GeniUncJ both 53.3 18.5049096786 89.7334871537 16.8665128463
CC026/GeniUncJ both 22.35 13.5140752741 48.9572570169 -4.2572570169
CC027/GeniUncJ both 72.825 12.4134707877 97.2653261799 48.3846738201
CC028/GeniUncJ both 77.3633 11.703532496 100.4058605016 54.3207394984
CC030/GeniUncJ both 116.5 18.5049096786 152.9334871537 80.0665128463
CC032/GeniUncJ both 43.7041666667 14.1333582218 71.5307021188 15.8776312145
CC035/UncJ both 46.9583333333 16.8925940926 80.2174046044 13.6992620622
CC036/UncJ both 82.7083333333 16.8925940926 115.9674046044 49.4492620622
CC040/TauUncJ both 53.1 18.5049096786 89.5334871537 16.6665128463
CC041/TauUncJ both 6.8916666667 11.9448678347 30.4093814984 -16.6260481651
CC044/UncJ both 6.3 18.5049096786 42.7334871537 -30.1334871537
CC051/TauUncJ both 54.4166666667 16.8925940926 87.6757379378 21.1575953956
CC057/UncJ both 56.375 18.5049096786 92.8084871537 19.9415128463
CC059/TauUncJ both 105.7833333333 14.1333582218 133.6098687855 77.9567978812
CC061/GeniUncJ both 98.75 18.5049096786 135.1834871537 62.3165128463
CC068/TauUncJ both 0.0 16.8925940926 33.2590712711 -33.2590712711
CC078/TauUncJ both 66.9333333333 16.8925940926 100.1924046044 33.6742620622
CC079/TauUncJ both 94.375 18.5049096786 130.8084871537 57.9415128463
CC084/TauJ both 84.375 16.8925940926 117.6340712711 51.1159287289
NOD/ShiLtJ both 69.3798701299 8.9470086998 86.9952344947 51.7645057651
NZO/HlLtJ both 56.6222727273 8.0853769949 72.5412090525 40.7033364021
PWK/PhJ both 94.2925 8.2756471918 110.5860507866 77.9989492134
WSB/EiJ both 45.8416666667 13.084947119 71.6040324953 20.079300838




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA