Project measure / variable:   CSNA03   infusions_do_0p032

ID, description, units MPD:110269   infusions_do_0p032   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, DO   [n]  0.032 mg/kg  
cocaine study
Data set, strains CSNA03   DO population w/par   8 strains     sex: both     age:
Procedure operant conditioning chamber
Ontology mappings

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Distribution of Individual Animals with Boxplots.





  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means66.98   n 74.62   n
Median of the strain means61.12   n 61.45   n
SD of the strain means± 24.204 ± 26.46
Coefficient of variation (CV)0.3614 0.3546
Min–max range of strain means39.933   –   107.0   n 51.75   –   121.5   n
Mean sample size per strain46.1   mice 43.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 639.9723 639.9723 0.3577 0.55
strain 6 27776.259 4629.3765 2.5875 0.0174
sex:strain 6 39311.3756 6551.8959 3.6621 0.0014
Residuals 702 1255960.1953 1789.1171


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 43.322 15.428   9 5.1427 0.3561 11.5, 62.0 -0.98
A/J m 121.5 55.51   7 20.982 0.4569 27.6, 189.5 1.77
C57BL/6J f 88.21 35.479   13 9.8401 0.4022 34.5, 149.0 0.88
C57BL/6J m 55.26 27.251   13 7.558 0.4931 9.0, 97.5 -0.73
CAST/EiJ f 107.0 0.0   1   0.0 0.0 107.0, 107.0 1.65
CAST/EiJ m 60.33 31.758   3 18.336 0.5264 41.5, 97.0 -0.54
J:DO f 62.39 40.465   311 2.2946 0.6486 -0.19
J:DO m 62.56 45.905   295 2.6727 0.7338 -0.46
NOD/ShiLtJ f 49.045 36.738   11 11.077 0.7491 8.5, 131.5 -0.74
NOD/ShiLtJ m 89.71 45.023   7 17.017 0.5018 6.4, 132.5 0.57
NZO/HlLtJ f 59.85 32.935   11 9.9303 0.5503 17.0, 104.5 -0.29
NZO/HlLtJ m 53.39 23.524   10 7.4388 0.4406 12.6, 86.0 -0.8
PWK/PhJ f 86.05 42.224   10 13.352 0.4907 28.0, 159.5 0.79
PWK/PhJ m 102.5 35.635   10 11.269 0.3475 43.6, 161.5 1.05
WSB/EiJ f 39.933 28.308   3 16.344 0.7089 16.8, 71.5 -1.12
WSB/EiJ m 51.75 52.63   6 21.485 1.017 19.0, 151.5 -0.86


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 43.3222222222 14.0993186886 71.004105796 15.6403386484
A/J m 121.5 15.9871246738 152.8883056106 90.1116943894
C57BL/6J f 88.2076923077 11.7313422648 111.2404116831 65.1749729323
C57BL/6J m 55.2615384615 11.7313422648 78.2942578369 32.2288190862
J:DO f 62.3919614148 2.3984970424 67.1010482398 57.6828745897
J:DO m 62.5554813559 2.4626822138 67.3905860745 57.7203766373
NOD/ShiLtJ f 49.0454545455 12.7533136063 74.0846603558 24.0062487351
NOD/ShiLtJ m 89.7142857143 15.9871246738 121.1025913249 58.3259801037
NZO/HlLtJ f 59.8545454545 12.7533136063 84.8937512649 34.8153396442
NZO/HlLtJ m 53.39 13.3757881538 79.651340605 27.128659395
PWK/PhJ f 86.05 13.3757881538 112.311340605 59.788659395
PWK/PhJ m 102.535 13.3757881538 128.796340605 76.273659395
WSB/EiJ f 39.9333333333 24.4207363208 87.8797621323 -8.0130954657
WSB/EiJ m 51.75 17.268068254 85.6532449374 17.8467550626


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 82.4111111111 10.6580831159 103.3366481848 61.4855740374
C57BL/6J both 71.7346153846 8.2953116679 88.0212074441 55.4480233251
J:DO both 62.4737213854 1.7188362159 65.8483967907 59.09904598
NOD/ShiLtJ both 69.3798701299 10.2253992988 89.455897854 49.3038424058
NZO/HlLtJ both 56.6222727273 9.2406536116 74.7649009684 38.4796444861
PWK/PhJ both 94.2925 9.4581105073 112.8620720249 75.7229279751
WSB/EiJ both 45.8416666667 14.9545857822 75.2027380532 16.4805952801




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA