Project measure / variable:   CSNA03   infusions_do_0p1

ID, description, units MPD:110266   infusions_do_0p1   dose response, number of infusions (intravenous self administration), DO   [n]  0.1 mg/kg  
cocaine study
Data set, strains CSNA03   DO population w/par   8 strains     sex: both     age:
Procedure operant conditioning chamber
Ontology mappings

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Plot Options Bins number: (min: 10, max: 40)


Distribution of Individual Animals with Boxplots.





  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means85.35   n 87.66   n
Median of the strain means82.46   n 79.88   n
SD of the strain means± 29.149 ± 28.759
Coefficient of variation (CV)0.3415 0.3281
Min–max range of strain means43.433   –   124.2   n 46.65   –   136.2   n
Mean sample size per strain48.1   mice 45.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 3307.3464 3307.3464 1.6249 0.2028
strain 7 72772.3243 10396.0463 5.1075 < 0.0001
sex:strain 7 32233.4076 4604.7725 2.2623 0.0278
Residuals 730 1485879.5749 2035.4515


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 60.43 50.93   11 15.357 0.8429 0.4, 164.0 -0.85
A/J m 136.2 89.62   7 33.874 0.658 10.5, 242.0 1.69
C57BL/6J f 100.8 41.036   13 11.381 0.4072 49.0, 175.0 0.53
C57BL/6J m 82.73 25.843   13 7.1675 0.3124 37.0, 119.0 -0.17
CAST/EiJ f 124.2 63.35   3 36.575 0.5102 65.0, 191.0 1.33
CAST/EiJ m 77.5 32.047   3 18.502 0.4135 40.5, 96.5 -0.35
J:DO f 70.93 40.978   320 2.2908 0.5777 0.6, 224.0 -0.49
J:DO m 75.45 48.236   302 2.7757 0.6393 0.8, 216.5 -0.42
NOD/ShiLtJ f 68.33 52.78   13 14.639 0.7725 8.8, 169.0 -0.58
NOD/ShiLtJ m 82.26 56.42   9 18.806 0.6859 -0.19
NZO/HlLtJ f 93.98 52.26   12 15.086 0.5561 27.8, 201.5 0.3
NZO/HlLtJ m 76.47 41.063   11 12.381 0.537 0.6, 117.0 -0.39
PWK/PhJ f 120.7 27.683   10 8.7541 0.2293 70.0, 154.0 1.21
PWK/PhJ m 124.0 37.996   10 12.015 0.3063 67.5, 200.0 1.26
WSB/EiJ f 43.433 46.048   3 26.586 1.0602 14.0, 96.5 -1.44
WSB/EiJ m 46.65 38.711   6 15.804 0.8298 20.5, 124.5 -1.43


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 60.4272727273 13.6029791941 87.1328995871 33.7216458675
A/J m 136.2142857143 17.0522368558 169.6915606625 102.7370107661
C57BL/6J f 100.7769230769 12.5129209297 125.342526869 76.2113192848
C57BL/6J m 82.7307692308 12.5129209297 107.2963730229 58.1651654387
CAST/EiJ f 124.1666666667 26.0477220533 175.304048837 73.0292844963
CAST/EiJ m 77.5 26.0477220533 128.6373821704 26.3626178296
J:DO f 70.93415625 2.522059843 75.8855119879 65.9828005121
J:DO m 75.4544701987 2.5961328044 80.5512473799 70.3576930175
NOD/ShiLtJ f 68.3307692308 12.5129209297 92.8963730229 43.7651654387
NOD/ShiLtJ m 82.2555555556 15.0386593393 111.7797369173 52.7313741938
NZO/HlLtJ f 93.9833333333 13.0238610267 119.5520244185 68.4146422482
NZO/HlLtJ m 76.4727272727 13.6029791941 103.1783541325 49.7671004129
PWK/PhJ f 120.74 14.2669249402 148.7490977465 92.7309022535
PWK/PhJ m 124.05 14.2669249402 152.0590977465 96.0409022535
WSB/EiJ f 43.4333333333 26.0477220533 94.5707155037 -7.704048837
WSB/EiJ m 46.65 18.4185208984 82.8095897048 10.4904102952


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 98.3207792208 10.9066473394 119.7329162226 76.908642219
C57BL/6J both 91.7538461538 8.8479712418 109.1243511792 74.3833411285
CAST/EiJ both 100.8333333333 18.4185208984 136.9929230381 64.6737436285
J:DO both 73.1943132243 1.8097438624 76.7472367134 69.6413897352
NOD/ShiLtJ both 75.2931623932 9.781800255 94.4969782558 56.0893465305
NZO/HlLtJ both 85.228030303 9.416235965 103.7141634153 66.7418971907
PWK/PhJ both 122.395 10.0882393719 142.2004229514 102.5895770486
WSB/EiJ both 45.0416666667 15.9509069981 76.3567899414 13.7265433919




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA