Project measure / variable:   CSNA03   infusions_do_0p056

ID, description, units MPD:110268   infusions_do_0p056   dose response, number of infusions (intravenous self administration), DO   [n]  0.056 mg/kg  
cocaine study
Data set, strains CSNA03   DO population w/par   8 strains     sex: both     age:
Procedure operant conditioning chamber
Ontology mappings

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Plot Options Bins number: (min: 10, max: 40)


Distribution of Individual Animals with Boxplots.





  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means68.18   n 77.79   n
Median of the strain means68.47   n 73.81   n
SD of the strain means± 31.147 ± 24.344
Coefficient of variation (CV)0.4568 0.3129
Min–max range of strain means11.4   –   105.2   n 52.5   –   130.4   n
Mean sample size per strain9.1   mice 10.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1742.0899 1742.0899 1.0693 0.303
strain 6 46787.8215 7797.9703 4.7863 0.0002
sex:strain 6 16415.9244 2735.9874 1.6793 0.1307
Residuals 134 218316.5067 1629.2277


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 39.322 26.197   9 8.7324 0.6662 -0.93
A/J m 77.76 52.94   7 20.011 0.6809 16.0, 180.0 0.0
C57BL/6J f 105.2 42.751   11 12.89 0.4065 53.0, 181.5 1.19
C57BL/6J m 79.69 35.092   11 10.581 0.4404 35.5, 139.5 0.08
CAST/EiJ f 92.0 41.012   2   29.0 0.4458 63.0, 121.0 0.76
CAST/EiJ m 63.0 23.754   3 13.714 0.377 39.5, 87.0 -0.61
J:DO f 64.63 48.867   19 11.211 0.7562 2.5, 185.5 -0.11
J:DO m 69.86 46.889   26 9.1958 0.6712 2.5, 152.0 -0.33
NOD/ShiLtJ f 71.01 34.468   10 10.9 0.4854 22.0, 134.0 0.09
NOD/ShiLtJ m 89.3 45.193   8 15.978 0.5061 5.2, 134.0 0.47
NZO/HlLtJ f 65.94 31.478   12 9.0871 0.4774 10.0, 112.5 -0.07
NZO/HlLtJ m 59.81 31.48   11 9.4917 0.5263 -0.74
PWK/PhJ f 95.94 39.453   9 13.151 0.4112 44.5, 165.5 0.89
PWK/PhJ m 130.4 26.677   10 8.4359 0.2045 91.0, 183.0 2.16
WSB/EiJ f 11.4 0.0   1   0.0 0.0 11.4, 11.4 -1.82
WSB/EiJ m 52.5 42.137   6 17.202 0.8026 19.0, 130.0 -1.04


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 39.3222222222 13.4545641234 65.9330057093 12.7114387352
A/J m 77.7571428571 15.2560417154 107.9309351283 47.583350586
C57BL/6J f 105.1636363636 12.1701111586 129.233995692 81.0932770353
C57BL/6J m 79.6909090909 12.1701111586 103.7612684192 55.6205497626
CAST/EiJ f 92.0 28.5414405886 148.4499963691 35.5500036309
CAST/EiJ m 63.0 23.3039886554 109.0912290288 16.9087709712
J:DO f 64.6263157895 9.2600661068 82.9411130571 46.3115185218
J:DO m 69.8551153846 7.9159713475 85.511527416 54.1987033532
NOD/ShiLtJ f 71.01 12.7641202664 96.2552058422 45.7647941578
NOD/ShiLtJ m 89.3 14.2707202943 117.5249981846 61.0750018154
NZO/HlLtJ f 65.9416666667 11.6519943277 88.9872811811 42.8960521523
NZO/HlLtJ m 59.8090909091 12.1701111586 83.8794502374 35.7387315808
PWK/PhJ f 95.9444444444 13.4545641234 122.5552279315 69.3336609574
PWK/PhJ m 130.45 12.7641202664 155.6952058422 105.2047941578


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 58.5396825397 10.1706944769 78.6555440538 38.4238210256
C57BL/6J both 92.4272727273 8.6055681281 109.4475870339 75.4069584206
CAST/EiJ both 77.5 18.4234206794 113.9383159718 41.0616840282
J:DO both 67.240715587 6.0912114287 79.2880704487 55.1933607254
NOD/ShiLtJ both 80.155 9.5730901998 99.0889043816 61.2210956184
NZO/HlLtJ both 62.8753787879 8.4243779804 79.5373305534 46.2134270224
PWK/PhJ both 113.1972222222 9.2729183907 131.5374390681 94.8570053764




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA