Project measure / variable:   CSNA03   infusions_cc_0p1

ID, description, units MPD:110395   infusions_cc_0p1   dose response, number of infusions (intravenous self administration), CC   [n]  0.1 mg/kg  
cocaine study
Data set, strains CSNA03   CC w/par   55 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - dose response, number of infusions (intravenous self administration), CC 0.1 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested53 strains51 strains
Mean of the strain means72.45   n 75.47   n
Median of the strain means68.33   n 77.43   n
SD of the strain means± 42.952 ± 44.314
Coefficient of variation (CV)0.5929 0.5872
Min–max range of strain means0.0   –   193.0   n 0.0   –   233.0   n
Mean sample size per strain3.5   mice 4.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 16.6786 16.6786 0.0089 0.925
strain 42 441417.1036 10509.931 5.5945 < 0.0001
sex:strain 42 77449.403 1844.0334 0.9816 0.5085
Residuals 282 529765.7295 1878.6019


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 60.43 50.93   11 15.357 0.8429 0.4, 164.0 -0.28
A/J m 136.2 89.62   7 33.874 0.658 10.5, 242.0 1.37
C57BL/6J f 100.8 41.036   13 11.381 0.4072 49.0, 175.0 0.66
C57BL/6J m 82.73 25.843   13 7.1675 0.3124 37.0, 119.0 0.16
CAST/EiJ f 124.2 63.35   3 36.575 0.5102 65.0, 191.0 1.2
CAST/EiJ m 77.5 32.047   3 18.502 0.4135 40.5, 96.5 0.05
CC001/UncJ f 128.3 24.394   3 14.084 0.1901 114.0, 156.5 1.3
CC001/UncJ m 88.88 57.27   4 28.636 0.6444 26.5, 162.0 0.3
CC002/UncJ f 116.0 95.75   3 55.28 0.8254 31.5, 220.0 1.01
CC002/UncJ m 127.0 40.305   2   28.5 0.3174 98.5, 155.5 1.16
CC003/UncJ f 51.25 6.0104   2   4.25 0.1173 47.0, 55.5 -0.49
CC003/UncJ m 15.575 9.9594   4 4.9797 0.6394 6.5, 27.0 -1.35
CC004/TauUncJ f 117.6 44.304   10 14.01 0.3768 59.5, 188.0 1.05
CC004/TauUncJ m 141.1 36.644   22 7.8126 0.2598 60.0, 215.5 1.48
CC005/TauUncJ f 64.62 32.322   4 16.161 0.5002 23.5, 102.5 -0.18
CC005/TauUncJ m 111.0 69.34   3 40.032 0.6249 36.4, 173.5 0.8
CC006/TauUncJ f 80.25 3.8891   2   2.75 0.0485 77.5, 83.0 0.18
CC006/TauUncJ m 69.0 97.58   2   69.0 1.4142 -0.15
CC007/UncJ f 87.5 8.4853   2   6.0 0.097 81.5, 93.5 0.35
CC007/UncJ m 66.5 56.58   3 32.669 0.8509 3.5, 113.0 -0.2
CC008/GeniUncJ f 12.85 5.1619   2   3.65 0.4017 9.2, 16.5 -1.39
CC008/GeniUncJ m 42.5 7.0711   2   5.0 0.1664 37.5, 47.5 -0.74
CC009/UncJ f 61.0 55.01   3 31.758 0.9018 5.5, 115.5 -0.27
CC009/UncJ m 14.933 15.531   3 8.9669 1.04 -1.37
CC011/UncJ f 81.5 37.403   5 16.727 0.4589 38.5, 138.0 0.21
CC011/UncJ m 90.5 58.85   5 26.319 0.6503 47.5, 190.0 0.34
CC012/GeniUncJ f 128.5 0.0   1   0.0 0.0 128.5, 128.5 1.3
CC012/GeniUncJ m 74.47 79.42   3 45.855 1.0666 1.4, 159.0 -0.02
CC013/GeniUncJ f 73.33 39.976   3 23.08 0.5451 27.5, 101.0 0.02
CC013/GeniUncJ m 54.5 8.0   3 4.6188 0.1468 46.5, 62.5 -0.47
CC015/UncJ f 47.55 63.57   2   44.95 1.3369 2.6, 92.5 -0.58
CC015/UncJ m 54.5 0.0   1   0.0 0.0 54.5, 54.5 -0.47
CC016/GeniUncJ f 126.0 95.46   2   67.5 0.7576 58.5, 193.5 1.25
CC016/GeniUncJ m 118.0 31.82   2   22.5 0.2697 95.5, 140.5 0.96
CC017/UncJ f 101.8 78.41   3 45.272 0.77 26.5, 183.0 0.68
CC017/UncJ m 37.375 42.37   4 21.185 1.1336 4.5, 97.0 -0.86
CC018/UncJ f 110.3 69.45   3 40.098 0.6295 31.5, 162.5 0.88
CC018/UncJ m 81.4 38.457   5 17.198 0.4724 28.5, 127.0 0.13
CC019/TauUncJ f 85.9 53.94   5 24.122 0.6279 25.0, 154.5 0.31
CC019/TauUncJ m 107.2 74.31   3 42.905 0.6932 63.2, 193.0 0.72
CC020/GeniUncJ f 47.0 0.0   1   0.0 0.0 47.0, 47.0 -0.59
CC023/GeniUncJ f 32.7 27.359   4 13.679 0.8367 0.8, 61.0 -0.93
CC023/GeniUncJ m 73.0 34.143   3 19.713 0.4677 48.5, 112.0 -0.06
CC024/GeniUncJ f 43.25 61.16   2   43.25 1.4142 -0.68
CC024/GeniUncJ m 4.25 1.7678   2   1.25 0.4159 3.0, 5.5 -1.61
CC025/GeniUncJ f 49.3 39.174   2   27.7 0.7946 21.6, 77.0 -0.54
CC025/GeniUncJ m 93.75 25.102   2   17.75 0.2678 76.0, 111.5 0.41
CC026/GeniUncJ f 33.2 24.206   5 10.825 0.7291 8.0, 65.5 -0.91
CC026/GeniUncJ m 38.5 36.404   3 21.018 0.9456 16.0, 80.5 -0.83
CC027/GeniUncJ f 77.9 60.08   4 30.042 0.7713 9.6, 142.0 0.13
CC027/GeniUncJ m 95.54 52.13   5 23.314 0.5456 44.2, 171.0 0.45
CC028/GeniUncJ f 61.8 24.232   5 10.837 0.3921 44.0, 102.5 -0.25
CC028/GeniUncJ m 80.28 34.083   5 15.242 0.4245 30.0, 119.4 0.11
CC029/UncJ f 3.2 0.0   1   0.0 0.0 3.2, 3.2 -1.61
CC029/UncJ m 26.0 0.0   1   0.0 0.0 26.0, 26.0 -1.12
CC030/GeniUncJ f 119.2 44.194   2   31.25 0.3706 88.0, 150.5 1.09
CC030/GeniUncJ m 79.0 33.234   2   23.5 0.4207 55.5, 102.5 0.08
CC032/GeniUncJ f 59.67 8.2513   3 4.7639 0.1383 50.5, 66.5 -0.3
CC032/GeniUncJ m 37.375 21.367   4 10.684 0.5717 16.0, 64.0 -0.86
CC033/GeniUncJ f 42.0 0.0   1   0.0 0.0 42.0, 42.0 -0.71
CC033/GeniUncJ m 84.05 99.63   2   70.45 1.1854 13.6, 154.5 0.19
CC035/UncJ f 57.17 25.181   3 14.538 0.4405 29.0, 77.5 -0.36
CC035/UncJ m 54.0 25.456   2   18.0 0.4714 36.0, 72.0 -0.48
CC036/UncJ f 95.5 21.378   3 12.342 0.2238 78.5, 119.5 0.54
CC036/UncJ m 64.5 28.284   2   20.0 0.4385 44.5, 84.5 -0.25
CC037/TauUncJ f 3.0 0.0   1   0.0 0.0 3.0, 3.0 -1.62
CC037/TauUncJ m 0.4 0.0   1   0.0 0.0 0.4, 0.4 -1.69
CC040/TauUncJ f 52.5 37.477   2   26.5 0.7138 26.0, 79.0 -0.46
CC040/TauUncJ m 95.25 35.709   2   25.25 0.3749 70.0, 120.5 0.45
CC041/TauUncJ f 10.778 17.516   3 10.113 1.6252 0.33333, 31.0 -1.44
CC041/TauUncJ m 3.75 9.0354   12 2.6083 2.4094 -1.62
CC043/GeniUncJ m 94.0 0.0   1   0.0 0.0 94.0, 94.0 0.42
CC044/UncJ f 5.75 8.1317   2   5.75 1.4142 -1.55
CC044/UncJ m 4.2 3.1113   2   2.2 0.7408 2.0, 6.4 -1.61
CC045/GeniUncJ f 193.0 0.0   1   0.0 0.0 193.0, 193.0 2.81
CC051/TauUncJ f 67.5 57.28   2   40.5 0.8485 27.0, 108.0 -0.12
CC051/TauUncJ m 77.43 8.3345   3 4.8119 0.1076 68.0, 83.8 0.04
CC057/UncJ f 72.25 30.759   2   21.75 0.4257 50.5, 94.0 0.0
CC057/UncJ m 69.75 6.0104   2   4.25 0.0862 65.5, 74.0 -0.13
CC059/TauUncJ f 138.0 40.023   4 20.011 0.29 87.5, 181.0 1.53
CC059/TauUncJ m 133.8 48.658   3 28.093 0.3636 104.5, 190.0 1.32
CC060/UncJ m 71.0 0.0   1   0.0 0.0 71.0, 71.0 -0.1
CC061/GeniUncJ f 104.8 22.274   2   15.75 0.2126 89.0, 120.5 0.75
CC061/GeniUncJ m 122.0 16.971   2   12.0 0.1391 110.0, 134.0 1.05
CC068/TauUncJ f 0.0 0.0   3 0.0 None -1.69
CC068/TauUncJ m 0.0 0.0   2   0.0 None -1.7
CC074/UncJ f 8.4 0.0   1   0.0 0.0 8.4, 8.4 -1.49
CC074/UncJ m 233.0 0.0   1   0.0 0.0 233.0, 233.0 3.55
CC075/UncJ f 7.0 0.0   1   0.0 0.0 7.0, 7.0 -1.52
CC078/TauUncJ f 105.2 35.709   2   25.25 0.3393 80.0, 130.5 0.76
CC078/TauUncJ m 74.0 21.166   3 12.22 0.286 50.0, 90.0 -0.03
CC079/TauUncJ f 119.2 22.981   2   16.25 0.1927 103.0, 135.5 1.09
CC079/TauUncJ m 78.0 31.82   2   22.5 0.4079 55.5, 100.5 0.06
CC080/TauUncJ f 30.15 20.718   2   14.65 0.6872 15.5, 44.8 -0.98
CC084/TauJ f 114.2 52.68   2   37.25 0.4611 77.0, 151.5 0.97
CC084/TauJ m 142.0 18.255   3 10.54 0.1286 123.5, 160.0 1.5
NOD/ShiLtJ f 68.33 52.78   13 14.639 0.7725 8.8, 169.0 -0.1
NOD/ShiLtJ m 82.26 56.42   9 18.806 0.6859 0.15
NZO/HlLtJ f 93.98 52.26   12 15.086 0.5561 27.8, 201.5 0.5
NZO/HlLtJ m 76.47 41.063   11 12.381 0.537 0.6, 117.0 0.02
PWK/PhJ f 120.7 27.683   10 8.7541 0.2293 70.0, 154.0 1.12
PWK/PhJ m 124.0 37.996   10 12.015 0.3063 67.5, 200.0 1.1
WSB/EiJ f 43.433 46.048   3 26.586 1.0602 14.0, 96.5 -0.68
WSB/EiJ m 46.65 38.711   6 15.804 0.8298 20.5, 124.5 -0.65


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 60.4272727273 13.0683583083 86.1511847413 34.7033607133
A/J m 136.2142857143 16.3820541081 168.4609159753 103.9676554532
C57BL/6J f 100.7769230769 12.0211412411 124.4394805535 77.1143656003
C57BL/6J m 82.7307692308 12.0211412411 106.3933267074 59.0682117542
CAST/EiJ f 124.1666666667 25.0240009964 173.4242080262 74.9091253072
CAST/EiJ m 77.5 25.0240009964 126.7575413595 28.2424586405
CC001/UncJ f 128.3333333333 25.0240009964 177.5908746928 79.0757919738
CC001/UncJ m 88.875 21.6714205672 131.5332821453 46.2167178547
CC002/UncJ f 116.0 25.0240009964 165.2575413595 66.7424586405
CC002/UncJ m 127.0 30.6480168821 187.3279211574 66.6720788426
CC003/UncJ f 51.25 30.6480168821 111.5779211574 -9.0779211574
CC003/UncJ m 15.575 21.6714205672 58.2332821453 -27.0832821453
CC004/TauUncJ f 117.58 13.7062098248 144.5594665298 90.6005334702
CC004/TauUncJ m 141.0681818182 9.2407247788 159.2577344419 122.8786291944
CC005/TauUncJ f 64.625 21.6714205672 107.2832821453 21.9667178547
CC005/TauUncJ m 110.9666666667 25.0240009964 160.2242080262 61.7091253072
CC006/TauUncJ f 80.25 30.6480168821 140.5779211574 19.9220788426
CC006/TauUncJ m 69.0 30.6480168821 129.3279211574 8.6720788426
CC007/UncJ f 87.5 30.6480168821 147.8279211574 27.1720788426
CC007/UncJ m 66.5 25.0240009964 115.7575413595 17.2424586405
CC008/GeniUncJ f 12.85 30.6480168821 73.1779211574 -47.4779211574
CC008/GeniUncJ m 42.5 30.6480168821 102.8279211574 -17.8279211574
CC009/UncJ f 61.0 25.0240009964 110.2575413595 11.7424586405
CC009/UncJ m 14.9333333333 25.0240009964 64.1908746928 -34.3242080262
CC011/UncJ f 81.5 19.3835078229 119.6547274721 43.3452725279
CC011/UncJ m 90.5 19.3835078229 128.6547274721 52.3452725279
CC013/GeniUncJ f 73.3333333333 25.0240009964 122.5908746928 24.0757919738
CC013/GeniUncJ m 54.5 25.0240009964 103.7575413595 5.2424586405
CC016/GeniUncJ f 126.0 30.6480168821 186.3279211574 65.6720788426
CC016/GeniUncJ m 118.0 30.6480168821 178.3279211574 57.6720788426
CC017/UncJ f 101.8333333333 25.0240009964 151.0908746928 52.5757919738
CC017/UncJ m 37.375 21.6714205672 80.0332821453 -5.2832821453
CC018/UncJ f 110.3333333333 25.0240009964 159.5908746928 61.0757919738
CC018/UncJ m 81.4 19.3835078229 119.5547274721 43.2452725279
CC019/TauUncJ f 85.9 19.3835078229 124.0547274721 47.7452725279
CC019/TauUncJ m 107.2 25.0240009964 156.4575413595 57.9424586405
CC023/GeniUncJ f 32.7 21.6714205672 75.3582821453 -9.9582821453
CC023/GeniUncJ m 73.0 25.0240009964 122.2575413595 23.7424586405
CC024/GeniUncJ f 43.25 30.6480168821 103.5779211574 -17.0779211574
CC024/GeniUncJ m 4.25 30.6480168821 64.5779211574 -56.0779211574
CC025/GeniUncJ f 49.3 30.6480168821 109.6279211574 -11.0279211574
CC025/GeniUncJ m 93.75 30.6480168821 154.0779211574 33.4220788426
CC026/GeniUncJ f 33.2 19.3835078229 71.3547274721 -4.9547274721
CC026/GeniUncJ m 38.5 25.0240009964 87.7575413595 -10.7575413595
CC027/GeniUncJ f 77.9 21.6714205672 120.5582821453 35.2417178547
CC027/GeniUncJ m 95.54 19.3835078229 133.6947274721 57.3852725279
CC028/GeniUncJ f 61.8 19.3835078229 99.9547274721 23.6452725279
CC028/GeniUncJ m 80.28 19.3835078229 118.4347274721 42.1252725279
CC030/GeniUncJ f 119.25 30.6480168821 179.5779211574 58.9220788426
CC030/GeniUncJ m 79.0 30.6480168821 139.3279211574 18.6720788426
CC032/GeniUncJ f 59.6666666667 25.0240009964 108.9242080262 10.4091253072
CC032/GeniUncJ m 37.375 21.6714205672 80.0332821453 -5.2832821453
CC035/UncJ f 57.1666666667 25.0240009964 106.4242080262 7.9091253072
CC035/UncJ m 54.0 30.6480168821 114.3279211574 -6.3279211574
CC036/UncJ f 95.5 25.0240009964 144.7575413595 46.2424586405
CC036/UncJ m 64.5 30.6480168821 124.8279211574 4.1720788426
CC040/TauUncJ f 52.5 30.6480168821 112.8279211574 -7.8279211574
CC040/TauUncJ m 95.25 30.6480168821 155.5779211574 34.9220788426
CC041/TauUncJ f 10.7777766667 25.0240009964 60.0353180262 -38.4797646928
CC041/TauUncJ m 3.75 12.5120004982 28.3787706797 -20.8787706797
CC044/UncJ f 5.75 30.6480168821 66.0779211574 -54.5779211574
CC044/UncJ m 4.2 30.6480168821 64.5279211574 -56.1279211574
CC051/TauUncJ f 67.5 30.6480168821 127.8279211574 7.1720788426
CC051/TauUncJ m 77.4333333333 25.0240009964 126.6908746928 28.1757919738
CC057/UncJ f 72.25 30.6480168821 132.5779211574 11.9220788426
CC057/UncJ m 69.75 30.6480168821 130.0779211574 9.4220788426
CC059/TauUncJ f 138.0 21.6714205672 180.6582821453 95.3417178547
CC059/TauUncJ m 133.8333333333 25.0240009964 183.0908746928 84.5757919738
CC061/GeniUncJ f 104.75 30.6480168821 165.0779211574 44.4220788426
CC061/GeniUncJ m 122.0 30.6480168821 182.3279211574 61.6720788426
CC068/TauUncJ f 0.0 25.0240009964 49.2575413595 -49.2575413595
CC068/TauUncJ m 0.0 30.6480168821 60.3279211574 -60.3279211574
CC078/TauUncJ f 105.25 30.6480168821 165.5779211574 44.9220788426
CC078/TauUncJ m 74.0 25.0240009964 123.2575413595 24.7424586405
CC079/TauUncJ f 119.25 30.6480168821 179.5779211574 58.9220788426
CC079/TauUncJ m 78.0 30.6480168821 138.3279211574 17.6720788426
CC084/TauJ f 114.25 30.6480168821 174.5779211574 53.9220788426
CC084/TauJ m 142.0 25.0240009964 191.2575413595 92.7424586405
NOD/ShiLtJ f 68.3307692308 12.0211412411 91.9933267074 44.6682117542
NOD/ShiLtJ m 82.2555555556 14.4476137115 110.6944103191 53.816700792
NZO/HlLtJ f 93.9833333333 12.5120004982 118.6121040131 69.3545626536
NZO/HlLtJ m 76.4727272727 13.0683583083 102.1966392867 50.7488152587
PWK/PhJ f 120.74 13.7062098248 147.7194665298 93.7605334702
PWK/PhJ m 124.05 13.7062098248 151.0294665298 97.0705334702
WSB/EiJ f 43.4333333333 25.0240009964 92.6908746928 -5.8242080262
WSB/EiJ m 46.65 17.694640797 81.4803415199 11.8196584801


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 98.3207792208 10.4779970137 118.9457932359 77.6957652057
C57BL/6J both 91.7538461538 8.5002304892 108.4858010058 75.0218913019
CAST/EiJ both 100.8333333333 17.694640797 135.6636748532 66.0029918135
CC001/UncJ both 108.6041666667 16.5518208611 141.1849678246 76.0233655087
CC002/UncJ both 121.5 19.7832098297 160.441505659 82.558494341
CC003/UncJ both 33.4125 18.7680007473 70.3556560196 -3.5306560196
CC004/TauUncJ both 129.3240909091 8.2651555067 145.5933213679 113.0548604503
CC005/TauUncJ both 87.7958333333 16.5518208611 120.3766344913 55.2150321754
CC006/TauUncJ both 74.625 21.6714205672 117.2832821453 31.9667178547
CC007/UncJ both 77.0 19.7832098297 115.941505659 38.058494341
CC008/GeniUncJ both 27.675 21.6714205672 70.3332821453 -14.9832821453
CC009/UncJ both 37.9666666667 17.694640797 72.7970081865 3.1363251468
CC011/UncJ both 86.0 13.7062098248 112.9794665298 59.0205334702
CC013/GeniUncJ both 63.9166666667 17.694640797 98.7470081865 29.0863251468
CC016/GeniUncJ both 122.0 21.6714205672 164.6582821453 79.3417178547
CC017/UncJ both 69.6041666667 16.5518208611 102.1849678246 37.0233655087
CC018/UncJ both 95.8666666667 15.8265678638 127.0198711939 64.7134621395
CC019/TauUncJ both 96.55 15.8265678638 127.7032045272 65.3967954728
CC023/GeniUncJ both 52.85 16.5518208611 85.4308011579 20.2691988421
CC024/GeniUncJ both 23.75 21.6714205672 66.4082821453 -18.9082821453
CC025/GeniUncJ both 71.525 21.6714205672 114.1832821453 28.8667178547
CC026/GeniUncJ both 35.85 15.8265678638 67.0032045272 4.6967954728
CC027/GeniUncJ both 86.72 14.5376308672 115.3360456041 58.1039543959
CC028/GeniUncJ both 71.04 13.7062098248 98.0194665298 44.0605334702
CC030/GeniUncJ both 99.125 21.6714205672 141.7832821453 56.4667178547
CC032/GeniUncJ both 48.5208333333 16.5518208611 81.1016344913 15.9400321754
CC035/UncJ both 55.5833333333 19.7832098297 94.5248389923 16.6418276744
CC036/UncJ both 80.0 19.7832098297 118.941505659 41.058494341
CC040/TauUncJ both 73.875 21.6714205672 116.5332821453 31.2167178547
CC041/TauUncJ both 7.2638883333 13.9888418243 34.7996910544 -20.2719143877
CC044/UncJ both 4.975 21.6714205672 47.6332821453 -37.6832821453
CC051/TauUncJ both 72.4666666667 19.7832098297 111.4081723256 33.5251610077
CC057/UncJ both 71.0 21.6714205672 113.6582821453 28.3417178547
CC059/TauUncJ both 135.9166666667 16.5518208611 168.4974678246 103.3358655087
CC061/GeniUncJ both 113.375 21.6714205672 156.0332821453 70.7167178547
CC068/TauUncJ both 0.0 19.7832098297 38.941505659 -38.941505659
CC078/TauUncJ both 89.625 19.7832098297 128.566505659 50.683494341
CC079/TauUncJ both 98.625 21.6714205672 141.2832821453 55.9667178547
CC084/TauJ both 128.125 19.7832098297 167.066505659 89.183494341
NOD/ShiLtJ both 75.2931623932 9.3973583881 93.7910344775 56.7952903088
NZO/HlLtJ both 85.228030303 9.0461614144 103.034602085 67.4214585211
PWK/PhJ both 122.395 9.6917539115 141.472363736 103.317636264
WSB/EiJ both 45.0416666667 15.324008441 75.2056272454 14.877706088




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA